Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis by the PDGFR/ROCK1 sign pathway

The targets of this research have been to analyze the position of the Notch1/PDGFRβ/ROCK1 signaling pathway within the pathogenesis of pulmonary fibrosis and to discover the opportunity of treating fibrosis by focusing on Notch1. Lung tissues from sufferers with pulmonary fibrosis have been examined for the expression of Notch1/PDGFRβ/ROCK1 utilizing RT-qPCR, western blotting, and immunostaining.
Cultured mouse lung pericytes have been transfected with Notch1-overexpressed vectors or shRNA focusing on PDGFRβ/ROCK1 to look at cell behaviors, together with proliferation, cell cycle arrest, and differentiation towards myofibroblasts.
Lastly, a mouse pulmonary fibrosis mannequin was ready, and a Notch1 inhibitor was administered to watch tissue morphology and pericyte cell behaviors. Human pulmonary fibrotic tissues offered with overexpression of Notch1, PDGFRβ, and ROCK1, along with a outstanding transition of pericytes into myofibroblasts.
In cultured mouse lung pericytes, overexpression of Notch1 led to the accelerated proliferation and differentiation of cells, and it additionally elevated the expression of the PDGFRβ and ROCK1 proteins. The knockdown of PDGFRβ/ROCK1 in pericytes remarkably suppressed pericyte proliferation and differentiation.
As additional substantiation, the administration of a Notch1 inhibitor in a mouse mannequin of lung fibrosis inhibited the PDGFRβ/ROCK1 pathway, suppressed pericyte proliferation and differentiation, and alleviated the severity of fibrosis.
vegf-a
vegf-a
Our outcomes confirmed that the Notch1 signaling pathway was aberrantly activated in pulmonary fibrosis, and this pathway could facilitate illness development by way of mediating pericyte proliferation and differentiation. The inhibition of the Notch1 pathway could present one promising remedy technique for pulmonary fibrosis.

 

Cy3 Conjugated anti-Mouse IgM SABC Kit

SA1073 1 kit
EUR 450

Cy3 Conjugated anti-Human IgG SABC Kit

SA1078 1 kit
EUR 426

Cy3 Conjugated anti-Rabbit IgG SABC Kit

SA1074 1 kit
EUR 426

GAPDH Monoclonal Antibody(2B8), Cy3 Conjugated

E44H11643 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

GAPDH Monoclonal Antibody(2B8), Cy5 Conjugated

E44H11644 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Histone H3 Monoclonal Antibody, Cy3 Conjugated

E44H11681 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Histone H3 Monoclonal Antibody, Cy5 Conjugated

E44H11682 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PCNA Monoclonal Antibody(12D10), Cy3 Conjugated

E44H11728 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PCNA Monoclonal Antibody(12D10), Cy5 Conjugated

E44H11729 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

COX IV Monoclonal Antibody(6C8), Cy3 Conjugated

E44H11604 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

COX IV Monoclonal Antibody(6C8), Cy5 Conjugated

E44H11605 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Anti-Human CD33 Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated

FC01508-PE-Cy7 25 Tests, 100 Tests, 200 Tests
EUR 234
Description: Mouse Monoclonal Human CD33 Antibody PE-Cy7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-Human CD3 Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated

FC02675-PE-Cy7 25 Tests, 100 Tests, 200 Tests
EUR 192
Description: Mouse Monoclonal Human CD3 Antibody PE-Cy7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD10 Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated

FC04065-PE-Cy7 25 Tests, 100 Tests, 200 Tests
EUR 199.2
Description: Mouse Monoclonal human CD10 Antibody PE-Cy7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-Human CD62L Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated

FC00652-PE-Cy7 25tests, 100tests, 200tests
EUR 225.6
Description: Mouse Monoclonal Human CD62L Antibody PE-Cy7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

V5-Tag Monoclonal Antibody(3C8), Cy3 Conjugated

E44H11750 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

V5-Tag Monoclonal Antibody(3C8), Cy5 Conjugated

E44H11751 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HA-Tag Monoclonal Antibody(1B10), Cy3 Conjugated

E44H11657 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HA-Tag Monoclonal Antibody(1B10), Cy5 Conjugated

E44H11658 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

His-Tag Monoclonal Antibody(4E6), Cy3 Conjugated

E44H11668 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

His-Tag Monoclonal Antibody(4E6), Cy5 Conjugated

E44H11669 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Lamin B1 Monoclonal Antibody(7C11), Cy3 Conjugated

E44H11700 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Lamin B1 Monoclonal Antibody(7C11), Cy5 Conjugated

E44H11701 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Myc-Tag Monoclonal Antibody(3E8), Cy3 Conjugated

E44H11715 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Myc-Tag Monoclonal Antibody(3E8), Cy5 Conjugated

E44H11716 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

β-actin Monoclonal Antibody(5B7), Cy3 Conjugated

E44H11785 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

β-actin Monoclonal Antibody(5B7), Cy5 Conjugated

E44H11786 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Flag-Tag Monoclonal Antibody(2C5), Cy3 Conjugated

E44H11627 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Flag-Tag Monoclonal Antibody(2C5), Cy5 Conjugated

E44H11628 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

β-Tubulin Monoclonal Antibody(5G3), Cy3 Conjugated

E44H11796 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

β-Tubulin Monoclonal Antibody(5G3), Cy5 Conjugated

E44H11797 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

α-tubulin Monoclonal Antibody(8F11), Cy3 Conjugated

E44H11773 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

α-tubulin Monoclonal Antibody(8F11), Cy5 Conjugated

E44H11774 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Goat anti-Human IgG(H+L) ,Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated

E16SPH1031-100 100μl
EUR 145

Goat anti-Human IgG(H+L) ,Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated

E16SPH1031-1000 1000μl
EUR 295

Goat anti-Human IgG(H+L) ,Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated

E16SPH1031-500 500μl
EUR 225

Anti-Human HLA-DR Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated

FC01340-PE-Cy7 25tests, 100tests, 200tests
EUR 225.6
Description: Anti-Human HLA-DR Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated

VSV-G-Tag Monoclonal Antibody(8D6), Cy3 Conjugated

E44H11761 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

VSV-G-Tag Monoclonal Antibody(8D6), Cy5 Conjugated

E44H11762 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Cyclophilin B Monoclonal Antibody(2B10), Cy3 Conjugated

E44H11616 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Cyclophilin B Monoclonal Antibody(2B10), Cy5 Conjugated

E44H11617 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated

E16SPH1021-100 100μl
EUR 145

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated

E16SPH1021-1000 1000μl
EUR 295

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated

E16SPH1021-500 500μl
EUR 225

Goat Anti-Human IgG Secondary Antibody Cy3 Conjugated

L30211 1.0 ml
EUR 85

Goat Anti-Mouse IgG Secondary Antibody Cy3 Conjugated

L30311 1.0 ml
EUR 85

Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated

E16SPH2011-100 100μl
EUR 145

Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated

E16SPH2011-1000 1000μl
EUR 295

Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated

E16SPH2011-500 500μl
EUR 225

Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated

E16SPH1022-100 100μl
EUR 145

Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated

E16SPH1022-1000 1000μl
EUR 295

Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated

E16SPH1022-500 500μl
EUR 225

Goat Anti-Rabbit IgG Secondary Antibody Cy3 Conjugated

L30111 1.0 ml
EUR 85

Cy2 Conjugated Affinity Purified anti-Rat IgG [H&L] [Goat]

SC015 250 µg
EUR 145

Cy5 Conjugated Affinity Purified anti-Rat IgG [H&L] [Goat]

SC016 250 µg
EUR 145

Cy3 Conjugated Affinity Purified anti-Rat IgG [H&L] [Goat]

SC025 250 µg
EUR 145

GFP (HRP conjugated)

E8ET1702-69 100ul
EUR 275
Description: Available in various conjugation types.

Cy5 Conjugated Affinity Purified anti-Mouse IgG [H&L] [Goat]

SC012 250 µg
EUR 145

Cy3 Conjugated Affinity Purified anti-Mouse IgG [H&L] [Goat]

SC023 250 µg
EUR 145

GAPDH (HRP Conjugated)

E11-12057 100ul
EUR 255
Description: Available in various conjugation types.

GAPDH (HRP conjugated)

E8ET1702-66 100ul
EUR 275
Description: Available in various conjugation types.

Cy2 Conjugated Affinity Purified anti-Goat IgG [H&L] [Donkey]

SC002 250 µg
EUR 145

Cy5 Conjugated Affinity Purified anti-Goat IgG [H&L] [Donkey]

SC004 250 µg
EUR 145

Cy2 Conjugated Affinity Purified anti-Rabbit IgG [H&L] [Goat]

SC013 250 µg
EUR 145

Cy5 Conjugated Affinity Purified anti-Rabbit IgG [H&L] [Goat]

SC014 250 µg
EUR 145

Cy3 Conjugated Affinity Purified anti-Goat IgG [H&L] [Donkey]

SC017 250 µg
EUR 145

Cy3 Conjugated Affinity Purified anti-Rabbit IgG (H&L) [Goat]

SC024 250 µg
EUR 145

HRP Conjugated Avidin

BA1081-0.5 0.5ml
EUR 175.2

HRP Conjugated Avidin

BA1081-1 1ml
EUR 279.6

BSA Conjugated Amylin

CPA812Hu11 10ug
EUR 120

OVA Conjugated Amylin

CPA812Hu21 10ug
EUR 120

OVA Conjugated Amylin

CPA812Hu22 10ug
EUR 140

KLH Conjugated Amylin

CPA812Hu33 10ug
EUR 132

BSA Conjugated Amylin

CPA812Mu11 10ug
EUR 120

OVA Conjugated Amylin

CPA812Mu21 10ug
EUR 120

BSA Conjugated Amylin

CPA812Ra11 10ug
EUR 120

OVA Conjugated Amylin

CPA812Ra21 10ug
EUR 120

OVA Conjugated Amylin

RPU50817-100ug 100ug
EUR 431.2

PDGFR-induced autocrine SDF-1 signaling in most cancers cells promotes metastasis in superior pores and skin carcinoma.

 

 

Superior and undifferentiated pores and skin squamous cell carcinomas (SCCs) exhibit aggressive development and enhanced metastasis functionality, which is related in mice with an growth of the most cancers stem-like cell (CSC) inhabitants and with adjustments within the regulatory mechanisms that management the proliferation and invasion of those cells. Certainly, autocrine activation of PDGFRα induces CSC invasion and promotes distant metastasis in superior SCCs. Nevertheless, the mechanisms concerned on this course of have been unclear.
Right here, we present that CSCs of mouse superior SCCs (L-CSCs) specific CXCR4 and CXCR7, each receptors of SDF-1. PDGFRα signaling induces SDF-1 expression and secretion, and the autocrine activation of this pathway in L-CSCs.
Autocrine SDF-1/CXCR4 signaling induces L-CSC proliferation and survival, and mediates PDGFRα-induced invasion, selling in vivo lung metastasis. Validation of those findings in affected person samples of pores and skin SCCs exhibits a powerful correlation between the expression of SDF1, PDGFRA, and PDGFRB, which is upregulated, alongside CXCR4 in tumor cells of superior SCCs.
Moreover, PDGFR regulates SDF-1 expression and inhibition of SDF-1/CXCR4 and PDGFR pathways blocks distant metastasis of human PD/S-SCCs. Our outcomes point out that purposeful crosstalk between PDGFR/SDF-1 signaling regulates tumor cell invasion and metastasis in human and mouse superior SCCs, and recommend that CXCR4 and/or PDGFR inhibitors might be used to dam metastasis of those aggressive tumors.

Corrigendum Antiproliferative results of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell strains by way of PDGFR‑β, PDGF‑BB, c‑Package and SCF expression.

 

  • An reader drew to our consideration that the above research appeared to comprise a excessive stage of overlap with an article by the identical authors revealed within the journal Drug Design, Improvement and Remedy [Kadivar A, Kamalidehghan B, Akbari Javar H, Karimi B, Sedghi R and Noordin MI: Antiproliferation effect of imatinib mesylate on MCF7, T‑47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF genes. Drug Des Devel Ther 11: 469‑481, 2017].
  • Following an inside investigation and likewise in liaison with the authors, it was established that, though the research have been performed alongside broadly comparable strains, the papers contained fully totally different knowledge involving two totally different subsets of cell strains; the submission to Drug Des Devel Ther aimed to discover the results of imatinib mesylate on three totally different teams, with every group being represented by a cell line, whereas the submission to Int J Mol Med explored the effectiveness of imatinib mesylate in breast most cancers cell strains.
  • Regardless of this, contemplating the relatedness of the articles and the truth that the paper to Drug Des Devel Ther was submitted first and revealed whereas the Int J Mol Med paper was passing by the peer‑evaluation course of, the authors concede that they need to have correctly referenced their paper submitted to Drug Des Devel Ther within the Int J Mol Med paper.
  • Notice that the publishers of Drug Des Devel Ther, with whom we have been liaising, agreed with the choice to concern a Corrigendum for this paper that acknowledges the article revealed in Drug Des Devel Ther.
  • The authors remorse their failure to acknowledge the associated paper on this occasion, and apologize to the readership for this oversight. [the original article was published in International Journal of Molecular Medicine 14: 414‑424, 2018; DOI: 10.3892/ijmm.2018.3590].

 

Myc-Tag Monoclonal Antibody(3E8), Cy5 Conjugated

E44H11716 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

β-actin Monoclonal Antibody(5B7), Cy5 Conjugated

E44H11786 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Flag-Tag Monoclonal Antibody(2C5), Cy5 Conjugated

E44H11628 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

β-Tubulin Monoclonal Antibody(5G3), Cy5 Conjugated

E44H11797 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

α-tubulin Monoclonal Antibody(8F11), Cy5 Conjugated

E44H11774 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Cyclophilin B Monoclonal Antibody(2B10), Cy5 Conjugated

E44H11617 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

VSV-G-Tag Monoclonal Antibody(8D6), Cy5 Conjugated

E44H11762 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Cy5 Conjugated Affinity Purified anti-Rat IgG [H&L] [Goat]

SC016 250 µg
EUR 145

Cy5 Conjugated Affinity Purified anti-Mouse IgG [H&L] [Goat]

SC012 250 µg
EUR 145

Cy5 Conjugated Affinity Purified anti-Goat IgG [H&L] [Donkey]

SC004 250 µg
EUR 145

Cy5 Conjugated Affinity Purified anti-Rabbit IgG [H&L] [Goat]

SC014 250 µg
EUR 145

Cy5 Conjugated Affinity Purified anti-Hamster IgG [H&L] [Goat]

SC006 250 µg
EUR 145

Cy5 Conjugated Affinity Purified anti-Human IgG [H&L] [Donkey]

SC008 250 µg
EUR 145

Mouse anti-Human CD3, PE-Cy5 Conjugated mAb

28006-50Tests 50 Tests
EUR 303.6

Mouse anti-Human CD4, PE-Cy5 Conjugated mAb

28013-50Tests 50 Tests
EUR 303.6

Mouse anti-Human CD8, PE-Cy5 Conjugated mAb

28028-50Tests 50 Tests
EUR 303.6

Mouse anti-Human CD3, PE-Cy5 Conjugated mAb.

E16HC003-050 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD3, PE-Cy5 Conjugated mAb.

E16HC003-100 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD4, PE-Cy5 Conjugated mAb.

E16HC004-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD4, PE-Cy5 Conjugated mAb.

E16HC004-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD4, PE-Cy5 Conjugated mAb.

E16HC0041-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD4, PE-Cy5 Conjugated mAb.

E16HC0041-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD8, PE-Cy5 Conjugated mAb.

E16HC008-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD8, PE-Cy5 Conjugated mAb.

E16HC008-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD14, PE-Cy5 Conjugated mAb

28053-50Tests 50 Tests
EUR 302.4

Mouse anti-Human CD19, PE-Cy5 Conjugated mAb

28074-50Tests 50 Tests
EUR 302.4

Mouse anti-Human CD45, PE-Cy5 Conjugated mAb

28144-50Tests 50 Tests
EUR 303.6

Mouse anti-Human CD14, PE-Cy5 Conjugated mAb.

E16HC0142-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD14, PE-Cy5 Conjugated mAb.

E16HC0142-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD19, PE-Cy5 Conjugated mAb.

E16HC019-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD19, PE-Cy5 Conjugated mAb.

E16HC019-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD20, PE-Cy5 Conjugated mAb.

E16HC020-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD20, PE-Cy5 Conjugated mAb.

E16HC020-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD25, PE-Cy5 Conjugated mAb.

E16HC0251-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD25, PE-Cy5 Conjugated mAb.

E16HC0251-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD34, PE-Cy5 Conjugated mAb.

E16HC0341-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD34, PE-Cy5 Conjugated mAb.

E16HC0341-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD38, PE-Cy5 Conjugated mAb.

E16HC0381-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD38, PE-Cy5 Conjugated mAb.

E16HC0381-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD40, PE-Cy5 Conjugated mAb.

E16HC040-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD40, PE-Cy5 Conjugated mAb.

E16HC040-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD41, PE-Cy5 Conjugated mAb.

E16HC0411-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD41, PE-Cy5 Conjugated mAb.

E16HC0411-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD45, PE-Cy5 Conjugated mAb.

E16HC045-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD45, PE-Cy5 Conjugated mAb.

E16HC045-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse IgM Isotype Control, PE-Cy5 Conjugated mAb

E16MCC004-050 50Tests
EUR 145
Description: Available in various conjugation types.

Mouse IgM Isotype Control, PE-Cy5 Conjugated mAb

E16MCC004-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control, PE-Cy5 Conjugated mAb

E16MCC001-050 50Tests
EUR 145
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control, PE-Cy5 Conjugated mAb

E16MCC001-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD45RO, PE-Cy5 Conjugated mAb.

E16HC0456-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD45RO, PE-Cy5 Conjugated mAb.

E16HC0456-100 100Tests
EUR 255
Description: Available in various conjugation types.

Streptavidin::Cy5 Conjugate

40180009-1 1 mg
EUR 147.68

Mouse IgG2a Isotype Control, PE-Cy5 Conjugated mAb

E16MCC002-050 50Tests
EUR 145
Description: Available in various conjugation types.

Mouse IgG2a Isotype Control, PE-Cy5 Conjugated mAb

E16MCC002-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse IgG2b Isotype Control, PE-Cy5 Conjugated mAb

E16MCC003-050 50Tests
EUR 145
Description: Available in various conjugation types.

Mouse IgG2b Isotype Control, PE-Cy5 Conjugated mAb

E16MCC003-100 100Tests
EUR 255
Description: Available in various conjugation types.

Cy5 biotin conjugate

3100-5mg 5 mg
EUR 222
Description: This bifunctional Cy5 biotin conjugate demonstrates excellent avidin binding and strong fluorescence.

Mouse anti-Human CD4/CD8/CD3, FITC/PE/PE-Cy5 Conjugated mAb

28249-20Tests 20 Tests
EUR 302.4

Mouse anti-Human CD4/CD8/CD3, FITC/PE/PE-Cy5 Conjugated mAb

E16HT001-020 50Tests
EUR 145
Description: Available in various conjugation types.

Mouse anti-Human CD4/CD8/CD3, FITC/PE/PE-Cy5 Conjugated mAb

E16HT001-050 100Tests
EUR 225
Description: Available in various conjugation types.

Mouse Anti-Human CD3/CD19/CD45, FITC/PE/PE-Cy5 Conjugated mAb

28252-20Tests 20 Tests
EUR 302.4

PE-Cy5 (Phycoerhthrin-Cy5 Conjugate)

7850-250 each
EUR 444

Cy3 Conjugated Goat Anti-Mouse IgG

TA130012 500 µg Ask for price

Cy3 Conjugated Goat Anti-Rabbit IgG

TA130020 500 µg Ask for price

Cy3 Conjugated Rabbit Anti-Goat IgG

TA130028 500 µg Ask for price

Cy3 Conjugated Rabbit Anti-Human IgG

TA130044 500 µg Ask for price

Cy3 Conjugated anti-Rat IgG SABC Kit

SA1079 1 kit
EUR 426

Cy3 Conjugated anti-Goat IgG SABC Kit

SA1076 1 kit
EUR 426

Cy3 Conjugated anti-Mouse IgG SABC Kit

SA1072 1 kit
EUR 426

Cy3 Conjugated anti-Mouse IgM SABC Kit

SA1073 1 kit
EUR 450

Cy3 Conjugated anti-Human IgG SABC Kit

SA1078 1 kit
EUR 426

Cy3 Conjugated anti-Rabbit IgG SABC Kit

SA1074 1 kit
EUR 426

GAPDH Monoclonal Antibody(2B8), Cy3 Conjugated

E44H11643 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Histone H3 Monoclonal Antibody, Cy3 Conjugated

E44H11681 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PCNA Monoclonal Antibody(12D10), Cy3 Conjugated

E44H11728 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

COX IV Monoclonal Antibody(6C8), Cy3 Conjugated

E44H11604 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

V5-Tag Monoclonal Antibody(3C8), Cy3 Conjugated

E44H11750 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HA-Tag Monoclonal Antibody(1B10), Cy3 Conjugated

E44H11657 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

His-Tag Monoclonal Antibody(4E6), Cy3 Conjugated

E44H11668 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Lamin B1 Monoclonal Antibody(7C11), Cy3 Conjugated

E44H11700 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Myc-Tag Monoclonal Antibody(3E8), Cy3 Conjugated

E44H11715 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

β-actin Monoclonal Antibody(5B7), Cy3 Conjugated

E44H11785 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Flag-Tag Monoclonal Antibody(2C5), Cy3 Conjugated

E44H11627 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody