Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells

 

Identifying effective anti-fibrotic therapies is a major clinical need that remains unmet. In the present study, roseotoxin B was shown to possess an improving effect on cholestatic liver fibrosis in bile duct-ligated mice, as proved by histochemical and immunohistochemical staining, hepatic biochemical parameters, and TUNEL apoptotic cell detection in tissue sections.

Using cellular thermal shift assay, computational molecular docking, microscale thermophoresis technology, and surface plasmon resonance biosensor, we confirmed that PDGFR-β was a direct target of roseotoxin B in fibrotic livers.

Platelet Derived Growth Factor C (PDGF-C) Antibody

Of note, human tissue microarrays detected pathologically high expression of p-PDGFR-β in liver samples of ~80% of patients with liver fibrosis and cirrhosis.
PDGF-B/PDGFR-β pathway promotes transdifferentiation and excessive proliferation of hepatic stellate cells (HSCs), which is a very crucial driver for liver fibrosis.
Meaningfully, roseotoxin B blocked the formation of PDGF-BB/PDGFR-ββ complex by targeting the D2 domain of PDGFR-β, thereby inhibiting the PDGF-B/PDGFR-β pathway in HSCs. In summary, our study provided roseotoxin B as a unique candidate agent for the treatment of liver fibrosis.

 

Activation PDGFR-α/AKT Mediated Signaling Pathways in Oral Squamous Cell Carcinoma by Mesenchymal Stem/Stromal Cells Promotes Anti-apoptosis and Decreased Sensitivity to Cisplatin.

 

 

Desmoplasia, a hallmark of a head and neck cancer, has both biologic and physiologic effects on cancer progression and chemotherapeutic response. Mesenchymal stem/stromal cells (MSCs), also known as mesenchymal stromal progenitor cells, have been shown to play a role in cancer progression, alter apoptotic responses, and confer resistance to chemotherapy in various carcinomas.

The pathophysiology of MSCs with respect to tumorigenesis is widely reported in other cancers and is sparsely reported in oral squamous cell carcinomas (OSCCs). We previously reported paracrine mediated PDGF-AA/PDGFR-α signaling to underlie MSCs chemotaxis in OSCC.

Mouse Anti-Hepatitis B Virus Core Antibody (HBcAb) ELISA Kit

Given the poor clinical response to primary chemotherapy, we hypothesized that MSCs may alter cancer cell sensitivity to cisplatin through activation of PDGFR-α mediated signaling pathways.
Co-culture of MSCs with human derived OSCC cell lines, JHU-012 and -019, resulted in a significant increase in the production of PDGF-AA and MCP-1 compared to cancer cells grown alone (p < 0.005) and was accompanied by an increase in the phosphorylation state of PDGFR-α (p < 0.02) and downstream target AKT at S473 (p < 0.025) and T308 (p < 0.02). JHU-012 and -019 cancer cells grown in co-culture were significantly less apoptotic (p < 0.001), expressed significantly higher levels of Bcl-2 (p < 0.04) with a concomitant significant decrease in bid expression (p < 0.001) compared to cancer cells grown alone.
There was a significant increase in the cisplatin dose response curve in cancer cell clones derived from JHU-012 and 019 cancer cells grown in co-culture with MSCs compared to clones derived from cancer cells grown alone (p < 0.001).
vegf-a
vegf-a
Moreover clones derived from JHU-012 cells grown in co-culture with MSCs were significantly more susceptible to cisplatin following pretreatment with, crenolanib, a PDGFR inhibitor, compared to cancer cells grown alone or in co-culture with MSCs (p < 0.0001).
These findings suggest that crosstalk between cancer cells and MSCs is mediated, at least in part, by activation of autocrine PDGF-AA/PDGFR-α loop driving AKT-mediated signaling pathways, resulting in reduced cancer cell sensitivity to cisplatin through alterations in apoptosis.

 

Mouse anti Human PDGF-BB
MBS226223-5x01mg 5x0.1mg
EUR 1425

Mouse anti Human PDGF-BB:Biotin
MBS226222-01mg 0.1mg
EUR 435

Mouse anti Human PDGF-BB:Biotin
MBS226222-5x01mg 5x0.1mg
EUR 1785

ELISA PLATE READER : MICRO READ 1000
1000 1 unit
EUR 2628

ELISA PLATE WASHER : MICRO WASH 1100
1100 1 unit
EUR 2403.6

ELISA PLATE SHAKER : MICRO SHAKE 1200
1200 1 unit
EUR 916.8

Mouse Monoclonal anti-human PDGF-B
hAP-0014 100ug
EUR 250

Mouse Monoclonal anti-human PDGF-B
hAP-0014A 100ug
EUR 250

RABBIT ANTI HUMAN PDGF AA HOMODIMER
MBS221730-01mg 0.1mg
EUR 660

RABBIT ANTI HUMAN PDGF AA HOMODIMER
MBS221730-5x01mg 5x0.1mg
EUR 2795

RABBIT ANTI HUMAN PDGF BB HOMODIMER
MBS221731-01mg 0.1mg
EUR 660

RABBIT ANTI HUMAN PDGF BB HOMODIMER
MBS221731-5x01mg 5x0.1mg
EUR 2795

Human PDGF-B Protein (His Tag)
MBS2545141-005mg 0.05mg
EUR 750

Human PDGF-B Protein (His Tag)
MBS2545141-1mg 1(mg)
EUR 4115

Human PDGF-B Protein (His Tag)
MBS2545141-5x1mg 5x1mg
EUR 18515

PDGF-B
E8ER1914-92 100ul
EUR 275
Description: Available in various conjugation types.

PDGF-B
MBS692680-01mg 0.1mg
EUR 725

PDGF-B
MBS692680-5x01mg 5x0.1mg
EUR 2965

PDGF-B
MBS8578178-01mL 0.1mL
EUR 345

PDGF-B
MBS8578178-01mLAF405L 0.1mL(AF405L)
EUR 565

PDGF-B
MBS8578178-01mLAF405S 0.1mL(AF405S)
EUR 565

PDGF-B
MBS8578178-01mLAF610 0.1mL(AF610)
EUR 565

PDGF-B
MBS8578178-01mLAF635 0.1mL(AF635)
EUR 565

PDGF-B Antibody
7199-002mg 0.02 mg
EUR 206.18
Description: PDGF-B Antibody: The platelet-derived growth factor beta (PDGF-B) is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB). Mutations in this gene are associated with meningioma , and reciprocal translocations between chromosomes 22 and 7, at sites where the PDGF-B gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans.

PDGF-B Antibody
7199-01mg 0.1 mg
EUR 523.7
Description: PDGF-B Antibody: The platelet-derived growth factor beta (PDGF-B) is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB). Mutations in this gene are associated with meningioma , and reciprocal translocations between chromosomes 22 and 7, at sites where the PDGF-B gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans.

PDGF-B Antibody
R31724 100 ug
EUR 356.15
Description: Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene. The protein encoded by this gene is a member of the platelet-derived growth factor family. PDGF-B can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Growth factor plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. PDGF-B plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGF-A.

PDGF-B Antibody
MBS153626-01mg 0.1mg
EUR 445

PDGF-B Antibody
MBS153626-5x01mg 5x0.1mg
EUR 1965

PDGF-B Antibody
C0299-100ul 100μl
EUR 217
Description: PDGF-B Rabbit Polyclonal Antibody

PDGF-B Antibody
C0299-50ul 50μl
EUR 143.5
Description: PDGF-B Rabbit Polyclonal Antibody

Recombinant Human PDGF-B Protein, No Tag
E40KMH1525 20ug
EUR 495

PDGF-B Protein, Human, Recombinant (His Tag)
MBS8120365-005mg 0.05mg
EUR 395

PDGF-B Protein, Human, Recombinant (His Tag)
MBS8120365-1mg 1mg
EUR 2610

PDGF-B Protein, Human, Recombinant (His Tag)
MBS8120365-5x1mg 5x1mg
EUR 11605

Human PDGF-BB
MBS691616-0002mg 0.002mg
EUR 225

Human PDGF-BB
MBS691616-5x0002mg 5x0.002mg
EUR 725

Human PDGF-AB
MBS691640-002mg 0.02mg
EUR 360

Human PDGF-AB
MBS691640-5x002mg 5x0.02mg
EUR 1325

Human PDGF-AA
MBS691878-0005mg 0.005mg
EUR 245

Human PDGF-AA
MBS691878-5x0005mg 5x0.005mg
EUR 800

Human PDGF-AB
MBS691944-0005mg 0.005mg
EUR 245

Human PDGF-AB
MBS691944-5x0005mg 5x0.005mg
EUR 800

Human PDGF-AA
MBS691946-002mg 0.02mg
EUR 360

Human PDGF-AA
MBS691946-5x002mg 5x0.02mg
EUR 1325

Human PDGF-AA
MBS691952-0002mg 0.002mg
EUR 225

Human PDGF-AA
MBS691952-5x0002mg 5x0.002mg
EUR 725

Human PDGF-AB
MBS691978-0002mg 0.002mg
EUR 225

Human PDGF-AB
MBS691978-5x0002mg 5x0.002mg
EUR 725

Human PDGF-BB
MBS692013-0005mg 0.005mg
EUR 245

Human PDGF-BB
MBS692013-5x0005mg 5x0.005mg
EUR 800

Human PDGF-CC
MBS692065-0005mg 0.005mg
EUR 300

Human PDGF-CC
MBS692065-002mg 0.02mg
EUR 450

Human PDGF-CC
MBS692065-5x002mg 5x0.02mg
EUR 1725

Human PDGF-BB
MBS692079-002mg 0.02mg
EUR 360

Human PDGF-BB
MBS692079-5x002mg 5x0.02mg
EUR 1325

PDGF, CF Human
PR15024CF 5 ug
EUR 1743.6

PDGF - A Human
PR27059 5 ug
EUR 229.2

PDGF - AA Human
PR27061 2 ug
EUR 229.2

PDGF - AB Human
PR27062 2 ug
EUR 229.2

PDGF - A Human
PR27059-B each
EUR 184.5

PDGF - AA Human
PR27061-B each
EUR 184.5

PDGF - AB Human
PR27062-B each
EUR 184.5

Human Platelet Derived Growth Factor B (PDGF-B) Protein
abx682008-100g 100 µg
EUR 850

Human Platelet Derived Growth Factor B (PDGF-B) Protein
abx682008-20g 20 µg
EUR 325

Human PDGF receptor
E01A7143 96T
EUR 700
Description: ELISA

PDGF-BB, Human
HY-P7055 10ug
EUR 321.6

PDGF-BB, human
RC216-21 2ug
EUR 125.26

PDGF-B Peptide
7199P 0.05 mg
EUR 197.7
Description: (CT) PDGF-B Peptide

PDGF-B Peptide
MBS154160-005mg 0.05mg
EUR 175

PDGF-B Peptide
MBS154160-5x005mg 5x0.05mg
EUR 770

Anti-Human PDGF-A Antibody
101-M44 100 µg
EUR 399
Description: Platelet-derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. It was found to be secreted from the α-granules of platelets activated during the coagulation of blood to form serum. Subsequent studies have demonstrated that PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGFAA, AB and BB are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed α and β. Differences exist in isoform binding to each receptor. In general, PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. In addition to its activity as a mitogen, PDGF is chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. Other reported activities for PDGF include stimulation of granule release by neutrophils and monocytes, facilitation of steroid synthesis by Leydig cells, stimulation of neutrophil phagocytosis, inhibition of natural killer (NK) cell activity, stimulation of collagen synthesis, modulation of thrombospondin expression and secretion, stimulation of collagenase activity and secretion, induction of contraction of rat aorta strips in vitro, and transient induction of T cell IL2 secretion accompanied by a downregulation of IL4 and IFNγ production, temporary effects that may allow clonal expansion of antigen-activated B and T helper lymphocytes prior to differentiation. PDGF also appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation.

Anti-Human PDGF-A Antibody
101-M821 100 µg
EUR 399
Description: Platelet-derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. It was found to be secreted from the α-granules of platelets activated during the coagulation of blood to form serum. Subsequent studies have demonstrated that PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGFAA, AB and BB are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed α and β. Differences exist in isoform binding to each receptor. In general, PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. In addition to its activity as a mitogen, PDGF is chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. Other reported activities for PDGF include stimulation of granule release by neutrophils and monocytes, facilitation of steroid synthesis by Leydig cells, stimulation of neutrophil phagocytosis, inhibition of natural killer (NK) cell activity, stimulation of collagen synthesis, modulation of thrombospondin expression and secretion, stimulation of collagenase activity and secretion, induction of contraction of rat aorta strips in vitro, and transient induction of T cell IL2 secretion accompanied by a downregulation of IL4 and IFNγ production, temporary effects that may allow clonal expansion of antigen-activated B and T helper lymphocytes prior to differentiation. PDGF also appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation.

Anti-Human PDGF-C Antibody
101-M823 100 µg
EUR 399
Description: Mouse platelet-derived growth factor C ( PDGF-C ) is one of the four member of the PDGF family of growth factors which are known mitogens and survival factors for cells of mesenchymal origin. They form four disulfide-linked homodimers ( PDGF-AA, -BB, -CC, and –DD ) and one heterodimer ( PDGF-AB ). PDGF-C has a unique two-domain structure consisting of an N-terminal CUB and a conserved C-terminal growth factor domain that are separated by a hinge region. PDGF-CC only binds to PDGF Rα with high affinity, activates the homodimerization of PDGF Rαβ, and induces the signal pathways, such as profibrotic pathways in hepatic fibrosis. PDGF-CC is involved in a variety of processes including angiogensis, morphogenesis and cardiovascular development, as well as the tumorigenesis. Meanwhile, recent studies have shown that the serine protease tissue plasminogen activator (tPA) used for treatment of acute stroke mediates the activation PDGF-CC, which suggests potential new strategies for cardiovascular and stroke treatment.

Anti-Human PDGF-A Antibody
102-P77 100 µg
EUR 245.7
Description: Platelet-derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. It was found to be secreted from the α-granules of platelets activated during the coagulation of blood to form serum. Subsequent studies have demonstrated that PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGFAA, AB and BB are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed α and β. Differences exist in isoform binding to each receptor. In general, PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. In addition to its activity as a mitogen, PDGF is chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. Other reported activities for PDGF include stimulation of granule release by neutrophils and monocytes, facilitation of steroid synthesis by Leydig cells, stimulation of neutrophil phagocytosis, inhibition of natural killer (NK) cell activity, stimulation of collagen synthesis, modulation of thrombospondin expression and secretion, stimulation of collagenase activity and secretion, induction of contraction of rat aorta strips in vitro, and transient induction of T cell IL2 secretion accompanied by a downregulation of IL4 and IFNγ production, temporary effects that may allow clonal expansion of antigen-activated B and T helper lymphocytes prior to differentiation. PDGF also appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation.

Anti-Human PDGF-BB Antibody
102-P78 100 µg
EUR 245.7
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Anti-Human PDGF-AA Antibody
MBS4158492-01mg 0.1mg
EUR 920

Anti-Human PDGF-AA Antibody
MBS4158492-5x01mg 5x0.1mg
EUR 3880

PDGF-B Polyclonal Antibody
ABP55531-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110

PDGF-B Polyclonal Antibody
ABP55531-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110

PDGF-B Polyclonal Antibody
ABP55531-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGF-B from Human, Mouse, Rat. This PDGF-B antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGF-B at AA range: 30-110

PDGF-B Polyclonal Antibody
ABP55531-100uL 100 μL
EUR 239
Description: Rabbit Anti-PDGF-B Polyclonal Antibody

PDGF-B Polyclonal Antibody
ABP55531-200uL 200 μL
EUR 379
Description: Rabbit Anti-PDGF-B Polyclonal Antibody

PDGF-B Polyclonal Antibody
ABP55531-30uL 30 μL
EUR 109
Description: Rabbit Anti-PDGF-B Polyclonal Antibody

PDGF-B Polyclonal Antibody
E20-73631 100ug
EUR 225
Description: Available in various conjugation types.

The emerging complexity of PDGFRs: activation, internalization and signal attenuation.

The platelet-derived growth factor receptor (PDGFR) family of receptor tyrosine kinases allows cells to communicate with the environment to regulate diverse cellular activities.
Here, we highlight recent data investigating the structural makeup of individual PDGFRs upon activation, revealing the importance of the whole receptor in the propagation of extracellular ligand binding and dimerization.
Furthermore, we review ongoing research demonstrating the significance of receptor internalization and signal attenuation in the regulation of PDGFR activity.

Human Anti-Brucella IgM ELISA Kit
Interactions with internalization machinery, signaling from endosomes, receptor degradation and receptor recycling are physiological means by which cells fine-tune PDGFR responses to growth factor stimulation.
In this review, we discuss the biophysical, structural, in silico and biochemical data that have provided evidence for these mechanisms. We further highlight the commonalities and differences between PDGFRα and PDGFRβ signaling, revealing critical gaps in knowledge.
In total, this review provides a conclusive summary on the state of the PDGFR field and underscores the need for novel techniques to fully elucidate the mechanisms of PDGFR activation, internalization and signal attenuation.

 

RABBIT ANTI HUMAN PDGF BB HOMODIMER
MBS221731-01mg 0.1mg
EUR 660

RABBIT ANTI HUMAN PDGF BB HOMODIMER
MBS221731-5x01mg 5x0.1mg
EUR 2795

PDGF-BB, Human
HY-P7055 10ug
EUR 321.6

PDGF-BB, human
RC216-21 2ug
EUR 125.26

rec PDGF BB (human)
4031083.0002 2 µg
EUR 102.27

rec PDGF BB (human)
4031083.001 10 µg
EUR 271.85

rec PDGF BB (human)
H-7530.0002 2.0µg
EUR 194.4

rec PDGF BB (human)
H-7530.0010 10.0µg
EUR 457.2

Human PDGF-BB Protein
abx060208-100ug 100 ug
EUR 627.6

Human PDGF-BB Protein
abx060258-100ug 100 ug
EUR 627.6

Human PDGF-BB Protein
abx060208-100g 100 µg Ask for price

Human PDGF-BB Protein
abx060208-10g 10 µg
EUR 243.75

Human PDGF-BB Protein
abx060208-50g 50 µg
EUR 437.5

Anti-Human PDGF-BB Antibody
102-P78 100 µg
EUR 245.7
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Human PDGF-BB
HEGFP-1601 10ug Ask for price

Recombinant Human PDGF-BB
EPT197 10ug
EUR 167.4
Description: Recombinant Human Platelet-Derived Growth Factor BB is produced by our E.coli expression system and the target gene encoding Ser82-Thr190 is expressed.

Recombinant Human PDGF-BB
SJA04-01 10µg/vial
EUR 307.2

PDGF-BB, human recombinant
4488-10 each
EUR 398.4

PDGF-BB, human recombinant
4488-1000 each
EUR 8346

PDGF-BB, human recombinant
4488-50 each
EUR 1123.2

PDGF-BB (human), (recombinant)
MBS567256-01mg 0.1mg
EUR 1130

PDGF-BB (human), (recombinant)
MBS567256-5x01mg 5x0.1mg
EUR 5020

Human PDGF-BB ELISA Kit
E16HE0073 96T
EUR 833.33

Human PDGF-BB ELISA Kit
EHP0050 96Tests
EUR 625.2

Human PDGF-BB ELISA Kit
EHP0634 96Tests
EUR 625.2

Human PDGF-BB ELISA KIT
EF000205 96tests
EUR 566

Human PDGF-BB ELISA Kit
GWB-SKR056 96 Tests Ask for price

Human PDGF-BB ELISA Kit
RK00323 96T
EUR 280

Human PDGF-BB ELISA Kit
RK04112 96 Tests
EUR 280

Human PDGF-BB ELISA Kit
MBS9135929-5x96Tests 5x96Tests
EUR 2615

Human PDGF-BB ELISA Kit
MBS9135929-96Tests 96Tests
EUR 570

Human PDGF-BB ELISA Kit
MBS9141976-5x96Tests 5x96Tests
EUR 2615

Human PDGF-BB ELISA Kit
MBS9141976-96Tests 96Tests
EUR 570

GMP Human PDGF-BB Protein
GMP-PDBH19 500ug
EUR 5384.6
Description: GMP Human PDGF-BB Protein (GMP-PDBH19) is expressed from E. coli cells. It contains AA Ser 82 - Thr 190 (Accession # P01127-1).

GMP Human PDGF-BB Protein
GMP-PDBH19-1mg 1mg
EUR 5384.6
Description: GMP Human PDGF-BB Protein (GMP-PDBH19) is expressed from E. coli cells. It contains AA Ser 82 - Thr 190 (Accession # P01127-1).

GMP Human PDGF-BB Protein
GMP-PDBH19-500ug 500ug
EUR 3847.7
Description: GMP Human PDGF-BB Protein (GMP-PDBH19) is expressed from E. coli cells. It contains AA Ser 82 - Thr 190 (Accession # P01127-1).

GMP Human PDGF-BB Protein
GMP-PDBH19-50ug 50ug
EUR 904.7
Description: GMP Human PDGF-BB Protein (GMP-PDBH19) is expressed from E. coli cells. It contains AA Ser 82 - Thr 190 (Accession # P01127-1).

Human PDGF-BB GENLISA ELISA
KB1100 1 x 96 wells
EUR 297

PDGF-BB (Human) ELISA Kit
EKA51872-5x96T 5x96T Ask for price

PDGF-BB (Human) ELISA Kit
EKA51872-96T 96T
EUR 446.9

Human PDGF-BB Recombinant Protein
200-055 5 µg
EUR 52.5
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Human PDGF-BB Recombinant Protein
200-055S 2 µg
EUR 47.25
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Human PDGF-BB Recombinant Protein
200-056 20 µg
EUR 136.5
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Human PDGF-BB Protein
E40KMP1742 20ug
EUR 495

Recombinant Human PDGF-BB Protein
PROTP01127-4 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Human PDGF-BB Protein
RP00834 10 μg
EUR 265.2

Recombinant Human PDGF-BB Protein
RP01763 100μg
EUR 195

Recombinant Human PDGF-BB protein
CD01148-10ug 10ug
EUR 409
Description: Platelet-derived growth factor (PDGF) presenting in serum but absent from plasma was first discovered in animal study by Lynch and co-workers in the late 1980s. It is a disulfide-linked dimer consisting of two peptides-chain A and chain B. PDGF has three subforms: PDGF-AA, PDGF-BB, PDGF-AB. It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two receptors (PDGFR-α and PDGFR-β).

Recombinant Human PDGF-BB protein
CD01148-2ug 2ug
EUR 176
Description: Platelet-derived growth factor (PDGF) presenting in serum but absent from plasma was first discovered in animal study by Lynch and co-workers in the late 1980s. It is a disulfide-linked dimer consisting of two peptides-chain A and chain B. PDGF has three subforms: PDGF-AA, PDGF-BB, PDGF-AB. It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two receptors (PDGFR-α and PDGFR-β).

Recombinant Human PDGF-BB protein
CD01149-10ug 10ug
EUR 353
Description: Recombinant Human Platelet-Derived Growth Factor BB is produced by our E.coli expression system and the target gene encoding Ser82-Thr190 is expressed.

Recombinant Human PDGF-BB protein
CD01149-50ug 50ug
EUR 1035
Description: Recombinant Human Platelet-Derived Growth Factor BB is produced by our E.coli expression system and the target gene encoding Ser82-Thr190 is expressed.

Recombinant Human PDGF-BB Protein
MBS9140264-005mg 0.05mg
EUR 500

Recombinant Human PDGF-BB Protein
MBS9140264-5x005mg 5x0.05mg
EUR 2075

RECOMBINANT HUMAN PDGF BB HOMODIMER
MBS232238-001mg 0.01mg
EUR 510

RECOMBINANT HUMAN PDGF BB HOMODIMER
MBS232238-5x001mg 5x0.01mg
EUR 2130

Sheep Polyclonal anti-human PDGF-BB
hAP-5392 50ug
EUR 400

PDGF BB
LF-PR012 10 ug
EUR 280.8
Description: PDGF BB protein

PDGF-BB
90800-1 10 µg
EUR 215
Description: Human recombinant PDGF-BB (GenBank Accession No. NM_002608) is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total a.a.) expressed in an E. coli expression system.

PDGF-BB
90800-2 100 µg
EUR 1185
Description: Human recombinant PDGF-BB (GenBank Accession No. NM_002608) is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total a.a.) expressed in an E. coli expression system.

PDGF-BB
90800-3 1000 µg
EUR 4320
Description: Human recombinant PDGF-BB (GenBank Accession No. NM_002608) is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total a.a.) expressed in an E. coli expression system.

PDGF-BB
E21-199 10ug
EUR 225
Description: Recombinant Human Platelet-Derived Growth Factor BB is produced by our E.coli expression system and the target gene encoding Ser82-Thr190 is expressed.

PDGF-BB
PR15027 50 ug
EUR 475.2

PDGF-BB
MBS8532870-001mg 0.01mg
EUR 305

PDGF-BB
MBS8532870-5x001mg 5x0.01mg
EUR 1220

PDGF-BB, human recombinant protein
P1047-.01 10 µg
EUR 222
Description: PDGF-BB, platelet-derived growth factor, expressed in E.Coli.

PDGF-BB, human recombinant protein
P1047-.05 50 µg
EUR 692
Description: PDGF-BB, platelet-derived growth factor, expressed in E.Coli.

PDGF-BB, human recombinant protein
P1047-1 1 mg
EUR 5414
Description: PDGF-BB, platelet-derived growth factor, expressed in E.Coli.

PDGF-BB, human recombinant protein
P1047-.1 100ug
EUR 1300.8
Description: Growth Factors|PDGF

PDGF-BB, human recombinant protein
P1047-.5 500ug
EUR 2918.4
Description: Growth Factors|PDGF

PDGF-BB (P.pastoris-expressed), Human
HY-P7055A 10ug
EUR 321.6

PDGF BB antibody
70R-PR020 50 ug
EUR 312
Description: Affinity purified Rabbit polyclonal PDGF BB antibody

PDGF BB Antibody
GWB-8EA460 0.025 mg Ask for price

PDGF BB antibody
MBS535905-005mg 0.05mg
EUR 465

PDGF BB antibody
MBS535905-5x005mg 5x0.05mg
EUR 1945

PDGF-BB Antibody
5488-200 each
EUR 379.2

PDGF-BB Antibody
5488-30T each
EUR 175.2

PDGF-BB Antibody
5489-100 each
EUR 379.2

PDGF-BB Antibody
5489-30T each
EUR 175.2

Nori Human PDGF-BB ELISA Kit
GR111035 96-well
EUR 461

Human PDGF-BB PicoKine ELISA Kit
EK0956 96 wells
EUR 510
Description: For quantitative detection of human PDGF-BB in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human/Rat PDGF-BB ELISA Kit
E28L0369 96T
EUR 666.67

Goat Polyclonal to Human PDGF-BB / PDGFB
MBS247170-005mg 0.05mg
EUR 595

Goat Polyclonal to Human PDGF-BB / PDGFB
MBS247170-5x005mg 5x0.05mg
EUR 2500

Human PDGF-BB Protein, premium grade
PDB-H4112 20ug
EUR 2354
Description: Human PDGF-BB, premium grade (PDB-H4112) is expressed from E. coli cells. It contains AA Ser 82 - Thr 190 (Accession # P01127-1).

Human PDGF-BB Protein, premium grade
PDB-H4112-1mg 1mg
EUR 2398
Description: Human PDGF-BB, premium grade (PDB-H4112) is expressed from E. coli cells. It contains AA Ser 82 - Thr 190 (Accession # P01127-1).

Human PDGF-BB Protein, premium grade
PDB-H4112-20ug 20ug
EUR 218
Description: Human PDGF-BB, premium grade (PDB-H4112) is expressed from E. coli cells. It contains AA Ser 82 - Thr 190 (Accession # P01127-1).

Human PDGF-BB Protein, premium grade
PDB-H4112-50ug 50ug
EUR 425.1
Description: Human PDGF-BB, premium grade (PDB-H4112) is expressed from E. coli cells. It contains AA Ser 82 - Thr 190 (Accession # P01127-1).

PDGF-BB (Human) LumiAb ELISA Kit
MBS9510810-10x96StripWells 10x96-Strip-Wells
EUR 4355

PDGF-BB (Human) LumiAb ELISA Kit
MBS9510810-5x96StripWells 5x96-Strip-Wells
EUR 2225

PDGF-BB (Human) LumiAb ELISA Kit
MBS9510810-96StripWells 96-Strip-Wells
EUR 500