Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells

 

Identifying effective anti-fibrotic therapies is a major clinical need that remains unmet. In the present study, roseotoxin B was shown to possess an improving effect on cholestatic liver fibrosis in bile duct-ligated mice, as proved by histochemical and immunohistochemical staining, hepatic biochemical parameters, and TUNEL apoptotic cell detection in tissue sections.

Using cellular thermal shift assay, computational molecular docking, microscale thermophoresis technology, and surface plasmon resonance biosensor, we confirmed that PDGFR-β was a direct target of roseotoxin B in fibrotic livers.

Platelet Derived Growth Factor C (PDGF-C) Antibody

Of note, human tissue microarrays detected pathologically high expression of p-PDGFR-β in liver samples of ~80% of patients with liver fibrosis and cirrhosis.
PDGF-B/PDGFR-β pathway promotes transdifferentiation and excessive proliferation of hepatic stellate cells (HSCs), which is a very crucial driver for liver fibrosis.
Meaningfully, roseotoxin B blocked the formation of PDGF-BB/PDGFR-ββ complex by targeting the D2 domain of PDGFR-β, thereby inhibiting the PDGF-B/PDGFR-β pathway in HSCs. In summary, our study provided roseotoxin B as a unique candidate agent for the treatment of liver fibrosis.

 

Activation PDGFR-α/AKT Mediated Signaling Pathways in Oral Squamous Cell Carcinoma by Mesenchymal Stem/Stromal Cells Promotes Anti-apoptosis and Decreased Sensitivity to Cisplatin.

 

 

Desmoplasia, a hallmark of a head and neck cancer, has both biologic and physiologic effects on cancer progression and chemotherapeutic response. Mesenchymal stem/stromal cells (MSCs), also known as mesenchymal stromal progenitor cells, have been shown to play a role in cancer progression, alter apoptotic responses, and confer resistance to chemotherapy in various carcinomas.

The pathophysiology of MSCs with respect to tumorigenesis is widely reported in other cancers and is sparsely reported in oral squamous cell carcinomas (OSCCs). We previously reported paracrine mediated PDGF-AA/PDGFR-α signaling to underlie MSCs chemotaxis in OSCC.

Mouse Anti-Hepatitis B Virus Core Antibody (HBcAb) ELISA Kit

Given the poor clinical response to primary chemotherapy, we hypothesized that MSCs may alter cancer cell sensitivity to cisplatin through activation of PDGFR-α mediated signaling pathways.
Co-culture of MSCs with human derived OSCC cell lines, JHU-012 and -019, resulted in a significant increase in the production of PDGF-AA and MCP-1 compared to cancer cells grown alone (p < 0.005) and was accompanied by an increase in the phosphorylation state of PDGFR-α (p < 0.02) and downstream target AKT at S473 (p < 0.025) and T308 (p < 0.02). JHU-012 and -019 cancer cells grown in co-culture were significantly less apoptotic (p < 0.001), expressed significantly higher levels of Bcl-2 (p < 0.04) with a concomitant significant decrease in bid expression (p < 0.001) compared to cancer cells grown alone.
There was a significant increase in the cisplatin dose response curve in cancer cell clones derived from JHU-012 and 019 cancer cells grown in co-culture with MSCs compared to clones derived from cancer cells grown alone (p < 0.001).
vegf-a
vegf-a
Moreover clones derived from JHU-012 cells grown in co-culture with MSCs were significantly more susceptible to cisplatin following pretreatment with, crenolanib, a PDGFR inhibitor, compared to cancer cells grown alone or in co-culture with MSCs (p < 0.0001).
These findings suggest that crosstalk between cancer cells and MSCs is mediated, at least in part, by activation of autocrine PDGF-AA/PDGFR-α loop driving AKT-mediated signaling pathways, resulting in reduced cancer cell sensitivity to cisplatin through alterations in apoptosis.

 

PDGF-B Polyclonal Antibody
ABP55531-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110

PDGF-B Polyclonal Antibody
ES6530-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGF-B from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

PDGF-B Polyclonal Antibody
ES6530-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGF-B from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

ELISA PLATE READER : MICRO READ 1000
1000 1 unit
EUR 2628

ELISA PLATE SHAKER : MICRO SHAKE 1200
1200 1 unit
EUR 916.8

ELISA PLATE WASHER : MICRO WASH 1100
1100 1 unit
EUR 2403.6

PDGF-B Recombinant Protein
96-936 0.05 mg
EUR 651.3
Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

PDGF, CF Human
PR15024CF 5 ug
EUR 1743.6

PDGF - A Human
PR27059 5 ug
EUR 229.2

PDGF - AA Human
PR27061 2 ug
EUR 229.2

PDGF - AB Human
PR27062 2 ug
EUR 229.2

PDGF-BB, Human
HY-P7055 10ug
EUR 321.6

PDGF-BB, human
RC216-21 2ug
EUR 125.26

Human Platelet-Derived Growth Factor-B,PDGF-B ELISA kit
201-12-2119 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit
QY-E00606 96T
EUR 480

Human Platelet-Derived Growth Factor-B,PDGF-B ELISA kit
YLA1163HU-48T 48T
EUR 435

Human Platelet-Derived Growth Factor-B,PDGF-B ELISA kit
YLA1163HU-96T 96T
EUR 562.5

Recombinant Human PDGF-B Protein, Untagged, E.coli-1mg
QP5307-1mg 1mg
EUR 4386

Recombinant Human PDGF-B Protein, Untagged, E.coli-2ug
QP10398-ec-2ug 2ug
EUR 184.8

Recombinant Human PDGF-B Protein, Untagged, E.coli-10ug
QP10398-ec-10ug 10ug
EUR 348

Recombinant Human PDGF-B Protein, Untagged, E.coli-500ug
QP5318-500ug 500ug
EUR 2960.4

Recombinant Human PDGF-B Protein, Untagged, E.coli-100ug
QP10398-ec-100ug 100ug
EUR 1522.8

Recombinant Human PDGF-B Protein, Untagged, E.coli-250ug
QP10398-ec-250ug 250ug
EUR 2686.8

PDGF-B Platelet-Derived Growth Factor B Human Recombinant Protein
PROTP01127-1 Regular: 20ug
EUR 380.4
Description: PDGF-B Human Recombinant mature chain produced in E.Coli is a non-glycosylated, polypeptide chain containing 109 amino acids fragment (82-190) and having a molecular mass of 16.75 kDa. The PDGF-B is fused with an amino-terminal hexahistidine tag and purified by proprietary chromatographic techniques.

Genorise® Human PDGF-B Expression Plasmid, 10 ug
GR163018 10 µg
EUR 219

Genorise® Goat Anti-porcine PDGF-B polyclonal antibody
GR105219 100 ug
EUR 438

Human PDGF ELISA Kit
EHP0040 96Tests
EUR 625.2

rec PDGF BB (human)
H-7530.0002 2.0µg
EUR 194.4

rec PDGF BB (human)
H-7530.0010 10.0µg
EUR 457.2

rec PDGF AA (human)
H-7640.0002 2.0µg
EUR 194.4

rec PDGF AA (human)
H-7640.0010 10.0µg
EUR 457.2

Human PDGF-BB Protein
abx060208-100ug 100 ug
EUR 627.6

Human PDGF-BB Protein
abx060258-100ug 100 ug
EUR 627.6

PDGF ELISA KIT|Human
EF007049 96 Tests
EUR 826.8

Human PDGF-αR ELISA Kit
EHP0039 96Tests
EUR 625.2

ELISA kit for Human PDGF-B (Platelet Derived Growth Factor Subunit B)
E-EL-H1670 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human PDGF-B (Platelet Derived Growth Factor Subunit B) in samples from Serum, Plasma, Cell supernatant

Recombinant Human PDGF-BB
SJA04-01 10µg/vial
EUR 307.2

Recombinant Human PDGF-AA
HEGFP-0508 10ug Ask for price

Recombinant Human PDGF-BB
HEGFP-1601 10ug Ask for price

Anti-PDGF beta/PDGFB Antibody
A00348 100ug/vial
EUR 352.8

Anti-PDGF beta/PDGFB Antibody
PB9311 100ug/vial
EUR 352.8

PDGF-AA, human recombinant
4482-10 each
EUR 398.4

PDGF-AA, human recombinant
4482-1000 each
EUR 8346

PDGF-AA, human recombinant
4482-50 each
EUR 1123.2

PDGF-AB, human recombinant
4485-10 each
EUR 398.4

PDGF-AB, human recombinant
4485-1000 each
EUR 8346

PDGF-AB, human recombinant
4485-50 each
EUR 1123.2

PDGF-BB, human recombinant
4488-10 each
EUR 398.4

PDGF-BB, human recombinant
4488-1000 each
EUR 8346

PDGF-BB, human recombinant
4488-50 each
EUR 1123.2

PDGF-CC, human recombinant
7183-10 each
EUR 248.4

PDGF-CC, human recombinant
7183-50 each
EUR 810

Human PDGF-AB ELISA kit
LF-EK50325 1×96T
EUR 777.6

Human PDGF-BB ELISA Kit
EHP0050 96Tests
EUR 625.2

Human PDGF-BB ELISA Kit
EHP0634 96Tests
EUR 625.2

Human PDGF-BB ELISA Kit
RK04112 96 Tests
EUR 625.2

PDGF/ Rat PDGF ELISA Kit
ELA-E0528r 96 Tests
EUR 1063.2

PDGF antibody
20R-PG003 1 mg
EUR 1003.2
Description: Goat polyclonal PDGF antibody

Recombinant Human PDGFAA/PDGF-AA Protein
RP00909 10 μg
EUR 265.2

PDGF-AB ELISA KIT|Human
EF000111 96 Tests
EUR 826.8

PDGF-BB ELISA KIT|Human
EF000205 96 Tests
EUR 826.8

PDGF-AA ELISA KIT|Human
EF007050 96 Tests
EUR 826.8

Human PDGF receptor ELISA kit
E01P0755-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human PDGF receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human PDGF receptor ELISA kit
E01P0755-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human PDGF receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human PDGF receptor ELISA kit
E01P0755-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human PDGF receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anti-PDGF-B antibody
STJ94996 200 µl
EUR 236.4
Description: PDGF-B a protein encoded by the PDGFB gene which is approximately 27,2 kDa. PDGF-B is secreted into the extracellular space. It is involved in RET signalling, apoptotic pathways, GAB1 signalosome and the GPCR pathway. It is a growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. It is required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. It also plays an important role in wound healing. PDGF-B is expressed at high levels in the heart, brain, placenta and foetal kidney. Mutations in the PDGFB gene may result in basal ganglia calcification and familial meningioma. STJ94996 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of PDGF-B protein.

Recombinant Human PDGF-BB Protein
PROTP01127-4 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Human PDGF-AA Protein
PROTP04085-4 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids).

Recombinant Human PDGF-AB Protein
PROTP20033-2 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).

Recombinant Human PDGF-CC Protein
PROTQ9NRA1-1 20ug
EUR 380.4
Description: The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules epithelial cell development. Mature PDGFs are stored in platelet α-granules and are released upon platelet activation. PDGF-AA, -AB, -BB and –CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor. Recombinant human PDGF-CC is a 25kDa protein consisting of two identical disulfide-linked 114 amino-acid polypeptide chains.

Human PDGF Signaling Primer Library
HPDGF-I 1 set
EUR 657.6

Recombinant Human PDGF-BB Protein
RP00834 10 μg
EUR 265.2

PDGF-DD (CHO-expressed), Human
HY-P7280 10ug
EUR 267.6

Nori® Human PDGF ELISA Kit
GR111094 96-well
EUR 461

ELISA kit for Human PDGF-AB
EK5210 96 tests
EUR 622.8
Description: Enzyme-linked immunosorbent assay kit for quantification of Human PDGF-AB in samples from serum, plasma, tissue homogenates and other biological fluids.

Nori Human PDGF-AA ELISA Kit
GR111034 96-well
EUR 461

Nori Human PDGF-BB ELISA Kit
GR111035 96-well
EUR 461

PDGF-CC (HEK293-expressed), Human
HY-P7279 10ug
EUR 267.6

Anti-PDGF Receptor beta/PDGFRB Antibody
A00096-1 100ug/vial
EUR 400.8

Human PDGF-AB ELISA kit (4X96T)
LF-EK50326 4×96T
EUR 2641.2

Anti-PDGF Receptor alpha/PDGFRA Antibody
PB9771 100ug/vial
EUR 400.8

Anti-PDGF Receptor alpha/PDGFRA Antibody
PA1678 100ug/vial
EUR 400.8

PDGF-BB, human recombinant protein
P1047-.01 10 µg
EUR 375.6
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein
P1047-.05 50 µg
EUR 1052.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

The emerging complexity of PDGFRs: activation, internalization and signal attenuation.

The platelet-derived growth factor receptor (PDGFR) family of receptor tyrosine kinases allows cells to communicate with the environment to regulate diverse cellular activities.
Here, we highlight recent data investigating the structural makeup of individual PDGFRs upon activation, revealing the importance of the whole receptor in the propagation of extracellular ligand binding and dimerization.
Furthermore, we review ongoing research demonstrating the significance of receptor internalization and signal attenuation in the regulation of PDGFR activity.

Human Anti-Brucella IgM ELISA Kit
Interactions with internalization machinery, signaling from endosomes, receptor degradation and receptor recycling are physiological means by which cells fine-tune PDGFR responses to growth factor stimulation.
In this review, we discuss the biophysical, structural, in silico and biochemical data that have provided evidence for these mechanisms. We further highlight the commonalities and differences between PDGFRα and PDGFRβ signaling, revealing critical gaps in knowledge.
In total, this review provides a conclusive summary on the state of the PDGFR field and underscores the need for novel techniques to fully elucidate the mechanisms of PDGFR activation, internalization and signal attenuation.

 

Recombinant Human PDGF-BB
HEGFP-1601 10ug Ask for price

PDGF-BB
90800-1 10 µg
EUR 215
Description: Human recombinant PDGF-BB (GenBank Accession No. NM_002608) is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total a.a.) expressed in an E. coli expression system.

PDGF-BB
90800-2 100 µg
EUR 1185
Description: Human recombinant PDGF-BB (GenBank Accession No. NM_002608) is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total a.a.) expressed in an E. coli expression system.

PDGF-BB
90800-3 1000 µg
EUR 4320
Description: Human recombinant PDGF-BB (GenBank Accession No. NM_002608) is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total a.a.) expressed in an E. coli expression system.

PDGF-BB
PR15027 50 ug
EUR 475.2

PDGF-BB
E21-199 10ug
EUR 411.6

PDGF-BB/ Rat PDGF- BB ELISA Kit
ELA-E0633r 96 Tests
EUR 1063.2

PDGF-BB, human recombinant
4488-10 each
EUR 398.4

PDGF-BB, human recombinant
4488-1000 each
EUR 8346

PDGF-BB, human recombinant
4488-50 each
EUR 1123.2

PDGF BB antibody
70R-PR020 50 ug
EUR 327.6
Description: Affinity purified Rabbit polyclonal PDGF BB antibody

PDGF-BB Antibody
5488-200 each
EUR 379.2

PDGF-BB Antibody
5488-30T each
EUR 175.2

PDGF-BB Antibody
5489-100 each
EUR 379.2

PDGF-BB Antibody
5489-30T each
EUR 175.2

Human PDGF-BB ELISA Kit
EHP0050 96Tests
EUR 625.2

Human PDGF-BB ELISA Kit
EHP0634 96Tests
EUR 625.2

Human PDGF-BB ELISA Kit
RK04112 96 Tests
EUR 625.2

PDGF-BB ELISA KIT|Human
EF000205 96 Tests
EUR 826.8

Recombinant Human PDGF-BB Protein
PROTP01127-4 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Human PDGF-BB Protein
RP00834 10 μg
EUR 265.2

PDGF-BB, CF
PR15026CF 50 ug
EUR 1304.4

PDGF-BB, CF
PR15027CF 50 ug
EUR 475.2

rHu PDGF-BB
AK8292-0002 2µg Ask for price

rHu PDGF-BB
AK8292-0010 10µg Ask for price

rHu PDGF-BB
AK8292-0100 100µg Ask for price

rHu PDGF-BB
AK8292-1000 1mg Ask for price

PDGF-BB, Rat
HY-P7278 50ug
EUR 459.6

PDGF-BB, human recombinant protein
P1047-.01 10 µg
EUR 375.6
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein
P1047-.05 50 µg
EUR 1052.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein
P1047-1 1 mg
EUR 7826.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB (P.pastoris-expressed), Human
HY-P7055A 10ug
EUR 321.6

PDGF BB protein
30R-2611 10 ug
EUR 430.8
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein
30R-2612 10 ug
EUR 362.4
Description: Purified recombinant Mouse PDGF BB protein

PDGF BB protein
30R-AP004 2 ug
EUR 159.6
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein
30R-AP051 10 ug
EUR 327.6
Description: Purified recombinant Human PDGF BB protein

PDGF-BB, Mouse
HY-P7087 100ug
EUR 1135.2

Nori Human PDGF-BB ELISA Kit
GR111035 96-well
EUR 461

Human PDGF-BB PicoKine ELISA Kit
EK0956 96 wells
EUR 510
Description: For quantitative detection of human PDGF-BB in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Polyclonal PDGF-BB Antibody
APR08990G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

Polyclonal PDGF-BB Antibody
APR00412G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

Genorise® Recombinant Human PDGF-BB
GR104258 5 µg
EUR 285

Human CellExp™ PDGF-BB, human recombinant
7276-10 each Ask for price

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Rat PDGF-BB
REGFP-1601 10ug Ask for price

PDGF-BB, murine recombinant
4489-10 each
EUR 320.4

PDGF-BB, murine recombinant
4489-1000 each
EUR 6434.4

PDGF-BB, murine recombinant
4489-50 each
EUR 874.8

Recombinant Murine PDGF-BB
MEGFP-1601 10ug Ask for price

Human PDGF-BB(Platelet Derived Growth Factor-BB) ELISA Kit
EH0254 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

PDGF-BB Recombinant Protein
11-380 0.05 mg
EUR 714.3
Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

PDGF-BB Recombinant Protein
40-158-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-158-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-458-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-458-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-607 0.01 mg
EUR 481.2
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet a-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-a and PDGFR-β. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). .

PDGF-BB Recombinant Protein
91-179 0.05 mg
EUR 821.4
Description: Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.

Human Platelet Derived Growth Factor-BB (PDGF-BB) CLIA Kit
abx197499-96tests 96 tests
EUR 990

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit
201-12-0073 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit
CN-03344H1 96T
EUR 548.4

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit
CN-03344H2 48T
EUR 367.2

Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit
CSB-E08923h-24T 1 plate of 24 wells
EUR 198
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit
1-CSB-E08923h
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit
GA-E0112HM-48T 48T
EUR 346.8

Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit
GA-E0112HM-96T 96T
EUR 559.2

Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit
QY-E00600 96T
EUR 433.2

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit
YLA1512HU-48T 48T
EUR 435

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit
YLA1512HU-96T 96T
EUR 562.5

anti-PDGF BB
YF-PA24331 50 ul
EUR 400.8
Description: Mouse polyclonal to PDGF BB

anti-PDGF BB
YF-PA13686 50 ug
EUR 435.6
Description: Mouse polyclonal to PDGF BB

Recombinant Human Platelet Derived Growth Factor-BB (rHu PDGF-BB)
AK8274-0100 100µg
EUR 1740

Recombinant Human Platelet Derived Growth Factor-BB (rHu PDGF-BB)
AK8274-1000 1mg
EUR 4500

ELISA kit for Human PDGF-BB (Platelet Derived Growth Factor BB)
E-EL-H1577 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human PDGF-BB (Platelet Derived Growth Factor BB) in samples from Serum, Plasma, Cell supernatant

Nori Human PDGF-BB ELISA Kit-2 Plates
GR111035-2 2 x 96-well
EUR 832

CLIA kit for Human PDGF-BB (Platelet Derived Growth Factor-BB)
E-CL-H1012 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human PDGF-BB (Platelet Derived Growth Factor-BB) in samples from Serum, Plasma, Cell supernatant

PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein
PROTP01127-2 Regular: 10ug
EUR 380.4
Description: Platelet-Derived Growth Factor BB Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.3 kDa. PDGF-BB is purified by proprietary chromatographic techniques.

Rat PDGF-BB ELISA Kit
ERP0050 96Tests
EUR 625.2

Rat PDGF-BB ELISA Kit
ERP0634 96Tests
EUR 625.2

Goat PDGF-BB ELISA Kit
EGTP0050 96Tests
EUR 625.2

Goat PDGF-BB ELISA Kit
EGTP0634 96Tests
EUR 625.2

Genorise® Anti-Canine PDGF-BB Polyclonal Antibody
GR105186 100 ug
EUR 438

Genorise® Anti-Equine PDGF-BB Polyclonal Antibody
GR105194 100 ug
EUR 438

Mouse PDGF-BB ELISA Kit
EMP0050 96Tests
EUR 625.2

Mouse PDGF-BB ELISA Kit
EMP0634 96Tests
EUR 625.2

Sheep PDGF-BB ELISA Kit
ESP0050 96Tests
EUR 625.2

Rabbit PDGF-BB ELISA Kit
ERTP0050 96Tests
EUR 625.2

Rabbit PDGF-BB ELISA Kit
ERTP0634 96Tests
EUR 625.2