Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells

 

Identifying effective anti-fibrotic therapies is a major clinical need that remains unmet. In the present study, roseotoxin B was shown to possess an improving effect on cholestatic liver fibrosis in bile duct-ligated mice, as proved by histochemical and immunohistochemical staining, hepatic biochemical parameters, and TUNEL apoptotic cell detection in tissue sections.

Using cellular thermal shift assay, computational molecular docking, microscale thermophoresis technology, and surface plasmon resonance biosensor, we confirmed that PDGFR-β was a direct target of roseotoxin B in fibrotic livers.

Platelet Derived Growth Factor C (PDGF-C) Antibody

Of note, human tissue microarrays detected pathologically high expression of p-PDGFR-β in liver samples of ~80% of patients with liver fibrosis and cirrhosis.
PDGF-B/PDGFR-β pathway promotes transdifferentiation and excessive proliferation of hepatic stellate cells (HSCs), which is a very crucial driver for liver fibrosis.
Meaningfully, roseotoxin B blocked the formation of PDGF-BB/PDGFR-ββ complex by targeting the D2 domain of PDGFR-β, thereby inhibiting the PDGF-B/PDGFR-β pathway in HSCs. In summary, our study provided roseotoxin B as a unique candidate agent for the treatment of liver fibrosis.

 

Activation PDGFR-α/AKT Mediated Signaling Pathways in Oral Squamous Cell Carcinoma by Mesenchymal Stem/Stromal Cells Promotes Anti-apoptosis and Decreased Sensitivity to Cisplatin.

 

 

Desmoplasia, a hallmark of a head and neck cancer, has both biologic and physiologic effects on cancer progression and chemotherapeutic response. Mesenchymal stem/stromal cells (MSCs), also known as mesenchymal stromal progenitor cells, have been shown to play a role in cancer progression, alter apoptotic responses, and confer resistance to chemotherapy in various carcinomas.

The pathophysiology of MSCs with respect to tumorigenesis is widely reported in other cancers and is sparsely reported in oral squamous cell carcinomas (OSCCs). We previously reported paracrine mediated PDGF-AA/PDGFR-α signaling to underlie MSCs chemotaxis in OSCC.

Mouse Anti-Hepatitis B Virus Core Antibody (HBcAb) ELISA Kit

Given the poor clinical response to primary chemotherapy, we hypothesized that MSCs may alter cancer cell sensitivity to cisplatin through activation of PDGFR-α mediated signaling pathways.
Co-culture of MSCs with human derived OSCC cell lines, JHU-012 and -019, resulted in a significant increase in the production of PDGF-AA and MCP-1 compared to cancer cells grown alone (p < 0.005) and was accompanied by an increase in the phosphorylation state of PDGFR-α (p < 0.02) and downstream target AKT at S473 (p < 0.025) and T308 (p < 0.02). JHU-012 and -019 cancer cells grown in co-culture were significantly less apoptotic (p < 0.001), expressed significantly higher levels of Bcl-2 (p < 0.04) with a concomitant significant decrease in bid expression (p < 0.001) compared to cancer cells grown alone.
There was a significant increase in the cisplatin dose response curve in cancer cell clones derived from JHU-012 and 019 cancer cells grown in co-culture with MSCs compared to clones derived from cancer cells grown alone (p < 0.001).
vegf-a
vegf-a
Moreover clones derived from JHU-012 cells grown in co-culture with MSCs were significantly more susceptible to cisplatin following pretreatment with, crenolanib, a PDGFR inhibitor, compared to cancer cells grown alone or in co-culture with MSCs (p < 0.0001).
These findings suggest that crosstalk between cancer cells and MSCs is mediated, at least in part, by activation of autocrine PDGF-AA/PDGFR-α loop driving AKT-mediated signaling pathways, resulting in reduced cancer cell sensitivity to cisplatin through alterations in apoptosis.

 

PDGF-B Polyclonal Antibody

ABP55531-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110

PDGF-B Polyclonal Antibody

ABP55531-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110

PDGF-B Polyclonal Antibody

ABP55531-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110

PDGF-B Recombinant Protein

96-936 0.05 mg
EUR 651.3
Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

Polyclonal PDGF-B Antibody

APR08989G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-B . This antibody is tested and proven to work in the following applications:

PDGF-B Polyclonal Antibody

ES6530-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGF-B from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

PDGF-B Polyclonal Antibody

ES6530-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGF-B from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

anti-PDGF AA

YF-PA24330 50 ul
EUR 400.8
Description: Mouse polyclonal to PDGF AA

anti-PDGF BB

YF-PA24331 50 ul
EUR 400.8
Description: Mouse polyclonal to PDGF BB

anti-PDGF AA

YF-PA13682 50 ug
EUR 435.6
Description: Mouse polyclonal to PDGF AA

anti-PDGF AA

YF-PA13683 100 ul
EUR 483.6
Description: Rabbit polyclonal to PDGF AA

anti-PDGF AA

YF-PA13684 100 ug
EUR 483.6
Description: Rabbit polyclonal to PDGF AA

anti-PDGF BB

YF-PA13686 50 ug
EUR 435.6
Description: Mouse polyclonal to PDGF BB

Genorise® Goat Anti-porcine PDGF-B polyclonal antibody

GR105219 100 ug
EUR 525.6

Human Platelet-Derived Growth Factor-B,PDGF-B ELISA kit

201-12-2119 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

PDGF-B Platelet-Derived Growth Factor B Human Recombinant Protein

PROTP01127-1 Regular: 20ug
EUR 380.4
Description: PDGF-B Human Recombinant mature chain produced in E.Coli is a non-glycosylated, polypeptide chain containing 109 amino acids fragment (82-190) and having a molecular mass of 16.75 kDa. The PDGF-B is fused with an amino-terminal hexahistidine tag and purified by proprietary chromatographic techniques.

Human Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit

QY-E00606 96T
EUR 480

Recombinant Human PDGF-B Protein, Untagged, E.coli-100ug

QP10398-ec-100ug 100ug
EUR 1522.8

Recombinant Human PDGF-B Protein, Untagged, E.coli-10ug

QP10398-ec-10ug 10ug
EUR 348

Recombinant Human PDGF-B Protein, Untagged, E.coli-250ug

QP10398-ec-250ug 250ug
EUR 2686.8

Recombinant Human PDGF-B Protein, Untagged, E.coli-2ug

QP10398-ec-2ug 2ug
EUR 184.8

Recombinant Human PDGF-B Protein, Untagged, E.coli-1mg

QP5307-1mg 1mg
EUR 4386

Recombinant Human PDGF-B Protein, Untagged, E.coli-500ug

QP5318-500ug 500ug
EUR 2960.4

Anti-PDGF-D Antibody

A01875 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for PDGF-D Antibody (PDGFD) detection. Tested for IHC, WB, ELISA in Human.

Anti-PDGF-C Antibody

A03092 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for PDGF-C Antibody (PDGFC) detection.tested for IHC in Human, Mouse, Rat.

Anti-PDGF-A antibody

STJ94995 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGF-A.

Anti-PDGF-C antibody

STJ98770 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGF-C.

Anti-PDGF-D antibody

STJ96664 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGF-D.

Anti-PDGF alpha antibody

STJ97793 200 µl
EUR 236.4
Description: PDGFRalpha is a protein encoded by the PDGFRA gene which is approximately 122,6 kDa. PDGFRalpha is localised to the cell membrane. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts and the GPCR pathway. It is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. It either promotes or inhibits cell proliferation and cell migration and plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. PDGFRalpha is widely expressed in the body including platelets, brain and colon. Mutations in the PDGFRA gene may result in gastrointestinal stromal tumor. STJ97793 was developed from clone 7A3 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of PDGFRalpha.

Anti-PDGF alpha antibody

STJ97794 200 µl
EUR 236.4
Description: Mouse monoclonal to PDGFRalpha.

anti-PDGF Receptor alpha

YF-PA13687 50 ug
EUR 435.6
Description: Mouse polyclonal to PDGF Receptor alpha

anti-PDGF Receptor alpha

YF-PA13688 100 ug
EUR 483.6
Description: Rabbit polyclonal to PDGF Receptor alpha

anti-PDGF Receptor beta

YF-PA13689 50 ug
EUR 435.6
Description: Mouse polyclonal to PDGF Receptor beta

anti-PDGF Receptor beta

YF-PA13690 100 ug
EUR 483.6
Description: Rabbit polyclonal to PDGF Receptor beta

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

Genorise® Recombinant rat PDGF-B Protein

GR125048 5 µg
EUR 342

Genorise® Recombinant Hamster PDGF-B Protein

GR237045 5 µg
EUR 342

Fmoc-b,b-diphenyl-Ala-OH

B-2725.0250 250.0mg
EUR 166.8
Description: Sum Formula: C30H25NO4; CAS# [201484-50-6]

Fmoc-b,b-diphenyl-Ala-OH

B-2725.1000 1.0g
EUR 428.4
Description: Sum Formula: C30H25NO4; CAS# [201484-50-6]

Fmoc-b,b-diphenyl-Ala-OH

B-2725.5000 5.0g
EUR 1603.2
Description: Sum Formula: C30H25NO4; CAS# [201484-50-6]

ELISA kit for Human PDGF-B (Platelet Derived Growth Factor Subunit B)

E-EL-H1670 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human PDGF-B (Platelet Derived Growth Factor Subunit B) in samples from Serum, Plasma, Cell supernatant

Genorise® Human PDGF-B Expression Plasmid, 10 ug

GR163018 10 µg
EUR 262.8

Rat Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit

QY-E10529 96T
EUR 433.2

Mouse Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit

QY-E21211 96T
EUR 433.2

PDGF-BB, Human

HY-P7055 10ug
EUR 321.6

PDGF, CF Human

PR15024CF 5 ug
EUR 1743.6

PDGF - A Human

PR27059 5 ug
EUR 229.2

PDGF - AA Human

PR27061 2 ug
EUR 229.2

PDGF - AB Human

PR27062 2 ug
EUR 229.2

PDGF-BB, human

RC216-21 2ug
EUR 125.26

Anti-PDGF beta/PDGFB Antibody

A00348 100ug/vial
EUR 352.8

Anti-PDGF beta/PDGFB Antibody

PB9311 100ug/vial
EUR 352.8

Anti-PDGF Receptor beta (4C12)

YF-MA14651 100 ug
EUR 435.6
Description: Mouse monoclonal to PDGF Receptor beta

Goat Anti-Protective Antigen 83 (PA83; B Anthracis) IgG-biotinylated

PA16-B 50 ug
EUR 489.6

PDGF/ Rat PDGF ELISA Kit

ELA-E0528r 96 Tests
EUR 1063.2

Phenolics Mix B

8040-B 1ML
EUR 61.56

Analyte Mix B

507-B 1ML
EUR 182.4

Analyte Mix B

5081-B 1ML
EUR 129.96

ELISA kit for Rat Platelet-derived growth factor-B (PDGF-B)

KTE100494-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Rat Platelet-derived growth factor-B (PDGF-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Platelet-derived growth factor-B (PDGF-B)

KTE100494-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Rat Platelet-derived growth factor-B (PDGF-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Platelet-derived growth factor-B (PDGF-B)

KTE100494-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Rat Platelet-derived growth factor-B (PDGF-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Recombinant Mouse PDGF-B Protein, Untagged, E.coli-100ug

QP5465-100ug 100ug
EUR 643.2

Recombinant Mouse PDGF-B Protein, Untagged, E.coli-10ug

QP5465-10ug 10ug
EUR 284.4

Recombinant Mouse PDGF-B Protein, Untagged, E.coli-1mg

QP5465-1mg 1mg
EUR 4386

Recombinant Mouse PDGF-B Protein, Untagged, E.coli-2ug

QP5465-2ug 2ug
EUR 163.2

Recombinant Mouse PDGF-B Protein, Untagged, E.coli-500ug

QP5465-500ug 500ug
EUR 2710.8

Fmoc-b-Ala-OPfp

B-1765.0005 5.0g
EUR 283.2
Description: Sum Formula: C24H16F5NO4; CAS# [149303-38-8]

Fmoc-b-Ala-OPfp

B-1765.0025 25.0g
EUR 1009.2
Description: Sum Formula: C24H16F5NO4; CAS# [149303-38-8]

Fmoc-b-Ala-OH

B-1025.0005 5.0g
EUR 138
Description: Sum Formula: C18H17NO4; CAS# [35737-10-1]

Fmoc-b-Ala-OH

B-1025.0025 25.0g
EUR 283.2
Description: Sum Formula: C18H17NO4; CAS# [35737-10-1]

Fmoc-b-Ala-OH

B-1025.0100 100.0g
EUR 762
Description: Sum Formula: C18H17NO4; CAS# [35737-10-1]

Purgeable Gases Mix B

624-B 1ML
EUR 249.66

Purgeable Gases Mix B

5022-B 1ML
EUR 27.36

Mouse Monoclonal Anti-Rat CD45RA/B Biotin (Clone OX-33) (mouse IgG1)

RCD045RAB-B 100 tests
EUR 562.8

ELISA kit for Rat PDGF-B (Platelet Derived Growth Factor Subunit B)

E-EL-R0753 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Rat PDGF-B (Platelet Derived Growth Factor Subunit B) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse PDGF-B (Platelet Derived Growth Factor Subunit B)

E-EL-M0924 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse PDGF-B (Platelet Derived Growth Factor Subunit B) in samples from Serum, Plasma, Cell supernatant

PDGF antibody

20R-PG003 1 mg
EUR 1003.2
Description: Goat polyclonal PDGF antibody

PDGF-BB

E21-199 10ug
EUR 411.6

PDGF BB

LF-PR012 10 ug
EUR 280.8
Description: PDGF BB protein

PDGF AA

LF-PR026 10 ug
EUR 252
Description: PDGF AA protein

PDGF Antagonist

H-8650.0001 1.0mg
EUR 428.4
Description: Sum Formula: C77H122N20O17; CAS# [143784-00-3]

The emerging complexity of PDGFRs: activation, internalization and signal attenuation.

The platelet-derived growth factor receptor (PDGFR) family of receptor tyrosine kinases allows cells to communicate with the environment to regulate diverse cellular activities.
Here, we highlight recent data investigating the structural makeup of individual PDGFRs upon activation, revealing the importance of the whole receptor in the propagation of extracellular ligand binding and dimerization.
Furthermore, we review ongoing research demonstrating the significance of receptor internalization and signal attenuation in the regulation of PDGFR activity.

Human Anti-Brucella IgM ELISA Kit

Interactions with internalization machinery, signaling from endosomes, receptor degradation and receptor recycling are physiological means by which cells fine-tune PDGFR responses to growth factor stimulation.
In this review, we discuss the biophysical, structural, in silico and biochemical data that have provided evidence for these mechanisms. We further highlight the commonalities and differences between PDGFRα and PDGFRβ signaling, revealing critical gaps in knowledge.
In total, this review provides a conclusive summary on the state of the PDGFR field and underscores the need for novel techniques to fully elucidate the mechanisms of PDGFR activation, internalization and signal attenuation.

 

PDGF-BB, human recombinant

4488-10
EUR 398.4

PDGF-BB, human recombinant

4488-1000
EUR 8346

PDGF-BB, human recombinant

4488-50
EUR 1123.2

Human PDGF-BB Protein

abx060208-100ug 100 ug
EUR 627.6

Human PDGF-BB Protein

abx060258-100ug 100 ug
EUR 627.6

rec PDGF BB (human)

H-7530.0002 2.0µg
EUR 194.4

rec PDGF BB (human)

H-7530.0010 10.0µg
EUR 457.2

Recombinant Human PDGF-BB

SJA04-01 10µg/vial
EUR 307.2

rHu PDGF-BB

AK8292-0002 2µg Ask for price

rHu PDGF-BB

AK8292-0010 10µg Ask for price

rHu PDGF-BB

AK8292-0100 100µg Ask for price

rHu PDGF-BB

AK8292-1000 1mg Ask for price

PDGF BB antibody

70R-PR020 50 ug
EUR 327.6
Description: Affinity purified Rabbit polyclonal PDGF BB antibody

PDGF-BB Antibody

5488-200
EUR 379.2

PDGF-BB Antibody

5488-30T
EUR 175.2

PDGF-BB Antibody

5489-100
EUR 379.2

PDGF-BB Antibody

5489-30T
EUR 175.2

PDGF BB protein

30R-2611 10 ug
EUR 430.8
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein

30R-2612 10 ug
EUR 362.4
Description: Purified recombinant Mouse PDGF BB protein

PDGF BB protein

30R-AP004 2 ug
EUR 159.6
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein

30R-AP051 10 ug
EUR 327.6
Description: Purified recombinant Human PDGF BB protein

PDGF-BB, Mouse

HY-P7087 100ug
EUR 1135.2

PDGF-BB, Rat

HY-P7278 50ug
EUR 459.6

PDGF-BB, CF

PR15026CF 50 ug
EUR 1304.4

PDGF-BB, CF

PR15027CF 50 ug
EUR 475.2

Human PDGF-BB ELISA Kit

EHP0050 96Tests
EUR 625.2

Human PDGF-BB ELISA Kit

EHP0634 96Tests
EUR 625.2

PDGF-BB, human recombinant protein

P1047-.01 10 µg
EUR 375.6
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein

P1047-.05 50 µg
EUR 1052.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein

P1047-1 1 mg
EUR 7826.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB (P.pastoris-expressed), Human

HY-P7055A 10ug
EUR 321.6

PDGF-BB ELISA KIT|Human

EF000205 96 Tests
EUR 826.8

Recombinant Human PDGF-BB Protein

PROTP01127-4 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Human PDGF-BB ELISA Kit

RK04112 96 Tests
EUR 625.2

Recombinant Human PDGF-BB Protein

RP00834 10 μg
EUR 265.2

PDGF-BB Recombinant Protein

40-158-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein

40-158-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein

40-458-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein

40-458-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein

91-179 0.05 mg
EUR 821.4
Description: Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.

PDGF-BB Recombinant Protein

40-607 0.01 mg
EUR 481.2
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet a-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-a and PDGFR-β. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). .

PDGF-BB, murine recombinant

4489-10
EUR 320.4

PDGF-BB, murine recombinant

4489-1000
EUR 6434.4

PDGF-BB, murine recombinant

4489-50
EUR 874.8

PDGF-BB Recombinant Protein

11-380 0.05 mg
EUR 714.3
Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

Polyclonal PDGF-BB Antibody

APR08990G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

Polyclonal PDGF-BB Antibody

APR00412G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Human PDGF-BB PicoKine ELISA Kit

EK0956 96 wells
EUR 510
Description: For quantitative detection of human PDGF-BB in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Genorise® Recombinant Human PDGF-BB

GR104258 5 µg
EUR 342

Nori Human PDGF-BB ELISA Kit

GR111035 96-well
EUR 553.2

Sheep PDGF-BB ELISA Kit

ESP0050 96Tests
EUR 625.2

Porcine PDGF-BB ELISA Kit

EPP0050 96Tests
EUR 625.2

Porcine PDGF-BB ELISA Kit

EPP0634 96Tests
EUR 625.2

Monkey PDGF-BB ELISA Kit

EMKP0050 96Tests
EUR 625.2

Mouse PDGF-BB ELISA Kit

EMP0050 96Tests
EUR 625.2

Mouse PDGF-BB ELISA Kit

EMP0634 96Tests
EUR 625.2

Rat PDGF-BB ELISA Kit

ERP0050 96Tests
EUR 625.2

Rat PDGF-BB ELISA Kit

ERP0634 96Tests
EUR 625.2

Rabbit PDGF-BB ELISA Kit

ERTP0050 96Tests
EUR 625.2

Rabbit PDGF-BB ELISA Kit

ERTP0634 96Tests
EUR 625.2

PDGF-BB, murine recombinant protein

P1048-.01 10 µg
EUR 375.6
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein

P1048-.05 50 µg
EUR 1052.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein

P1048-1 1 mg
EUR 7826.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

Goat PDGF-BB ELISA Kit

EGTP0050 96Tests
EUR 625.2

Goat PDGF-BB ELISA Kit

EGTP0634 96Tests
EUR 625.2

Anserini PDGF-BB ELISA Kit

EAP0634 96Tests
EUR 625.2

Bovine PDGF-BB ELISA Kit

EBP0050 96Tests
EUR 625.2

Bovine PDGF-BB ELISA Kit

EBP0634 96Tests
EUR 625.2

Chicken PDGF-BB ELISA Kit

ECKP0050 96Tests
EUR 625.2

Canine PDGF-BB ELISA Kit

ECP0050 96Tests
EUR 625.2

Canine PDGF-BB ELISA Kit

ECP0634 96Tests
EUR 625.2

Recombinant Murine PDGF-BB Protein

PROTP31240-1 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Human CellExp™ PDGF-BB, human recombinant

7276-10 Ask for price

Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit

CSB-E08923h-24T 1 plate of 24 wells
EUR 198
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit

1-CSB-E08923h
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

CN-03344H1 96T
EUR 548.4

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

CN-03344H2 48T
EUR 367.2

Recombinant Human Platelet Derived Growth Factor-BB (rHu PDGF-BB)

AK8274-0100 100µg
EUR 1740

Recombinant Human Platelet Derived Growth Factor-BB (rHu PDGF-BB)

AK8274-1000 1mg
EUR 4500

Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit

GA-E0112HM-48T 48T
EUR 346.8

Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit

GA-E0112HM-96T 96T
EUR 559.2

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

201-12-0073 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Platelet Derived Growth Factor-BB (PDGF-BB) CLIA Kit

abx197499-96tests 96 tests
EUR 990

Human PDGF-BB(Platelet Derived Growth Factor-BB) ELISA Kit

EH0254 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein

PROTP01127-2 Regular: 10ug
EUR 380.4
Description: Platelet-Derived Growth Factor BB Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.3 kDa. PDGF-BB is purified by proprietary chromatographic techniques.

Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit

QY-E00600 96T
EUR 433.2