Dysregulated mesenchymal PDGFR-β drives kidney fibrosis

Kidney fibrosis is characterised by growth and activation of platelet-derived development issue receptor-β (PDGFR-β)-positive mesenchymal cells. To review the implications of PDGFR-β activation, we developed a mannequin of major renal fibrosis utilizing transgenic mice with PDGFR-β activation particularly in renal mesenchymal cells, driving their pathological proliferation and phenotypic change towards myofibroblasts.
This resulted in progressive mesangioproliferative glomerulonephritis, mesangial sclerosis, and interstitial fibrosis with progressive anemia as a consequence of lack of erythropoietin manufacturing by fibroblasts.
Fibrosis induced secondary tubular epithelial harm at later levels, coinciding with microinflammation, and aggravated the development of hypertensive and obstructive nephropathy.

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

Inhibition of PDGFR activation reversed fibrosis extra successfully within the tubulointerstitium in comparison with glomeruli. Gene expression signatures in mice with PDGFR-β activation resembled these present in sufferers.
In conclusion, PDGFR-β activation alone is ample to induce progressive renal fibrosis and failure, mimicking key facets of continual kidney illness in people. Our information present direct proof that fibrosis per se can drive continual organ harm and set up a mannequin of major fibrosis permitting particular research focusing on fibrosis development and regression.

 

 

AFC1 Compound Attenuated MI/R-Induced Ventricular Transforming through Inhibiting PDGFR and STAT Pathway.

 

Background: Efficient interventions to enhance the result of sufferers subjected to myocardial ischemia reperfusion (MI/R) are pressing in medical settings. Tanshinone IIA (TSA) is reported to attenuate myocardial harm and enhance ventricular reworking publish MI/R. Right here, we evaluated the efficacy of AFC1 compound that’s much like TSA construction in murine MI/R fashions.

 

PDGF-BB (P.pastoris-expressed), Human

 

We discovered that AFC1 had a comparable impact of enhancing murine cardiac perform after MI/R whereas it was superior to TSA in security profile. Administration of AFC1 diminished reactive oxygen species (ROS) manufacturing, inflammatory cells infiltration, and the expression of platelet derived development issue receptors (PDGFR) in infarcted myocardium.

 

Remedy with AFC1 additionally attenuated MI/R-induced cardiac reworking and contributed to the restoration of cardiac perform. Moreover, AFC1 reversed the elevation of PDGFR expression induced by PDGF-AB in each neonatal rat cardiomyocytes (NCMs) and neonatal rat cardiac fibroblasts (NCFs) and suppressed PDGF-AB induced NCM hypertrophy through STAT3 pathway and NCF collagen synthesis by means of p38-MAPK signaling in vitro. Equally, AFC1 could contribute to the restoration of cardiac perform in mice publish MI/R through suppressing STAT signaling.

Our outcomes confirmed that AFC1 exerts anti-hypertrophic and anti-fibrotic results towards MI/R-induced cardiac reworking, and counsel that AFC1 could have a promising potential in enhancing the result of sufferers who suffered from MI/R.

Human Complement Factor Bb (CFB-Bb) Antibody

 

 

PDGF-BB/ Rat PDGF- BB ELISA Kit
ELA-E0633r 96 Tests
EUR 1063.2

Polyclonal PDGF-BB Antibody
APR00412G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

Polyclonal PDGF-BB Antibody
APR08990G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

PDGF BB protein
30R-2611 10 ug
EUR 430.8
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein
30R-2612 10 ug
EUR 362.4
Description: Purified recombinant Mouse PDGF BB protein

PDGF BB protein
30R-AP004 2 ug
EUR 159.6
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein
30R-AP051 10 ug
EUR 327.6
Description: Purified recombinant Human PDGF BB protein

rHu PDGF-BB
AK8292-0002 2µg Ask for price

rHu PDGF-BB
AK8292-0010 10µg Ask for price

rHu PDGF-BB
AK8292-0100 100µg Ask for price

rHu PDGF-BB
AK8292-1000 1mg Ask for price

PDGF-BB, Human
HY-P7055 10ug
EUR 321.6

PDGF-BB, Mouse
HY-P7087 100ug
EUR 1135.2

PDGF-BB, Rat
HY-P7278 50ug
EUR 459.6

PDGF-BB, CF
PR15026CF 50 ug
EUR 1304.4

PDGF-BB, CF
PR15027CF 50 ug
EUR 475.2

PDGF-BB, human
RC216-21 2ug
EUR 125.26

anti-PDGF BB
YF-PA24331 50 ul
EUR 400.8
Description: Mouse polyclonal to PDGF BB

anti-PDGF BB
YF-PA13686 50 ug
EUR 435.6
Description: Mouse polyclonal to PDGF BB

PDGF-BB, human recombinant
4488-10
EUR 398.4

PDGF-BB, human recombinant
4488-1000
EUR 8346

PDGF-BB, human recombinant
4488-50
EUR 1123.2

PDGF-BB, murine recombinant
4489-10
EUR 320.4

PDGF-BB, murine recombinant
4489-1000
EUR 6434.4

PDGF-BB, murine recombinant
4489-50
EUR 874.8

PDGF-BB Recombinant Protein
40-158-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-158-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-607 0.01 mg
EUR 481.2
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet a-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-a and PDGFR-β. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). .

PDGF-BB Recombinant Protein
40-458-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-458-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
11-380 0.05 mg
EUR 714.3
Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

PDGF-BB Recombinant Protein
91-179 0.05 mg
EUR 821.4
Description: Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.

Human PDGF-BB Protein
abx060208-100ug 100 ug
EUR 627.6

Human PDGF-BB Protein
abx060258-100ug 100 ug
EUR 627.6

rec PDGF BB (human)
H-7530.0002 2.0µg
EUR 194.4

rec PDGF BB (human)
H-7530.0010 10.0µg
EUR 457.2

Recombinant Human PDGF-BB
SJA04-01 10µg/vial
EUR 307.2

Polyclonal PDGF-BB Antibody (aa21-70)
APR08991G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB (aa21-70). This antibody is tested and proven to work in the following applications:

Polyclonal PDGF-BB Antibody (C-Terminus)
APR08992G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PDGF-BB (C-Terminus). This antibody is tested and proven to work in the following applications:

Porcine PDGF-BB ELISA Kit
EPP0050 96Tests
EUR 625.2

Porcine PDGF-BB ELISA Kit
EPP0634 96Tests
EUR 625.2

Rabbit PDGF-BB ELISA Kit
ERTP0050 96Tests
EUR 625.2

Rabbit PDGF-BB ELISA Kit
ERTP0634 96Tests
EUR 625.2

Rat PDGF-BB ELISA Kit
ERP0050 96Tests
EUR 625.2

Rat PDGF-BB ELISA Kit
ERP0634 96Tests
EUR 625.2

Goat PDGF-BB ELISA Kit
EGTP0050 96Tests
EUR 625.2

Goat PDGF-BB ELISA Kit
EGTP0634 96Tests
EUR 625.2

Monkey PDGF-BB ELISA Kit
EMKP0050 96Tests
EUR 625.2

Mouse PDGF-BB ELISA Kit
EMP0050 96Tests
EUR 625.2

Mouse PDGF-BB ELISA Kit
EMP0634 96Tests
EUR 625.2

PDGF-BB, human recombinant protein
P1047-.01 10 µg
EUR 375.6
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein
P1047-.05 50 µg
EUR 1052.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein
P1047-1 1 mg
EUR 7826.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein
P1048-.01 10 µg
EUR 375.6
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein
P1048-.05 50 µg
EUR 1052.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein
P1048-1 1 mg
EUR 7826.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

Human PDGF-BB ELISA Kit
EHP0050 96Tests
EUR 625.2

Human PDGF-BB ELISA Kit
EHP0634 96Tests
EUR 625.2

Bovine PDGF-BB ELISA Kit
EBP0050 96Tests
EUR 625.2

Bovine PDGF-BB ELISA Kit
EBP0634 96Tests
EUR 625.2

Chicken PDGF-BB ELISA Kit
ECKP0050 96Tests
EUR 625.2

Canine PDGF-BB ELISA Kit
ECP0050 96Tests
EUR 625.2

Canine PDGF-BB ELISA Kit
ECP0634 96Tests
EUR 625.2

Anserini PDGF-BB ELISA Kit
EAP0634 96Tests
EUR 625.2

PDGF-BB ELISA KIT|Human
EF000205 96 Tests
EUR 826.8

Sheep PDGF-BB ELISA Kit
ESP0050 96Tests
EUR 625.2

PDGF-BB (P.pastoris-expressed), Human
HY-P7055A 10ug
EUR 321.6

Recombinant Human PDGF-BB Protein
PROTP01127-4 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Murine PDGF-BB Protein
PROTP31240-1 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Human PDGF-BB Protein
RP00834 10 μg
EUR 265.2

Human PDGF-BB ELISA Kit
RK04112 96 Tests
EUR 625.2

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Genorise® Chicken PDGF-BB Polyclonal Antibody
GR128034 100 µg
EUR 477.6

Genorise® Sheep PDGF-BB Polyclonal Antibody
GR130039 100 µg
EUR 477.6

Genorise® Mouse PDGF-BB Polyclonal Antibody
GR131039 100 µg
EUR 477.6

Genorise® Rat PDGF-BB Polyclonal Antibody
GR132039 100 µg
EUR 477.6

Genorise® Hamster PDGF-BB Polyclonal Antibody
GR208039 100 µg
EUR 477.6

Genorise® Feline PDGF-BB Polyclonal Antibody
GR195039 100 µg
EUR 477.6

 

Cadherin-11 binds to PDGFRβ and enhances cell proliferation and tissue regeneration through the PDGFR-AKT signaling axis.

 

 

Intercellular adhesion by means of homotypic interplay between cadherins regulates a number of mobile processes together with cytoskeletal group, proliferation, and survival. On this paper, we offer proof that cadherin-11 (CDH11) binds to and promotes cell proliferation each in vitro and in vivo in synergy with the platelet-derived development issue receptor beta (PDGFRβ).
Engagement of CDH11 elevated the sensitivity of cells to PDGF-BB by 10- to 100-fold, leading to fast and sustained phosphorylation of AKT, finally selling and cell proliferation and tissue regeneration.
Certainly, wound therapeutic experiments confirmed that therapeutic was severely compromised in Cdh11-/- mice, as evidenced by considerably decreased proliferation, AKT phosphorylation, and extracellular matrix (ECM) synthesis of dermal cells.

Human Glycogen phosphorylase BB,GP-BB ELISA Kit

Our outcomes shed gentle into understanding how intercellular adhesion can promote cell proliferation and will have implications for tissue regeneration and most cancers development.

 

anti-PDGF AA
YF-PA13683 100 ul
EUR 483.6
Description: Rabbit polyclonal to PDGF AA

anti-PDGF AA
YF-PA13684 100 ug
EUR 483.6
Description: Rabbit polyclonal to PDGF AA

anti-PDGF BB
YF-PA13686 50 ug
EUR 435.6
Description: Mouse polyclonal to PDGF BB

Genorise® Biotinylated Hamster PDGF Polyclonal Antibody
GR209037 100 µg
EUR 477.6

Genorise® Biotinylated Bovine PDGF polyclonal antibody
GR134004 50 µg
EUR 477.6

Genorise® Biotinylated Feline PDGF Polyclonal Antibody
GR196037 100 µg
EUR 477.6

Anti-PDGF-D Antibody
A01875 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for PDGF-D Antibody (PDGFD) detection. Tested for IHC, WB, ELISA in Human.

Anti-PDGF-C Antibody
A03092 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for PDGF-C Antibody (PDGFC) detection.tested for IHC in Human, Mouse, Rat.

Anti-PDGF-A antibody
STJ94995 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGF-A.

Anti-PDGF-B antibody
STJ94996 200 µl
EUR 236.4
Description: PDGF-B a protein encoded by the PDGFB gene which is approximately 27,2 kDa. PDGF-B is secreted into the extracellular space. It is involved in RET signalling, apoptotic pathways, GAB1 signalosome and the GPCR pathway. It is a growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. It is required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. It also plays an important role in wound healing. PDGF-B is expressed at high levels in the heart, brain, placenta and foetal kidney. Mutations in the PDGFB gene may result in basal ganglia calcification and familial meningioma. STJ94996 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of PDGF-B protein.

Anti-PDGF-D antibody
STJ96664 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGF-D.

Anti-PDGF-C antibody
STJ98770 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGF-C.

Anti-PDGF alpha antibody
STJ97793 200 µl
EUR 236.4
Description: PDGFRalpha is a protein encoded by the PDGFRA gene which is approximately 122,6 kDa. PDGFRalpha is localised to the cell membrane. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts and the GPCR pathway. It is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. It either promotes or inhibits cell proliferation and cell migration and plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. PDGFRalpha is widely expressed in the body including platelets, brain and colon. Mutations in the PDGFRA gene may result in gastrointestinal stromal tumor. STJ97793 was developed from clone 7A3 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of PDGFRalpha.

Anti-PDGF alpha antibody
STJ97794 200 µl
EUR 236.4
Description: Mouse monoclonal to PDGFRalpha.

anti-PDGF Receptor alpha
YF-PA13687 50 ug
EUR 435.6
Description: Mouse polyclonal to PDGF Receptor alpha

anti-PDGF Receptor alpha
YF-PA13688 100 ug
EUR 483.6
Description: Rabbit polyclonal to PDGF Receptor alpha

anti-PDGF Receptor beta
YF-PA13689 50 ug
EUR 435.6
Description: Mouse polyclonal to PDGF Receptor beta

anti-PDGF Receptor beta
YF-PA13690 100 ug
EUR 483.6
Description: Rabbit polyclonal to PDGF Receptor beta

Genorise® Biotinylated Hamster PDGF-AA Polyclonal Antibody
GR209038 100 µg
EUR 477.6

Genorise® Biotinylated Hamster PDGF-BB Polyclonal Antibody
GR209039 100 µg
EUR 477.6

Genorise® Biotinylated Bovine PDGF-AA polyclonal antibody
GR134005 50 µg
EUR 477.6

Genorise® Biotinylated Bovine PDGF-BB polyclonal antibody
GR134006 50 µg
EUR 477.6

Genorise® Biotinylated Feline PDGF-AA Polyclonal Antibody
GR196038 100 µg
EUR 477.6

Genorise® Biotinylated Feline PDGF-BB Polyclonal Antibody
GR196039 100 µg
EUR 477.6

Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 336

PDGF-BB, Human
HY-P7055 10ug
EUR 321.6

PDGF, CF Human
PR15024CF 5 ug
EUR 1743.6

PDGF - A Human
PR27059 5 ug
EUR 229.2

PDGF - B Human
PR27060 5 ug
EUR 229.2

PDGF - AA Human
PR27061 2 ug
EUR 229.2

PDGF - AB Human
PR27062 2 ug
EUR 229.2

PDGF-BB, human
RC216-21 2ug
EUR 125.26

Anti-PDGF beta/PDGFB Antibody
A00348 100ug/vial
EUR 352.8

Anti-PDGF beta/PDGFB Antibody
PB9311 100ug/vial
EUR 352.8

Anti-PDGF Receptor beta (4C12)
YF-MA14651 100 ug
EUR 435.6
Description: Mouse monoclonal to PDGF Receptor beta

PDGF/ Rat PDGF ELISA Kit
ELA-E0528r 96 Tests
EUR 1063.2

PDGF antibody
20R-PG003 1 mg
EUR 1003.2
Description: Goat polyclonal PDGF antibody

PDGF BB
LF-PR012 10 ug
EUR 280.8
Description: PDGF BB protein

PDGF AA
LF-PR026 10 ug
EUR 252
Description: PDGF AA protein

PDGF-BB
E21-199 10ug
EUR 411.6

PDGF-C
GT15151 100 ug
EUR 631.2

PDGF Antagonist
H-8650.0001 1.0mg
EUR 428.4
Description: Sum Formula: C77H122N20O17; CAS# [143784-00-3]

PDGF Antagonist
H-8650.0005 5.0mg
EUR 1603.2
Description: Sum Formula: C77H122N20O17; CAS# [143784-00-3]

PDGF-BB
PR15027 50 ug
EUR 475.2

Human PDGF ELISA Kit
EHP0040 96Tests
EUR 625.2

PDGF-CC, human recombinant
7183-10
EUR 248.4

PDGF-CC, human recombinant
7183-50
EUR 810

PDGF-AA, human recombinant
4482-10
EUR 398.4

PDGF-AA, human recombinant
4482-1000
EUR 8346

PDGF-AA, human recombinant
4482-50
EUR 1123.2

PDGF-AB, human recombinant
4485-10
EUR 398.4

PDGF-AB, human recombinant
4485-1000
EUR 8346

PDGF-AB, human recombinant
4485-50
EUR 1123.2

PDGF-BB, human recombinant
4488-10
EUR 398.4

PDGF-BB, human recombinant
4488-1000
EUR 8346

PDGF-BB, human recombinant
4488-50
EUR 1123.2

Human PDGF-BB Protein
abx060208-100ug 100 ug
EUR 627.6

Human PDGF-BB Protein
abx060258-100ug 100 ug
EUR 627.6

rec PDGF BB (human)
H-7530.0002 2.0µg
EUR 194.4

rec PDGF BB (human)
H-7530.0010 10.0µg
EUR 457.2

rec PDGF AA (human)
H-7640.0002 2.0µg
EUR 194.4

rec PDGF AA (human)
H-7640.0010 10.0µg
EUR 457.2

PDGF ELISA KIT|Human
EF007049 96 Tests
EUR 826.8

Recombinant Human PDGF-BB
SJA04-01 10µg/vial
EUR 307.2

Anti-PDGF Receptor beta/PDGFRB Antibody
A00096-1 100ug/vial
EUR 400.8

Anti-PDGF Receptor alpha/PDGFRA Antibody
PA1678 100ug/vial
EUR 400.8

anti-PDGF Receptor β (Ab-752)
LF-PA20392 100 ul
EUR 400.8
Description: Rabbit polyclonal to PDGF Receptor β

anti-PDGF Receptor β (Phospho-Tyr751)
LF-PA20626 100 ul
EUR 424.8
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr751)

anti-PDGF Receptor β (Ab-751)
LF-PA20719 100 ul
EUR 400.8
Description: Rabbit polyclonal to PDGF Receptor β

anti-PDGF Receptor β (Phospho-Tyr579)
LF-PA0033 100 ul
EUR 400.8
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr579)

anti-PDGF Receptor β (Phospho-Tyr716)
LF-PA0035 100 ul
EUR 400.8
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr716)

anti-PDGF Receptor β (Phospho-Tyr740)
LF-PA0036 100 ul
EUR 400.8
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr740)

anti-PDGF Receptor β (Phospho-Tyr771)
LF-PA0038 100 ul
EUR 400.8
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr771)

anti-PDGF Receptor β (Phospho-Tyr857)
LF-PA0039 100 ul
EUR 400.8
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr857)

anti-PDGF Receptor β (Phospho-Tyr1009)
LF-PA0040 100 ul
EUR 400.8
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1009)

anti-PDGF Receptor β (Phospho-Tyr1021)
LF-PA0041 100 ul
EUR 400.8
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1021)

anti-PDGF Receptor β (Phospho-Tyr1021)
LF-PA0094 100 ul
EUR 400.8
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1021)

Anti-PDGF Receptor alpha/PDGFRA Antibody
PB9771 100ug/vial
EUR 400.8

Anti-PDGF Receptor alpha (2D2-1A11)
YF-MA14649 100 ug
EUR 435.6
Description: Mouse monoclonal to PDGF Receptor alpha

Anti-PDGF Receptor alpha (4H1-1C9)
YF-MA14650 100 ug
EUR 435.6
Description: Mouse monoclonal to PDGF Receptor alpha

PDGF-AB/ Rat PDGF- AB ELISA Kit
ELA-E0112r 96 Tests
EUR 1063.2

PDGF-BB/ Rat PDGF- BB ELISA Kit
ELA-E0633r 96 Tests
EUR 1063.2

Anti-PDGF Receptor Beta Antibody (Monoclonal, 42G12)
M00096 100ug/vial
EUR 476.4
Description: Mouse Monoclonal PDGF Receptor Beta Antibody (Monoclonal, 42G12). Validated in IHC, WB and tested in Mouse, Rat.

Anti-PDGF Receptor beta Rabbit Monoclonal Antibody
M00096-1 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal PDGF Receptor beta Antibody. Validated in IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

Genorise® Anti-Equine PDGF Polyclonal Antibody
GR105192 100 ug
EUR 525.6

Genorise® Anti-Canine PDGF Polyclonal Antibody
GR105196 100 ug
EUR 525.6

Human PDGF receptor ELISA kit
E01P0755-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human PDGF receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human PDGF receptor ELISA kit
E01P0755-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human PDGF receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human PDGF receptor ELISA kit
E01P0755-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human PDGF receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human PDGF-αR ELISA Kit
EHP0039 96Tests
EUR 625.2

Human PDGF-BB ELISA Kit
EHP0050 96Tests
EUR 625.2