Dysregulated mesenchymal PDGFR-β drives kidney fibrosis

Kidney fibrosis is characterised by growth and activation of platelet-derived development issue receptor-β (PDGFR-β)-positive mesenchymal cells. To review the implications of PDGFR-β activation, we developed a mannequin of major renal fibrosis utilizing transgenic mice with PDGFR-β activation particularly in renal mesenchymal cells, driving their pathological proliferation and phenotypic change towards myofibroblasts.
This resulted in progressive mesangioproliferative glomerulonephritis, mesangial sclerosis, and interstitial fibrosis with progressive anemia as a consequence of lack of erythropoietin manufacturing by fibroblasts.
Fibrosis induced secondary tubular epithelial harm at later levels, coinciding with microinflammation, and aggravated the development of hypertensive and obstructive nephropathy.

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

Inhibition of PDGFR activation reversed fibrosis extra successfully within the tubulointerstitium in comparison with glomeruli. Gene expression signatures in mice with PDGFR-β activation resembled these present in sufferers.
In conclusion, PDGFR-β activation alone is ample to induce progressive renal fibrosis and failure, mimicking key facets of continual kidney illness in people. Our information present direct proof that fibrosis per se can drive continual organ harm and set up a mannequin of major fibrosis permitting particular research focusing on fibrosis development and regression.

 

 

AFC1 Compound Attenuated MI/R-Induced Ventricular Transforming through Inhibiting PDGFR and STAT Pathway.

 

Background: Efficient interventions to enhance the result of sufferers subjected to myocardial ischemia reperfusion (MI/R) are pressing in medical settings. Tanshinone IIA (TSA) is reported to attenuate myocardial harm and enhance ventricular reworking publish MI/R. Right here, we evaluated the efficacy of AFC1 compound that’s much like TSA construction in murine MI/R fashions.

 

PDGF-BB (P.pastoris-expressed), Human

 

We discovered that AFC1 had a comparable impact of enhancing murine cardiac perform after MI/R whereas it was superior to TSA in security profile. Administration of AFC1 diminished reactive oxygen species (ROS) manufacturing, inflammatory cells infiltration, and the expression of platelet derived development issue receptors (PDGFR) in infarcted myocardium.

 

Remedy with AFC1 additionally attenuated MI/R-induced cardiac reworking and contributed to the restoration of cardiac perform. Moreover, AFC1 reversed the elevation of PDGFR expression induced by PDGF-AB in each neonatal rat cardiomyocytes (NCMs) and neonatal rat cardiac fibroblasts (NCFs) and suppressed PDGF-AB induced NCM hypertrophy through STAT3 pathway and NCF collagen synthesis by means of p38-MAPK signaling in vitro. Equally, AFC1 could contribute to the restoration of cardiac perform in mice publish MI/R through suppressing STAT signaling.

Our outcomes confirmed that AFC1 exerts anti-hypertrophic and anti-fibrotic results towards MI/R-induced cardiac reworking, and counsel that AFC1 could have a promising potential in enhancing the result of sufferers who suffered from MI/R.

Human Complement Factor Bb (CFB-Bb) Antibody

 

 

PDGF-BB/ Rat PDGF- BB ELISA Kit

ELA-E0633r 96 Tests
EUR 886

rHu PDGF-BB

AK8292-0002 2µg Ask for price

rHu PDGF-BB

AK8292-0010 10µg Ask for price

rHu PDGF-BB

AK8292-0100 100µg Ask for price

rHu PDGF-BB

AK8292-1000 1mg Ask for price

anti-PDGF BB

YF-PA13686 50 ug
EUR 363
Description: Mouse polyclonal to PDGF BB

anti-PDGF BB

YF-PA24331 50 ul
EUR 334
Description: Mouse polyclonal to PDGF BB

PDGF BB protein

30R-2611 10 ug
EUR 359
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein

30R-2612 10 ug
EUR 302
Description: Purified recombinant Mouse PDGF BB protein

PDGF BB protein

30R-AP004 2 ug
EUR 133
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein

30R-AP051 10 ug
EUR 273
Description: Purified recombinant Human PDGF BB protein

PDGF-BB, Human

HY-P7055 10ug
EUR 268

PDGF-BB, Mouse

HY-P7087 100ug
EUR 946

PDGF-BB, Rat

HY-P7278 50ug
EUR 383

PDGF-BB, human

RC216-21 2ug
EUR 104.38

PDGF-BB, CF

PR15026CF 50 ug
EUR 1087

PDGF-BB, CF

PR15027CF 50 ug
EUR 396

Polyclonal PDGF-BB Antibody

APR08990G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

Polyclonal PDGF-BB Antibody

APR00412G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

PDGF-BB, human recombinant

4488-10
EUR 332

PDGF-BB, human recombinant

4488-1000
EUR 6955

PDGF-BB, human recombinant

4488-50
EUR 936

PDGF-BB, murine recombinant

4489-10
EUR 267

PDGF-BB, murine recombinant

4489-1000
EUR 5362

PDGF-BB, murine recombinant

4489-50
EUR 729

Recombinant Human PDGF-BB

SJA04-01 10µg/vial
EUR 256

Human PDGF-BB Protein

abx060208-100ug 100 ug
EUR 523

Human PDGF-BB Protein

abx060258-100ug 100 ug
EUR 523

rec PDGF BB (human)

H-7530.0002 2.0µg
EUR 162

rec PDGF BB (human)

H-7530.0010 10.0µg
EUR 381

Polyclonal PDGF-BB Antibody (aa21-70)

APR08991G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB (aa21-70). This antibody is tested and proven to work in the following applications:

Polyclonal PDGF-BB Antibody (C-Terminus)

APR08992G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PDGF-BB (C-Terminus). This antibody is tested and proven to work in the following applications:

PDGF-BB ELISA KIT|Human

EF000205 96 Tests
EUR 689

rHu PDGF-BB (yeast) (cGMP)

AK8274-1000 1mg Ask for price

PDGF-BB (P.pastoris-expressed), Human

HY-P7055A 10ug
EUR 268

Sheep PDGF-BB ELISA Kit

ESP0050 96Tests
EUR 521

Rabbit PDGF-BB ELISA Kit

ERTP0634 96Tests
EUR 521

Monkey PDGF-BB ELISA Kit

EMKP0050 96Tests
EUR 521

Mouse PDGF-BB ELISA Kit

EMP0050 96Tests
EUR 521

Mouse PDGF-BB ELISA Kit

EMP0634 96Tests
EUR 521

Porcine PDGF-BB ELISA Kit

EPP0050 96Tests
EUR 521

Porcine PDGF-BB ELISA Kit

EPP0634 96Tests
EUR 521

Rat PDGF-BB ELISA Kit

ERP0050 96Tests
EUR 521

Rat PDGF-BB ELISA Kit

ERP0634 96Tests
EUR 521

Rabbit PDGF-BB ELISA Kit

ERTP0050 96Tests
EUR 521

Recombinant Human PDGF-BB Protein

PROTP01127-4 10ug
EUR 317
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Bovine PDGF-BB ELISA Kit

EBP0634 96Tests
EUR 521

Chicken PDGF-BB ELISA Kit

ECKP0050 96Tests
EUR 521

Canine PDGF-BB ELISA Kit

ECP0050 96Tests
EUR 521

Canine PDGF-BB ELISA Kit

ECP0634 96Tests
EUR 521

Human PDGF-BB ELISA Kit

EHP0050 96Tests
EUR 521

Human PDGF-BB ELISA Kit

EHP0634 96Tests
EUR 521

Anserini PDGF-BB ELISA Kit

EAP0634 96Tests
EUR 521

Bovine PDGF-BB ELISA Kit

EBP0050 96Tests
EUR 521

Goat PDGF-BB ELISA Kit

EGTP0050 96Tests
EUR 521

Goat PDGF-BB ELISA Kit

EGTP0634 96Tests
EUR 521

Human PDGF-BB ELISA Kit

RK04112 96 Tests
EUR 521

Recombinant Human PDGF-BB Protein

RP00834 10 μg
EUR 221

Recombinant Murine PDGF-BB Protein

PROTP31240-1 10ug
EUR 317
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB, human recombinant protein

P1047-.01 10 µg
EUR 313
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein

P1047-.05 50 µg
EUR 877
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein

P1047-1 1 mg
EUR 6522
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein

P1048-.01 10 µg
EUR 313
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein

P1048-.05 50 µg
EUR 877
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein

P1048-1 1 mg
EUR 6522
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-10ug 10ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-50ug 50ug
EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Human CellExp? PDGF-BB, human recombinant

7276-10
EUR 419

Human PDGF-BB PicoKine ELISA Kit

EK0956 96 wells
EUR 425
Description: For quantitative detection of human PDGF-BB in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Guinea Pig PDGF-BB ELISA Kit

EGP0050 96Tests
EUR 521

Guinea Pig PDGF-BB ELISA Kit

EGP0634 96Tests
EUR 521

Rat platelet-derived growth factor-BB,PDGF-BB ELISA Kit

CN-01428R1 96T
EUR 478

Rat platelet-derived growth factor-BB,PDGF-BB ELISA Kit

CN-01428R2 48T
EUR 329

Mouse platelet-derived growth factor-BB,PDGF-BB ELISA Kit

CN-02297M1 96T
EUR 492

Mouse platelet-derived growth factor-BB,PDGF-BB ELISA Kit

CN-02297M2 48T
EUR 341

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

CN-03344H1 96T
EUR 457

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

CN-03344H2 48T
EUR 306

Horse platelet-derived growth factor-BB(PDGF-BB) ELISA kit

CSB-EQ027241HO-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Horse platelet-derived growth factor-BB (PDGF-BB) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Horse platelet-derived growth factor-BB(PDGF-BB) ELISA kit

1-CSB-EQ027241HO
  • EUR 703.00
  • EUR 4843.00
  • EUR 2570.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Horse platelet-derived growth factor-BB(PDGF-BB) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

 

Cadherin-11 binds to PDGFRβ and enhances cell proliferation and tissue regeneration through the PDGFR-AKT signaling axis.

 

 

Intercellular adhesion by means of homotypic interplay between cadherins regulates a number of mobile processes together with cytoskeletal group, proliferation, and survival. On this paper, we offer proof that cadherin-11 (CDH11) binds to and promotes cell proliferation each in vitro and in vivo in synergy with the platelet-derived development issue receptor beta (PDGFRβ).
Engagement of CDH11 elevated the sensitivity of cells to PDGF-BB by 10- to 100-fold, leading to fast and sustained phosphorylation of AKT, finally selling and cell proliferation and tissue regeneration.
Certainly, wound therapeutic experiments confirmed that therapeutic was severely compromised in Cdh11-/- mice, as evidenced by considerably decreased proliferation, AKT phosphorylation, and extracellular matrix (ECM) synthesis of dermal cells.

Human Glycogen phosphorylase BB,GP-BB ELISA Kit

Our outcomes shed gentle into understanding how intercellular adhesion can promote cell proliferation and will have implications for tissue regeneration and most cancers development.

 

anti-PDGF BB

YF-PA13686 50 ug
EUR 363
Description: Mouse polyclonal to PDGF BB

anti-PDGF AA

YF-PA24330 50 ul
EUR 334
Description: Mouse polyclonal to PDGF AA

anti-PDGF BB

YF-PA24331 50 ul
EUR 334
Description: Mouse polyclonal to PDGF BB

anti-PDGF Receptor alpha

YF-PA13687 50 ug
EUR 363
Description: Mouse polyclonal to PDGF Receptor alpha

anti-PDGF Receptor alpha

YF-PA13688 100 ug
EUR 403
Description: Rabbit polyclonal to PDGF Receptor alpha

anti-PDGF Receptor beta

YF-PA13689 50 ug
EUR 363
Description: Mouse polyclonal to PDGF Receptor beta

anti-PDGF Receptor beta

YF-PA13690 100 ug
EUR 403
Description: Rabbit polyclonal to PDGF Receptor beta

Anti-PDGF-D Antibody

A01875 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for PDGF-D Antibody (PDGFD) detection. Tested for IHC, WB, ELISA in Human.

Anti-PDGF-C Antibody

A03092 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for PDGF-C Antibody (PDGFC) detection.tested for IHC in Human, Mouse, Rat.

Anti-PDGF-D antibody

STJ96664 200 µl
EUR 197
Description: Rabbit polyclonal to PDGF-D.

Anti-PDGF alpha antibody

STJ97793 200 µl
EUR 197
Description: PDGFRalpha is a protein encoded by the PDGFRA gene which is approximately 122,6 kDa. PDGFRalpha is localised to the cell membrane. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts and the GPCR pathway. It is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. It either promotes or inhibits cell proliferation and cell migration and plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. PDGFRalpha is widely expressed in the body including platelets, brain and colon. Mutations in the PDGFRA gene may result in gastrointestinal stromal tumor. STJ97793 was developed from clone 7A3 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of PDGFRalpha.

Anti-PDGF alpha antibody

STJ97794 200 µl
EUR 197
Description: Mouse monoclonal to PDGFRalpha.

Anti-PDGF-C antibody

STJ98770 200 µl
EUR 197
Description: Rabbit polyclonal to PDGF-C.

Anti-PDGF-A antibody

STJ94995 200 µl
EUR 197
Description: Rabbit polyclonal to PDGF-A.

Anti-PDGF-B antibody

STJ94996 200 µl
EUR 197
Description: PDGF-B a protein encoded by the PDGFB gene which is approximately 27,2 kDa. PDGF-B is secreted into the extracellular space. It is involved in RET signalling, apoptotic pathways, GAB1 signalosome and the GPCR pathway. It is a growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. It is required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. It also plays an important role in wound healing. PDGF-B is expressed at high levels in the heart, brain, placenta and foetal kidney. Mutations in the PDGFB gene may result in basal ganglia calcification and familial meningioma. STJ94996 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of PDGF-B protein.

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

PDGF, CF Human

PR15024CF 5 ug
EUR 1453

PDGF - A Human

PR27059 5 ug
EUR 191

PDGF - B Human

PR27060 5 ug
EUR 191

PDGF - AA Human

PR27061 2 ug
EUR 191

PDGF - AB Human

PR27062 2 ug
EUR 191

PDGF-BB, human

RC216-21 2ug
EUR 104.38

PDGF-BB, Human

HY-P7055 10ug
EUR 268

Anti-PDGF Receptor beta (4C12)

YF-MA14651 100 ug
EUR 363
Description: Mouse monoclonal to PDGF Receptor beta

Anti-PDGF beta/PDGFB Antibody

A00348 100ug/vial
EUR 294

Anti-PDGF beta/PDGFB Antibody

PB9311 100ug/vial
EUR 294

PDGF/ Rat PDGF ELISA Kit

ELA-E0528r 96 Tests
EUR 886

PDGF antibody

20R-PG003 1 mg
EUR 836
Description: Goat polyclonal PDGF antibody

PDGF BB

LF-PR012 10 ug
EUR 234
Description: PDGF BB protein

PDGF AA

LF-PR026 10 ug
EUR 210
Description: PDGF AA protein

PDGF-BB

PR15027 50 ug
EUR 396

PDGF-C

GT15151 100 ug
EUR 526

PDGF-BB

E21-199 10ug
EUR 343

PDGF Antagonist

H-8650.0001 1.0mg
EUR 357
Description: Sum Formula: C77H122N20O17; CAS# [143784-00-3]

PDGF Antagonist

H-8650.0005 5.0mg
EUR 1336
Description: Sum Formula: C77H122N20O17; CAS# [143784-00-3]

Anti-PDGF Receptor alpha (2D2-1A11)

YF-MA14649 100 ug
EUR 363
Description: Mouse monoclonal to PDGF Receptor alpha

Anti-PDGF Receptor alpha (4H1-1C9)

YF-MA14650 100 ug
EUR 363
Description: Mouse monoclonal to PDGF Receptor alpha

anti-PDGF Receptor β (Phospho-Tyr579)

LF-PA0033 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr579)

anti-PDGF Receptor β (Phospho-Tyr716)

LF-PA0035 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr716)

anti-PDGF Receptor β (Phospho-Tyr740)

LF-PA0036 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr740)

anti-PDGF Receptor β (Phospho-Tyr771)

LF-PA0038 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr771)

anti-PDGF Receptor β (Phospho-Tyr857)

LF-PA0039 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr857)

anti-PDGF Receptor β (Phospho-Tyr1009)

LF-PA0040 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1009)

anti-PDGF Receptor β (Phospho-Tyr1021)

LF-PA0041 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1021)

anti-PDGF Receptor β (Phospho-Tyr1021)

LF-PA0094 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1021)

anti-PDGF Receptor β (Ab-752)

LF-PA20392 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β

anti-PDGF Receptor β (Phospho-Tyr751)

LF-PA20626 100 ul
EUR 354
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr751)

anti-PDGF Receptor β (Ab-751)

LF-PA20719 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β

Anti-PDGF Receptor beta/PDGFRB Antibody

A00096-1 100ug/vial
EUR 334

Anti-PDGF Receptor alpha/PDGFRA Antibody

PA1678 100ug/vial
EUR 334

Anti-PDGF Receptor alpha/PDGFRA Antibody

PB9771 100ug/vial
EUR 334

PDGF-CC, human recombinant

7183-10
EUR 207

PDGF-CC, human recombinant

7183-50
EUR 675

PDGF ELISA KIT|Human

EF007049 96 Tests
EUR 689

PDGF-AA, human recombinant

4482-10
EUR 332

PDGF-AA, human recombinant

4482-1000
EUR 6955

PDGF-AA, human recombinant

4482-50
EUR 936

PDGF-AB, human recombinant

4485-10
EUR 332

PDGF-AB, human recombinant

4485-1000
EUR 6955

PDGF-AB, human recombinant

4485-50
EUR 936

PDGF-BB, human recombinant

4488-10
EUR 332

PDGF-BB, human recombinant

4488-1000
EUR 6955

PDGF-BB, human recombinant

4488-50
EUR 936

Recombinant Human PDGF-BB

SJA04-01 10µg/vial
EUR 256

Human PDGF-BB Protein

abx060208-100ug 100 ug
EUR 523

Human PDGF-BB Protein

abx060258-100ug 100 ug
EUR 523

Human PDGF ELISA Kit

EHP0040 96Tests
EUR 521

rec PDGF BB (human)

H-7530.0002 2.0µg
EUR 162

rec PDGF BB (human)

H-7530.0010 10.0µg
EUR 381

rec PDGF AA (human)

H-7640.0002 2.0µg
EUR 162

rec PDGF AA (human)

H-7640.0010 10.0µg
EUR 381

PDGF-AB/ Rat PDGF- AB ELISA Kit

ELA-E0112r 96 Tests
EUR 886

PDGF-BB/ Rat PDGF- BB ELISA Kit

ELA-E0633r 96 Tests
EUR 886

Anti-PDGF Receptor Beta Antibody (Monoclonal, 42G12)

M00096 100ug/vial
EUR 397
Description: Mouse Monoclonal PDGF Receptor Beta Antibody (Monoclonal, 42G12). Validated in IHC, WB and tested in Mouse, Rat.

Anti-PDGF Receptor beta Rabbit Monoclonal Antibody

M00096-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal PDGF Receptor beta Antibody. Validated in IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

PDGF-AB ELISA KIT|Human

EF000111 96 Tests
EUR 689

PDGF-BB ELISA KIT|Human

EF000205 96 Tests
EUR 689

PDGF-AA ELISA KIT|Human

EF007050 96 Tests
EUR 689

Human PDGF Signaling Primer Library

HPDGF-I 1 set
EUR 548

Human PDGF receptor ELISA kit

E01P0755-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Human PDGF receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human PDGF receptor ELISA kit

E01P0755-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Human PDGF receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human PDGF receptor ELISA kit

E01P0755-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Human PDGF receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human PDGF-AB ELISA kit

LF-EK50325 1×96T
EUR 648

Recombinant Human PDGF-CC Protein

PROTQ9NRA1-1 20ug
EUR 317
Description: The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules epithelial cell development. Mature PDGFs are stored in platelet α-granules and are released upon platelet activation. PDGF-AA, -AB, -BB and –CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor. Recombinant human PDGF-CC is a 25kDa protein consisting of two identical disulfide-linked 114 amino-acid polypeptide chains.

Human PDGF-BB ELISA Kit

RK04112 96 Tests
EUR 521

Recombinant Human PDGF-BB Protein

RP00834 10 μg
EUR 221

Recombinant Human PDGF-BB Protein

PROTP01127-4 10ug
EUR 317
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Human PDGF-AA Protein

PROTP04085-4 10ug
EUR 317
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids).

Recombinant Human PDGF-AB Protein

PROTP20033-2 10ug
EUR 317
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).

PDGF-BB (P.pastoris-expressed), Human

HY-P7055A 10ug
EUR 268

PDGF-CC (HEK293-expressed), Human

HY-P7279 10ug
EUR 223