Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells

 

Identifying effective anti-fibrotic therapies is a major clinical need that remains unmet. In the present study, roseotoxin B was shown to possess an improving effect on cholestatic liver fibrosis in bile duct-ligated mice, as proved by histochemical and immunohistochemical staining, hepatic biochemical parameters, and TUNEL apoptotic cell detection in tissue sections.

Using cellular thermal shift assay, computational molecular docking, microscale thermophoresis technology, and surface plasmon resonance biosensor, we confirmed that PDGFR-β was a direct target of roseotoxin B in fibrotic livers.

Platelet Derived Growth Factor C (PDGF-C) Antibody

Of note, human tissue microarrays detected pathologically high expression of p-PDGFR-β in liver samples of ~80% of patients with liver fibrosis and cirrhosis.
PDGF-B/PDGFR-β pathway promotes transdifferentiation and excessive proliferation of hepatic stellate cells (HSCs), which is a very crucial driver for liver fibrosis.
Meaningfully, roseotoxin B blocked the formation of PDGF-BB/PDGFR-ββ complex by targeting the D2 domain of PDGFR-β, thereby inhibiting the PDGF-B/PDGFR-β pathway in HSCs. In summary, our study provided roseotoxin B as a unique candidate agent for the treatment of liver fibrosis.

 

Activation PDGFR-α/AKT Mediated Signaling Pathways in Oral Squamous Cell Carcinoma by Mesenchymal Stem/Stromal Cells Promotes Anti-apoptosis and Decreased Sensitivity to Cisplatin.

 

 

Desmoplasia, a hallmark of a head and neck cancer, has both biologic and physiologic effects on cancer progression and chemotherapeutic response. Mesenchymal stem/stromal cells (MSCs), also known as mesenchymal stromal progenitor cells, have been shown to play a role in cancer progression, alter apoptotic responses, and confer resistance to chemotherapy in various carcinomas.

The pathophysiology of MSCs with respect to tumorigenesis is widely reported in other cancers and is sparsely reported in oral squamous cell carcinomas (OSCCs). We previously reported paracrine mediated PDGF-AA/PDGFR-α signaling to underlie MSCs chemotaxis in OSCC.

Mouse Anti-Hepatitis B Virus Core Antibody (HBcAb) ELISA Kit

Given the poor clinical response to primary chemotherapy, we hypothesized that MSCs may alter cancer cell sensitivity to cisplatin through activation of PDGFR-α mediated signaling pathways.
Co-culture of MSCs with human derived OSCC cell lines, JHU-012 and -019, resulted in a significant increase in the production of PDGF-AA and MCP-1 compared to cancer cells grown alone (p < 0.005) and was accompanied by an increase in the phosphorylation state of PDGFR-α (p < 0.02) and downstream target AKT at S473 (p < 0.025) and T308 (p < 0.02). JHU-012 and -019 cancer cells grown in co-culture were significantly less apoptotic (p < 0.001), expressed significantly higher levels of Bcl-2 (p < 0.04) with a concomitant significant decrease in bid expression (p < 0.001) compared to cancer cells grown alone.
There was a significant increase in the cisplatin dose response curve in cancer cell clones derived from JHU-012 and 019 cancer cells grown in co-culture with MSCs compared to clones derived from cancer cells grown alone (p < 0.001).
vegf-a
vegf-a
Moreover clones derived from JHU-012 cells grown in co-culture with MSCs were significantly more susceptible to cisplatin following pretreatment with, crenolanib, a PDGFR inhibitor, compared to cancer cells grown alone or in co-culture with MSCs (p < 0.0001).
These findings suggest that crosstalk between cancer cells and MSCs is mediated, at least in part, by activation of autocrine PDGF-AA/PDGFR-α loop driving AKT-mediated signaling pathways, resulting in reduced cancer cell sensitivity to cisplatin through alterations in apoptosis.

 

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

anti-PDGF AA

YF-PA13682 50 ug
EUR 363
Description: Mouse polyclonal to PDGF AA

anti-PDGF AA

YF-PA13683 100 ul
EUR 403
Description: Rabbit polyclonal to PDGF AA

anti-PDGF AA

YF-PA13684 100 ug
EUR 403
Description: Rabbit polyclonal to PDGF AA

anti-PDGF BB

YF-PA13686 50 ug
EUR 363
Description: Mouse polyclonal to PDGF BB

anti-PDGF AA

YF-PA24330 50 ul
EUR 334
Description: Mouse polyclonal to PDGF AA

anti-PDGF BB

YF-PA24331 50 ul
EUR 334
Description: Mouse polyclonal to PDGF BB

Human Platelet-Derived Growth Factor-B,PDGF-B ELISA kit

201-12-2119 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

PDGF-B Platelet-Derived Growth Factor B Human Recombinant Protein

PROTP01127-1 Regular: 20ug
EUR 317
Description: PDGF-B Human Recombinant mature chain produced in E.Coli is a non-glycosylated, polypeptide chain containing 109 amino acids fragment (82-190) and having a molecular mass of 16.75 kDa. The PDGF-B is fused with an amino-terminal hexahistidine tag and purified by proprietary chromatographic techniques.

Human Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit

QY-E00606 96T
EUR 400

anti-PDGF Receptor alpha

YF-PA13687 50 ug
EUR 363
Description: Mouse polyclonal to PDGF Receptor alpha

anti-PDGF Receptor alpha

YF-PA13688 100 ug
EUR 403
Description: Rabbit polyclonal to PDGF Receptor alpha

anti-PDGF Receptor beta

YF-PA13689 50 ug
EUR 363
Description: Mouse polyclonal to PDGF Receptor beta

anti-PDGF Receptor beta

YF-PA13690 100 ug
EUR 403
Description: Rabbit polyclonal to PDGF Receptor beta

Anti-PDGF-D Antibody

A01875 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for PDGF-D Antibody (PDGFD) detection. Tested for IHC, WB, ELISA in Human.

Anti-PDGF-C Antibody

A03092 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for PDGF-C Antibody (PDGFC) detection.tested for IHC in Human, Mouse, Rat.

Anti-PDGF-D antibody

STJ96664 200 µl
EUR 197
Description: Rabbit polyclonal to PDGF-D.

Anti-PDGF alpha antibody

STJ97793 200 µl
EUR 197
Description: PDGFRalpha is a protein encoded by the PDGFRA gene which is approximately 122,6 kDa. PDGFRalpha is localised to the cell membrane. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts and the GPCR pathway. It is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. It either promotes or inhibits cell proliferation and cell migration and plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. PDGFRalpha is widely expressed in the body including platelets, brain and colon. Mutations in the PDGFRA gene may result in gastrointestinal stromal tumor. STJ97793 was developed from clone 7A3 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of PDGFRalpha.

Anti-PDGF alpha antibody

STJ97794 200 µl
EUR 197
Description: Mouse monoclonal to PDGFRalpha.

Anti-PDGF-C antibody

STJ98770 200 µl
EUR 197
Description: Rabbit polyclonal to PDGF-C.

Anti-PDGF-A antibody

STJ94995 200 µl
EUR 197
Description: Rabbit polyclonal to PDGF-A.

Recombinant Human PDGF-B Protein, Untagged, E.coli-100ug

QP10398-ec-100ug 100ug
EUR 1269

Recombinant Human PDGF-B Protein, Untagged, E.coli-10ug

QP10398-ec-10ug 10ug
EUR 290

Recombinant Human PDGF-B Protein, Untagged, E.coli-250ug

QP10398-ec-250ug 250ug
EUR 2239

Recombinant Human PDGF-B Protein, Untagged, E.coli-2ug

QP10398-ec-2ug 2ug
EUR 154

Recombinant Human PDGF-B Protein, Untagged, E.coli-1mg

QP5307-1mg 1mg
EUR 3655

Recombinant Human PDGF-B Protein, Untagged, E.coli-500ug

QP5318-500ug 500ug
EUR 2467

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

PDGF, CF Human

PR15024CF 5 ug
EUR 1453

PDGF - A Human

PR27059 5 ug
EUR 191

PDGF - AA Human

PR27061 2 ug
EUR 191

PDGF - AB Human

PR27062 2 ug
EUR 191

PDGF-BB, human

RC216-21 2ug
EUR 104.38

PDGF-BB, Human

HY-P7055 10ug
EUR 268

Anti-PDGF Receptor beta (4C12)

YF-MA14651 100 ug
EUR 363
Description: Mouse monoclonal to PDGF Receptor beta

Anti-PDGF beta/PDGFB Antibody

A00348 100ug/vial
EUR 294

Anti-PDGF beta/PDGFB Antibody

PB9311 100ug/vial
EUR 294

ELISA kit for Human PDGF-B (Platelet Derived Growth Factor Subunit B)

E-EL-H1670 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human PDGF-B (Platelet Derived Growth Factor Subunit B) in samples from Serum, Plasma, Cell supernatant

Rat Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit

QY-E10529 96T
EUR 361

Mouse Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit

QY-E21211 96T
EUR 361

PDGF/ Rat PDGF ELISA Kit

ELA-E0528r 96 Tests
EUR 886

Fmoc-b,b-diphenyl-Ala-OH

B-2725.0250 250.0mg
EUR 139
Description: Sum Formula: C30H25NO4; CAS# [201484-50-6]

Fmoc-b,b-diphenyl-Ala-OH

B-2725.1000 1.0g
EUR 357
Description: Sum Formula: C30H25NO4; CAS# [201484-50-6]

Fmoc-b,b-diphenyl-Ala-OH

B-2725.5000 5.0g
EUR 1336
Description: Sum Formula: C30H25NO4; CAS# [201484-50-6]

Goat Anti-Protective Antigen 83 (PA83; B Anthracis) IgG-biotinylated

PA16-B 50 ug
EUR 408

Recombinant Mouse PDGF-B Protein, Untagged, E.coli-100ug

QP5465-100ug 100ug
EUR 536

Recombinant Mouse PDGF-B Protein, Untagged, E.coli-10ug

QP5465-10ug 10ug
EUR 237

Recombinant Mouse PDGF-B Protein, Untagged, E.coli-1mg

QP5465-1mg 1mg
EUR 3655

Recombinant Mouse PDGF-B Protein, Untagged, E.coli-2ug

QP5465-2ug 2ug
EUR 136

Recombinant Mouse PDGF-B Protein, Untagged, E.coli-500ug

QP5465-500ug 500ug
EUR 2259

ELISA kit for Rat Platelet-derived growth factor-B (PDGF-B)

KTE100494-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Rat Platelet-derived growth factor-B (PDGF-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Platelet-derived growth factor-B (PDGF-B)

KTE100494-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Rat Platelet-derived growth factor-B (PDGF-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Platelet-derived growth factor-B (PDGF-B)

KTE100494-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Rat Platelet-derived growth factor-B (PDGF-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

PDGF antibody

20R-PG003 1 mg
EUR 836
Description: Goat polyclonal PDGF antibody

PDGF BB

LF-PR012 10 ug
EUR 234
Description: PDGF BB protein

PDGF AA

LF-PR026 10 ug
EUR 210
Description: PDGF AA protein

PDGF-BB

PR15027 50 ug
EUR 396

PDGF-C

GT15151 100 ug
EUR 526

PDGF-BB

E21-199 10ug
EUR 343

PDGF Antagonist

H-8650.0001 1.0mg
EUR 357
Description: Sum Formula: C77H122N20O17; CAS# [143784-00-3]

PDGF Antagonist

H-8650.0005 5.0mg
EUR 1336
Description: Sum Formula: C77H122N20O17; CAS# [143784-00-3]

Anti-PDGF Receptor alpha (2D2-1A11)

YF-MA14649 100 ug
EUR 363
Description: Mouse monoclonal to PDGF Receptor alpha

Anti-PDGF Receptor alpha (4H1-1C9)

YF-MA14650 100 ug
EUR 363
Description: Mouse monoclonal to PDGF Receptor alpha

anti-PDGF Receptor β (Phospho-Tyr579)

LF-PA0033 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr579)

anti-PDGF Receptor β (Phospho-Tyr716)

LF-PA0035 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr716)

anti-PDGF Receptor β (Phospho-Tyr740)

LF-PA0036 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr740)

anti-PDGF Receptor β (Phospho-Tyr771)

LF-PA0038 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr771)

anti-PDGF Receptor β (Phospho-Tyr857)

LF-PA0039 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr857)

anti-PDGF Receptor β (Phospho-Tyr1009)

LF-PA0040 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1009)

anti-PDGF Receptor β (Phospho-Tyr1021)

LF-PA0041 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1021)

anti-PDGF Receptor β (Phospho-Tyr1021)

LF-PA0094 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1021)

anti-PDGF Receptor β (Ab-752)

LF-PA20392 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β

anti-PDGF Receptor β (Phospho-Tyr751)

LF-PA20626 100 ul
EUR 354
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr751)

anti-PDGF Receptor β (Ab-751)

LF-PA20719 100 ul
EUR 334
Description: Rabbit polyclonal to PDGF Receptor β

Anti-PDGF Receptor beta/PDGFRB Antibody

A00096-1 100ug/vial
EUR 334

Anti-PDGF Receptor alpha/PDGFRA Antibody

PA1678 100ug/vial
EUR 334

Anti-PDGF Receptor alpha/PDGFRA Antibody

PB9771 100ug/vial
EUR 334

PDGF-CC, human recombinant

7183-10
EUR 207

PDGF-CC, human recombinant

7183-50
EUR 675

PDGF ELISA KIT|Human

EF007049 96 Tests
EUR 689

PDGF-AA, human recombinant

4482-10
EUR 332

PDGF-AA, human recombinant

4482-1000
EUR 6955

The emerging complexity of PDGFRs: activation, internalization and signal attenuation.

The platelet-derived growth factor receptor (PDGFR) family of receptor tyrosine kinases allows cells to communicate with the environment to regulate diverse cellular activities.
Here, we highlight recent data investigating the structural makeup of individual PDGFRs upon activation, revealing the importance of the whole receptor in the propagation of extracellular ligand binding and dimerization.
Furthermore, we review ongoing research demonstrating the significance of receptor internalization and signal attenuation in the regulation of PDGFR activity.

Human Anti-Brucella IgM ELISA Kit

Interactions with internalization machinery, signaling from endosomes, receptor degradation and receptor recycling are physiological means by which cells fine-tune PDGFR responses to growth factor stimulation.
In this review, we discuss the biophysical, structural, in silico and biochemical data that have provided evidence for these mechanisms. We further highlight the commonalities and differences between PDGFRα and PDGFRβ signaling, revealing critical gaps in knowledge.
In total, this review provides a conclusive summary on the state of the PDGFR field and underscores the need for novel techniques to fully elucidate the mechanisms of PDGFR activation, internalization and signal attenuation.

 

PDGF-BB, human recombinant

4488-10
EUR 332

PDGF-BB, human recombinant

4488-1000
EUR 6955

PDGF-BB, human recombinant

4488-50
EUR 936

Recombinant Human PDGF-BB

SJA04-01 10µg/vial
EUR 256

Human PDGF-BB Protein

abx060208-100ug 100 ug
EUR 523

Human PDGF-BB Protein

abx060258-100ug 100 ug
EUR 523

rec PDGF BB (human)

H-7530.0002 2.0µg
EUR 162

rec PDGF BB (human)

H-7530.0010 10.0µg
EUR 381

PDGF BB antibody

70R-PR020 50 ug
EUR 273
Description: Affinity purified Rabbit polyclonal PDGF BB antibody

rHu PDGF-BB

AK8292-0002 2µg Ask for price

rHu PDGF-BB

AK8292-0010 10µg Ask for price

rHu PDGF-BB

AK8292-0100 100µg Ask for price

rHu PDGF-BB

AK8292-1000 1mg Ask for price

PDGF BB protein

30R-2611 10 ug
EUR 359
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein

30R-2612 10 ug
EUR 302
Description: Purified recombinant Mouse PDGF BB protein

PDGF BB protein

30R-AP004 2 ug
EUR 133
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein

30R-AP051 10 ug
EUR 273
Description: Purified recombinant Human PDGF BB protein

PDGF-BB Antibody

5488-200
EUR 316

PDGF-BB Antibody

5488-30T
EUR 146

PDGF-BB Antibody

5489-100
EUR 316

PDGF-BB Antibody

5489-30T
EUR 146

PDGF-BB, CF

PR15026CF 50 ug
EUR 1087

PDGF-BB, CF

PR15027CF 50 ug
EUR 396

PDGF-BB, Mouse

HY-P7087 100ug
EUR 946

PDGF-BB, Rat

HY-P7278 50ug
EUR 383

PDGF-BB ELISA KIT|Human

EF000205 96 Tests
EUR 689

Human PDGF-BB ELISA Kit

RK04112 96 Tests
EUR 521

Recombinant Human PDGF-BB Protein

RP00834 10 μg
EUR 221

Recombinant Human PDGF-BB Protein

PROTP01127-4 10ug
EUR 317
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB (P.pastoris-expressed), Human

HY-P7055A 10ug
EUR 268

Human PDGF-BB ELISA Kit

EHP0050 96Tests
EUR 521

Human PDGF-BB ELISA Kit

EHP0634 96Tests
EUR 521

PDGF-BB, human recombinant protein

P1047-.01 10 µg
EUR 313
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein

P1047-.05 50 µg
EUR 877
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein

P1047-1 1 mg
EUR 6522
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant

4489-10
EUR 267

PDGF-BB, murine recombinant

4489-1000
EUR 5362

PDGF-BB, murine recombinant

4489-50
EUR 729

Polyclonal PDGF-BB Antibody

APR08990G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

Polyclonal PDGF-BB Antibody

APR00412G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

Human CellExp? PDGF-BB, human recombinant

7276-10
EUR 419

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-10ug 10ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-50ug 50ug
EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Human PDGF-BB PicoKine ELISA Kit

EK0956 96 wells
EUR 425
Description: For quantitative detection of human PDGF-BB in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

rHu PDGF-BB (yeast) (cGMP)

AK8274-1000 1mg Ask for price

Sheep PDGF-BB ELISA Kit

ESP0050 96Tests
EUR 521

Recombinant Murine PDGF-BB Protein

PROTP31240-1 10ug
EUR 317
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Anserini PDGF-BB ELISA Kit

EAP0634 96Tests
EUR 521

Rat PDGF-BB ELISA Kit

ERP0050 96Tests
EUR 521

Rat PDGF-BB ELISA Kit

ERP0634 96Tests
EUR 521

Rabbit PDGF-BB ELISA Kit

ERTP0050 96Tests
EUR 521

Rabbit PDGF-BB ELISA Kit

ERTP0634 96Tests
EUR 521

Monkey PDGF-BB ELISA Kit

EMKP0050 96Tests
EUR 521

Mouse PDGF-BB ELISA Kit

EMP0050 96Tests
EUR 521

Mouse PDGF-BB ELISA Kit

EMP0634 96Tests
EUR 521

Porcine PDGF-BB ELISA Kit

EPP0050 96Tests
EUR 521

Porcine PDGF-BB ELISA Kit

EPP0634 96Tests
EUR 521

Chicken PDGF-BB ELISA Kit

ECKP0050 96Tests
EUR 521

Canine PDGF-BB ELISA Kit

ECP0050 96Tests
EUR 521

Canine PDGF-BB ELISA Kit

ECP0634 96Tests
EUR 521

Bovine PDGF-BB ELISA Kit

EBP0050 96Tests
EUR 521

Bovine PDGF-BB ELISA Kit

EBP0634 96Tests
EUR 521

Goat PDGF-BB ELISA Kit

EGTP0050 96Tests
EUR 521

Goat PDGF-BB ELISA Kit

EGTP0634 96Tests
EUR 521

PDGF-BB, murine recombinant protein

P1048-.01 10 µg
EUR 313
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein

P1048-.05 50 µg
EUR 877
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein

P1048-1 1 mg
EUR 6522
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

CN-03344H1 96T
EUR 457

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

CN-03344H2 48T
EUR 306

Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit

CSB-E08923h-24T 1 plate of 24 wells
EUR 165
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit

1-CSB-E08923h
  • EUR 900.00
  • EUR 5476.00
  • EUR 2900.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

201-12-0073 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Platelet Derived Growth Factor-BB (PDGF-BB) CLIA Kit

abx197499-96tests 96 tests
EUR 825

Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit

GA-E0112HM-48T 48T
EUR 289

Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit

GA-E0112HM-96T 96T
EUR 466

PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein

PROTP01127-2 Regular: 10ug
EUR 317
Description: Platelet-Derived Growth Factor BB Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.3 kDa. PDGF-BB is purified by proprietary chromatographic techniques.

Human PDGF-BB(Platelet Derived Growth Factor-BB) ELISA Kit

EH0254 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit

QY-E00600 96T
EUR 361

Polyclonal PDGF-BB Antibody (aa21-70)

APR08991G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB (aa21-70). This antibody is tested and proven to work in the following applications:

Polyclonal PDGF-BB Antibody (C-Terminus)

APR08992G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PDGF-BB (C-Terminus). This antibody is tested and proven to work in the following applications:

Guinea Pig PDGF-BB ELISA Kit

EGP0050 96Tests
EUR 521

Guinea Pig PDGF-BB ELISA Kit

EGP0634 96Tests
EUR 521

CLIA kit for Human PDGF-BB (Platelet Derived Growth Factor-BB)

E-CL-H1012 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Human PDGF-BB (Platelet Derived Growth Factor-BB) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human Platelet-Derived Growth Factor-BB (PDGF-BB)

KTE61270-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Human Platelet-Derived Growth Factor-BB (PDGF-BB) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Platelet-Derived Growth Factor-BB (PDGF-BB)

KTE61270-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Human Platelet-Derived Growth Factor-BB (PDGF-BB) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Platelet-Derived Growth Factor-BB (PDGF-BB)

KTE61270-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Human Platelet-Derived Growth Factor-BB (PDGF-BB) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human PDGF-BB (Platelet Derived Growth Factor BB)

E-EL-H1577 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human PDGF-BB (Platelet Derived Growth Factor BB) in samples from Serum, Plasma, Cell supernatant

PDGF-BB Platelet Derived Growth Factor-BB Human Recombinant Protein, HEK

PROTP01127-3 Regular: 10ug
EUR 317
Description: PDGF-BB Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight of 25kDa due to glycosylation.;The PDGF-BB is purified by proprietary chromatographic techniques.