PDGFR-β Promoter Varieties a Emptiness G-Quadruplex that Might be Crammed-in by dGMP: Answer Construction and Molecular Recognition of Guanine Metabolites and Medication.

 

Aberrant expression of PDGFR-β is related to a lot of ailments. The G-quadruplexes (G4s) shaped in PDGFR-β gene promoter are transcriptional modulators and amenable to small molecule focusing on.
The main G4 shaped within the PDGFR-β gene promoter was beforehand proven to have a damaged G-strand. Herein, we report that the PDGFR-β gene promoter sequence varieties a emptiness G-quadruplex (vG4) which might be filled-in and stabilized by physiologically related guanine metabolites, reminiscent of dGMP, GMP, and cGMP, in addition to guanine-derivative medication.
We decided the NMR construction of the dGMP-fill-in PDGFR-β vG4 in Okay+ answer.
That is the primary construction of a guanine-metabolite-fill-in vG4 primarily based on a human gene promoter sequence.
vegf-a
vegf-a
Our construction and systematic evaluation elucidate the contributions of Hoogsten hydrogen bonds, sugar, and phosphate moieties to the particular G-vacancy fill-in. Intriguingly, an equilibrium of 3- and 5-end vG4s is current within the PDGFR-β promoter sequence and dGMP favors the 5-end fill-in. Guanine metabolites and medicines had been examined and confirmed a conserved selectivity for the 5-vacancy, apart from cGMP. cGMP binds each the 3- and 5-end vG4s and varieties two fill-in G4s with comparable inhabitants.

Anti-Phospho-PDGFR-beta (Y771) antibody

Considerably, guanine metabolites are concerned in lots of physiological and pathological processes in human cells, thus our outcomes present a structural foundation to grasp their potential regulatory capabilities by interplay with promoter vG4s. Furthermore, the NMR construction can information rational design of ligands that concentrate on the PDGFR-β vG4.

 

PDGFR-β and kidney fibrosis.

 

Power kidney illness (CKD) is without doubt one of the quickest rising world causes of loss of life, estimated to rank among the many high 5 by 2040 (Foreman et al, 2018). This illustrates present pitfalls in prognosis and administration of CKD. Superior CKD requires renal operate substitute by dialysis or transplantation.

Nonetheless, earlier CKD levels, even when renal operate remains to be regular, are already related to an elevated threat of untimely loss of life (Perez-Gomez et al, 2019). Thus, novel approaches to diagnose and deal with CKD are wanted.

 

 

Antibody for Human PDGFR beta

 

The histopathological hallmark of CKD is kidney fibrosis, which is carefully related to native irritation and lack of kidney parenchymal cells. Thus, kidney fibrosis is a lovely course of to develop exams permitting an earlier prognosis of CKD and represents a possible therapeutic goal to sluggish CKD development or promote regression.

 

 

 

 

PDGFR beta Antibody

ABF6132 100 ug
EUR 525.6

PDGFR beta Antibody

ABF6133 100 ug
EUR 525.6

PDGFR beta Antibody (CD140b)

F50659-0.4ML 0.4 ml
EUR 322.15
Description: PDGFRB is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses the gene to that of the translocation, ETS, leukemia gene, results in chronic myelomonocytic leukemia.

PDGFR beta antibody (Tyr740)

70R-33645 100 ug
EUR 294
Description: Rabbit polyclonal PDGFR beta antibody (Tyr740)

PDGFR beta antibody (Tyr1021)

70R-33647 100 ug
EUR 294
Description: Rabbit polyclonal PDGFR beta antibody (Tyr1021)

PDGFR beta (pY771) Antibody

E38PA6046 100ul
EUR 225
Description: Available in various conjugation types.

PDGFR beta (pY857) Antibody

E38PA6358 100ul
EUR 225
Description: Available in various conjugation types.

PDGFR beta (pY751) Antibody

20-abx133055
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

PDGFR beta (pY740) Antibody

abx011959-100ug 100 ug
EUR 526.8

PDGFR beta (pT1009) Antibody

20-abx009684
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

PDGFR beta (pY1021) Antibody

abx011955-100ug 100 ug
EUR 526.8

Polyclonal PDGFRB / PDGFR Beta Antibody

APR02743G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGFRB / PDGFR Beta . This antibody is tested and proven to work in the following applications:

PDGFR beta Polyclonal Antibody

A72113 50 μl
EUR 408

PDGFR beta Polyclonal Antibody

E-AB-67422-120uL 120uL
EUR 320
Description: Unconjugated

PDGFR beta Polyclonal Antibody

E-AB-67422-200uL 200uL
EUR 530
Description: Unconjugated

PDGFR beta Polyclonal Antibody

E-AB-67422-60uL 60uL
EUR 200
Description: Unconjugated

PDGFR beta Polyclonal Antibody

E-AB-67422-each each Ask for price
Description: Unconjugated

Rabbit Polyclonal PDGFR beta Antibody

TA325768 100 µl Ask for price

Rabbit Polyclonal PDGFR beta Antibody

TA325769 100 µl Ask for price

OAAD00312-100UL - PDGFR Beta Antibody

OAAD00312-100UL 0.1ml
EUR 369

Antibody for Human PDGFR beta

SPC-1185D-A565 0.1ml
EUR 480
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 565.

Antibody for Human PDGFR beta

SPC-1185D-A633 0.1ml
EUR 480
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 633.

Antibody for Human PDGFR beta

SPC-1185D-A655 0.1ml
EUR 480
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 655.

Antibody for Human PDGFR beta

SPC-1185D-A680 0.1ml
EUR 480
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 680.

Antibody for Human PDGFR beta

SPC-1185D-A700 0.1ml
EUR 480
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 700.

Antibody for Human PDGFR beta

SPC-1185D-ALP 0.1ml
EUR 472.8
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Alkaline Phosphatase.

Antibody for Human PDGFR beta

SPC-1185D-APC 0.1ml
EUR 478.8
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to APC .

Antibody for Human PDGFR beta

SPC-1185D-APCCY7 0.1ml
EUR 565.2
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to APC/Cy7.

Antibody for Human PDGFR beta

SPC-1185D-DY350 0.1ml
EUR 570
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Dylight 350.

Antibody for Human PDGFR beta

SPC-1185D-DY405 0.1ml
EUR 542.4
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Dylight 405.

Antibody for Human PDGFR beta

SPC-1185D-DY488 0.1ml
EUR 518.4
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Dylight 488.

Antibody for Human PDGFR beta

SPC-1185D-DY594 0.1ml
EUR 523.2
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Dylight 594.

Antibody for Human PDGFR beta

SPC-1185D-DY633 0.1ml
EUR 511.2
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Dylight 633.

Antibody for Human PDGFR beta

SPC-1185D-HRP 0.1ml
EUR 465.6
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to HRP.

Antibody for Human PDGFR beta

SPC-1185D-P594 0.1ml
EUR 488.4
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to PE/ATTO 594.

Antibody for Human PDGFR beta

SPC-1185D-PCP 0.1ml
EUR 478.8
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to PerCP.

Antibody for Human PDGFR beta

SPC-1185D-RPE 0.1ml
EUR 476.4
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to RPE .

Antibody for Human PDGFR beta

SPC-1185D-STR 0.1ml
EUR 477.6
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Streptavidin.

Phospho- PDGFR beta (Tyr740) Antibody

ABF3132 100 ug
EUR 525.6

Phospho- PDGFR beta (Tyr1021) Antibody

ABF3133 100 ug
EUR 525.6

PDGFR beta (Phospho-Tyr740) Antibody

11941-100ul 100ul
EUR 302.4

PDGFR beta (Phospho-Tyr740) Antibody

11941-50ul 50ul
EUR 224.4

PDGFR beta (Phospho-Tyr740) Antibody

E011941 100μg/100μl
EUR 255
Description: Available in various conjugation types.

PDGFR beta Rabbit Monoclonal Antibody

E10G20978 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PDGFR beta Rabbit Polyclonal Antibody

E10G22756 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-A565 0.1ml
EUR 480
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to ATTO 565.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-A633 0.1ml
EUR 480
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to ATTO 633.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-A655 0.1ml
EUR 480
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to ATTO 655.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-A680 0.1ml
EUR 480
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to ATTO 680.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-A700 0.1ml
EUR 480
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to ATTO 700.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-ALP 0.1ml
EUR 472.8
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to Alkaline Phosphatase.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-APC 0.1ml
EUR 478.8
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to APC .

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-APCCY7 0.1ml
EUR 565.2
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to APC/Cy7.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-DY350 0.1ml
EUR 496.8
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to Dylight 350.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-DY405 0.1ml
EUR 483.6
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to Dylight 405.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-DY488 0.1ml
EUR 471.6
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to Dylight 488.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-DY594 0.1ml
EUR 474
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to Dylight 594.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-DY633 0.1ml
EUR 468
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to Dylight 633.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-HRP 0.1ml
EUR 465.6
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to HRP.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-P594 0.1ml
EUR 488.4
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to PE/ATTO 594.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-PCP 0.1ml
EUR 478.8
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to PerCP.

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-RPE 0.1ml
EUR 476.4
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to RPE .

Antibody for Human PDGFR beta (pTyr751)

SPC-1415D-STR 0.1ml
EUR 477.6
Description: A polyclonal antibody for PDGFR beta (pTyr751) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human PDGFR beta around the phosphorylation site of tyrosine 751 (pTyr751).. The Antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:250-1:1000). This PDGFR beta (pTyr751) antibody is conjugated to Streptavidin.

Anti-Mouse PDGFR-beta Antibody

103-M44 100 µg
EUR 399
Description: The platelet-derived growth factor (PDGF) family consists of proteins derived from four genes (PDGF-A, B, C, and D) that form disulfidelinked homodimers (PDGF-AA, BB, CC, and DD) and a heterodimer (PDGF-AB). These proteins regulate diverse cellular functions by binding to and inducing the homo- or heterodimerization of two receptors (PDGF Rα and Rβ). Whereas α/α homodimerization is induced by PDGF-AA, BB, CC, and AB, α/β heterodimerization is induced by PDGF-AB, -BB, CC, and DD, and β/β homodimerization is induced only by PDGF-BB, and DD. Both PDGF-Rα and -Rβ are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for MCSF, SCF and Flt3-ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. Ligand-induced receptor dimerization results in autophosphorylation in trans resulting in the activation of several intracellular signaling pathways that can lead to cell proliferation, cell survival, cytoskeletal rearrangement, and cell migration. Many cell types, including fibroblasts and smooth muscle cells, express both the α and β receptors. Others have only the α receptors (oligodendrocyte progenitor cells, mesothelial cells, liver sinusoidal endothelial cells, astrocytes, platelets and megakaryocytes) or only the β receptors (myoblasts, capillary endothelial cells, pericytes, T cells, myeloid hematopoietic cells and macrophages). A soluble PDGF Rα has been detected in normal human plasma and serum as well as in the conditioned medium of the human osteosarcoma cell line MG63. Both the recombinant mouse and human soluble PDGF Rα bind PDGF with high affinity and are potent PDGF antagonists.

Anti-Human PDGFR-beta Antibody

101-M43 100 µg
EUR 399
Description: PDGF is a major serum mitogen that can exist as a homo or heterodimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF Rα binds all three PDGF isoforms with high affinity, PDGF Rβ binds PDGF-BB only with highaffinity. Both PDGF Rα and PDGF Rβ are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M CSF, SCF and Flt3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo- and heterodimerization and signal transduction. The expression of the α and β receptors is independently regulated in various cell types. Recombinant soluble PDGF Rβ binds PDGF with high affinity and is potent PDGF antagonist.

Anti-Human PDGFR-beta Antibody

101-M43A 100 µg
EUR 399
Description: PDGF is a major serum mitogen that can exist as a homo or heterodimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF Rα binds all three PDGF isoforms with high affinity, PDGF Rβ binds PDGF-BB only with highaffinity. Both PDGF Rα and PDGF Rβ are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M CSF, SCF and Flt3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo- and heterodimerization and signal transduction. The expression of the α and β receptors is independently regulated in various cell types. Recombinant soluble PDGF Rβ binds PDGF with high affinity and is potent PDGF antagonist.

Polyclonal PDGFRB / PDGFR Beta Antibody (Extracellular Domain)

APR02138G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGFRB / PDGFR Beta (Extracellular Domain). This antibody is tested and proven to work in the following applications:

OAAF05570-100UG - PDGFR Beta Antibody (Phospho-Tyr740)

OAAF05570-100UG 100ug
EUR 329

OAAF07589-100UG - PDGFR beta Antibody (Phospho-Tyr1021)

OAAF07589-100UG 100ug
EUR 329

Rabbit polyclonal PDGFR beta (Ab-1021) antibody

TA312018 100 µl Ask for price

Rat Monoclonal anti-mouse PDGFR beta

mAP-0005 100ug
EUR 250

Monoclonal PDGFRB / PDGFR Beta Antibody (clone 42G12), Clone: 42G12

AMM01839G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human PDGFRB / PDGFR Beta (clone 42G12). The antibodies are raised in Mouse and are from clone 42G12. This antibody is applicable in WB and IHC-P

Mouse Monoclonal anti-human PDGFR beta

hAP-0005A 100ug
EUR 250

Rabbit Anti-Human PDGFR beta Polyclonal

SPC-1185D 0.1ml
EUR 331
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is unconjugated.

Rabbit Anti-Human PDGFR beta Polyclonal

SPC-1185D-A390 0.1ml
EUR 385
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 390.

Rabbit Anti-Human PDGFR beta Polyclonal

SPC-1185D-A488 0.1ml
EUR 384
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 488.

Rabbit Anti-Human PDGFR beta Polyclonal

SPC-1185D-A594 0.1ml
EUR 384
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to ATTO 594.

Rabbit Anti-Human PDGFR beta Polyclonal

SPC-1185D-BI 0.1ml
EUR 380
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to Biotin.

Rabbit Anti-Human PDGFR beta Polyclonal

SPC-1185D-FITC 0.1ml
EUR 375
Description: A polyclonal antibody for PDGFR beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human PDGFR beta (AA164-178). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PDGFR beta antibody is conjugated to FITC.

PDGFR alpha + beta Antibody (phospho Tyr572 / Try574)

GWB-D0D641 0.05 ml Ask for price

PDGFR beta (Phospho-Tyr740) Polyclonal Conjugated Antibody

C11941 100ul
EUR 476.4

PDGFR-Beta Polyclonal Antibody

ABP52167-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751

PDGFR-Beta Polyclonal Antibody

ABP52167-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751

PDGFR-Beta Polyclonal Antibody

ABP52167-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751

 

Synergistic therapeutic impact of mixed PDGFR and SGK1 inhibition in metastasis-initiating cells of breast most cancers.

Lack of perception into the id of the cells that provoke metastasis hampers the event of antimetastatic therapies. Solely a tiny fraction of tumor cells termed metastasis-initiating cells (MICs) are capable of efficiently seed metastases, inflicting recurrence and therapeutic resistance.
Utilizing metastasis fashions, we describe a subpopulation of MIC derivates from lung metastases that do not need proliferation benefits, categorical excessive ranges of the PDGF receptors and EMT/stemness-related genes, and are distinctive of their capacity to provoke metastasis.
PDGF components particularly increase the metastatic potential of MIC populations in a PDGFR-dependent method. Nonetheless, PDGFR inhibition preferentially suppresses lung metastases, however doesn’t scale back the first tumor burden.

PDGFR beta (Phospho-Tyr740) Polyclonal Conjugated Antibody

 

Thus, we discovered that PDGFR inhibition blocks AKT activation, whereas SGK1, which shares high-similarity kinase area and overlap substrates with AKT overexpression stays energetic in MICs. SGK1 and PDGF signaling act in live performance to advertise metastatic formation, and SGK1 inhibition confers vulnerability to PDGFR inhibitors, additionally eliciting a strong antitumor impact.
In vivo, SGK1 inhibitors sensitize xenograft tumors to PDGFR-targeted therapies by decreasing major tumor development and lung metastasis. Consequently, twin inhibition of PDGFR and SGK1 exhibited sturdy antitumor actions in established breast most cancers cell strains in vitro and in vivo.
Subsequently, this strategy not solely offers perception into MIC transformation but in addition aids the design of improved therapeutic methods for superior breast most cancers.

 

PDGFRB Antibody

ABD6903 100 ug
EUR 525.6

PDGFRB antibody

20R-PR095 50 ug
EUR 709
Description: Rabbit polyclonal PDGFRB antibody

PDGFRB antibody

20R-PR096 50 ug
EUR 709
Description: Rabbit polyclonal PDGFRB antibody

PDGFRB Antibody

32646 100ul
EUR 439

PDGFRB Antibody

32646-100ul 100ul
EUR 302.4

PDGFRb Antibody

E18-6134-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

PDGFRb Antibody

E18-6134-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PDGFRB Antibody

E19-6903 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PDGFRB Antibody

1-CSB-PA017713GA01HU
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  • 150ul
  • 50ul
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

PDGFRB Antibody

1-CSB-PA017713LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

PDGFRB antibody

E39-09972 100ug/100ul
EUR 225
Description: Available in various conjugation types.

PDGFRB Antibody

E92180 100ul
EUR 255
Description: Available in various conjugation types.

PDGFRB Antibody

E310049 200ul
EUR 275
Description: Available in various conjugation types.

PDGFRB antibody

CAF50412-100ug 100ug
EUR 338

PDGFRB antibody

70R-19180 50 ul
EUR 289
Description: Rabbit polyclonal PDGFRB antibody

PDGFRb antibody

70R-32714 100 ug
EUR 294
Description: Rabbit polyclonal PDGFRb antibody

PDGFRB Antibody

1-CSB-PA003726
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  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000

PDGFRB Antibody

1-CSB-PA004625
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

PDGFRb Antibody

ABF6134 100 ug
EUR 525.6

PDGFRB Antibody

1-CSB-PA030008
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

PDGFRB Antibody

1-CSB-PA030009
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000

PDGFRB Antibody

1-CSB-PA030010
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

PDGFRB Antibody

1-CSB-PA208206
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  • 100ul
  • 50ul
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:1000-1:5000, WB:1:200-1:1000

PDGFRB Antibody

1-CSB-PA266610
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  • 100ul
  • 50ul
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:1000-1:2000, WB:1:200-1:1000

PDGFRB Antibody

F50660-0.4ML 0.4 ml
EUR 322.15
Description: PDGFRB is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides.

PDGFRB antibody

PAab09972 100 ug
EUR 463.2

PDGFRB antibody

PAab10079 100 ug
EUR 463.2

PDGFRb antibody (Tyr771)

70R-32713 100 ug
EUR 294
Description: Rabbit polyclonal PDGFRb antibody (Tyr771)

PDGFRB antibody (Tyr751)

70R-37416 100 ug
EUR 344
Description: Rabbit Polyclonal PDGFRB antibody (Tyr751)

Anti-PDGF Receptor beta/PDGFRB Antibody

A00096-1 100ug/vial
EUR 400.8

PDGFRB Antibody, HRP conjugated

1-CSB-PA017713LB01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PDGFRb (pT740) Antibody

20-abx124159
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  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

PDGFRb (pY771) Antibody

abx011957-100ug 100 ug
EUR 526.8

PDGFRb (pY857) Antibody

abx217690-100ug 100 ug
EUR 526.8

PDGFRB (pY740) Antibody

abx333509-100ul 100 ul
EUR 560.4

PDGFRb (pY751) Antibody

abx123278-100l 100 µl
EUR 200

PDGFRb (pY751) Antibody

abx123278-1ml 1 ml
EUR 475

PDGFRb (pY751) Antibody

abx123278-200l 200 µl
EUR 325

PDGFRB (pY740) Antibody

abx242998-96tests 96 tests
EUR 287.5

PDGFRb (pT740) Antibody

abx124159-100l 100 µl
EUR 200

PDGFRb (pT740) Antibody

abx124159-1ml 1 ml
EUR 475

PDGFRb (pT740) Antibody

abx124159-200l 200 µl
EUR 325

PDGFRB (pY740) Antibody

abx333509-100g 100 µg Ask for price

PDGFRB (pY740) Antibody

abx333509-20g 20 µg
EUR 412.5

PDGFRB (pY740) Antibody

abx333509-50g 50 µg Ask for price

PDGFRB Antibody, FITC conjugated

1-CSB-PA017713LC01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

PDGFRB (pY1009) Antibody

abx217688-100ug 100 ug
EUR 526.8

PDGFRb (pY1009) Antibody

abx123279-100l 100 µl
EUR 200

PDGFRb (pY1009) Antibody

abx123279-1ml 1 ml
EUR 475

PDGFRb (pY1009) Antibody

abx123279-200l 200 µl
EUR 325

OACA03428-50UG - PDGFRB Antibody

OACA03428-50UG 50ug
EUR 179

OALA03470-50UG - PDGFRB Antibody

OALA03470-50UG 50ug
EUR 539

OAEE00644-100T - PDGFRB Antibody

OAEE00644-100T 100tests
EUR 299

OAEE00645-100T - PDGFRB Antibody

OAEE00645-100T 100tests
EUR 299

PDGFRB Antibody, Biotin conjugated

1-CSB-PA017713LD01HU
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  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFRB. Recognizes PDGFRB from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OACA03428-100UG - PDGFRB Antibody

OACA03428-100UG 100ug
EUR 319

OASG05755-100UL - PDGFRB Antibody

OASG05755-100UL 100ul
EUR 239

OAAB04748-400UL - PDGFRB Antibody

OAAB04748-400UL 400ul
EUR 389

OAAB20006-400UL - PDGFRB Antibody

OAAB20006-400UL 400ul
EUR 419

OAAJ07377-100UL - PDGFRB Antibody

OAAJ07377-100UL 100uL
EUR 319

OAAF00817-100UG - PDGFRB Antibody

OAAF00817-100UG 100ug
EUR 329

OAAF01073-100UG - PDGFRB Antibody

OAAF01073-100UG 100ug
EUR 329

OASA01244-100UG - PDGFRB Antibody

OASA01244-100UG 0.1mg
EUR 309

OAED00016-100UG - PDGFRB Antibody

OAED00016-100UG 100ug
EUR 319

OAEE00088-100UG - PDGFRB Antibody

OAEE00088-100UG 0.1mg
EUR 209

Rabbit Polyclonal PDGFRb Antibody

TA325770 100 µl Ask for price

Human PDGFRB Antibody Pair Set

ABPR-ZB294 5 plates, 15 plates Ask for price
Description: Quantitative determination of Human PDGFRB

PDGFRB Polyclonal Antibody

A60210
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  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PDGFRB Polyclonal Antibody

E-AB-93114-120uL 120uL
EUR 320
Description: Unconjugated

PDGFRB Polyclonal Antibody

E-AB-93114-200uL 200uL
EUR 530
Description: Unconjugated

PDGFRB Polyclonal Antibody

E-AB-93114-60uL 60uL
EUR 200
Description: Unconjugated

PDGFRB Polyclonal Antibody

E-AB-93114-each each Ask for price
Description: Unconjugated

PDGFRB Polyclonal Antibody

E-AB-32531-120uL 120uL
EUR 240
Description: Unconjugated

PDGFRB Polyclonal Antibody

E-AB-32531-200uL 200uL
EUR 399
Description: Unconjugated

PDGFRB Polyclonal Antibody

E-AB-32531-20uL 20uL
EUR 73
Description: Unconjugated

PDGFRB Polyclonal Antibody

E-AB-32531-60uL 60uL
EUR 143
Description: Unconjugated

PDGFRb (Ab-771) Antibody

33246-100ul 100ul
EUR 302.4

PDGFRb (Ab-771) Antibody

33246-50ul 50ul
EUR 224.4

PDGFRB (Ab-751) Antibody

CSB-PA828739- each
EUR 402
Description: A polyclonal antibody against PDGFRB (Ab-751). Recognizes PDGFRB (Ab-751) from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

PDGFRB (Ab-751) Antibody

CSB-PA828739-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against PDGFRB (Ab-751). Recognizes PDGFRB (Ab-751) from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

PDGFRb (Ab-771) Antibody

E033246 100μg/100μl
EUR 255
Description: Available in various conjugation types.