Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis by the PDGFR/ROCK1 sign pathway

The targets of this research have been to analyze the position of the Notch1/PDGFRβ/ROCK1 signaling pathway within the pathogenesis of pulmonary fibrosis and to discover the opportunity of treating fibrosis by focusing on Notch1. Lung tissues from sufferers with pulmonary fibrosis have been examined for the expression of Notch1/PDGFRβ/ROCK1 utilizing RT-qPCR, western blotting, and immunostaining.
Cultured mouse lung pericytes have been transfected with Notch1-overexpressed vectors or shRNA focusing on PDGFRβ/ROCK1 to look at cell behaviors, together with proliferation, cell cycle arrest, and differentiation towards myofibroblasts.
Lastly, a mouse pulmonary fibrosis mannequin was ready, and a Notch1 inhibitor was administered to watch tissue morphology and pericyte cell behaviors. Human pulmonary fibrotic tissues offered with overexpression of Notch1, PDGFRβ, and ROCK1, along with a outstanding transition of pericytes into myofibroblasts.
In cultured mouse lung pericytes, overexpression of Notch1 led to the accelerated proliferation and differentiation of cells, and it additionally elevated the expression of the PDGFRβ and ROCK1 proteins. The knockdown of PDGFRβ/ROCK1 in pericytes remarkably suppressed pericyte proliferation and differentiation.
As additional substantiation, the administration of a Notch1 inhibitor in a mouse mannequin of lung fibrosis inhibited the PDGFRβ/ROCK1 pathway, suppressed pericyte proliferation and differentiation, and alleviated the severity of fibrosis.
vegf-a
vegf-a
Our outcomes confirmed that the Notch1 signaling pathway was aberrantly activated in pulmonary fibrosis, and this pathway could facilitate illness development by way of mediating pericyte proliferation and differentiation. The inhibition of the Notch1 pathway could present one promising remedy technique for pulmonary fibrosis.

 

Anti-Mouse Ly-6G (Gr-1) Monoclonal Antibody PE-Cyanine7 Conjugated, Flow Validated

FC30404-1-PE-Cy7 25ug, 100ug
EUR 131
Description: Rat Monoclonal Mouse Ly-6G (Gr-1) Antibody PE-Cyanine7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Mouse.

CY7

HY-D0825 10mM/1mL
EUR 506

CY7-SE

HY-D0824 25mg
EUR 394

APC-Cy7 Tandem

2625 1 mg
EUR 219

Cy7-PEG-NH2,2K

FL080005-2K-50mg 50mg
EUR 667
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy7-PEG-NH2,3.4K

FL080005-3.4K-50mg 50mg
EUR 667
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy7-PEG-NH2,5K

FL080005-5K-50mg 50mg
EUR 667
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy7-PEG-NH2

abx085304-2kDa50mg 2 kDa; 50 mg
EUR 954

Cy7-PEG-NH2

abx085304-34kDa50mg 3.4 kDa; 50 mg
EUR 954

CY7-PEG-DSPE

abx085409-2kDa50mg 2 kDa; 50 mg
EUR 901

Cy7 NHS ester

A8109-25 25 mg
EUR 1036
Description: Sulfo-Cy7 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. This reagent allows prepare Cy7-labeled biomolecules, especially useful for the labeling of delicate proteins, and proteins prone to denaturation.

Cy7 NHS ester

A8109-5 5 mg
EUR 525
Description: Sulfo-Cy7 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. This reagent allows prepare Cy7-labeled biomolecules, especially useful for the labeling of delicate proteins, and proteins prone to denaturation.

Fluorescein Isothiocyanate (APC-Cy7) Monoclonal Antibody (Pan-species), APC-Cy7

4-MAO843Ge21-APC-Cy7
  • EUR 572.00
  • EUR 6466.00
  • EUR 1714.00
  • EUR 763.00
  • EUR 320.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Pan-species Fluorescein Isothiocyanate (APC-Cy7). This antibody is labeled with APC-Cy7.

Cy7®-streptavidin conjugate

16914 1 mg
EUR 176

RPE-Cy7-streptavidin conjugate

16916 100 ug
EUR 219

RPE-Cy7-streptavidin conjugate

16917 1 mg
EUR 876

Annexin V-Cy7 conjugate

20068 100 Tests
EUR 219

Anti-EGFR PE-Cy7

T7-680-T025 25 tests
EUR 154

Anti-EGFR PE-Cy7

T7-680-T100 100 tests
EUR 268

Anti-Helios PE-Cy7

T7-771-T025 25 tests
EUR 154

Anti-Helios PE-Cy7

T7-771-T100 100 tests
EUR 268

CY7-PEG-DSPE?2K

FL080096-2K-50mg 50mg
EUR 494
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Streptavidin-PE-Cy7 conjugate

SV-PEC7-100 100 tests
EUR 286

Cy7 azide (non-sulfonated)

A8115-25 25 mg
EUR 1616
Description: Cy7 azide is a labeling reagent that ready for the use in Click Chemistry labeling. This labeling dye is a near-infrared dye which has low aqueous solubility.

Cy7 azide (non-sulfonated)

A8115-5 5 mg
EUR 583
Description: Cy7 azide is a labeling reagent that ready for the use in Click Chemistry labeling. This labeling dye is a near-infrared dye which has low aqueous solubility.

Cy7 maleimide (non-sulfonated)

A8141-25 25 mg
EUR 525
Description: Cy7 maleimide is a near-infrared, sulfhydryl reactive dye which has low aqueous solubility. This reagent can label the proteins contain free sulfhydryl groups.

Cy7 maleimide (non-sulfonated)

A8141-5 5 mg
EUR 293
Description: Cy7 maleimide is a near-infrared, sulfhydryl reactive dye which has low aqueous solubility. This reagent can label the proteins contain free sulfhydryl groups.

CD117 antibody (Allophycocyanin-CY7)

61R-CD117bMSAP5 100 ug
EUR 327
Description: Rat monoclonal CD117 antibody (Allophycocyanin-CY7)

CD11a antibody (PE-CY7)

61R-CD11aaMSPE7 100 ug
EUR 435
Description: Rat monoclonal CD11a antibody (PE-CY7)

CD16 antibody (PE-CY7)

61R-CD16gMSPEC7 100 ug
EUR 300
Description: Rat monoclonal CD16 antibody (PE-CY7)

CD19 antibody (PE-CY7)

61R-CD19aMSPEC7 100 ug
EUR 327
Description: Rat monoclonal CD19 antibody (PE-CY7)

CD19 antibody (Allophycocyanin-CY7)

61R-CD19cHUAPC7 100 tests
EUR 457
Description: Mouse monoclonal CD19 antibody (Allophycocyanin-CY7)

CD19 antibody (PE-CY7)

61R-CD19cHUPEC7 100 tests
EUR 446
Description: Mouse monoclonal CD19 antibody (PE-CY7)

CD20 antibody (Allophycocyanin-CY7)

61R-CD20bHUAPC7 100 tests
EUR 446
Description: Mouse monoclonal CD20 antibody (Allophycocyanin-CY7)

CD20 antibody (PE-CY7)

61R-CD20bHUPEC7 100 tests
EUR 446
Description: Mouse monoclonal CD20 antibody (PE-CY7)

CD23 antibody (PE-CY7)

61R-CD23cMSPEC7 100 ug
EUR 327
Description: Rat monoclonal CD23 antibody (PE-CY7)

CD25 antibody (PE-CY7)

61R-CD25cMSPEC7 100 ug
EUR 300
Description: Rat monoclonal CD25 antibody (PE-CY7)

CD25 antibody (PE-CY7)

61R-CD25dMSPEC7 100 ug
EUR 370
Description: Rat monoclonal CD25 antibody (PE-CY7)

CD31 antibody (PE-CY7)

61R-CD31jMSPEC7 100 ug
EUR 300
Description: Rat monoclonal CD31 antibody (PE-CY7)

CD3 antibody (Allophycocyanin-CY7)

61R-CD3gHUAPCC7 100 tests
EUR 446
Description: Mouse monoclonal CD3 antibody (Allophycocyanin-CY7)

CD3 antibody (PE-CY7)

61R-CD3gHUPEC7 100 tests
EUR 446
Description: Mouse monoclonal CD3 antibody (PE-CY7)

CD44 antibody (PE-CY7)

61R-CD44hHUPEC7 100 tests
EUR 446
Description: Mouse monoclonal CD44 antibody (PE-CY7)

CD45.1 antibody (Allophycocyanin-CY7)

61R-CD45gMSAPC7 100 ug
EUR 381
Description: Mouse monoclonal CD45.1 antibody (Allophycocyanin-CY7)

CD45.1 antibody (PE-CY7)

61R-CD45gMSPEC7 100 ug
EUR 300
Description: Mouse monoclonal CD45.1 antibody (PE-CY7)

CD45.2 antibody (PE-CY7)

61R-CD45hMSAPC7 100 ug
EUR 316
Description: Mouse monoclonal CD45.2 antibody (PE-CY7)

CD45R antibody (PE-CY7)

61R-CD45RcMSPE7 100 ug
EUR 300
Description: Rat monoclonal CD45R antibody (PE-CY7)

CD49b antibody (Allophycocyanin-CY7)

61R-CD49cMSAPC7 100 ug
EUR 435
Description: Rat monoclonal CD49b antibody (Allophycocyanin-CY7)

CD4 antibody (PE-CY7)

61R-CD4eMSPEC7 100 ug
EUR 300
Description: Rat monoclonal CD4 antibody (PE-CY7)

CD4 antibody (Allophycocyanin-CY7)

61R-CD4kHUAPCC7 100 tests
EUR 457
Description: Mouse monoclonal CD4 antibody (Allophycocyanin-CY7)

CD4 antibody (PE-CY7)

61R-CD4kHUPEC7 100 tests
EUR 446
Description: Mouse monoclonal CD4 antibody (PE-CY7)

CD62L antibody (Allophycocyanin-CY7)

61R-CD62dMSAPC7 100 ug
EUR 381
Description: Rat monoclonal CD62L antibody (Allophycocyanin-CY7)

CD62L antibody (PE-CY7)

61R-CD62dMSPEC7 100 ug
EUR 300
Description: Rat monoclonal CD62L antibody (PE-CY7)

CD69 antibody (PE-CY7)

61R-CD69aMSPEC 100 ug
EUR 300
Description: Hamster monoclonal CD69 antibody (PE-CY7)

CD86 antibody (PE-CY7)

61R-CD86bMSPEC7 100 ug
EUR 370
Description: Rat monoclonal CD86 antibody (PE-CY7)

CD86 antibody (PE-CY7)

61R-CD86cMSPEC7 100 ug
EUR 403
Description: Rat monoclonal CD86 antibody (PE-CY7)

CD8a antibody (PE-CY7)

61R-CD8abMSPEC7 100 ug
EUR 300
Description: Rat monoclonal CD8a antibody (PE-CY7)

Anti-Hu CD45 APC-Cy7

T4-160-T100 100 tests
EUR 268

Anti-Hu CD49d APC-Cy7

T4-171-T100 100 tests
EUR 268

Anti-Hu CD3 APC-Cy7

T4-173-T025 25 tests
EUR 154

Anti-Hu CD3 APC-Cy7

T4-173-T100 100 tests
EUR 268

Anti-Hu CD8 APC-Cy7

T4-207-T025 25 tests
EUR 154

Anti-Hu CD8 APC-Cy7

T4-207-T100 100 tests
EUR 268

Anti-Hu CD9 APC-Cy7

T4-208-T025 25 tests
EUR 154

Anti-Hu CD9 APC-Cy7

T4-208-T100 100 tests
EUR 268

Anti-Hu CD10 APC-Cy7

T4-209-T025 25 tests
EUR 154

Anti-Hu CD10 APC-Cy7

T4-209-T100 100 tests
EUR 268

Anti-Hu CD25 APC-Cy7

T4-218-T100 100 tests
EUR 268

Anti-Hu CD43 APC-Cy7

T4-220-T025 25 tests
EUR 154

Anti-Hu CD43 APC-Cy7

T4-220-T100 100 tests
EUR 268

Anti-Hu CD45 APC-Cy7

T4-222-T025 25 tests
EUR 154

Anti-Hu CD45 APC-Cy7

T4-222-T100 100 tests
EUR 268

Anti-Hu CD71 APC-Cy7

T4-235-T025 25 tests
EUR 154

Anti-Hu CD71 APC-Cy7

T4-235-T100 100 tests
EUR 268

Anti-Hu CD14 APC-Cy7

T4-293-T025 25 tests
EUR 154

Anti-Hu CD14 APC-Cy7

T4-293-T100 100 tests
EUR 268

Anti-Hu CD19 APC-Cy7

T4-305-T025 25 tests
EUR 154

Anti-Hu CD19 APC-Cy7

T4-305-T100 100 tests
EUR 268

Anti-Hu CD27 APC-Cy7

T4-308-T100 100 tests
EUR 268

PDGFR-induced autocrine SDF-1 signaling in most cancers cells promotes metastasis in superior pores and skin carcinoma.

 

 

Superior and undifferentiated pores and skin squamous cell carcinomas (SCCs) exhibit aggressive development and enhanced metastasis functionality, which is related in mice with an growth of the most cancers stem-like cell (CSC) inhabitants and with adjustments within the regulatory mechanisms that management the proliferation and invasion of those cells. Certainly, autocrine activation of PDGFRα induces CSC invasion and promotes distant metastasis in superior SCCs. Nevertheless, the mechanisms concerned on this course of have been unclear.
Right here, we present that CSCs of mouse superior SCCs (L-CSCs) specific CXCR4 and CXCR7, each receptors of SDF-1. PDGFRα signaling induces SDF-1 expression and secretion, and the autocrine activation of this pathway in L-CSCs.
Autocrine SDF-1/CXCR4 signaling induces L-CSC proliferation and survival, and mediates PDGFRα-induced invasion, selling in vivo lung metastasis. Validation of those findings in affected person samples of pores and skin SCCs exhibits a powerful correlation between the expression of SDF1, PDGFRA, and PDGFRB, which is upregulated, alongside CXCR4 in tumor cells of superior SCCs.
Moreover, PDGFR regulates SDF-1 expression and inhibition of SDF-1/CXCR4 and PDGFR pathways blocks distant metastasis of human PD/S-SCCs. Our outcomes point out that purposeful crosstalk between PDGFR/SDF-1 signaling regulates tumor cell invasion and metastasis in human and mouse superior SCCs, and recommend that CXCR4 and/or PDGFR inhibitors might be used to dam metastasis of those aggressive tumors.

Corrigendum Antiproliferative results of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell strains by way of PDGFR‑β, PDGF‑BB, c‑Package and SCF expression.

 

  • An reader drew to our consideration that the above research appeared to comprise a excessive stage of overlap with an article by the identical authors revealed within the journal Drug Design, Improvement and Remedy [Kadivar A, Kamalidehghan B, Akbari Javar H, Karimi B, Sedghi R and Noordin MI: Antiproliferation effect of imatinib mesylate on MCF7, T‑47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF genes. Drug Des Devel Ther 11: 469‑481, 2017].
  • Following an inside investigation and likewise in liaison with the authors, it was established that, though the research have been performed alongside broadly comparable strains, the papers contained fully totally different knowledge involving two totally different subsets of cell strains; the submission to Drug Des Devel Ther aimed to discover the results of imatinib mesylate on three totally different teams, with every group being represented by a cell line, whereas the submission to Int J Mol Med explored the effectiveness of imatinib mesylate in breast most cancers cell strains.
  • Regardless of this, contemplating the relatedness of the articles and the truth that the paper to Drug Des Devel Ther was submitted first and revealed whereas the Int J Mol Med paper was passing by the peer‑evaluation course of, the authors concede that they need to have correctly referenced their paper submitted to Drug Des Devel Ther within the Int J Mol Med paper.
  • Notice that the publishers of Drug Des Devel Ther, with whom we have been liaising, agreed with the choice to concern a Corrigendum for this paper that acknowledges the article revealed in Drug Des Devel Ther.
  • The authors remorse their failure to acknowledge the associated paper on this occasion, and apologize to the readership for this oversight. [the original article was published in International Journal of Molecular Medicine 14: 414‑424, 2018; DOI: 10.3892/ijmm.2018.3590].

 

CY5-SE

HY-D0819 25mg
EUR 463

CY5-YNE

HY-D0820 10mM/1mL
EUR 786

CY5-N3

HY-D0832 5mg
EUR 533

Cy5 azide

A8128-25 25 mg
EUR 1732
Description: Sulfo-Cy5 azide is a sulfonated, hydrophilic and highly water soluble dye for Click chemistry. Due to this features, the dye can be used for labeling biomolecules, especially useful for the labeling of delicate proteins and proteins prone to denaturation, purely aqueous conditions.

Cy5 azide

A8128-5 5 mg
EUR 618
Description: Sulfo-Cy5 azide is a sulfonated, hydrophilic and highly water soluble dye for Click chemistry. Due to this features, the dye can be used for labeling biomolecules, especially useful for the labeling of delicate proteins and proteins prone to denaturation, purely aqueous conditions.

Mouse anti-Human CD3, PE-Cy5 Conjugated mAb

28006-50Tests 50 Tests
EUR 253

Mouse anti-Human CD4, PE-Cy5 Conjugated mAb

28013-50Tests 50 Tests
EUR 253

Mouse anti-Human CD8, PE-Cy5 Conjugated mAb

28028-50Tests 50 Tests
EUR 253

Mouse anti-Human CD14, PE-Cy5 Conjugated mAb

28053-50Tests 50 Tests
EUR 252

Mouse anti-Human CD19, PE-Cy5 Conjugated mAb

28074-50Tests 50 Tests
EUR 252

Mouse anti-Human CD45, PE-Cy5 Conjugated mAb

28144-50Tests 50 Tests
EUR 253

Azido-Cy5 tyramide

11061 1 mg
EUR 306

PE-Cy5 Tandem

2610 1 mg
EUR 219

Cy5-PEG-SH

abx085228-1kDa50mg 1 kDa; 50 mg
EUR 871

Cy5-PEG-SH

abx085228-2kDa50mg 2 kDa; 50 mg
EUR 913

Cy5-PEG-SH

abx085228-34kDa50mg 3.4 kDa; 50 mg
EUR 940

Cy5-PEG-SH

abx085228-5kDa50mg 5 kDa; 50 mg
EUR 940

Cy5-PEG-COOH

abx085357-10kDa50mg 10 kDa; 50 mg
EUR 499

Cy5-PEG-COOH

abx085357-20kDa50mg 20 kDa; 50 mg
EUR 499

Cy5-PEG-COOH

abx085357-2kDa50mg 2 kDa; 50 mg
EUR 535

Cy5-PEG-COOH

abx085357-5kDa50mg 5 kDa; 50 mg
EUR 535

Cy5-PEG-Mal

abx085358-10kDa50mg 10 kDa; 50 mg
EUR 546

Cy5-PEG-Mal

abx085358-1kDa50mg 1 kDa; 50 mg
EUR 546

Cy5-PEG-Mal

abx085358-2kDa50mg 2 kDa; 50 mg
EUR 570

Glucagon-Cy5 Peptide

abx267068-1mg 1 mg
EUR 2068

Cy5 NHS ester

A8108-25 25 mg
EUR 746
Description: Sulfo-Cy5 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. For the labeling of various amine-containing molecules in aqueous phase, no organic co-solvent is needed.

Cy5 NHS ester

A8108-5 5 mg
EUR 293
Description: Sulfo-Cy5 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. For the labeling of various amine-containing molecules in aqueous phase, no organic co-solvent is needed.

Cy5 carboxylic acid

A8137-25 25 mg
EUR 1036
Description: Sulfo-Cy5 carboxylic acid is a non-activated, sulfonated, hydrophilic and highly water soluble dye. Non-Sulfo-Cy5 carboxylic acid analog is available. For kinds of researches related experiments, using pre-activated sulfo-Cy5 NHS ester is preferred

Cy5 carboxylic acid

A8137-5 5 mg
EUR 525
Description: Sulfo-Cy5 carboxylic acid is a non-activated, sulfonated, hydrophilic and highly water soluble dye. Non-Sulfo-Cy5 carboxylic acid analog is available. For kinds of researches related experiments, using pre-activated sulfo-Cy5 NHS ester is preferred

CD117 antibody (CY5)

61R-CD117bMSCY5 100 ug
EUR 413
Description: Rat monoclonal CD117 antibody (CY5)

CD11b antibody (CY5)

61R-CD11baMSCY5 100 ug
EUR 413
Description: Rat monoclonal CD11b antibody (CY5)

CD19 antibody (CY5)

61R-CD19aMSCY5 100 ug
EUR 435
Description: Rat monoclonal CD19 antibody (CY5)

CD19 antibody (CY5)

61R-CD19cHUCY5 100 tests
EUR 435
Description: Mouse monoclonal CD19 antibody (CY5)

CD3e antibody (CY5)

61R-CD3egMSCY 100 ug
EUR 284
Description: Hamster monoclonal CD3e antibody (CY5)

CD3e antibody (CY5)

61R-CD3ehMSCY 100 ug
EUR 284
Description: Rat monoclonal CD3e antibody (CY5)

CD3 antibody (CY5)

61R-CD3gHUCY5 100 tests
EUR 446
Description: Mouse monoclonal CD3 antibody (CY5)

CD45.1 antibody (CY5)

61R-CD45gMSCY5 100 ug
EUR 457
Description: Mouse monoclonal CD45.1 antibody (CY5)

CD45.2 antibody (CY5)

61R-CD45hMSCY5 100 ug
EUR 381
Description: Mouse monoclonal CD45.2 antibody (CY5)

CD45R antibody (CY5)

61R-CD45RcMSCY5 100 ug
EUR 413
Description: Rat monoclonal CD45R antibody (CY5)

CD4 antibody (CY5)

61R-CD4eMSCY 100 ug
EUR 403
Description: Rat monoclonal CD4 antibody (CY5)

CD4 antibody (CY5)

61R-CD4kHUCY5 100 tests
EUR 435
Description: Mouse monoclonal CD4 antibody (CY5)

CD8a antibody (CY5)

61R-CD8abMSCY5 100 ug
EUR 413
Description: Rat monoclonal CD8a antibody (CY5)

CD8a antibody (CY5)

61R-CD8adCKCY5 100 ug
EUR 543
Description: Mouse monoclonal CD8a antibody (CY5)

CD8a antibody (CY5)

61R-CD8aeCKCY5 100 ug
EUR 457
Description: Mouse monoclonal CD8a antibody (CY5)

Cy5®-streptavidin conjugate

16913 1 mg
EUR 176

Annexin V-Cy5 conjugate

20066 100 Tests
EUR 219

FMOC-Lys(Cy5)-OH

5055 100 mg
EUR 654

Streptavidin: RPE-Cy5 Conjugate

R-1099 0.2 ml Ask for price
Description: fast delivery possible

PE-Cy5 Calibration Kit

ECFP-F4-5K 5X1 mL
EUR 310
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Cy5-PEG-SH,10K

FL078003-10K-50mg 50mg
EUR 544
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-SH,1K

FL078003-1K-50mg 50mg
EUR 605
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-SH,2K

FL078003-2K-50mg 50mg
EUR 568
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-SH,3.4K

FL078003-3.4K-50mg 50mg
EUR 544
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-SH,5K

FL078003-5K-50mg 50mg
EUR 544
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-COOH,10K

FL078017-10K-50mg 50mg
EUR 470
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-COOH,1K

FL078017-1K-50mg 50mg
EUR 470
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-COOH,20K

FL078017-20K-50mg 50mg
EUR 470
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-COOH,2K

FL078017-2K-50mg 50mg
EUR 470
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-COOH,3.4K

FL078017-3.4K-50mg 50mg
EUR 470
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-COOH,5K

FL078017-5K-50mg 50mg
EUR 470
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-Mal,10K

FL078022-10K-50mg 50mg
EUR 470
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-Mal,1K

FL078022-1K-50mg 50mg
EUR 470
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-Mal,20K

FL078022-20K-50mg 50mg
EUR 470
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-Mal,2K

FL078022-2K-50mg 50mg
EUR 470
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-Mal,3.4K

FL078022-3.4K-50mg 50mg
EUR 470
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-Mal,5K

FL078022-5K-50mg 50mg
EUR 470
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

CD45RO Antibody (PE-Cy5)

abx134008-100Assays 100 Assays
EUR 495

CD45RO Antibody (PE-Cy5)

abx134008-50Assays 50 Assays
EUR 398

Cy5 azide (non-sulfonated)

A8113-25 25 mg
EUR 1616
Description: Cy5 azide is a labeling reagent ready for the use in Click Chemistry reaction which available as 10 mM solution in DMSO. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction.

Cy5 azide (non-sulfonated)

A8113-5 5 mg
EUR 583
Description: Cy5 azide is a labeling reagent ready for the use in Click Chemistry reaction which available as 10 mM solution in DMSO. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction.

Cy5 alkyne (non-sulfonated)

A8131-25 25 mg
EUR 1616
Description: Cy5 alkyne, with low aqueous solubility is a dye ready for the use in Click Chemistry reaction. Various molecules via Click Chemistry reaction can be attached by this deeply colored, and photostable Cy5 fluorophore.

Cy5 alkyne (non-sulfonated)

A8131-5 5 mg
EUR 583
Description: Cy5 alkyne, with low aqueous solubility is a dye ready for the use in Click Chemistry reaction. Various molecules via Click Chemistry reaction can be attached by this deeply colored, and photostable Cy5 fluorophore.

Cy5 maleimide (non-sulfonated)

A8139-25 25 mg
EUR 525
Description: Cy5 maleimide is a mono-reactive dye for selectively labeling peptides and proteins which couples with thiol groups.

Cy5 maleimide (non-sulfonated)

A8139-5 5 mg
EUR 293
Description: Cy5 maleimide is a mono-reactive dye for selectively labeling peptides and proteins which couples with thiol groups.

Cy5 amine (non-sulfonated)

A8143-25 25 mg
EUR 525
Description: Cy5 amine is a reactive dye which contains amino group. This dye can be coupled with a variety of activated esters and other electrophilic reagents.

Cy5 amine (non-sulfonated)

A8143-5 5 mg
EUR 293
Description: Cy5 amine is a reactive dye which contains amino group. This dye can be coupled with a variety of activated esters and other electrophilic reagents.

Cy5 hydrazide (non-sulfonated)

A8145-25 25 mg
EUR 525
Description: Cy5 hydrazide is a reactive dye which reacts smoothly and nearly quantitatively with various carbonyl groups encountered in biomolecules. The labeling regent is used for the labeling of aldehydes and ketones.

Cy5 hydrazide (non-sulfonated)

A8145-5 5 mg
EUR 293
Description: Cy5 hydrazide is a reactive dye which reacts smoothly and nearly quantitatively with various carbonyl groups encountered in biomolecules. The labeling regent is used for the labeling of aldehydes and ketones.

Cy5 NHS ester(Et)

A8769-25 25 mg
EUR 525

Cy5 NHS ester(Et)

A8769-5 5 mg
EUR 293

Cy5 Bis NHS ester

A8773-25 25 mg
EUR 525

Cy5 Bis NHS ester

A8773-5 5 mg
EUR 293

Cy5 Bis carboxylic acid

A8775-25 25 mg
EUR 525