Dysregulated mesenchymal PDGFR-β drives kidney fibrosis

Kidney fibrosis is characterised by growth and activation of platelet-derived development issue receptor-β (PDGFR-β)-positive mesenchymal cells. To review the implications of PDGFR-β activation, we developed a mannequin of major renal fibrosis utilizing transgenic mice with PDGFR-β activation particularly in renal mesenchymal cells, driving their pathological proliferation and phenotypic change towards myofibroblasts.
This resulted in progressive mesangioproliferative glomerulonephritis, mesangial sclerosis, and interstitial fibrosis with progressive anemia as a consequence of lack of erythropoietin manufacturing by fibroblasts.
Fibrosis induced secondary tubular epithelial harm at later levels, coinciding with microinflammation, and aggravated the development of hypertensive and obstructive nephropathy.

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

Inhibition of PDGFR activation reversed fibrosis extra successfully within the tubulointerstitium in comparison with glomeruli. Gene expression signatures in mice with PDGFR-β activation resembled these present in sufferers.
In conclusion, PDGFR-β activation alone is ample to induce progressive renal fibrosis and failure, mimicking key facets of continual kidney illness in people. Our information present direct proof that fibrosis per se can drive continual organ harm and set up a mannequin of major fibrosis permitting particular research focusing on fibrosis development and regression.

 

 

AFC1 Compound Attenuated MI/R-Induced Ventricular Transforming through Inhibiting PDGFR and STAT Pathway.

 

Background: Efficient interventions to enhance the result of sufferers subjected to myocardial ischemia reperfusion (MI/R) are pressing in medical settings. Tanshinone IIA (TSA) is reported to attenuate myocardial harm and enhance ventricular reworking publish MI/R. Right here, we evaluated the efficacy of AFC1 compound that’s much like TSA construction in murine MI/R fashions.

 

PDGF-BB (P.pastoris-expressed), Human

 

We discovered that AFC1 had a comparable impact of enhancing murine cardiac perform after MI/R whereas it was superior to TSA in security profile. Administration of AFC1 diminished reactive oxygen species (ROS) manufacturing, inflammatory cells infiltration, and the expression of platelet derived development issue receptors (PDGFR) in infarcted myocardium.

 

Remedy with AFC1 additionally attenuated MI/R-induced cardiac reworking and contributed to the restoration of cardiac perform. Moreover, AFC1 reversed the elevation of PDGFR expression induced by PDGF-AB in each neonatal rat cardiomyocytes (NCMs) and neonatal rat cardiac fibroblasts (NCFs) and suppressed PDGF-AB induced NCM hypertrophy through STAT3 pathway and NCF collagen synthesis by means of p38-MAPK signaling in vitro. Equally, AFC1 could contribute to the restoration of cardiac perform in mice publish MI/R through suppressing STAT signaling.

Our outcomes confirmed that AFC1 exerts anti-hypertrophic and anti-fibrotic results towards MI/R-induced cardiac reworking, and counsel that AFC1 could have a promising potential in enhancing the result of sufferers who suffered from MI/R.

Human Complement Factor Bb (CFB-Bb) Antibody

 

 

PDGF-BB/ Rat PDGF- BB ELISA Kit

ELA-E0633r 96 Tests
EUR 886

Polyclonal PDGF-BB Antibody

APR08990G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

Polyclonal PDGF-BB Antibody

APR00412G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

PDGF-BB, human

RC216-21 2ug
EUR 104.38

PDGF-BB, Human

HY-P7055 10ug
EUR 268

PDGF-BB, Mouse

HY-P7087 100ug
EUR 946

PDGF-BB, Rat

HY-P7278 50ug
EUR 383

PDGF-BB, CF

PR15026CF 50 ug
EUR 1087

PDGF-BB, CF

PR15027CF 50 ug
EUR 396

rHu PDGF-BB

AK8292-0002 2µg Ask for price

rHu PDGF-BB

AK8292-0010 10µg Ask for price

rHu PDGF-BB

AK8292-0100 100µg Ask for price

rHu PDGF-BB

AK8292-1000 1mg Ask for price

PDGF BB protein

30R-2611 10 ug
EUR 359
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein

30R-2612 10 ug
EUR 302
Description: Purified recombinant Mouse PDGF BB protein

PDGF BB protein

30R-AP004 2 ug
EUR 133
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein

30R-AP051 10 ug
EUR 273
Description: Purified recombinant Human PDGF BB protein

anti-PDGF BB

YF-PA13686 50 ug
EUR 363
Description: Mouse polyclonal to PDGF BB

anti-PDGF BB

YF-PA24331 50 ul
EUR 334
Description: Mouse polyclonal to PDGF BB

Human PDGF-BB Protein

abx060208-100ug 100 ug
EUR 523

Human PDGF-BB Protein

abx060258-100ug 100 ug
EUR 523

rec PDGF BB (human)

H-7530.0002 2.0µg
EUR 162

rec PDGF BB (human)

H-7530.0010 10.0µg
EUR 381

PDGF-BB Recombinant Protein

11-380 0.05 mg
EUR 595.25
Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

PDGF-BB Recombinant Protein

40-607 0.01 mg
EUR 401
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet a-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-a and PDGFR-β. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). .

PDGF-BB Recombinant Protein

40-158-0002mg 0.002 mg
EUR 259.25
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein

40-158-001mg 0.01 mg
EUR 364.25
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein

40-458-0002mg 0.002 mg
EUR 259.25
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein

40-458-001mg 0.01 mg
EUR 364.25
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Human PDGF-BB

SJA04-01 10µg/vial
EUR 256

PDGF-BB, human recombinant

4488-10
EUR 332

PDGF-BB, human recombinant

4488-1000
EUR 6955

PDGF-BB, human recombinant

4488-50
EUR 936

PDGF-BB, murine recombinant

4489-10
EUR 267

PDGF-BB, murine recombinant

4489-1000
EUR 5362

PDGF-BB, murine recombinant

4489-50
EUR 729

PDGF-BB Recombinant Protein

91-179 0.05 mg
EUR 684.5
Description: Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.

Polyclonal PDGF-BB Antibody (aa21-70)

APR08991G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB (aa21-70). This antibody is tested and proven to work in the following applications:

Polyclonal PDGF-BB Antibody (C-Terminus)

APR08992G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PDGF-BB (C-Terminus). This antibody is tested and proven to work in the following applications:

Human PDGF-BB ELISA Kit

RK04112 96 Tests
EUR 521

Recombinant Human PDGF-BB Protein

RP00834 10 μg
EUR 221

Sheep PDGF-BB ELISA Kit

ESP0050 96Tests
EUR 521

Recombinant Human PDGF-BB Protein

PROTP01127-4 10ug
EUR 317
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Murine PDGF-BB Protein

PROTP31240-1 10ug
EUR 317
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB (P.pastoris-expressed), Human

HY-P7055A 10ug
EUR 268

Anserini PDGF-BB ELISA Kit

EAP0634 96Tests
EUR 521

Rat PDGF-BB ELISA Kit

ERP0050 96Tests
EUR 521

Rat PDGF-BB ELISA Kit

ERP0634 96Tests
EUR 521

Rabbit PDGF-BB ELISA Kit

ERTP0050 96Tests
EUR 521

Rabbit PDGF-BB ELISA Kit

ERTP0634 96Tests
EUR 521

Monkey PDGF-BB ELISA Kit

EMKP0050 96Tests
EUR 521

Mouse PDGF-BB ELISA Kit

EMP0050 96Tests
EUR 521

Mouse PDGF-BB ELISA Kit

EMP0634 96Tests
EUR 521

Porcine PDGF-BB ELISA Kit

EPP0050 96Tests
EUR 521

Porcine PDGF-BB ELISA Kit

EPP0634 96Tests
EUR 521

Human PDGF-BB ELISA Kit

EHP0050 96Tests
EUR 521

Human PDGF-BB ELISA Kit

EHP0634 96Tests
EUR 521

Chicken PDGF-BB ELISA Kit

ECKP0050 96Tests
EUR 521

Canine PDGF-BB ELISA Kit

ECP0050 96Tests
EUR 521

Canine PDGF-BB ELISA Kit

ECP0634 96Tests
EUR 521

Bovine PDGF-BB ELISA Kit

EBP0050 96Tests
EUR 521

Bovine PDGF-BB ELISA Kit

EBP0634 96Tests
EUR 521

Goat PDGF-BB ELISA Kit

EGTP0050 96Tests
EUR 521

Goat PDGF-BB ELISA Kit

EGTP0634 96Tests
EUR 521

PDGF-BB, human recombinant protein

P1047-.01 10 µg
EUR 313
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein

P1047-.05 50 µg
EUR 877
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein

P1047-1 1 mg
EUR 6522
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein

P1048-.01 10 µg
EUR 313
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein

P1048-.05 50 µg
EUR 877
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein

P1048-1 1 mg
EUR 6522
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

rHu PDGF-BB (yeast) (cGMP)

AK8274-1000 1mg Ask for price

PDGF-BB ELISA KIT|Human

EF000205 96 Tests
EUR 689

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-10ug 10ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-50ug 50ug
EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Genorise® Chicken PDGF-BB Polyclonal Antibody

GR128034 100 µg
EUR 398

Genorise® Sheep PDGF-BB Polyclonal Antibody

GR130039 100 µg
EUR 398

Genorise® Mouse PDGF-BB Polyclonal Antibody

GR131039 100 µg
EUR 398

Genorise® Rat PDGF-BB Polyclonal Antibody

GR132039 100 µg
EUR 398

Genorise® Feline PDGF-BB Polyclonal Antibody

GR195039 100 µg
EUR 398

 

Cadherin-11 binds to PDGFRβ and enhances cell proliferation and tissue regeneration through the PDGFR-AKT signaling axis.

 

 

Intercellular adhesion by means of homotypic interplay between cadherins regulates a number of mobile processes together with cytoskeletal group, proliferation, and survival. On this paper, we offer proof that cadherin-11 (CDH11) binds to and promotes cell proliferation each in vitro and in vivo in synergy with the platelet-derived development issue receptor beta (PDGFRβ).
Engagement of CDH11 elevated the sensitivity of cells to PDGF-BB by 10- to 100-fold, leading to fast and sustained phosphorylation of AKT, finally selling and cell proliferation and tissue regeneration.
Certainly, wound therapeutic experiments confirmed that therapeutic was severely compromised in Cdh11-/- mice, as evidenced by considerably decreased proliferation, AKT phosphorylation, and extracellular matrix (ECM) synthesis of dermal cells.

Human Glycogen phosphorylase BB,GP-BB ELISA Kit

Our outcomes shed gentle into understanding how intercellular adhesion can promote cell proliferation and will have implications for tissue regeneration and most cancers development.

 

anti-PDGF BB

YF-PA13686 50 ug
EUR 363
Description: Mouse polyclonal to PDGF BB

anti-PDGF AA

YF-PA24330 50 ul
EUR 334
Description: Mouse polyclonal to PDGF AA

anti-PDGF BB

YF-PA24331 50 ul
EUR 334
Description: Mouse polyclonal to PDGF BB

Genorise® Biotinylated Bovine PDGF polyclonal antibody

GR134004 50 µg
EUR 398

Genorise® Biotinylated Feline PDGF Polyclonal Antibody

GR196037 100 µg
EUR 398

Genorise® Biotinylated Hamster PDGF Polyclonal Antibody

GR209037 100 µg
EUR 398

Anti-PDGF-D Antibody

A01875 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for PDGF-D Antibody (PDGFD) detection. Tested for IHC, WB, ELISA in Human.

Anti-PDGF-C Antibody

A03092 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for PDGF-C Antibody (PDGFC) detection.tested for IHC in Human, Mouse, Rat.

Anti-PDGF-D antibody

STJ96664 200 µl
EUR 197
Description: Rabbit polyclonal to PDGF-D.

Anti-PDGF alpha antibody

STJ97793 200 µl
EUR 197
Description: PDGFRalpha is a protein encoded by the PDGFRA gene which is approximately 122,6 kDa. PDGFRalpha is localised to the cell membrane. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts and the GPCR pathway. It is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. It either promotes or inhibits cell proliferation and cell migration and plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. PDGFRalpha is widely expressed in the body including platelets, brain and colon. Mutations in the PDGFRA gene may result in gastrointestinal stromal tumor. STJ97793 was developed from clone 7A3 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of PDGFRalpha.

Anti-PDGF alpha antibody

STJ97794 200 µl
EUR 197
Description: Mouse monoclonal to PDGFRalpha.

Anti-PDGF-C antibody

STJ98770 200 µl
EUR 197
Description: Rabbit polyclonal to PDGF-C.

Anti-PDGF-A antibody

STJ94995 200 µl
EUR 197
Description: Rabbit polyclonal to PDGF-A.

Anti-PDGF-B antibody

STJ94996 200 µl
EUR 197
Description: PDGF-B a protein encoded by the PDGFB gene which is approximately 27,2 kDa. PDGF-B is secreted into the extracellular space. It is involved in RET signalling, apoptotic pathways, GAB1 signalosome and the GPCR pathway. It is a growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. It is required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. It also plays an important role in wound healing. PDGF-B is expressed at high levels in the heart, brain, placenta and foetal kidney. Mutations in the PDGFB gene may result in basal ganglia calcification and familial meningioma. STJ94996 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of PDGF-B protein.

anti-PDGF Receptor alpha

YF-PA13687 50 ug
EUR 363
Description: Mouse polyclonal to PDGF Receptor alpha

anti-PDGF Receptor alpha

YF-PA13688 100 ug
EUR 403
Description: Rabbit polyclonal to PDGF Receptor alpha

anti-PDGF Receptor beta

YF-PA13689 50 ug
EUR 363
Description: Mouse polyclonal to PDGF Receptor beta

anti-PDGF Receptor beta

YF-PA13690 100 ug
EUR 403
Description: Rabbit polyclonal to PDGF Receptor beta

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Genorise® Biotinylated Bovine PDGF-AA polyclonal antibody

GR134005 50 µg
EUR 398

Genorise® Biotinylated Bovine PDGF-BB polyclonal antibody

GR134006 50 µg
EUR 398

Genorise® Biotinylated Feline PDGF-AA Polyclonal Antibody

GR196038 100 µg
EUR 398

Genorise® Biotinylated Feline PDGF-BB Polyclonal Antibody

GR196039 100 µg
EUR 398

Genorise® Biotinylated Hamster PDGF-AA Polyclonal Antibody

GR209038 100 µg
EUR 398

Genorise® Biotinylated Hamster PDGF-BB Polyclonal Antibody

GR209039 100 µg
EUR 398

Anti-PDGF beta/PDGFB Antibody

PB9311 100ug/vial
EUR 294

Anti-PDGF beta/PDGFB Antibody

A00348 100ug/vial
EUR 294

Anti-PDGF Receptor beta (4C12)

YF-MA14651 100 ug
EUR 363
Description: Mouse monoclonal to PDGF Receptor beta

PDGF-BB, human

RC216-21 2ug
EUR 104.38

PDGF-BB, Human

HY-P7055 10ug
EUR 268

PDGF, CF Human

PR15024CF 5 ug
EUR 1453

PDGF - A Human

PR27059 5 ug
EUR 191

PDGF - B Human

PR27060 5 ug
EUR 191

PDGF - AA Human

PR27061 2 ug
EUR 191

PDGF - AB Human

PR27062 2 ug
EUR 191

PDGF/ Rat PDGF ELISA Kit

ELA-E0528r 96 Tests
EUR 886

Anti-PDGF Receptor alpha/PDGFRA Antibody

PA1678 100ug/vial
EUR 334

Anti-PDGF Receptor alpha/PDGFRA Antibody

PB9771 100ug/vial
EUR 334

Anti-PDGF Receptor beta/PDGFRB Antibody

A00096-1 100ug/vial
EUR 334

anti-PDGF Receptor β (Phospho-Tyr579)

LF-PA0033 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr579)

anti-PDGF Receptor β (Phospho-Tyr716)

LF-PA0035 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr716)

anti-PDGF Receptor β (Phospho-Tyr740)

LF-PA0036 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr740)

anti-PDGF Receptor β (Phospho-Tyr771)

LF-PA0038 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr771)

anti-PDGF Receptor β (Phospho-Tyr857)

LF-PA0039 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr857)

anti-PDGF Receptor β (Phospho-Tyr1009)

LF-PA0040 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1009)

anti-PDGF Receptor β (Phospho-Tyr1021)

LF-PA0041 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1021)

anti-PDGF Receptor β (Phospho-Tyr1021)

LF-PA0094 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1021)

anti-PDGF Receptor β (Ab-752)

LF-PA20392 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β

anti-PDGF Receptor β (Phospho-Tyr751)

LF-PA20626 100 ul
EUR 354
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr751)

anti-PDGF Receptor β (Ab-751)

LF-PA20719 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β

Anti-PDGF Receptor alpha (2D2-1A11)

YF-MA14649 100 ug
EUR 363
Description: Mouse monoclonal to PDGF Receptor alpha

Anti-PDGF Receptor alpha (4H1-1C9)

YF-MA14650 100 ug
EUR 363
Description: Mouse monoclonal to PDGF Receptor alpha

PDGF-BB

E21-199 10ug
EUR 343

PDGF-BB

PR15027 50 ug
EUR 396

PDGF-C

GT15151 100 ug
EUR 526

PDGF Antagonist

H-8650.0001 1.0mg
EUR 357
Description: Sum Formula: C77H122N20O17; CAS# [143784-00-3]

PDGF Antagonist

H-8650.0005 5.0mg
EUR 1336
Description: Sum Formula: C77H122N20O17; CAS# [143784-00-3]

PDGF BB

LF-PR012 10 ug
EUR 234
Description: PDGF BB protein

PDGF AA

LF-PR026 10 ug
EUR 210
Description: PDGF AA protein

PDGF antibody

20R-PG003 1 mg
EUR 836
Description: Goat polyclonal PDGF antibody

Human PDGF ELISA Kit

EHP0040 96Tests
EUR 521

Human PDGF-BB Protein

abx060208-100ug 100 ug
EUR 523

Human PDGF-BB Protein

abx060258-100ug 100 ug
EUR 523

rec PDGF BB (human)

H-7530.0002 2.0µg
EUR 162

rec PDGF BB (human)

H-7530.0010 10.0µg
EUR 381

rec PDGF AA (human)

H-7640.0002 2.0µg
EUR 162

rec PDGF AA (human)

H-7640.0010 10.0µg
EUR 381

PDGF ELISA KIT|Human

EF007049 96 Tests
EUR 689

Recombinant Human PDGF-BB

SJA04-01 10µg/vial
EUR 256

PDGF-AA, human recombinant

4482-10
EUR 332

PDGF-AA, human recombinant

4482-1000
EUR 6955

PDGF-AA, human recombinant

4482-50
EUR 936

PDGF-AB, human recombinant

4485-10
EUR 332

PDGF-AB, human recombinant

4485-1000
EUR 6955

PDGF-AB, human recombinant

4485-50
EUR 936

PDGF-BB, human recombinant

4488-10
EUR 332

PDGF-BB, human recombinant

4488-1000
EUR 6955

PDGF-BB, human recombinant

4488-50
EUR 936

PDGF-CC, human recombinant

7183-10
EUR 207

PDGF-CC, human recombinant

7183-50
EUR 675

PDGF-AB/ Rat PDGF- AB ELISA Kit

ELA-E0112r 96 Tests
EUR 886

PDGF-BB/ Rat PDGF- BB ELISA Kit

ELA-E0633r 96 Tests
EUR 886

Anti-PDGF Receptor Beta Antibody (Monoclonal, 42G12)

M00096 100ug/vial
EUR 397
Description: Mouse Monoclonal PDGF Receptor Beta Antibody (Monoclonal, 42G12). Validated in IHC, WB and tested in Mouse, Rat.

Anti-PDGF Receptor beta Rabbit Monoclonal Antibody

M00096-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal PDGF Receptor beta Antibody. Validated in IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

Genorise® Anti-Equine PDGF Polyclonal Antibody

GR105192 100 ug
EUR 438

Genorise® Anti-Canine PDGF Polyclonal Antibody

GR105196 100 ug
EUR 438

Rabbit anti-Human CD40 IgG, Biotinylated

CD4011-BTN 50 ug
EUR 518

Biotinylated Goat anti-Human Eotaxin antibody

60-5011 25 ug
EUR 300
Description: Purified Biotinylated Goat anti-Human Eotaxin polyclonal antibody

Anti-CHO Biotinylated Concentrate

F017B 1 mg
EUR 3145
Description: Anti-CHO Biotinylated Concentrate by Cygnus Technologies is available in Europe via Gentaur.

Anti-PON1 Biotinylated Antibody

A00516-Biotin 50ug/vial
EUR 294

Anti-FGF21 Biotinylated Antibody

A00802-Biotin 50ug/vial
EUR 294