PDGFR-β Promoter Varieties a Emptiness G-Quadruplex that Might be Crammed-in by dGMP: Answer Construction and Molecular Recognition of Guanine Metabolites and Medication.

 

Aberrant expression of PDGFR-β is related to a lot of ailments. The G-quadruplexes (G4s) shaped in PDGFR-β gene promoter are transcriptional modulators and amenable to small molecule focusing on.
The main G4 shaped within the PDGFR-β gene promoter was beforehand proven to have a damaged G-strand. Herein, we report that the PDGFR-β gene promoter sequence varieties a emptiness G-quadruplex (vG4) which might be filled-in and stabilized by physiologically related guanine metabolites, reminiscent of dGMP, GMP, and cGMP, in addition to guanine-derivative medication.
We decided the NMR construction of the dGMP-fill-in PDGFR-β vG4 in Okay+ answer.
That is the primary construction of a guanine-metabolite-fill-in vG4 primarily based on a human gene promoter sequence.
vegf-a
vegf-a
Our construction and systematic evaluation elucidate the contributions of Hoogsten hydrogen bonds, sugar, and phosphate moieties to the particular G-vacancy fill-in. Intriguingly, an equilibrium of 3- and 5-end vG4s is current within the PDGFR-β promoter sequence and dGMP favors the 5-end fill-in. Guanine metabolites and medicines had been examined and confirmed a conserved selectivity for the 5-vacancy, apart from cGMP. cGMP binds each the 3- and 5-end vG4s and varieties two fill-in G4s with comparable inhabitants.

Anti-Phospho-PDGFR-beta (Y771) antibody
Considerably, guanine metabolites are concerned in lots of physiological and pathological processes in human cells, thus our outcomes present a structural foundation to grasp their potential regulatory capabilities by interplay with promoter vG4s. Furthermore, the NMR construction can information rational design of ligands that concentrate on the PDGFR-β vG4.

 

PDGFR-β and kidney fibrosis.

 

Power kidney illness (CKD) is without doubt one of the quickest rising world causes of loss of life, estimated to rank among the many high 5 by 2040 (Foreman et al, 2018). This illustrates present pitfalls in prognosis and administration of CKD. Superior CKD requires renal operate substitute by dialysis or transplantation.

Nonetheless, earlier CKD levels, even when renal operate remains to be regular, are already related to an elevated threat of untimely loss of life (Perez-Gomez et al, 2019). Thus, novel approaches to diagnose and deal with CKD are wanted.

 

 

Antibody for Human PDGFR beta

 

The histopathological hallmark of CKD is kidney fibrosis, which is carefully related to native irritation and lack of kidney parenchymal cells. Thus, kidney fibrosis is a lovely course of to develop exams permitting an earlier prognosis of CKD and represents a possible therapeutic goal to sluggish CKD development or promote regression.

 

 

 

 

PDGFR beta antibody
70R-33648 100 ug
EUR 327
Description: Rabbit polyclonal PDGFR beta antibody

PDGFR beta Antibody
AF6132 200ul
EUR 304
Description: PDGFR beta Antibody detects endogenous levels of total PDGFR beta.

PDGFR beta Antibody
AF6133 200ul
EUR 304
Description: PDGFR beta Antibody detects endogenous levels of total PDGFR beta.

PDGFR beta Antibody
ABF6132 100 ug
EUR 438

PDGFR beta Antibody
ABF6133 100 ug
EUR 438

PDGFr beta antibody
10R-1809 100 ul
EUR 403
Description: Mouse monoclonal PDGFr beta antibody

Anti-Phospho-PDGFR beta-Y751 antibody
STJ11100964 100 µl
EUR 393
Description: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Anti-Phospho-PDGFR-beta (Y751) antibody
STJ91283 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-PDGFR-beta (Y751).

Anti-Phospho-PDGFR-beta (Y771) antibody
STJ90591 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-PDGFR-beta (Y771).

Anti-Phospho-PDGFR-beta (Y740) antibody
STJ90902 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-PDGFR-beta (Y740).

Anti-Phospho-PDGFR-beta (Y1021) antibody
STJ91154 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-PDGFR-beta (Y1021).

PDGFR beta antibody (Tyr740)
70R-33645 100 ug
EUR 327
Description: Rabbit polyclonal PDGFR beta antibody (Tyr740)

PDGFR beta antibody (Tyr1021)
70R-33647 100 ug
EUR 327
Description: Rabbit polyclonal PDGFR beta antibody (Tyr1021)

PDGFR-Beta Polyclonal Antibody
ABP52167-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751

PDGFR-Beta Polyclonal Antibody
ABP52167-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751

PDGFR-Beta Polyclonal Antibody
ABP52167-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751

PDGFR-Beta Polyclonal Antibody
ABP52752-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Rat. This PDGFR-Beta antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771

PDGFR-Beta Polyclonal Antibody
ABP52752-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Rat. This PDGFR-Beta antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771

PDGFR-Beta Polyclonal Antibody
ABP52752-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Rat. This PDGFR-Beta antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771

PDGFR-Beta Polyclonal Antibody
ABP55545-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009

PDGFR-Beta Polyclonal Antibody
ABP55545-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009

PDGFR-Beta Polyclonal Antibody
ABP55545-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009

PDGFR-Beta Polyclonal Antibody
ABP55546-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021

PDGFR-Beta Polyclonal Antibody
ABP55546-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021

PDGFR-Beta Polyclonal Antibody
ABP55546-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021

PDGFR-Beta Polyclonal Antibody
ABP55547-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740

PDGFR-Beta Polyclonal Antibody
ABP55547-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740

PDGFR-Beta Polyclonal Antibody
ABP55547-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740

PDGFR beta (pY751) Antibody
20-abx133055
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul

PDGFR beta (pT1009) Antibody
20-abx009684
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul

PDGFR beta (pY1021) Antibody
abx011955-100ug 100 ug
EUR 439

PDGFR beta (pY740) Antibody
abx011959-100ug 100 ug
EUR 439

PDGFR beta, Active
7770-5
EUR 370

PDGFR beta protein
30R-2880 5 ug
EUR 503
Description: Purified recombinant Human PDGFR beta protein

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349

Phospho-PDGFR beta (Tyr740) Antibody
AF3132 200ul
EUR 304
Description: Phospho-PDGFR beta (Tyr740) Antibody detects endogenous levels of PDGFR beta only when phosphorylated at Tyrosine 740.

Phospho-PDGFR beta (Tyr1021) Antibody
AF3133 200ul
EUR 304
Description: Phospho-PDGFR beta (Tyr1021) Antibody detects endogenous levels of PDGFR beta only when phosphorylated at Tyrosine 1021.

Phospho- PDGFR beta (Tyr740) Antibody
ABF3132 100 ug
EUR 438

Phospho- PDGFR beta (Tyr1021) Antibody
ABF3133 100 ug
EUR 438

Polyclonal PDGFRB / PDGFR Beta Antibody
APR02743G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGFRB / PDGFR Beta . This antibody is tested and proven to work in the following applications:

PDGFR beta (Phospho-Tyr740) Antibody
11941-100ul 100ul
EUR 252

PDGFR beta (Phospho-Tyr740) Antibody
11941-50ul 50ul
EUR 187

Antibody for Human PDGFR beta
SPC-1185D 0.1ml
EUR 354
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is unconjugated.

Antibody for Human PDGFR beta
SPC-1185D-A390 0.1ml
EUR 401
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 390.

Antibody for Human PDGFR beta
SPC-1185D-A488 0.1ml
EUR 400
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 488.

Antibody for Human PDGFR beta
SPC-1185D-A565 0.1ml
EUR 400
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 565.

Antibody for Human PDGFR beta
SPC-1185D-A594 0.1ml
EUR 400
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 594.

Antibody for Human PDGFR beta
SPC-1185D-A633 0.1ml
EUR 400
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 633.

Antibody for Human PDGFR beta
SPC-1185D-A655 0.1ml
EUR 400
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 655.

Antibody for Human PDGFR beta
SPC-1185D-A680 0.1ml
EUR 400
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 680.

Antibody for Human PDGFR beta
SPC-1185D-A700 0.1ml
EUR 400
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 700.

Antibody for Human PDGFR beta
SPC-1185D-ALP 0.1ml
EUR 394
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Alkaline Phosphatase.

Antibody for Human PDGFR beta
SPC-1185D-APC 0.1ml
EUR 399
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to APC .

Antibody for Human PDGFR beta
SPC-1185D-APCCY7 0.1ml
EUR 471
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to APC/Cy7.

Antibody for Human PDGFR beta
SPC-1185D-BI 0.1ml
EUR 396
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Biotin.

Antibody for Human PDGFR beta
SPC-1185D-DY350 0.1ml
EUR 475
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Dylight 350.

Antibody for Human PDGFR beta
SPC-1185D-DY405 0.1ml
EUR 452
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Dylight 405.

Antibody for Human PDGFR beta
SPC-1185D-DY488 0.1ml
EUR 432
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Dylight 488.

Antibody for Human PDGFR beta
SPC-1185D-DY594 0.1ml
EUR 436
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Dylight 594.

Antibody for Human PDGFR beta
SPC-1185D-DY633 0.1ml
EUR 426
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Dylight 633.

Antibody for Human PDGFR beta
SPC-1185D-FITC 0.1ml
EUR 392
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to FITC.

Antibody for Human PDGFR beta
SPC-1185D-HRP 0.1ml
EUR 388
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to HRP.

Antibody for Human PDGFR beta
SPC-1185D-P594 0.1ml
EUR 407
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to PE/ATTO 594.

Antibody for Human PDGFR beta
SPC-1185D-PCP 0.1ml
EUR 399
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to PerCP.

Antibody for Human PDGFR beta
SPC-1185D-RPE 0.1ml
EUR 397
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to RPE .

Antibody for Human PDGFR beta
SPC-1185D-STR 0.1ml
EUR 398
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Streptavidin.

PDGFR beta Blocking Peptide
AF6132-BP 1mg
EUR 195

PDGFR beta Blocking Peptide
AF6133-BP 1mg
EUR 195

PDGFR beta Blocking Peptide
20-abx063061
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

PDGFR beta Rabbit pAb
A2180-100ul 100 ul
EUR 308

PDGFR beta Rabbit pAb
A2180-200ul 200 ul
EUR 459

PDGFR beta Rabbit pAb
A2180-20ul 20 ul
EUR 183

PDGFR beta Rabbit pAb
A2180-50ul 50 ul
EUR 223

Anti-PDGFR alpha Antibody
A30446 100ul
EUR 397
Description: Rabbit Polyclonal PDGFR alpha Antibody. Validated in IF, IHC and tested in Human, Mouse, Rat.

Anti-PDGFR-alpha antibody
STJ96630 200 µl
EUR 197
Description: Rabbit polyclonal to PDGFR-alpha.

Anti-PDGFR-alpha antibody
STJ94997 200 µl
EUR 197
Description: Rabbit polyclonal to PDGFR-alpha.

Anti-PDGFR-alpha antibody
STJ94998 200 µl
EUR 197
Description: Rabbit polyclonal to PDGFR-alpha.

Anti-PDGFR-alpha antibody
STJ94999 200 µl
EUR 197
Description: Rabbit polyclonal to PDGFR-alpha.

Anti-PDGFR-alpha antibody
STJ95000 200 µl
EUR 197
Description: Rabbit polyclonal to PDGFR-alpha.

Anti-PDGFR-alpha antibody
STJ95001 200 µl
EUR 197
Description: Rabbit polyclonal to PDGFR-alpha.

Anti-PDGFR alpha antibody
STJ99637 200 µl
EUR 197
Description: Rabbit polyclonal to PDGFR alpha.

Phospho-PDGFR beta (Tyr716) polyconal Antibody
A1035-100
EUR 370

PDGFR-Beta (phospho Tyr1021) Polyclonal Antibody
ABP50527-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Beta phospho Tyr1021) from Human, Mouse, Rat. This PDGFR-Beta phospho Tyr1021) antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the phosphorylation site of Y1021

PDGFR-Beta (phospho Tyr1021) Polyclonal Antibody
ABP50527-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Beta phospho Tyr1021) from Human, Mouse, Rat. This PDGFR-Beta phospho Tyr1021) antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the phosphorylation site of Y1021

 

Synergistic therapeutic impact of mixed PDGFR and SGK1 inhibition in metastasis-initiating cells of breast most cancers.

Lack of perception into the id of the cells that provoke metastasis hampers the event of antimetastatic therapies. Solely a tiny fraction of tumor cells termed metastasis-initiating cells (MICs) are capable of efficiently seed metastases, inflicting recurrence and therapeutic resistance.
Utilizing metastasis fashions, we describe a subpopulation of MIC derivates from lung metastases that do not need proliferation benefits, categorical excessive ranges of the PDGF receptors and EMT/stemness-related genes, and are distinctive of their capacity to provoke metastasis.
PDGF components particularly increase the metastatic potential of MIC populations in a PDGFR-dependent method. Nonetheless, PDGFR inhibition preferentially suppresses lung metastases, however doesn’t scale back the first tumor burden.

PDGFR beta (Phospho-Tyr740) Polyclonal Conjugated Antibody

 

Thus, we discovered that PDGFR inhibition blocks AKT activation, whereas SGK1, which shares high-similarity kinase area and overlap substrates with AKT overexpression stays energetic in MICs. SGK1 and PDGF signaling act in live performance to advertise metastatic formation, and SGK1 inhibition confers vulnerability to PDGFR inhibitors, additionally eliciting a strong antitumor impact.
In vivo, SGK1 inhibitors sensitize xenograft tumors to PDGFR-targeted therapies by decreasing major tumor development and lung metastasis. Consequently, twin inhibition of PDGFR and SGK1 exhibited sturdy antitumor actions in established breast most cancers cell strains in vitro and in vivo.
Subsequently, this strategy not solely offers perception into MIC transformation but in addition aids the design of improved therapeutic methods for superior breast most cancers.

 

anti- PDGFRB antibody
FNab06266 100µg
EUR 548.75
Description: Antibody raised against PDGFRB

anti- PDGFRB antibody
FNab09972 100µg
EUR 548.75
Description: Antibody raised against PDGFRB

anti-PDGFRB
YF-PA27318 100 ul
EUR 403
Description: Rabbit polyclonal to PDGFRB

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349

Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) ELISA Kit
DLR-PDGFRb-Hu-48T 48T
EUR 463
Description: A sandwich quantitative ELISA assay kit for detection of Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) ELISA Kit
DLR-PDGFRb-Hu-96T 96T
EUR 599
Description: A sandwich quantitative ELISA assay kit for detection of Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) ELISA Kit
RD-PDGFRb-Hu-48Tests 48 Tests
EUR 460

Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) ELISA Kit
RD-PDGFRb-Hu-96Tests 96 Tests
EUR 636

Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) ELISA Kit
RDR-PDGFRb-Hu-48Tests 48 Tests
EUR 481

Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) ELISA Kit
RDR-PDGFRb-Hu-96Tests 96 Tests
EUR 665

Anti-Phospho-PDGFRB-(Y1021) antibody
STJ117913 100 µl
EUR 393
Description: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Anti-PDGFRb (Phospho-Tyr857) Antibody
STJ193215 200 µl
EUR 197

Anti-Phospho-PDGFRB-Y771 antibody
STJ11101100 100 µl
EUR 393
Description: The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia.

Anti-Phospho-PDGFRB-(Y740) antibody
STJ113494 100 µl
EUR 393
Description: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

PDGFRb antibody
70R-32714 100 ug
EUR 327
Description: Rabbit polyclonal PDGFRb antibody

PDGFRb Antibody
AF6134 200ul
EUR 304
Description: PDGFRb Antibody detects endogenous levels of total PDGFRb.

PDGFRb Antibody
ABF6134 100 ug
EUR 438

PDGFRB Antibody
ABD6903 100 ug
EUR 438

PDGFRB antibody
20R-PR095 50 ug
EUR 656
Description: Rabbit polyclonal PDGFRB antibody

PDGFRB antibody
20R-PR096 50 ug
EUR 656
Description: Rabbit polyclonal PDGFRB antibody

PDGFRB antibody
70R-19180 50 ul
EUR 435
Description: Rabbit polyclonal PDGFRB antibody

PDGFRB Antibody
DF6903 200ul
EUR 304
Description: PDGFRB Antibody detects endogenous levels of total PDGFRB.

PDGFRB Antibody
1-CSB-PA266610
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:1000-1:2000, WB:1:200-1:1000

PDGFRB Antibody
1-CSB-PA208206
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:1000-1:5000, WB:1:200-1:1000

PDGFRB antibody
PAab09972 100 ug
EUR 386

PDGFRB antibody
PAab10079 100 ug
EUR 386

PDGFRB Antibody
1-CSB-PA003726
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000

PDGFRB Antibody
1-CSB-PA004625
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

PDGFRB Antibody
1-CSB-PA017713GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

PDGFRB Antibody
1-CSB-PA017713LA01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

PDGFRB Antibody
1-CSB-PA030008
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

PDGFRB Antibody
1-CSB-PA030009
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000

PDGFRB Antibody
1-CSB-PA030010
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

PDGFRB Antibody
32646-100ul 100ul
EUR 252

Anti-PDGF Receptor beta/PDGFRB Antibody
A00096-1 100ug/vial
EUR 334

PDGFRB antibody (Tyr751)
70R-37416 100 ug
EUR 349
Description: Rabbit Polyclonal PDGFRB antibody (Tyr751)

PDGFRb antibody (Tyr771)
70R-32713 100 ug
EUR 327
Description: Rabbit polyclonal PDGFRb antibody (Tyr771)

PDGFRb (pT740) Antibody
20-abx124159
  • EUR 495.00
  • EUR 704.00
  • EUR 217.00
  • EUR 356.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

PDGFRB (pY1009) Antibody
abx217688-100ug 100 ug
EUR 439

PDGFRb (pY857) Antibody
abx217690-100ug 100 ug
EUR 439

PDGFRB (pY740) Antibody
abx333509-100ul 100 ul
EUR 467

PDGFRb (pY771) Antibody
abx011957-100ug 100 ug
EUR 439

PDGFRB Polyclonal Antibody
A60210 100 µg
EUR 570.55
Description: reagents widely cited

PDGFRB siRNA
20-abx928118
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

PDGFRB siRNA
20-abx928119
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

PDGFRB siRNA
20-abx903906
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 280

Phospho-PDGFRb (Tyr771) Antibody
AF3134 200ul
EUR 304
Description: Phospho-PDGFRb (Tyr771) Antibody detects endogenous levels of PDGFRb only when phosphorylated at Tyrosine 771.

Phospho-PDGFRB (Tyr1009) Antibody
AF8015 200ul
EUR 376
Description: PDGFRB (Phospho-Tyr1009) Antibody detects endogenous levels of PDGFRB only when phosphorylated at Tyr1009.

Phospho-PDGFRb (Tyr857) Antibody
AF8181 200ul
EUR 376
Description: PDGFRb (Phospho-Tyr857) Antibody detects endogenous levels of PDGFRb only when phosphorylated at Tyr857.

PDGFRB (Phospho- Tyr1009) Antibody
ABF8015 100 ug
EUR 438

PDGFRb (Phospho- Tyr857) Antibody
ABF8181 100 ug
EUR 438

Phospho- PDGFRb (Tyr771) Antibody
ABF3134 100 ug
EUR 438

Phospho-PDGFRB (Tyr740) Antibody
CSB-PA979025-
EUR 335
Description: A polyclonal antibody against Phospho-PDGFRB (Tyr740). Recognizes Phospho-PDGFRB (Tyr740) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-PDGFRB (Tyr740) Antibody
CSB-PA979025-100ul 100ul
EUR 362
Description: A polyclonal antibody against Phospho-PDGFRB (Tyr740). Recognizes Phospho-PDGFRB (Tyr740) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

PDGFRB (Ab-751) Antibody
CSB-PA828739-
EUR 335
Description: A polyclonal antibody against PDGFRB (Ab-751). Recognizes PDGFRB (Ab-751) from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

PDGFRB (Ab-751) Antibody
CSB-PA828739-100ul 100ul
EUR 316
Description: A polyclonal antibody against PDGFRB (Ab-751). Recognizes PDGFRB (Ab-751) from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-PDGFRB (Y1021) Antibody
1-CSB-PA000745
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-PDGFRB (Y1021). Recognizes Phospho-PDGFRB (Y1021) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;IHC:1/100-1/300.ELISA:1/5000

PDGFRB Antibody, HRP conjugated
1-CSB-PA017713LB01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PDGFRB Antibody, FITC conjugated
1-CSB-PA017713LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

PDGFRB Antibody, Biotin conjugated
1-CSB-PA017713LD01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Phospho-PDGFRB (Y771) Antibody
1-CSB-PA030005
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-PDGFRB (Y771). Recognizes Phospho-PDGFRB (Y771) from Human, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

Phospho-PDGFRB (Y740) Antibody
1-CSB-PA030006
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-PDGFRB (Y740). Recognizes Phospho-PDGFRB (Y740) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

Phospho-PDGFRB (Y751) Antibody
1-CSB-PA030007
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-PDGFRB (Y751). Recognizes Phospho-PDGFRB (Y751) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

PDGFRB (Ab-771) Antibody
CSB-PA556830-
EUR 335
Description: A polyclonal antibody against PDGFRB (Ab-771). Recognizes PDGFRB (Ab-771) from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

PDGFRB (Ab-771) Antibody
CSB-PA556830-100ul 100ul
EUR 316
Description: A polyclonal antibody against PDGFRB (Ab-771). Recognizes PDGFRB (Ab-771) from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

PDGFRb (pY579+T581) Antibody
abx217689-100ug 100 ug
EUR 439

PDGFRb (Phospho-Tyr771) Antibody
20-abx012622
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

PDGFRb (Phospho-Tyr771) Antibody
11907-100ul 100ul
EUR 252

PDGFRb (Phospho-Tyr771) Antibody
11907-50ul 50ul
EUR 187

PDGFRb (Ab-771) Antibody
33246-100ul 100ul
EUR 252

PDGFRb (Ab-771) Antibody
33246-50ul 50ul
EUR 187

Rabbit Anti-PDGFRB monoclonal antibody, clone TZ21-19
DCABH-210 100 ul
EUR 777

PDGFRb Blocking Peptide
AF6134-BP 1mg
EUR 195

PDGFRB Blocking Peptide
DF6903-BP 1mg
EUR 195

PDGFRB cloning plasmid
CSB-CL017713HU-10ug 10ug
EUR 1217
Description: A cloning plasmid for the PDGFRB gene.

Phospho-PDGFRb (Tyr579+Tyr581) Antibody
AF8180 200ul
EUR 376
Description: PDGFRb (Phospho-Tyr579+Tyr581) Antibody detects endogenous levels of PDGFRb only when phosphorylated at Tyr579+Tyr581.

PDGFRb (Phospho- Tyr579+ Tyr581) Antibody
ABF8180 100 ug
EUR 438

PDGFRB Polyclonal Antibody, Biotin Conjugated
A60211 100 µg
EUR 570.55
Description: Ask the seller for details