Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells
Identifying effective anti-fibrotic therapies is a major clinical need that remains unmet. In the present study, roseotoxin B was shown to possess an improving effect on cholestatic liver fibrosis in bile duct-ligated mice, as proved by histochemical and immunohistochemical staining, hepatic biochemical parameters, and TUNEL apoptotic cell detection in tissue sections.
Using cellular thermal shift assay, computational molecular docking, microscale thermophoresis technology, and surface plasmon resonance biosensor, we confirmed that PDGFR-β was a direct target of roseotoxin B in fibrotic livers.
Platelet Derived Growth Factor C (PDGF-C) Antibody |
Of note, human tissue microarrays detected pathologically high expression of p-PDGFR-β in liver samples of ~80% of patients with liver fibrosis and cirrhosis.
PDGF-B/PDGFR-β pathway promotes transdifferentiation and excessive proliferation of hepatic stellate cells (HSCs), which is a very crucial driver for liver fibrosis.
Meaningfully, roseotoxin B blocked the formation of PDGF-BB/PDGFR-ββ complex by targeting the D2 domain of PDGFR-β, thereby inhibiting the PDGF-B/PDGFR-β pathway in HSCs. In summary, our study provided roseotoxin B as a unique candidate agent for the treatment of liver fibrosis.
Activation PDGFR-α/AKT Mediated Signaling Pathways in Oral Squamous Cell Carcinoma by Mesenchymal Stem/Stromal Cells Promotes Anti-apoptosis and Decreased Sensitivity to Cisplatin.
Desmoplasia, a hallmark of a head and neck cancer, has both biologic and physiologic effects on cancer progression and chemotherapeutic response. Mesenchymal stem/stromal cells (MSCs), also known as mesenchymal stromal progenitor cells, have been shown to play a role in cancer progression, alter apoptotic responses, and confer resistance to chemotherapy in various carcinomas.
The pathophysiology of MSCs with respect to tumorigenesis is widely reported in other cancers and is sparsely reported in oral squamous cell carcinomas (OSCCs). We previously reported paracrine mediated PDGF-AA/PDGFR-α signaling to underlie MSCs chemotaxis in OSCC.
Mouse Anti-Hepatitis B Virus Core Antibody (HBcAb) ELISA Kit |
Given the poor clinical response to primary chemotherapy, we hypothesized that MSCs may alter cancer cell sensitivity to cisplatin through activation of PDGFR-α mediated signaling pathways.
Co-culture of MSCs with human derived OSCC cell lines, JHU-012 and -019, resulted in a significant increase in the production of PDGF-AA and MCP-1 compared to cancer cells grown alone (p < 0.005) and was accompanied by an increase in the phosphorylation state of PDGFR-α (p < 0.02) and downstream target AKT at S473 (p < 0.025) and T308 (p < 0.02). JHU-012 and -019 cancer cells grown in co-culture were significantly less apoptotic (p < 0.001), expressed significantly higher levels of Bcl-2 (p < 0.04) with a concomitant significant decrease in bid expression (p < 0.001) compared to cancer cells grown alone.
There was a significant increase in the cisplatin dose response curve in cancer cell clones derived from JHU-012 and 019 cancer cells grown in co-culture with MSCs compared to clones derived from cancer cells grown alone (p < 0.001).
Moreover clones derived from JHU-012 cells grown in co-culture with MSCs were significantly more susceptible to cisplatin following pretreatment with, crenolanib, a PDGFR inhibitor, compared to cancer cells grown alone or in co-culture with MSCs (p < 0.0001).
These findings suggest that crosstalk between cancer cells and MSCs is mediated, at least in part, by activation of autocrine PDGF-AA/PDGFR-α loop driving AKT-mediated signaling pathways, resulting in reduced cancer cell sensitivity to cisplatin through alterations in apoptosis.
Polyclonal PDGF-B Antibody |
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| APR08989G | Leading Biology | 0.1 mg | EUR 659 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-B . This antibody is tested and proven to work in the following applications: |
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PDGF-B Polyclonal Antibody |
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| ABP55531-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110 |
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PDGF-B Polyclonal Antibody |
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| ABP55531-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110 |
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PDGF-B Polyclonal Antibody |
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| ABP55531-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110 |
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PDGF-B Recombinant Protein |
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| 96-936 | ProSci | 0.05 mg | EUR 542.75 |
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Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. |
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anti-PDGF AA |
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| YF-PA13682 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse polyclonal to PDGF AA |
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anti-PDGF AA |
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| YF-PA13683 | Abfrontier | 100 ul | EUR 403 |
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Description: Rabbit polyclonal to PDGF AA |
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anti-PDGF AA |
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| YF-PA13684 | Abfrontier | 100 ug | EUR 403 |
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Description: Rabbit polyclonal to PDGF AA |
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anti-PDGF BB |
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| YF-PA13686 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse polyclonal to PDGF BB |
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anti-PDGF AA |
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| YF-PA24330 | Abfrontier | 50 ul | EUR 334 |
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Description: Mouse polyclonal to PDGF AA |
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anti-PDGF BB |
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| YF-PA24331 | Abfrontier | 50 ul | EUR 334 |
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Description: Mouse polyclonal to PDGF BB |
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Genorise® Goat Anti-porcine PDGF-B polyclonal antibody |
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| GR105219 | Genorise Scientific | 100 ug | EUR 438 |
PDGF-B Platelet-Derived Growth Factor B Human Recombinant Protein |
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| PROTP01127-1 | BosterBio | Regular: 20ug | EUR 317 |
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Description: PDGF-B Human Recombinant mature chain produced in E.Coli is a non-glycosylated, polypeptide chain containing 109 amino acids fragment (82-190) and having a molecular mass of 16.75 kDa. The PDGF-B is fused with an amino-terminal hexahistidine tag and purified by proprietary chromatographic techniques. |
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Human Platelet-Derived Growth Factor-B,PDGF-B ELISA kit |
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| 201-12-2119 | SunredBio | 96 tests | EUR 440 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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Human Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit |
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| QY-E00606 | Qayee Biotechnology | 96T | EUR 400 |
Anti-PDGF-D Antibody |
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| A01875 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for PDGF-D Antibody (PDGFD) detection. Tested for IHC, WB, ELISA in Human. |
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Anti-PDGF-C Antibody |
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| A03092 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for PDGF-C Antibody (PDGFC) detection.tested for IHC in Human, Mouse, Rat. |
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Anti-PDGF-D antibody |
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| STJ96664 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to PDGF-D. |
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Anti-PDGF alpha antibody |
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| STJ97793 | St John's Laboratory | 200 µl | EUR 197 |
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Description: PDGFRalpha is a protein encoded by the PDGFRA gene which is approximately 122,6 kDa. PDGFRalpha is localised to the cell membrane. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts and the GPCR pathway. It is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. It either promotes or inhibits cell proliferation and cell migration and plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. PDGFRalpha is widely expressed in the body including platelets, brain and colon. Mutations in the PDGFRA gene may result in gastrointestinal stromal tumor. STJ97793 was developed from clone 7A3 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of PDGFRalpha. |
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Anti-PDGF alpha antibody |
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| STJ97794 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Mouse monoclonal to PDGFRalpha. |
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Anti-PDGF-C antibody |
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| STJ98770 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to PDGF-C. |
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Anti-PDGF-A antibody |
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| STJ94995 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to PDGF-A. |
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anti-PDGF Receptor alpha |
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| YF-PA13687 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse polyclonal to PDGF Receptor alpha |
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anti-PDGF Receptor alpha |
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| YF-PA13688 | Abfrontier | 100 ug | EUR 403 |
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Description: Rabbit polyclonal to PDGF Receptor alpha |
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anti-PDGF Receptor beta |
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| YF-PA13689 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse polyclonal to PDGF Receptor beta |
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anti-PDGF Receptor beta |
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| YF-PA13690 | Abfrontier | 100 ug | EUR 403 |
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Description: Rabbit polyclonal to PDGF Receptor beta |
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Recombinant Human PDGF-B Protein, Untagged, E.coli-100ug |
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| QP10398-ec-100ug | EnQuireBio | 100ug | EUR 1269 |
Recombinant Human PDGF-B Protein, Untagged, E.coli-10ug |
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| QP10398-ec-10ug | EnQuireBio | 10ug | EUR 290 |
Recombinant Human PDGF-B Protein, Untagged, E.coli-250ug |
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| QP10398-ec-250ug | EnQuireBio | 250ug | EUR 2239 |
Recombinant Human PDGF-B Protein, Untagged, E.coli-2ug |
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| QP10398-ec-2ug | EnQuireBio | 2ug | EUR 154 |
Recombinant Human PDGF-B Protein, Untagged, E.coli-1mg |
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| QP5307-1mg | EnQuireBio | 1mg | EUR 3655 |
Recombinant Human PDGF-B Protein, Untagged, E.coli-500ug |
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| QP5318-500ug | EnQuireBio | 500ug | EUR 2467 |
Polyclonal Goat anti-GST α-form |
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| GST-ANTI-1 | Detroit R&D | 50 uL | EUR 280 |
Polyclonal Goat anti-GST μ-form |
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| GST-ANTI-2 | Detroit R&D | 50 uL | EUR 280 |
Polyclonal Goat anti-GST p-form |
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| GST-ANTI-3 | Detroit R&D | 50 uL | EUR 280 |
Fmoc-b,b-diphenyl-Ala-OH |
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| B-2725.0250 | Bachem | 250.0mg | EUR 139 |
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Description: Sum Formula: C30H25NO4; CAS# [201484-50-6] |
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Fmoc-b,b-diphenyl-Ala-OH |
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| B-2725.1000 | Bachem | 1.0g | EUR 357 |
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Description: Sum Formula: C30H25NO4; CAS# [201484-50-6] |
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Fmoc-b,b-diphenyl-Ala-OH |
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| B-2725.5000 | Bachem | 5.0g | EUR 1336 |
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Description: Sum Formula: C30H25NO4; CAS# [201484-50-6] |
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Goat Anti-Protective Antigen 83 (PA83; B Anthracis) IgG-biotinylated |
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| PA16-B | Alpha Diagnostics | 50 ug | EUR 408 |
Genorise® Recombinant rat PDGF-B Protein |
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| GR125048 | Genorise Scientific | 5 µg | EUR 285 |
Genorise® Recombinant Hamster PDGF-B Protein |
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| GR237045 | Genorise Scientific | 5 µg | EUR 285 |
Anti-PDGF beta/PDGFB Antibody |
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| PB9311 | BosterBio | 100ug/vial | EUR 294 |
Anti-PDGF beta/PDGFB Antibody |
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| A00348 | BosterBio | 100ug/vial | EUR 294 |
Anti-PDGF Receptor beta (4C12) |
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| YF-MA14651 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to PDGF Receptor beta |
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Rat Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit |
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| QY-E10529 | Qayee Biotechnology | 96T | EUR 361 |
Mouse Platelet-Derived Growth Factor-B(PDGF-B)ELISA Kit |
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| QY-E21211 | Qayee Biotechnology | 96T | EUR 361 |
ELISA kit for Human PDGF-B (Platelet Derived Growth Factor Subunit B) |
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| E-EL-H1670 | Elabscience Biotech | 1 plate of 96 wells | EUR 534 |
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Description: A sandwich ELISA kit for quantitative measurement of Human PDGF-B (Platelet Derived Growth Factor Subunit B) in samples from Serum, Plasma, Cell supernatant |
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Genorise® Human PDGF-B Expression Plasmid, 10 ug |
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| GR163018 | Genorise Scientific | 10 µg | EUR 219 |
PDGF-BB, human |
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| RC216-21 | Bio Basic | 2ug | EUR 104.38 |
PDGF-BB, Human |
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| HY-P7055 | MedChemExpress | 10ug | EUR 268 |
PDGF, CF Human |
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| PR15024CF | Neuromics | 5 ug | EUR 1453 |
PDGF - A Human |
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| PR27059 | Neuromics | 5 ug | EUR 191 |
PDGF - AA Human |
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| PR27061 | Neuromics | 2 ug | EUR 191 |
PDGF - AB Human |
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| PR27062 | Neuromics | 2 ug | EUR 191 |
Mouse Monoclonal Anti-Rat CD45RA/B Biotin (Clone OX-33) (mouse IgG1) |
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| RCD045RAB-B | Alpha Diagnostics | 100 tests | EUR 469 |
PDGF/ Rat PDGF ELISA Kit |
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| ELA-E0528r | Lifescience Market | 96 Tests | EUR 886 |
ELISA kit for Rat Platelet-derived growth factor-B (PDGF-B) |
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| KTE100494-48T | Abbkine | 48T | EUR 354 |
|
Description: Quantitative sandwich ELISA for measuring Rat Platelet-derived growth factor-B (PDGF-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Rat Platelet-derived growth factor-B (PDGF-B) |
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| KTE100494-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2252 |
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Description: Quantitative sandwich ELISA for measuring Rat Platelet-derived growth factor-B (PDGF-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Rat Platelet-derived growth factor-B (PDGF-B) |
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| KTE100494-96T | Abbkine | 96T | EUR 572 |
|
Description: Quantitative sandwich ELISA for measuring Rat Platelet-derived growth factor-B (PDGF-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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Fmoc-b-Ala-OH |
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| B-1025.0005 | Bachem | 5.0g | EUR 115 |
|
Description: Sum Formula: C18H17NO4; CAS# [35737-10-1] |
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Fmoc-b-Ala-OH |
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| B-1025.0025 | Bachem | 25.0g | EUR 236 |
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Description: Sum Formula: C18H17NO4; CAS# [35737-10-1] |
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Fmoc-b-Ala-OH |
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| B-1025.0100 | Bachem | 100.0g | EUR 635 |
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Description: Sum Formula: C18H17NO4; CAS# [35737-10-1] |
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Fmoc-b-Ala-OPfp |
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| B-1765.0005 | Bachem | 5.0g | EUR 236 |
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Description: Sum Formula: C24H16F5NO4; CAS# [149303-38-8] |
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Fmoc-b-Ala-OPfp |
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| B-1765.0025 | Bachem | 25.0g | EUR 841 |
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Description: Sum Formula: C24H16F5NO4; CAS# [149303-38-8] |
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Recombinant Mouse PDGF-B Protein, Untagged, E.coli-100ug |
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| QP5465-100ug | EnQuireBio | 100ug | EUR 536 |
Recombinant Mouse PDGF-B Protein, Untagged, E.coli-10ug |
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| QP5465-10ug | EnQuireBio | 10ug | EUR 237 |
Recombinant Mouse PDGF-B Protein, Untagged, E.coli-1mg |
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| QP5465-1mg | EnQuireBio | 1mg | EUR 3655 |
Recombinant Mouse PDGF-B Protein, Untagged, E.coli-2ug |
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| QP5465-2ug | EnQuireBio | 2ug | EUR 136 |
Recombinant Mouse PDGF-B Protein, Untagged, E.coli-500ug |
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| QP5465-500ug | EnQuireBio | 500ug | EUR 2259 |
Anti-PDGF Receptor alpha/PDGFRA Antibody |
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| PA1678 | BosterBio | 100ug/vial | EUR 334 |
Anti-PDGF Receptor alpha/PDGFRA Antibody |
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| PB9771 | BosterBio | 100ug/vial | EUR 334 |
Anti-PDGF Receptor beta/PDGFRB Antibody |
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| A00096-1 | BosterBio | 100ug/vial | EUR 334 |
anti-PDGF Receptor β (Phospho-Tyr579) |
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| LF-PA0033 | Abfrontier | 100 ul | EUR 334 |
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Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr579) |
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anti-PDGF Receptor β (Phospho-Tyr716) |
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| LF-PA0035 | Abfrontier | 100 ul | EUR 334 |
|
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr716) |
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anti-PDGF Receptor β (Phospho-Tyr740) |
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| LF-PA0036 | Abfrontier | 100 ul | EUR 334 |
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Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr740) |
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anti-PDGF Receptor β (Phospho-Tyr771) |
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| LF-PA0038 | Abfrontier | 100 ul | EUR 334 |
|
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr771) |
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anti-PDGF Receptor β (Phospho-Tyr857) |
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| LF-PA0039 | Abfrontier | 100 ul | EUR 334 |
|
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr857) |
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anti-PDGF Receptor β (Phospho-Tyr1009) |
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| LF-PA0040 | Abfrontier | 100 ul | EUR 334 |
|
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1009) |
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anti-PDGF Receptor β (Phospho-Tyr1021) |
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| LF-PA0041 | Abfrontier | 100 ul | EUR 334 |
|
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1021) |
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anti-PDGF Receptor β (Phospho-Tyr1021) |
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| LF-PA0094 | Abfrontier | 100 ul | EUR 334 |
|
Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr1021) |
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anti-PDGF Receptor β (Ab-752) |
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| LF-PA20392 | Abfrontier | 100 ul | EUR 334 |
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Description: Rabbit polyclonal to PDGF Receptor β |
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anti-PDGF Receptor β (Phospho-Tyr751) |
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| LF-PA20626 | Abfrontier | 100 ul | EUR 354 |
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Description: Rabbit polyclonal to PDGF Receptor β (Phospho-Tyr751) |
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anti-PDGF Receptor β (Ab-751) |
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| LF-PA20719 | Abfrontier | 100 ul | EUR 334 |
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Description: Rabbit polyclonal to PDGF Receptor β |
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Anti-PDGF Receptor alpha (2D2-1A11) |
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| YF-MA14649 | Abfrontier | 100 ug | EUR 363 |
|
Description: Mouse monoclonal to PDGF Receptor alpha |
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The emerging complexity of PDGFRs: activation, internalization and signal attenuation.
The platelet-derived growth factor receptor (PDGFR) family of receptor tyrosine kinases allows cells to communicate with the environment to regulate diverse cellular activities.
Here, we highlight recent data investigating the structural makeup of individual PDGFRs upon activation, revealing the importance of the whole receptor in the propagation of extracellular ligand binding and dimerization.
Furthermore, we review ongoing research demonstrating the significance of receptor internalization and signal attenuation in the regulation of PDGFR activity.
Human Anti-Brucella IgM ELISA Kit |
Interactions with internalization machinery, signaling from endosomes, receptor degradation and receptor recycling are physiological means by which cells fine-tune PDGFR responses to growth factor stimulation.
In this review, we discuss the biophysical, structural, in silico and biochemical data that have provided evidence for these mechanisms. We further highlight the commonalities and differences between PDGFRα and PDGFRβ signaling, revealing critical gaps in knowledge.
In total, this review provides a conclusive summary on the state of the PDGFR field and underscores the need for novel techniques to fully elucidate the mechanisms of PDGFR activation, internalization and signal attenuation.
Human PDGF-BB Protein |
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| abx060208-100ug | Abbexa | 100 ug | EUR 523 |
Human PDGF-BB Protein |
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| abx060258-100ug | Abbexa | 100 ug | EUR 523 |
rec PDGF BB (human) |
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| H-7530.0002 | Bachem | 2.0µg | EUR 162 |
rec PDGF BB (human) |
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| H-7530.0010 | Bachem | 10.0µg | EUR 381 |
Recombinant Human PDGF-BB |
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| SJA04-01 | Amyotop | 10µg/vial | EUR 256 |
PDGF-BB, human recombinant |
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| 4488-10 | Biovision | EUR 332 | |
PDGF-BB, human recombinant |
|||
| 4488-1000 | Biovision | EUR 6955 | |
PDGF-BB, human recombinant |
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| 4488-50 | Biovision | EUR 936 | |
PDGF-BB, Mouse |
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| HY-P7087 | MedChemExpress | 100ug | EUR 946 |
PDGF-BB, Rat |
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| HY-P7278 | MedChemExpress | 50ug | EUR 383 |
PDGF-BB, CF |
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| PR15026CF | Neuromics | 50 ug | EUR 1087 |
PDGF-BB, CF |
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| PR15027CF | Neuromics | 50 ug | EUR 396 |
rHu PDGF-BB |
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| AK8292-0002 | Akron Biotech | 2µg | Ask for price |
rHu PDGF-BB |
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| AK8292-0010 | Akron Biotech | 10µg | Ask for price |
rHu PDGF-BB |
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| AK8292-0100 | Akron Biotech | 100µg | Ask for price |
rHu PDGF-BB |
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| AK8292-1000 | Akron Biotech | 1mg | Ask for price |
PDGF BB antibody |
|||
| 70R-PR020 | Fitzgerald | 50 ug | EUR 273 |
|
Description: Affinity purified Rabbit polyclonal PDGF BB antibody |
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PDGF BB protein |
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| 30R-2611 | Fitzgerald | 10 ug | EUR 359 |
|
Description: Purified recombinant Human PDGF BB protein |
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PDGF BB protein |
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| 30R-2612 | Fitzgerald | 10 ug | EUR 302 |
|
Description: Purified recombinant Mouse PDGF BB protein |
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PDGF BB protein |
|||
| 30R-AP004 | Fitzgerald | 2 ug | EUR 133 |
|
Description: Purified recombinant Human PDGF BB protein |
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PDGF BB protein |
|||
| 30R-AP051 | Fitzgerald | 10 ug | EUR 273 |
|
Description: Purified recombinant Human PDGF BB protein |
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PDGF-BB Antibody |
|||
| 5488-200 | Biovision | EUR 316 | |
PDGF-BB Antibody |
|||
| 5488-30T | Biovision | EUR 146 | |
PDGF-BB Antibody |
|||
| 5489-100 | Biovision | EUR 316 | |
PDGF-BB Antibody |
|||
| 5489-30T | Biovision | EUR 146 | |
Human PDGF-BB ELISA Kit |
|||
| RK04112 | Abclonal | 96 Tests | EUR 521 |
Recombinant Human PDGF-BB Protein |
|||
| RP00834 | Abclonal | 10 μg | EUR 221 |
Recombinant Human PDGF-BB Protein |
|||
| PROTP01127-4 | BosterBio | 10ug | EUR 317 |
|
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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PDGF-BB (P.pastoris-expressed), Human |
|||
| HY-P7055A | MedChemExpress | 10ug | EUR 268 |
Human PDGF-BB ELISA Kit |
|||
| EHP0050 | Abclonal | 96Tests | EUR 521 |
Human PDGF-BB ELISA Kit |
|||
| EHP0634 | Abclonal | 96Tests | EUR 521 |
PDGF-BB, human recombinant protein |
|||
| P1047-.01 | ApexBio | 10 µg | EUR 313 |
|
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB, human recombinant protein |
|||
| P1047-.05 | ApexBio | 50 µg | EUR 877 |
|
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB, human recombinant protein |
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| P1047-1 | ApexBio | 1 mg | EUR 6522 |
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Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB ELISA KIT|Human |
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| EF000205 | Lifescience Market | 96 Tests | EUR 689 |
Polyclonal PDGF-BB Antibody |
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| APR08990G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications: |
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Polyclonal PDGF-BB Antibody |
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| APR00412G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications: |
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PDGF-BB Recombinant Protein |
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| 11-380 | ProSci | 0.05 mg | EUR 595.25 |
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Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. |
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PDGF-BB Recombinant Protein |
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| 40-607 | ProSci | 0.01 mg | EUR 401 |
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Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet a-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-a and PDGFR-β. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). . |
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PDGF-BB Recombinant Protein |
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| 40-158-0002mg | ProSci | 0.002 mg | EUR 259.25 |
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Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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PDGF-BB Recombinant Protein |
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| 40-158-001mg | ProSci | 0.01 mg | EUR 364.25 |
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Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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PDGF-BB Recombinant Protein |
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| 40-458-0002mg | ProSci | 0.002 mg | EUR 259.25 |
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Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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PDGF-BB Recombinant Protein |
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| 40-458-001mg | ProSci | 0.01 mg | EUR 364.25 |
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Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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PDGF-BB, murine recombinant |
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| 4489-10 | Biovision | EUR 267 | |
PDGF-BB, murine recombinant |
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| 4489-1000 | Biovision | EUR 5362 | |
PDGF-BB, murine recombinant |
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| 4489-50 | Biovision | EUR 729 | |
PDGF-BB Recombinant Protein |
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| 91-179 | ProSci | 0.05 mg | EUR 684.5 |
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Description: Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. |
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Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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| C199-10ug | Novoprotein | 10ug | EUR 202 |
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Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
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Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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| C199-1mg | Novoprotein | 1mg | EUR 2283 |
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Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
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Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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| C199-500ug | Novoprotein | 500ug | EUR 1613 |
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Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
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Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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| C199-50ug | Novoprotein | 50ug | EUR 496 |
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Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
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Human PDGF-BB PicoKine ELISA Kit |
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| EK0956 | BosterBio | 96 wells | EUR 425 |
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Description: For quantitative detection of human PDGF-BB in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
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Nori Human PDGF-BB ELISA Kit |
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| GR111035 | Genorise Scientific | 96-well | EUR 461 |
Genorise® Recombinant Human PDGF-BB |
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| GR104258 | Genorise Scientific | 5 µg | EUR 285 |
Sheep PDGF-BB ELISA Kit |
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| ESP0050 | Abclonal | 96Tests | EUR 521 |
Recombinant Murine PDGF-BB Protein |
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| PROTP31240-1 | BosterBio | 10ug | EUR 317 |
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Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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Anserini PDGF-BB ELISA Kit |
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| EAP0634 | Abclonal | 96Tests | EUR 521 |
Rat PDGF-BB ELISA Kit |
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| ERP0050 | Abclonal | 96Tests | EUR 521 |
Rat PDGF-BB ELISA Kit |
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| ERP0634 | Abclonal | 96Tests | EUR 521 |
Rabbit PDGF-BB ELISA Kit |
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| ERTP0050 | Abclonal | 96Tests | EUR 521 |
Rabbit PDGF-BB ELISA Kit |
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| ERTP0634 | Abclonal | 96Tests | EUR 521 |
Monkey PDGF-BB ELISA Kit |
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| EMKP0050 | Abclonal | 96Tests | EUR 521 |
Mouse PDGF-BB ELISA Kit |
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| EMP0050 | Abclonal | 96Tests | EUR 521 |
Mouse PDGF-BB ELISA Kit |
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| EMP0634 | Abclonal | 96Tests | EUR 521 |
Porcine PDGF-BB ELISA Kit |
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| EPP0050 | Abclonal | 96Tests | EUR 521 |
Porcine PDGF-BB ELISA Kit |
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| EPP0634 | Abclonal | 96Tests | EUR 521 |
Chicken PDGF-BB ELISA Kit |
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| ECKP0050 | Abclonal | 96Tests | EUR 521 |
Canine PDGF-BB ELISA Kit |
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| ECP0050 | Abclonal | 96Tests | EUR 521 |
Canine PDGF-BB ELISA Kit |
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| ECP0634 | Abclonal | 96Tests | EUR 521 |
Bovine PDGF-BB ELISA Kit |
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| EBP0050 | Abclonal | 96Tests | EUR 521 |
Bovine PDGF-BB ELISA Kit |
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| EBP0634 | Abclonal | 96Tests | EUR 521 |
Goat PDGF-BB ELISA Kit |
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| EGTP0050 | Abclonal | 96Tests | EUR 521 |
Goat PDGF-BB ELISA Kit |
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| EGTP0634 | Abclonal | 96Tests | EUR 521 |
PDGF-BB, murine recombinant protein |
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| P1048-.01 | ApexBio | 10 µg | EUR 313 |
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Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB, murine recombinant protein |
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| P1048-.05 | ApexBio | 50 µg | EUR 877 |
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Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB, murine recombinant protein |
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| P1048-1 | ApexBio | 1 mg | EUR 6522 |
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Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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rHu PDGF-BB (yeast) (cGMP) |
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| AK8274-1000 | Akron Biotech | 1mg | Ask for price |
Genorise® Anti-Canine PDGF-BB Polyclonal Antibody |
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| GR105186 | Genorise Scientific | 100 ug | EUR 438 |
Genorise® Anti-Equine PDGF-BB Polyclonal Antibody |
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| GR105194 | Genorise Scientific | 100 ug | EUR 438 |
Human CellExp™ PDGF-BB, human recombinant |
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| 7276-10 | Biovision | Ask for price | |
Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit |
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| CSB-E08923h-24T | Cusabio | 1 plate of 24 wells | EUR 165 |
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Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit |
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| 1-CSB-E08923h | Cusabio |
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Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit |
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| GA-E0112HM-48T | GenAsia Biotech | 48T | EUR 289 |
Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit |
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| GA-E0112HM-96T | GenAsia Biotech | 96T | EUR 466 |
PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein |
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| PROTP01127-2 | BosterBio | Regular: 10ug | EUR 317 |
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Description: Platelet-Derived Growth Factor BB Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.3 kDa. PDGF-BB is purified by proprietary chromatographic techniques. |
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Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit |
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| 201-12-0073 | SunredBio | 96 tests | EUR 440 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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Human Platelet Derived Growth Factor-BB (PDGF-BB) CLIA Kit |
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| abx197499-96tests | Abbexa | 96 tests | EUR 825 |
Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit |
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| QY-E00600 | Qayee Biotechnology | 96T | EUR 361 |
Human PDGF-BB(Platelet Derived Growth Factor-BB) ELISA Kit |
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| EH0254 | FN Test | 96T | EUR 524.1 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml |
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Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit |
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| CN-03344H1 | ChemNorm | 96T | EUR 457 |
