Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis by the PDGFR/ROCK1 sign pathway
The targets of this research have been to analyze the position of the Notch1/PDGFRβ/ROCK1 signaling pathway within the pathogenesis of pulmonary fibrosis and to discover the opportunity of treating fibrosis by focusing on Notch1. Lung tissues from sufferers with pulmonary fibrosis have been examined for the expression of Notch1/PDGFRβ/ROCK1 utilizing RT-qPCR, western blotting, and immunostaining.
Cultured mouse lung pericytes have been transfected with Notch1-overexpressed vectors or shRNA focusing on PDGFRβ/ROCK1 to look at cell behaviors, together with proliferation, cell cycle arrest, and differentiation towards myofibroblasts.
Lastly, a mouse pulmonary fibrosis mannequin was ready, and a Notch1 inhibitor was administered to watch tissue morphology and pericyte cell behaviors. Human pulmonary fibrotic tissues offered with overexpression of Notch1, PDGFRβ, and ROCK1, along with a outstanding transition of pericytes into myofibroblasts.
In cultured mouse lung pericytes, overexpression of Notch1 led to the accelerated proliferation and differentiation of cells, and it additionally elevated the expression of the PDGFRβ and ROCK1 proteins. The knockdown of PDGFRβ/ROCK1 in pericytes remarkably suppressed pericyte proliferation and differentiation.
As additional substantiation, the administration of a Notch1 inhibitor in a mouse mannequin of lung fibrosis inhibited the PDGFRβ/ROCK1 pathway, suppressed pericyte proliferation and differentiation, and alleviated the severity of fibrosis.

Our outcomes confirmed that the Notch1 signaling pathway was aberrantly activated in pulmonary fibrosis, and this pathway could facilitate illness development by way of mediating pericyte proliferation and differentiation. The inhibition of the Notch1 pathway could present one promising remedy technique for pulmonary fibrosis.
Cy3 Conjugated anti-Rabbit IgG SABC Kit |
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SA1074 | BosterBio | 1 kit | EUR 426 |
Cy7®-streptavidin conjugate |
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16914 | AAT Bioquest | 1 mg | EUR 166 |
Anti-Human CD33 Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated |
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FC01508-PE-Cy7 | BosterBio | 25 Tests, 100 Tests, 200 Tests | EUR 234 |
Description: Mouse Monoclonal Human CD33 Antibody PE-Cy7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
Anti-Human CD3 Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated |
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FC02675-PE-Cy7 | BosterBio | 25 Tests, 100 Tests, 200 Tests | EUR 192 |
Description: Mouse Monoclonal Human CD3 Antibody PE-Cy7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
Anti-human CD10 Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated |
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FC04065-PE-Cy7 | BosterBio | 25 Tests, 100 Tests, 200 Tests | EUR 199.2 |
Description: Mouse Monoclonal human CD10 Antibody PE-Cy7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
Goat anti-Human IgG(H+L) ,Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1031-100 | EnoGene | 100μl | EUR 286.8 |
Goat anti-Human IgG(H+L) ,Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1031-1000 | EnoGene | 1000μl | EUR 520.8 |
Goat anti-Human IgG(H+L) ,Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1031-500 | EnoGene | 500μl | EUR 411.6 |
Anti-Human CD62L Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated |
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FC00652-PE-Cy7 | BosterBio | 25tests, 100tests, 200tests | EUR 225.6 |
Description: Mouse Monoclonal Human CD62L Antibody PE-Cy7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH2011-100 | EnoGene | 100μl | EUR 286.8 |
Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH2011-1000 | EnoGene | 1000μl | EUR 520.8 |
Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH2011-500 | EnoGene | 500μl | EUR 411.6 |
Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1021-100 | EnoGene | 100μl | EUR 286.8 |
Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1021-1000 | EnoGene | 1000μl | EUR 520.8 |
Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1021-500 | EnoGene | 500μl | EUR 411.6 |
GFP (HRP conjugated) |
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E8ET1702-69 | EnoGene | 100ul | EUR 275 |
Description: Available in various conjugation types. |
Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1022-100 | EnoGene | 100μl | EUR 286.8 |
Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1022-1000 | EnoGene | 1000μl | EUR 520.8 |
Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1022-500 | EnoGene | 500μl | EUR 411.6 |
Goat Anti-Human IgG Secondary Antibody Cy3 Conjugated |
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L30211 | SAB | 1.0 ml | EUR 134.4 |
Goat Anti-Mouse IgG Secondary Antibody Cy3 Conjugated |
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L30311 | SAB | 1.0 ml | EUR 134.4 |
Goat Anti-Rabbit IgG Secondary Antibody Cy3 Conjugated |
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L30111 | SAB | 1.0 ml | EUR 134.4 |
Anti-Human HLA-DR Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated |
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FC01340-PE-Cy7 | BosterBio | 25tests, 100tests, 200tests | EUR 225.6 |
Description: Anti-Human HLA-DR Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated |
GAPDH (HRP conjugated) |
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E8ET1702-66 | EnoGene | 100ul | EUR 275 |
Description: Available in various conjugation types. |
GAPDH (HRP Conjugated) |
|||
E11-12057 | EnoGene | 100ul | EUR 255 |
Description: Available in various conjugation types. |
HRP Conjugated Avidin |
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BA1081-0.5 | BosterBio | 0.5ml | EUR 175.2 |
HRP Conjugated Avidin |
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BA1081-1 | BosterBio | 1ml | EUR 279.6 |
OVA Conjugated Amylin |
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RPU50817-100ug | Biomatik Corporation | 100ug | EUR 431.2 |
OVA Conjugated Amylin |
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RPU50817-1mg | Biomatik Corporation | 1mg | EUR 1911 |
OVA Conjugated Amylin |
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RPU50817-50ug | Biomatik Corporation | 50ug | EUR 336 |
BSA Conjugated Amylin |
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RPU50156-100ug | Biomatik Corporation | 100ug | EUR 475.2 |
BSA Conjugated Amylin |
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RPU50156-1mg | Biomatik Corporation | 1mg | EUR 1872 |
BSA Conjugated Amylin |
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RPU50156-50ug | Biomatik Corporation | 50ug | EUR 288 |
OVA Conjugated Amylin |
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RPU50157-100ug | Biomatik Corporation | 100ug | EUR 475.2 |
OVA Conjugated Amylin |
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RPU50157-1mg | Biomatik Corporation | 1mg | EUR 1872 |
OVA Conjugated Amylin |
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RPU50157-50ug | Biomatik Corporation | 50ug | EUR 288 |
BSA Conjugated Amylin |
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RPU50158-100ug | Biomatik Corporation | 100ug | EUR 475.2 |
BSA Conjugated Amylin |
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RPU50158-1mg | Biomatik Corporation | 1mg | EUR 1872 |
BSA Conjugated Amylin |
|||
RPU50158-50ug | Biomatik Corporation | 50ug | EUR 288 |
OVA Conjugated Amylin |
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RPU50159-100ug | Biomatik Corporation | 100ug | EUR 475.2 |
OVA Conjugated Amylin |
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RPU50159-1mg | Biomatik Corporation | 1mg | EUR 1872 |
OVA Conjugated Amylin |
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RPU50159-50ug | Biomatik Corporation | 50ug | EUR 288 |
BSA Conjugated Amylin |
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RPU50160-100ug | Biomatik Corporation | 100ug | EUR 475.2 |
BSA Conjugated Amylin |
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RPU50160-1mg | Biomatik Corporation | 1mg | EUR 1872 |
BSA Conjugated Amylin |
|||
RPU50160-50ug | Biomatik Corporation | 50ug | EUR 288 |
OVA Conjugated Amylin |
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RPU50161-100ug | Biomatik Corporation | 100ug | EUR 475.2 |
OVA Conjugated Amylin |
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RPU50161-1mg | Biomatik Corporation | 1mg | EUR 1872 |
OVA Conjugated Amylin |
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RPU50161-50ug | Biomatik Corporation | 50ug | EUR 288 |
KLH Conjugated Amylin |
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RPU50224-100ug | Biomatik Corporation | 100ug | EUR 522.5 |
KLH Conjugated Amylin |
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RPU50224-1mg | Biomatik Corporation | 1mg | EUR 2059.2 |
KLH Conjugated Amylin |
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RPU50224-50ug | Biomatik Corporation | 50ug | EUR 316.8 |
CS Conjugated Antibody |
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C43035 | SAB | 100ul | EUR 476.4 |
KL Conjugated Antibody |
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C43404 | SAB | 100ul | EUR 476.4 |
XK Conjugated Antibody |
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C43438 | SAB | 100ul | EUR 476.4 |
Rb Conjugated Antibody |
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C48804 | SAB | 100ul | EUR 476.4 |
C3 Conjugated Antibody |
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C49413 | SAB | 100ul | EUR 476.4 |
C4 Conjugated Antibody |
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C49604 | SAB | 100ul | EUR 476.4 |
F8 Conjugated Antibody |
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C38232 | SAB | 100ul | EUR 476.4 |
F3 Conjugated Antibody |
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C38235 | SAB | 100ul | EUR 476.4 |
GC Conjugated Antibody |
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C38683 | SAB | 100ul | EUR 476.4 |
F2 Conjugated Antibody |
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C40244 | SAB | 100ul | EUR 476.4 |
TG Conjugated Antibody |
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C40380 | SAB | 100ul | EUR 476.4 |
F5 Conjugated Antibody |
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C45256 | SAB | 100ul | EUR 476.4 |
Ob Conjugated Antibody |
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C45370 | SAB | 100ul | EUR 476.4 |
ST Conjugated Antibody |
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C45395 | SAB | 100ul | EUR 476.4 |
CP Conjugated Antibody |
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C45875 | SAB | 100ul | EUR 476.4 |
C7 Conjugated Antibody |
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C46376 | SAB | 100ul | EUR 476.4 |
GK Conjugated Antibody |
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C36507 | SAB | 100ul | EUR 476.4 |
TF Conjugated Antibody |
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C36753 | SAB | 100ul | EUR 476.4 |
TH Conjugated Antibody |
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C37059 | SAB | 100ul | EUR 476.4 |
FC Conjugated Antibody |
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C48379 | SAB | 100ul | EUR 476.4 |
T Conjugated Antibody |
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C48451 | SAB | 100ul | EUR 476.4 |
CP Conjugated Antibody |
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C46543 | SAB | 100ul | EUR 476.4 |
OR Conjugated Antibody |
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C44609 | SAB | 100ul | EUR 476.4 |
FITC Conjugated Avidin |
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BA1125-0.5 | BosterBio | 0.5ml | EUR 224.4 |
FITC Conjugated Avidin |
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BA1125-1 | BosterBio | 1ml | EUR 400.8 |
PC Conjugated Antibody |
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C31111 | SAB | 100ul | EUR 476.4 |
F3 Conjugated Antibody |
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C31131 | SAB | 100ul | EUR 476.4 |
PDGFR-induced autocrine SDF-1 signaling in most cancers cells promotes metastasis in superior pores and skin carcinoma.
Superior and undifferentiated pores and skin squamous cell carcinomas (SCCs) exhibit aggressive development and enhanced metastasis functionality, which is related in mice with an growth of the most cancers stem-like cell (CSC) inhabitants and with adjustments within the regulatory mechanisms that management the proliferation and invasion of those cells. Certainly, autocrine activation of PDGFRα induces CSC invasion and promotes distant metastasis in superior SCCs. Nevertheless, the mechanisms concerned on this course of have been unclear.
Right here, we present that CSCs of mouse superior SCCs (L-CSCs) specific CXCR4 and CXCR7, each receptors of SDF-1. PDGFRα signaling induces SDF-1 expression and secretion, and the autocrine activation of this pathway in L-CSCs.
Autocrine SDF-1/CXCR4 signaling induces L-CSC proliferation and survival, and mediates PDGFRα-induced invasion, selling in vivo lung metastasis. Validation of those findings in affected person samples of pores and skin SCCs exhibits a powerful correlation between the expression of SDF1, PDGFRA, and PDGFRB, which is upregulated, alongside CXCR4 in tumor cells of superior SCCs.
Moreover, PDGFR regulates SDF-1 expression and inhibition of SDF-1/CXCR4 and PDGFR pathways blocks distant metastasis of human PD/S-SCCs. Our outcomes point out that purposeful crosstalk between PDGFR/SDF-1 signaling regulates tumor cell invasion and metastasis in human and mouse superior SCCs, and recommend that CXCR4 and/or PDGFR inhibitors might be used to dam metastasis of those aggressive tumors.
Corrigendum Antiproliferative results of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell strains by way of PDGFR‑β, PDGF‑BB, c‑Package and SCF expression.
- An reader drew to our consideration that the above research appeared to comprise a excessive stage of overlap with an article by the identical authors revealed within the journal Drug Design, Improvement and Remedy [Kadivar A, Kamalidehghan B, Akbari Javar H, Karimi B, Sedghi R and Noordin MI: Antiproliferation effect of imatinib mesylate on MCF7, T‑47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF genes. Drug Des Devel Ther 11: 469‑481, 2017].
- Following an inside investigation and likewise in liaison with the authors, it was established that, though the research have been performed alongside broadly comparable strains, the papers contained fully totally different knowledge involving two totally different subsets of cell strains; the submission to Drug Des Devel Ther aimed to discover the results of imatinib mesylate on three totally different teams, with every group being represented by a cell line, whereas the submission to Int J Mol Med explored the effectiveness of imatinib mesylate in breast most cancers cell strains.
- Regardless of this, contemplating the relatedness of the articles and the truth that the paper to Drug Des Devel Ther was submitted first and revealed whereas the Int J Mol Med paper was passing by the peer‑evaluation course of, the authors concede that they need to have correctly referenced their paper submitted to Drug Des Devel Ther within the Int J Mol Med paper.
- Notice that the publishers of Drug Des Devel Ther, with whom we have been liaising, agreed with the choice to concern a Corrigendum for this paper that acknowledges the article revealed in Drug Des Devel Ther.
- The authors remorse their failure to acknowledge the associated paper on this occasion, and apologize to the readership for this oversight. [the original article was published in International Journal of Molecular Medicine 14: 414‑424, 2018; DOI: 10.3892/ijmm.2018.3590].
Mouse anti-Human CD4, PE-Cy5 Conjugated mAb. |
|||
E16HC004-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD4, PE-Cy5 Conjugated mAb. |
|||
E16HC004-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse anti-Human CD4, PE-Cy5 Conjugated mAb. |
|||
E16HC0041-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD4, PE-Cy5 Conjugated mAb. |
|||
E16HC0041-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse anti-Human CD8, PE-Cy5 Conjugated mAb. |
|||
E16HC008-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD8, PE-Cy5 Conjugated mAb. |
|||
E16HC008-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse anti-Human CD14, PE-Cy5 Conjugated mAb |
|||
28053-50Tests | SAB | 50 Tests | EUR 302.4 |
Mouse anti-Human CD19, PE-Cy5 Conjugated mAb |
|||
28074-50Tests | SAB | 50 Tests | EUR 302.4 |
Mouse anti-Human CD45, PE-Cy5 Conjugated mAb |
|||
28144-50Tests | SAB | 50 Tests | EUR 303.6 |
Mouse anti-Human CD14, PE-Cy5 Conjugated mAb. |
|||
E16HC0142-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD14, PE-Cy5 Conjugated mAb. |
|||
E16HC0142-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse anti-Human CD19, PE-Cy5 Conjugated mAb. |
|||
E16HC019-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD19, PE-Cy5 Conjugated mAb. |
|||
E16HC019-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse anti-Human CD20, PE-Cy5 Conjugated mAb. |
|||
E16HC020-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD20, PE-Cy5 Conjugated mAb. |
|||
E16HC020-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse anti-Human CD25, PE-Cy5 Conjugated mAb. |
|||
E16HC0251-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD25, PE-Cy5 Conjugated mAb. |
|||
E16HC0251-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse anti-Human CD34, PE-Cy5 Conjugated mAb. |
|||
E16HC0341-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD34, PE-Cy5 Conjugated mAb. |
|||
E16HC0341-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse anti-Human CD38, PE-Cy5 Conjugated mAb. |
|||
E16HC0381-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD38, PE-Cy5 Conjugated mAb. |
|||
E16HC0381-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse anti-Human CD40, PE-Cy5 Conjugated mAb. |
|||
E16HC040-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD40, PE-Cy5 Conjugated mAb. |
|||
E16HC040-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse anti-Human CD41, PE-Cy5 Conjugated mAb. |
|||
E16HC0411-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD41, PE-Cy5 Conjugated mAb. |
|||
E16HC0411-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse anti-Human CD45, PE-Cy5 Conjugated mAb. |
|||
E16HC045-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD45, PE-Cy5 Conjugated mAb. |
|||
E16HC045-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse IgM Isotype Control, PE-Cy5 Conjugated mAb |
|||
E16MCC004-050 | EnoGene | 50Tests | EUR 145 |
Description: Available in various conjugation types. |
Mouse IgM Isotype Control, PE-Cy5 Conjugated mAb |
|||
E16MCC004-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse IgG1 Isotype Control, PE-Cy5 Conjugated mAb |
|||
E16MCC001-050 | EnoGene | 50Tests | EUR 145 |
Description: Available in various conjugation types. |
Mouse IgG1 Isotype Control, PE-Cy5 Conjugated mAb |
|||
E16MCC001-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse anti-Human CD45RO, PE-Cy5 Conjugated mAb. |
|||
E16HC0456-050 | EnoGene | 50Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse anti-Human CD45RO, PE-Cy5 Conjugated mAb. |
|||
E16HC0456-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse IgG2a Isotype Control, PE-Cy5 Conjugated mAb |
|||
E16MCC002-050 | EnoGene | 50Tests | EUR 145 |
Description: Available in various conjugation types. |
Mouse IgG2a Isotype Control, PE-Cy5 Conjugated mAb |
|||
E16MCC002-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Mouse IgG2b Isotype Control, PE-Cy5 Conjugated mAb |
|||
E16MCC003-050 | EnoGene | 50Tests | EUR 145 |
Description: Available in various conjugation types. |
Mouse IgG2b Isotype Control, PE-Cy5 Conjugated mAb |
|||
E16MCC003-100 | EnoGene | 100Tests | EUR 255 |
Description: Available in various conjugation types. |
Cy3 Conjugated Avidin |
|||
BA1037 | BosterBio | 0.5ml | EUR 194.4 |
Cy5®-streptavidin conjugate |
|||
16913 | AAT Bioquest | 1 mg | EUR 166 |
PE-Cy5 (Phycoerhthrin-Cy5 Conjugate) |
|||
7850-250 | Biovision | each | EUR 444 |
Mouse anti-Human CD4/CD8/CD3, FITC/PE/PE-Cy5 Conjugated mAb |
|||
28249-20Tests | SAB | 20 Tests | EUR 302.4 |
Mouse anti-Human CD4/CD8/CD3, FITC/PE/PE-Cy5 Conjugated mAb |
|||
E16HT001-020 | EnoGene | 50Tests | EUR 145 |
Description: Available in various conjugation types. |
Mouse anti-Human CD4/CD8/CD3, FITC/PE/PE-Cy5 Conjugated mAb |
|||
E16HT001-050 | EnoGene | 100Tests | EUR 225 |
Description: Available in various conjugation types. |
Mouse Anti-Human CD3/CD19/CD45, FITC/PE/PE-Cy5 Conjugated mAb |
|||
28252-20Tests | SAB | 20 Tests | EUR 302.4 |
Cy3 Conjugated anti-Rat IgG SABC Kit |
|||
SA1079 | BosterBio | 1 kit | EUR 426 |
Cy3 Conjugated anti-Goat IgG SABC Kit |
|||
SA1076 | BosterBio | 1 kit | EUR 426 |
Cy3 Conjugated anti-Mouse IgG SABC Kit |
|||
SA1072 | BosterBio | 1 kit | EUR 426 |
Cy3 Conjugated anti-Mouse IgM SABC Kit |
|||
SA1073 | BosterBio | 1 kit | EUR 450 |
Cy3 Conjugated anti-Human IgG SABC Kit |
|||
SA1078 | BosterBio | 1 kit | EUR 426 |
Cy3 Conjugated anti-Rabbit IgG SABC Kit |
|||
SA1074 | BosterBio | 1 kit | EUR 426 |
Annexin V-Cy5 conjugate |
|||
20066 | AAT Bioquest | 100 Tests | EUR 222 |
Annexin V-Cy5 conjugate |
|||
20066-100Tests | AAT Bioquest | 100 Tests | EUR 222 |
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium. |
Goat anti-Human IgG(H+L) ,Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
|||
E16SPH1031-100 | EnoGene | 100μl | EUR 286.8 |
Goat anti-Human IgG(H+L) ,Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
|||
E16SPH1031-1000 | EnoGene | 1000μl | EUR 520.8 |
Goat anti-Human IgG(H+L) ,Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
|||
E16SPH1031-500 | EnoGene | 500μl | EUR 411.6 |
Streptavidin: RPE-Cy5 Conjugate |
|||
R-1099 | EpiGentek | 0.2 ml | Ask for price |
RatioWorks™ Cal-590L®/Cy5-Dextran Conjugate *MW 10,000* |
|||
20527-1mg | AAT Bioquest | 1 mg | EUR 505 |
Description: Calcium measurement is critical for numerous biological investigations. |
RatioWorks™ Cal-520L®/Cy5-Dextran Conjugate *MW 10,000* |
|||
20603-1mg | AAT Bioquest | 1 mg | EUR 558 |
Description: Calcium measurement is critical for numerous biological investigations. |
2',3'-cGAMP-Cy5 conjugate |
|||
20318 | AAT Bioquest | 100 ug | EUR 989 |
2',3'-cGAMP-Cy5 conjugate |
|||
20318-100ug | AAT Bioquest | 100 ug | EUR 989 |
Description: 2',3'-cGAMP or cGAMP (Cyclic guanosine monophosphate"adenosine monophosphate) is produced in mammalian cells by cGAS (cGAMP synthase) from ATP and GTP upon cytosolic DNA stimulation. |
RPE-Cy5-streptavidin conjugate |
|||
16918 | AAT Bioquest | 100 ug | EUR 99 |
RPE-Cy5-streptavidin conjugate |
|||
16919 | AAT Bioquest | 1 mg | EUR 308 |
RPE-Cy5-streptavidin conjugate |
|||
16918-100ug | AAT Bioquest | 100 ug | EUR 99 |
Description: Streptavidin conjugates are widely used together with a biotin conjugate for specific detection of a variety of biological molecules since streptavidin has a very high binding affinity for biotin and its conjugates. |
RPE-Cy5-streptavidin conjugate |
|||
16919-1mg | AAT Bioquest | 1 mg | EUR 308 |
Description: Streptavidin conjugates are widely used together with a biotin conjugate for specific detection of a variety of biological molecules since streptavidin has a very high binding affinity for biotin and its conjugates. |
RatioWorks™ Cal-520L®/Cy5-Dextran Conjugate *MW 10,000* |
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20603 | AAT Bioquest | 1 mg | EUR 558 |
Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH2011-100 | EnoGene | 100μl | EUR 286.8 |
Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH2011-1000 | EnoGene | 1000μl | EUR 520.8 |
Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH2011-500 | EnoGene | 500μl | EUR 411.6 |
Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1021-100 | EnoGene | 100μl | EUR 286.8 |
Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1021-1000 | EnoGene | 1000μl | EUR 520.8 |
Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1021-500 | EnoGene | 500μl | EUR 411.6 |
GFP (HRP conjugated) |
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E8ET1702-69 | EnoGene | 100ul | EUR 275 |
Description: Available in various conjugation types. |
Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1022-100 | EnoGene | 100μl | EUR 286.8 |
Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1022-1000 | EnoGene | 1000μl | EUR 520.8 |
Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated |
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E16SPH1022-500 | EnoGene | 500μl | EUR 411.6 |
Goat Anti-Human IgG Secondary Antibody Cy3 Conjugated |
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L30211 | SAB | 1.0 ml | EUR 134.4 |
Goat Anti-Mouse IgG Secondary Antibody Cy3 Conjugated |
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L30311 | SAB | 1.0 ml | EUR 134.4 |
Goat Anti-Rabbit IgG Secondary Antibody Cy3 Conjugated |
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L30111 | SAB | 1.0 ml | EUR 134.4 |
GAPDH (HRP conjugated) |
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E8ET1702-66 | EnoGene | 100ul | EUR 275 |
Description: Available in various conjugation types. |
GAPDH (HRP Conjugated) |
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E11-12057 | EnoGene | 100ul | EUR 255 |
Description: Available in various conjugation types. |
HRP Conjugated Avidin |
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BA1081-0.5 | BosterBio | 0.5ml | EUR 175.2 |
HRP Conjugated Avidin |
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BA1081-1 | BosterBio | 1ml | EUR 279.6 |
OVA Conjugated Amylin |
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RPU50817-100ug | Biomatik Corporation | 100ug | EUR 431.2 |