Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells
Identifying effective anti-fibrotic therapies is a major clinical need that remains unmet. In the present study, roseotoxin B was shown to possess an improving effect on cholestatic liver fibrosis in bile duct-ligated mice, as proved by histochemical and immunohistochemical staining, hepatic biochemical parameters, and TUNEL apoptotic cell detection in tissue sections.
Using cellular thermal shift assay, computational molecular docking, microscale thermophoresis technology, and surface plasmon resonance biosensor, we confirmed that PDGFR-β was a direct target of roseotoxin B in fibrotic livers.
Platelet Derived Growth Factor C (PDGF-C) Antibody |
Of note, human tissue microarrays detected pathologically high expression of p-PDGFR-β in liver samples of ~80% of patients with liver fibrosis and cirrhosis.
PDGF-B/PDGFR-β pathway promotes transdifferentiation and excessive proliferation of hepatic stellate cells (HSCs), which is a very crucial driver for liver fibrosis.
Meaningfully, roseotoxin B blocked the formation of PDGF-BB/PDGFR-ββ complex by targeting the D2 domain of PDGFR-β, thereby inhibiting the PDGF-B/PDGFR-β pathway in HSCs. In summary, our study provided roseotoxin B as a unique candidate agent for the treatment of liver fibrosis.
Activation PDGFR-α/AKT Mediated Signaling Pathways in Oral Squamous Cell Carcinoma by Mesenchymal Stem/Stromal Cells Promotes Anti-apoptosis and Decreased Sensitivity to Cisplatin.
Desmoplasia, a hallmark of a head and neck cancer, has both biologic and physiologic effects on cancer progression and chemotherapeutic response. Mesenchymal stem/stromal cells (MSCs), also known as mesenchymal stromal progenitor cells, have been shown to play a role in cancer progression, alter apoptotic responses, and confer resistance to chemotherapy in various carcinomas.
The pathophysiology of MSCs with respect to tumorigenesis is widely reported in other cancers and is sparsely reported in oral squamous cell carcinomas (OSCCs). We previously reported paracrine mediated PDGF-AA/PDGFR-α signaling to underlie MSCs chemotaxis in OSCC.
Mouse Anti-Hepatitis B Virus Core Antibody (HBcAb) ELISA Kit |
Given the poor clinical response to primary chemotherapy, we hypothesized that MSCs may alter cancer cell sensitivity to cisplatin through activation of PDGFR-α mediated signaling pathways.
Co-culture of MSCs with human derived OSCC cell lines, JHU-012 and -019, resulted in a significant increase in the production of PDGF-AA and MCP-1 compared to cancer cells grown alone (p < 0.005) and was accompanied by an increase in the phosphorylation state of PDGFR-α (p < 0.02) and downstream target AKT at S473 (p < 0.025) and T308 (p < 0.02). JHU-012 and -019 cancer cells grown in co-culture were significantly less apoptotic (p < 0.001), expressed significantly higher levels of Bcl-2 (p < 0.04) with a concomitant significant decrease in bid expression (p < 0.001) compared to cancer cells grown alone.
There was a significant increase in the cisplatin dose response curve in cancer cell clones derived from JHU-012 and 019 cancer cells grown in co-culture with MSCs compared to clones derived from cancer cells grown alone (p < 0.001).
Moreover clones derived from JHU-012 cells grown in co-culture with MSCs were significantly more susceptible to cisplatin following pretreatment with, crenolanib, a PDGFR inhibitor, compared to cancer cells grown alone or in co-culture with MSCs (p < 0.0001).
These findings suggest that crosstalk between cancer cells and MSCs is mediated, at least in part, by activation of autocrine PDGF-AA/PDGFR-α loop driving AKT-mediated signaling pathways, resulting in reduced cancer cell sensitivity to cisplatin through alterations in apoptosis.
PDGF-B Polyclonal Antibody |
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| ABP55531-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110 |
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PDGF-B Polyclonal Antibody |
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| ABP55531-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110 |
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PDGF-B Polyclonal Antibody |
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| ABP55531-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110 |
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PDGF-B Recombinant Protein |
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| 96-936 | ProSci | 0.05 mg | EUR 651.3 |
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Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. |
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Polyclonal PDGF-B Antibody |
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| APR08989G | Leading Biology | 0.1 mg | EUR 790.8 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-B . This antibody is tested and proven to work in the following applications: |
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PDGF-B Polyclonal Antibody |
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| ES6530-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against PDGF-B from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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PDGF-B Polyclonal Antibody |
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| ES6530-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against PDGF-B from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Rabbit Polyclonal antibody Anti-CRBN |
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| Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
anti-PDGF AA |
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| YF-PA24330 | Abfrontier | 50 ul | EUR 400.8 |
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Description: Mouse polyclonal to PDGF AA |
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anti-PDGF BB |
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| YF-PA24331 | Abfrontier | 50 ul | EUR 400.8 |
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Description: Mouse polyclonal to PDGF BB |
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anti-PDGF AA |
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| YF-PA13682 | Abfrontier | 50 ug | EUR 435.6 |
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Description: Mouse polyclonal to PDGF AA |
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anti-PDGF AA |
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| YF-PA13683 | Abfrontier | 100 ul | EUR 483.6 |
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Description: Rabbit polyclonal to PDGF AA |
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anti-PDGF AA |
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| YF-PA13684 | Abfrontier | 100 ug | EUR 483.6 |
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Description: Rabbit polyclonal to PDGF AA |
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anti-PDGF BB |
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| YF-PA13686 | Abfrontier | 50 ug | EUR 435.6 |
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Description: Mouse polyclonal to PDGF BB |
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Genorise® Goat Anti-porcine PDGF-B polyclonal antibody |
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| GR105219 | Genorise Scientific | 100 ug | EUR 525.6 |
Human Platelet-Derived Growth Factor-B,PDGF-B ELISA kit |
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| 201-12-2119 | SunredBio | 96 tests | EUR 528 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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PDGF-B Platelet-Derived Growth Factor B Human Recombinant Protein |
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| PROTP01127-1 | BosterBio | Regular: 20ug | EUR 380.4 |
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Description: PDGF-B Human Recombinant mature chain produced in E.Coli is a non-glycosylated, polypeptide chain containing 109 amino acids fragment (82-190) and having a molecular mass of 16.75 kDa. The PDGF-B is fused with an amino-terminal hexahistidine tag and purified by proprietary chromatographic techniques. |
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Human Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit |
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| QY-E00606 | Qayee Biotechnology | 96T | EUR 480 |
Recombinant Human PDGF-B Protein, Untagged, E.coli-100ug |
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| QP10398-ec-100ug | EnQuireBio | 100ug | EUR 1522.8 |
Recombinant Human PDGF-B Protein, Untagged, E.coli-10ug |
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| QP10398-ec-10ug | EnQuireBio | 10ug | EUR 348 |
Recombinant Human PDGF-B Protein, Untagged, E.coli-250ug |
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| QP10398-ec-250ug | EnQuireBio | 250ug | EUR 2686.8 |
Recombinant Human PDGF-B Protein, Untagged, E.coli-2ug |
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| QP10398-ec-2ug | EnQuireBio | 2ug | EUR 184.8 |
Recombinant Human PDGF-B Protein, Untagged, E.coli-1mg |
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| QP5307-1mg | EnQuireBio | 1mg | EUR 4386 |
Recombinant Human PDGF-B Protein, Untagged, E.coli-500ug |
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| QP5318-500ug | EnQuireBio | 500ug | EUR 2960.4 |
Anti-PDGF-D Antibody |
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| A01875 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal Antibody for PDGF-D Antibody (PDGFD) detection. Tested for IHC, WB, ELISA in Human. |
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Anti-PDGF-C Antibody |
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| A03092 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal Antibody for PDGF-C Antibody (PDGFC) detection.tested for IHC in Human, Mouse, Rat. |
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Anti-PDGF-A antibody |
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| STJ94995 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to PDGF-A. |
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Anti-PDGF-C antibody |
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| STJ98770 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to PDGF-C. |
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Anti-PDGF-D antibody |
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| STJ96664 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to PDGF-D. |
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Anti-PDGF alpha antibody |
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| STJ97793 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: PDGFRalpha is a protein encoded by the PDGFRA gene which is approximately 122,6 kDa. PDGFRalpha is localised to the cell membrane. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts and the GPCR pathway. It is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. It either promotes or inhibits cell proliferation and cell migration and plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. PDGFRalpha is widely expressed in the body including platelets, brain and colon. Mutations in the PDGFRA gene may result in gastrointestinal stromal tumor. STJ97793 was developed from clone 7A3 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of PDGFRalpha. |
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Anti-PDGF alpha antibody |
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| STJ97794 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Mouse monoclonal to PDGFRalpha. |
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anti-PDGF Receptor alpha |
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| YF-PA13687 | Abfrontier | 50 ug | EUR 435.6 |
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Description: Mouse polyclonal to PDGF Receptor alpha |
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anti-PDGF Receptor alpha |
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| YF-PA13688 | Abfrontier | 100 ug | EUR 483.6 |
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Description: Rabbit polyclonal to PDGF Receptor alpha |
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anti-PDGF Receptor beta |
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| YF-PA13689 | Abfrontier | 50 ug | EUR 435.6 |
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Description: Mouse polyclonal to PDGF Receptor beta |
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anti-PDGF Receptor beta |
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| YF-PA13690 | Abfrontier | 100 ug | EUR 483.6 |
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Description: Rabbit polyclonal to PDGF Receptor beta |
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Polyclonal Goat anti-GST α-form |
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| GST-ANTI-1 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST μ-form |
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| GST-ANTI-2 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST p-form |
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| GST-ANTI-3 | Detroit R&D | 50 uL | EUR 336 |
Genorise® Recombinant rat PDGF-B Protein |
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| GR125048 | Genorise Scientific | 5 µg | EUR 342 |
Genorise® Recombinant Hamster PDGF-B Protein |
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| GR237045 | Genorise Scientific | 5 µg | EUR 342 |
Fmoc-b,b-diphenyl-Ala-OH |
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| B-2725.0250 | Bachem | 250.0mg | EUR 166.8 |
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Description: Sum Formula: C30H25NO4; CAS# [201484-50-6] |
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Fmoc-b,b-diphenyl-Ala-OH |
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| B-2725.1000 | Bachem | 1.0g | EUR 428.4 |
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Description: Sum Formula: C30H25NO4; CAS# [201484-50-6] |
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Fmoc-b,b-diphenyl-Ala-OH |
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| B-2725.5000 | Bachem | 5.0g | EUR 1603.2 |
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Description: Sum Formula: C30H25NO4; CAS# [201484-50-6] |
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ELISA kit for Human PDGF-B (Platelet Derived Growth Factor Subunit B) |
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| E-EL-H1670 | Elabscience Biotech | 1 plate of 96 wells | EUR 640.8 |
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Description: A sandwich ELISA kit for quantitative measurement of Human PDGF-B (Platelet Derived Growth Factor Subunit B) in samples from Serum, Plasma, Cell supernatant |
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Genorise® Human PDGF-B Expression Plasmid, 10 ug |
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| GR163018 | Genorise Scientific | 10 µg | EUR 262.8 |
Rat Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit |
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| QY-E10529 | Qayee Biotechnology | 96T | EUR 433.2 |
Mouse Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit |
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| QY-E21211 | Qayee Biotechnology | 96T | EUR 433.2 |
PDGF-BB, Human |
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| HY-P7055 | MedChemExpress | 10ug | EUR 321.6 |
PDGF, CF Human |
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| PR15024CF | Neuromics | 5 ug | EUR 1743.6 |
PDGF - A Human |
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| PR27059 | Neuromics | 5 ug | EUR 229.2 |
PDGF - AA Human |
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| PR27061 | Neuromics | 2 ug | EUR 229.2 |
PDGF - AB Human |
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| PR27062 | Neuromics | 2 ug | EUR 229.2 |
PDGF-BB, human |
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| RC216-21 | Bio Basic | 2ug | EUR 125.26 |
Anti-PDGF beta/PDGFB Antibody |
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| A00348 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-PDGF beta/PDGFB Antibody |
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| PB9311 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-PDGF Receptor beta (4C12) |
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| YF-MA14651 | Abfrontier | 100 ug | EUR 435.6 |
|
Description: Mouse monoclonal to PDGF Receptor beta |
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Goat Anti-Protective Antigen 83 (PA83; B Anthracis) IgG-biotinylated |
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| PA16-B | Alpha Diagnostics | 50 ug | EUR 489.6 |
PDGF/ Rat PDGF ELISA Kit |
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| ELA-E0528r | Lifescience Market | 96 Tests | EUR 1063.2 |
Phenolics Mix B |
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| 8040-B | Scientific Laboratory Supplies | 1ML | EUR 61.56 |
Analyte Mix B |
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| 507-B | Scientific Laboratory Supplies | 1ML | EUR 182.4 |
Analyte Mix B |
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| 5081-B | Scientific Laboratory Supplies | 1ML | EUR 129.96 |
ELISA kit for Rat Platelet-derived growth factor-B (PDGF-B) |
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| KTE100494-48T | Abbkine | 48T | EUR 424.8 |
|
Description: Quantitative sandwich ELISA for measuring Rat Platelet-derived growth factor-B (PDGF-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Rat Platelet-derived growth factor-B (PDGF-B) |
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| KTE100494-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2702.4 |
|
Description: Quantitative sandwich ELISA for measuring Rat Platelet-derived growth factor-B (PDGF-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Rat Platelet-derived growth factor-B (PDGF-B) |
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| KTE100494-96T | Abbkine | 96T | EUR 686.4 |
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Description: Quantitative sandwich ELISA for measuring Rat Platelet-derived growth factor-B (PDGF-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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Recombinant Mouse PDGF-B Protein, Untagged, E.coli-100ug |
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| QP5465-100ug | EnQuireBio | 100ug | EUR 643.2 |
Recombinant Mouse PDGF-B Protein, Untagged, E.coli-10ug |
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| QP5465-10ug | EnQuireBio | 10ug | EUR 284.4 |
Recombinant Mouse PDGF-B Protein, Untagged, E.coli-1mg |
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| QP5465-1mg | EnQuireBio | 1mg | EUR 4386 |
Recombinant Mouse PDGF-B Protein, Untagged, E.coli-2ug |
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| QP5465-2ug | EnQuireBio | 2ug | EUR 163.2 |
Recombinant Mouse PDGF-B Protein, Untagged, E.coli-500ug |
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| QP5465-500ug | EnQuireBio | 500ug | EUR 2710.8 |
Fmoc-b-Ala-OPfp |
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| B-1765.0005 | Bachem | 5.0g | EUR 283.2 |
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Description: Sum Formula: C24H16F5NO4; CAS# [149303-38-8] |
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Fmoc-b-Ala-OPfp |
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| B-1765.0025 | Bachem | 25.0g | EUR 1009.2 |
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Description: Sum Formula: C24H16F5NO4; CAS# [149303-38-8] |
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Fmoc-b-Ala-OH |
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| B-1025.0005 | Bachem | 5.0g | EUR 138 |
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Description: Sum Formula: C18H17NO4; CAS# [35737-10-1] |
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Fmoc-b-Ala-OH |
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| B-1025.0025 | Bachem | 25.0g | EUR 283.2 |
|
Description: Sum Formula: C18H17NO4; CAS# [35737-10-1] |
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Fmoc-b-Ala-OH |
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| B-1025.0100 | Bachem | 100.0g | EUR 762 |
|
Description: Sum Formula: C18H17NO4; CAS# [35737-10-1] |
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Purgeable Gases Mix B |
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| 624-B | Scientific Laboratory Supplies | 1ML | EUR 249.66 |
Purgeable Gases Mix B |
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| 5022-B | Scientific Laboratory Supplies | 1ML | EUR 27.36 |
Mouse Monoclonal Anti-Rat CD45RA/B Biotin (Clone OX-33) (mouse IgG1) |
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| RCD045RAB-B | Alpha Diagnostics | 100 tests | EUR 562.8 |
ELISA kit for Rat PDGF-B (Platelet Derived Growth Factor Subunit B) |
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| E-EL-R0753 | Elabscience Biotech | 1 plate of 96 wells | EUR 640.8 |
|
Description: A sandwich ELISA kit for quantitative measurement of Rat PDGF-B (Platelet Derived Growth Factor Subunit B) in samples from Serum, Plasma, Cell supernatant |
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ELISA kit for Mouse PDGF-B (Platelet Derived Growth Factor Subunit B) |
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| E-EL-M0924 | Elabscience Biotech | 1 plate of 96 wells | EUR 640.8 |
|
Description: A sandwich ELISA kit for quantitative measurement of Mouse PDGF-B (Platelet Derived Growth Factor Subunit B) in samples from Serum, Plasma, Cell supernatant |
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PDGF antibody |
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| 20R-PG003 | Fitzgerald | 1 mg | EUR 1003.2 |
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Description: Goat polyclonal PDGF antibody |
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PDGF-BB |
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| E21-199 | EnoGene | 10ug | EUR 411.6 |
PDGF BB |
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| LF-PR012 | Abfrontier | 10 ug | EUR 280.8 |
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Description: PDGF BB protein |
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PDGF AA |
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| LF-PR026 | Abfrontier | 10 ug | EUR 252 |
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Description: PDGF AA protein |
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PDGF Antagonist |
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| H-8650.0001 | Bachem | 1.0mg | EUR 428.4 |
|
Description: Sum Formula: C77H122N20O17; CAS# [143784-00-3] |
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The emerging complexity of PDGFRs: activation, internalization and signal attenuation.
The platelet-derived growth factor receptor (PDGFR) family of receptor tyrosine kinases allows cells to communicate with the environment to regulate diverse cellular activities.
Here, we highlight recent data investigating the structural makeup of individual PDGFRs upon activation, revealing the importance of the whole receptor in the propagation of extracellular ligand binding and dimerization.
Furthermore, we review ongoing research demonstrating the significance of receptor internalization and signal attenuation in the regulation of PDGFR activity.
Human Anti-Brucella IgM ELISA Kit |
Interactions with internalization machinery, signaling from endosomes, receptor degradation and receptor recycling are physiological means by which cells fine-tune PDGFR responses to growth factor stimulation.
In this review, we discuss the biophysical, structural, in silico and biochemical data that have provided evidence for these mechanisms. We further highlight the commonalities and differences between PDGFRα and PDGFRβ signaling, revealing critical gaps in knowledge.
In total, this review provides a conclusive summary on the state of the PDGFR field and underscores the need for novel techniques to fully elucidate the mechanisms of PDGFR activation, internalization and signal attenuation.
PDGF-BB, human recombinant |
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| 4488-10 | Biovision | EUR 398.4 | |
PDGF-BB, human recombinant |
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| 4488-1000 | Biovision | EUR 8346 | |
PDGF-BB, human recombinant |
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| 4488-50 | Biovision | EUR 1123.2 | |
Human PDGF-BB Protein |
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| abx060208-100ug | Abbexa | 100 ug | EUR 627.6 |
Human PDGF-BB Protein |
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| abx060258-100ug | Abbexa | 100 ug | EUR 627.6 |
rec PDGF BB (human) |
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| H-7530.0002 | Bachem | 2.0µg | EUR 194.4 |
rec PDGF BB (human) |
|||
| H-7530.0010 | Bachem | 10.0µg | EUR 457.2 |
Recombinant Human PDGF-BB |
|||
| SJA04-01 | Amyotop | 10µg/vial | EUR 307.2 |
rHu PDGF-BB |
|||
| AK8292-0002 | Akron Biotech | 2µg | Ask for price |
rHu PDGF-BB |
|||
| AK8292-0010 | Akron Biotech | 10µg | Ask for price |
rHu PDGF-BB |
|||
| AK8292-0100 | Akron Biotech | 100µg | Ask for price |
rHu PDGF-BB |
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| AK8292-1000 | Akron Biotech | 1mg | Ask for price |
PDGF BB antibody |
|||
| 70R-PR020 | Fitzgerald | 50 ug | EUR 327.6 |
|
Description: Affinity purified Rabbit polyclonal PDGF BB antibody |
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PDGF-BB Antibody |
|||
| 5488-200 | Biovision | EUR 379.2 | |
PDGF-BB Antibody |
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| 5488-30T | Biovision | EUR 175.2 | |
PDGF-BB Antibody |
|||
| 5489-100 | Biovision | EUR 379.2 | |
PDGF-BB Antibody |
|||
| 5489-30T | Biovision | EUR 175.2 | |
PDGF BB protein |
|||
| 30R-2611 | Fitzgerald | 10 ug | EUR 430.8 |
|
Description: Purified recombinant Human PDGF BB protein |
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PDGF BB protein |
|||
| 30R-2612 | Fitzgerald | 10 ug | EUR 362.4 |
|
Description: Purified recombinant Mouse PDGF BB protein |
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PDGF BB protein |
|||
| 30R-AP004 | Fitzgerald | 2 ug | EUR 159.6 |
|
Description: Purified recombinant Human PDGF BB protein |
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PDGF BB protein |
|||
| 30R-AP051 | Fitzgerald | 10 ug | EUR 327.6 |
|
Description: Purified recombinant Human PDGF BB protein |
|||
PDGF-BB, Mouse |
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| HY-P7087 | MedChemExpress | 100ug | EUR 1135.2 |
PDGF-BB, Rat |
|||
| HY-P7278 | MedChemExpress | 50ug | EUR 459.6 |
PDGF-BB, CF |
|||
| PR15026CF | Neuromics | 50 ug | EUR 1304.4 |
PDGF-BB, CF |
|||
| PR15027CF | Neuromics | 50 ug | EUR 475.2 |
Human PDGF-BB ELISA Kit |
|||
| EHP0050 | Abclonal | 96Tests | EUR 625.2 |
Human PDGF-BB ELISA Kit |
|||
| EHP0634 | Abclonal | 96Tests | EUR 625.2 |
PDGF-BB, human recombinant protein |
|||
| P1047-.01 | ApexBio | 10 µg | EUR 375.6 |
|
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB, human recombinant protein |
|||
| P1047-.05 | ApexBio | 50 µg | EUR 1052.4 |
|
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB, human recombinant protein |
|||
| P1047-1 | ApexBio | 1 mg | EUR 7826.4 |
|
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB (P.pastoris-expressed), Human |
|||
| HY-P7055A | MedChemExpress | 10ug | EUR 321.6 |
PDGF-BB ELISA KIT|Human |
|||
| EF000205 | Lifescience Market | 96 Tests | EUR 826.8 |
Recombinant Human PDGF-BB Protein |
|||
| PROTP01127-4 | BosterBio | 10ug | EUR 380.4 |
|
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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Human PDGF-BB ELISA Kit |
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| RK04112 | Abclonal | 96 Tests | EUR 625.2 |
Recombinant Human PDGF-BB Protein |
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| RP00834 | Abclonal | 10 μg | EUR 265.2 |
PDGF-BB Recombinant Protein |
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| 40-158-0002mg | ProSci | 0.002 mg | EUR 311.1 |
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Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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PDGF-BB Recombinant Protein |
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| 40-158-001mg | ProSci | 0.01 mg | EUR 437.1 |
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Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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PDGF-BB Recombinant Protein |
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| 40-458-0002mg | ProSci | 0.002 mg | EUR 311.1 |
|
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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PDGF-BB Recombinant Protein |
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| 40-458-001mg | ProSci | 0.01 mg | EUR 437.1 |
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Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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PDGF-BB Recombinant Protein |
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| 91-179 | ProSci | 0.05 mg | EUR 821.4 |
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Description: Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. |
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PDGF-BB Recombinant Protein |
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| 40-607 | ProSci | 0.01 mg | EUR 481.2 |
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Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet a-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-a and PDGFR-β. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). . |
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PDGF-BB, murine recombinant |
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| 4489-10 | Biovision | EUR 320.4 | |
PDGF-BB, murine recombinant |
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| 4489-1000 | Biovision | EUR 6434.4 | |
PDGF-BB, murine recombinant |
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| 4489-50 | Biovision | EUR 874.8 | |
PDGF-BB Recombinant Protein |
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| 11-380 | ProSci | 0.05 mg | EUR 714.3 |
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Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. |
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Polyclonal PDGF-BB Antibody |
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| APR08990G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications: |
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Polyclonal PDGF-BB Antibody |
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| APR00412G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications: |
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Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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| C199-10ug | Novoprotein | 10ug | EUR 242.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
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Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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| C199-1mg | Novoprotein | 1mg | EUR 2739.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
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Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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| C199-500ug | Novoprotein | 500ug | EUR 1935.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
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Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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| C199-50ug | Novoprotein | 50ug | EUR 595.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
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Human PDGF-BB PicoKine ELISA Kit |
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| EK0956 | BosterBio | 96 wells | EUR 510 |
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Description: For quantitative detection of human PDGF-BB in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
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Genorise® Recombinant Human PDGF-BB |
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| GR104258 | Genorise Scientific | 5 µg | EUR 342 |
Nori Human PDGF-BB ELISA Kit |
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| GR111035 | Genorise Scientific | 96-well | EUR 553.2 |
Sheep PDGF-BB ELISA Kit |
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| ESP0050 | Abclonal | 96Tests | EUR 625.2 |
Porcine PDGF-BB ELISA Kit |
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| EPP0050 | Abclonal | 96Tests | EUR 625.2 |
Porcine PDGF-BB ELISA Kit |
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| EPP0634 | Abclonal | 96Tests | EUR 625.2 |
Monkey PDGF-BB ELISA Kit |
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| EMKP0050 | Abclonal | 96Tests | EUR 625.2 |
Mouse PDGF-BB ELISA Kit |
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| EMP0050 | Abclonal | 96Tests | EUR 625.2 |
Mouse PDGF-BB ELISA Kit |
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| EMP0634 | Abclonal | 96Tests | EUR 625.2 |
Rat PDGF-BB ELISA Kit |
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| ERP0050 | Abclonal | 96Tests | EUR 625.2 |
Rat PDGF-BB ELISA Kit |
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| ERP0634 | Abclonal | 96Tests | EUR 625.2 |
Rabbit PDGF-BB ELISA Kit |
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| ERTP0050 | Abclonal | 96Tests | EUR 625.2 |
Rabbit PDGF-BB ELISA Kit |
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| ERTP0634 | Abclonal | 96Tests | EUR 625.2 |
PDGF-BB, murine recombinant protein |
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| P1048-.01 | ApexBio | 10 µg | EUR 375.6 |
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Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB, murine recombinant protein |
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| P1048-.05 | ApexBio | 50 µg | EUR 1052.4 |
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Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB, murine recombinant protein |
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| P1048-1 | ApexBio | 1 mg | EUR 7826.4 |
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Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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Goat PDGF-BB ELISA Kit |
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| EGTP0050 | Abclonal | 96Tests | EUR 625.2 |
Goat PDGF-BB ELISA Kit |
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| EGTP0634 | Abclonal | 96Tests | EUR 625.2 |
Anserini PDGF-BB ELISA Kit |
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| EAP0634 | Abclonal | 96Tests | EUR 625.2 |
Bovine PDGF-BB ELISA Kit |
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| EBP0050 | Abclonal | 96Tests | EUR 625.2 |
Bovine PDGF-BB ELISA Kit |
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| EBP0634 | Abclonal | 96Tests | EUR 625.2 |
Chicken PDGF-BB ELISA Kit |
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| ECKP0050 | Abclonal | 96Tests | EUR 625.2 |
Canine PDGF-BB ELISA Kit |
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| ECP0050 | Abclonal | 96Tests | EUR 625.2 |
Canine PDGF-BB ELISA Kit |
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| ECP0634 | Abclonal | 96Tests | EUR 625.2 |
Recombinant Murine PDGF-BB Protein |
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| PROTP31240-1 | BosterBio | 10ug | EUR 380.4 |
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Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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Human CellExp™ PDGF-BB, human recombinant |
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| 7276-10 | Biovision | Ask for price | |
Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit |
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| CSB-E08923h-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit |
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| 1-CSB-E08923h | Cusabio |
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Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit |
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| CN-03344H1 | ChemNorm | 96T | EUR 548.4 |
Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit |
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| CN-03344H2 | ChemNorm | 48T | EUR 367.2 |
Recombinant Human Platelet Derived Growth Factor-BB (rHu PDGF-BB) |
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| AK8274-0100 | Akron Biotech | 100µg | EUR 1740 |
Recombinant Human Platelet Derived Growth Factor-BB (rHu PDGF-BB) |
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| AK8274-1000 | Akron Biotech | 1mg | EUR 4500 |
Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit |
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| GA-E0112HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit |
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| GA-E0112HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit |
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| 201-12-0073 | SunredBio | 96 tests | EUR 528 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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Human Platelet Derived Growth Factor-BB (PDGF-BB) CLIA Kit |
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| abx197499-96tests | Abbexa | 96 tests | EUR 990 |
Human PDGF-BB(Platelet Derived Growth Factor-BB) ELISA Kit |
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| EH0254 | FN Test | 96T | EUR 628.92 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml |
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PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein |
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| PROTP01127-2 | BosterBio | Regular: 10ug | EUR 380.4 |
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Description: Platelet-Derived Growth Factor BB Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.3 kDa. PDGF-BB is purified by proprietary chromatographic techniques. |
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Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit |
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| QY-E00600 | Qayee Biotechnology | 96T | EUR 433.2 |
