Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis by the PDGFR/ROCK1 sign pathway

The targets of this research have been to analyze the position of the Notch1/PDGFRβ/ROCK1 signaling pathway within the pathogenesis of pulmonary fibrosis and to discover the opportunity of treating fibrosis by focusing on Notch1. Lung tissues from sufferers with pulmonary fibrosis have been examined for the expression of Notch1/PDGFRβ/ROCK1 utilizing RT-qPCR, western blotting, and immunostaining.
Cultured mouse lung pericytes have been transfected with Notch1-overexpressed vectors or shRNA focusing on PDGFRβ/ROCK1 to look at cell behaviors, together with proliferation, cell cycle arrest, and differentiation towards myofibroblasts.
Lastly, a mouse pulmonary fibrosis mannequin was ready, and a Notch1 inhibitor was administered to watch tissue morphology and pericyte cell behaviors. Human pulmonary fibrotic tissues offered with overexpression of Notch1, PDGFRβ, and ROCK1, along with a outstanding transition of pericytes into myofibroblasts.
In cultured mouse lung pericytes, overexpression of Notch1 led to the accelerated proliferation and differentiation of cells, and it additionally elevated the expression of the PDGFRβ and ROCK1 proteins. The knockdown of PDGFRβ/ROCK1 in pericytes remarkably suppressed pericyte proliferation and differentiation.
As additional substantiation, the administration of a Notch1 inhibitor in a mouse mannequin of lung fibrosis inhibited the PDGFRβ/ROCK1 pathway, suppressed pericyte proliferation and differentiation, and alleviated the severity of fibrosis.
vegf-a
vegf-a
Our outcomes confirmed that the Notch1 signaling pathway was aberrantly activated in pulmonary fibrosis, and this pathway could facilitate illness development by way of mediating pericyte proliferation and differentiation. The inhibition of the Notch1 pathway could present one promising remedy technique for pulmonary fibrosis.

 

Cy3 Conjugated anti-Rabbit IgG SABC Kit
SA1074 1 kit
EUR 426

Cy7®-streptavidin conjugate
16914 1 mg
EUR 166

Anti-Human CD33 Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated
FC01508-PE-Cy7 25 Tests, 100 Tests, 200 Tests
EUR 234
Description: Mouse Monoclonal Human CD33 Antibody PE-Cy7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-Human CD3 Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated
FC02675-PE-Cy7 25 Tests, 100 Tests, 200 Tests
EUR 192
Description: Mouse Monoclonal Human CD3 Antibody PE-Cy7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD10 Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated
FC04065-PE-Cy7 25 Tests, 100 Tests, 200 Tests
EUR 199.2
Description: Mouse Monoclonal human CD10 Antibody PE-Cy7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Goat anti-Human IgG(H+L) ，Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1031-100 100μl
EUR 286.8

Goat anti-Human IgG(H+L) ，Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1031-1000 1000μl
EUR 520.8

Goat anti-Human IgG(H+L) ，Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1031-500 500μl
EUR 411.6

Anti-Human CD62L Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated
FC00652-PE-Cy7 25tests, 100tests, 200tests
EUR 225.6
Description: Mouse Monoclonal Human CD62L Antibody PE-Cy7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH2011-100 100μl
EUR 286.8

Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH2011-1000 1000μl
EUR 520.8

Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH2011-500 500μl
EUR 411.6

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1021-100 100μl
EUR 286.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1021-1000 1000μl
EUR 520.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1021-500 500μl
EUR 411.6

GFP (HRP conjugated)
E8ET1702-69 100ul
EUR 275
Description: Available in various conjugation types.

Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1022-100 100μl
EUR 286.8

Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1022-1000 1000μl
EUR 520.8

Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1022-500 500μl
EUR 411.6

Goat Anti-Human IgG Secondary Antibody Cy3 Conjugated
L30211 1.0 ml
EUR 134.4

Goat Anti-Mouse IgG Secondary Antibody Cy3 Conjugated
L30311 1.0 ml
EUR 134.4

Goat Anti-Rabbit IgG Secondary Antibody Cy3 Conjugated
L30111 1.0 ml
EUR 134.4

Anti-Human HLA-DR Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated
FC01340-PE-Cy7 25tests, 100tests, 200tests
EUR 225.6
Description: Anti-Human HLA-DR Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated

GAPDH (HRP conjugated)
E8ET1702-66 100ul
EUR 275
Description: Available in various conjugation types.

GAPDH (HRP Conjugated)
E11-12057 100ul
EUR 255
Description: Available in various conjugation types.

HRP Conjugated Avidin
BA1081-0.5 0.5ml
EUR 175.2

HRP Conjugated Avidin
BA1081-1 1ml
EUR 279.6

OVA Conjugated Amylin
RPU50817-100ug 100ug
EUR 431.2

OVA Conjugated Amylin
RPU50817-1mg 1mg
EUR 1911

OVA Conjugated Amylin
RPU50817-50ug 50ug
EUR 336

BSA Conjugated Amylin
RPU50156-100ug 100ug
EUR 475.2

BSA Conjugated Amylin
RPU50156-1mg 1mg
EUR 1872

BSA Conjugated Amylin
RPU50156-50ug 50ug
EUR 288

OVA Conjugated Amylin
RPU50157-100ug 100ug
EUR 475.2

OVA Conjugated Amylin
RPU50157-1mg 1mg
EUR 1872

OVA Conjugated Amylin
RPU50157-50ug 50ug
EUR 288

BSA Conjugated Amylin
RPU50158-100ug 100ug
EUR 475.2

BSA Conjugated Amylin
RPU50158-1mg 1mg
EUR 1872

BSA Conjugated Amylin
RPU50158-50ug 50ug
EUR 288

OVA Conjugated Amylin
RPU50159-100ug 100ug
EUR 475.2

OVA Conjugated Amylin
RPU50159-1mg 1mg
EUR 1872

OVA Conjugated Amylin
RPU50159-50ug 50ug
EUR 288

BSA Conjugated Amylin
RPU50160-100ug 100ug
EUR 475.2

BSA Conjugated Amylin
RPU50160-1mg 1mg
EUR 1872

BSA Conjugated Amylin
RPU50160-50ug 50ug
EUR 288

OVA Conjugated Amylin
RPU50161-100ug 100ug
EUR 475.2

OVA Conjugated Amylin
RPU50161-1mg 1mg
EUR 1872

OVA Conjugated Amylin
RPU50161-50ug 50ug
EUR 288

KLH Conjugated Amylin
RPU50224-100ug 100ug
EUR 522.5

KLH Conjugated Amylin
RPU50224-1mg 1mg
EUR 2059.2

KLH Conjugated Amylin
RPU50224-50ug 50ug
EUR 316.8

CS Conjugated Antibody
C43035 100ul
EUR 476.4

KL Conjugated Antibody
C43404 100ul
EUR 476.4

XK Conjugated Antibody
C43438 100ul
EUR 476.4

Rb Conjugated Antibody
C48804 100ul
EUR 476.4

C3 Conjugated Antibody
C49413 100ul
EUR 476.4

C4 Conjugated Antibody
C49604 100ul
EUR 476.4

F8 Conjugated Antibody
C38232 100ul
EUR 476.4

F3 Conjugated Antibody
C38235 100ul
EUR 476.4

GC Conjugated Antibody
C38683 100ul
EUR 476.4

F2 Conjugated Antibody
C40244 100ul
EUR 476.4

TG Conjugated Antibody
C40380 100ul
EUR 476.4

F5 Conjugated Antibody
C45256 100ul
EUR 476.4

Ob Conjugated Antibody
C45370 100ul
EUR 476.4

ST Conjugated Antibody
C45395 100ul
EUR 476.4

CP Conjugated Antibody
C45875 100ul
EUR 476.4

C7 Conjugated Antibody
C46376 100ul
EUR 476.4

GK Conjugated Antibody
C36507 100ul
EUR 476.4

TF Conjugated Antibody
C36753 100ul
EUR 476.4

TH Conjugated Antibody
C37059 100ul
EUR 476.4

FC Conjugated Antibody
C48379 100ul
EUR 476.4

T Conjugated Antibody
C48451 100ul
EUR 476.4

CP Conjugated Antibody
C46543 100ul
EUR 476.4

OR Conjugated Antibody
C44609 100ul
EUR 476.4

FITC Conjugated Avidin
BA1125-0.5 0.5ml
EUR 224.4

FITC Conjugated Avidin
BA1125-1 1ml
EUR 400.8

PC Conjugated Antibody
C31111 100ul
EUR 476.4

F3 Conjugated Antibody
C31131 100ul
EUR 476.4

PDGFR-induced autocrine SDF-1 signaling in most cancers cells promotes metastasis in superior pores and skin carcinoma.

 

 

Superior and undifferentiated pores and skin squamous cell carcinomas (SCCs) exhibit aggressive development and enhanced metastasis functionality, which is related in mice with an growth of the most cancers stem-like cell (CSC) inhabitants and with adjustments within the regulatory mechanisms that management the proliferation and invasion of those cells. Certainly, autocrine activation of PDGFRα induces CSC invasion and promotes distant metastasis in superior SCCs. Nevertheless, the mechanisms concerned on this course of have been unclear.
Right here, we present that CSCs of mouse superior SCCs (L-CSCs) specific CXCR4 and CXCR7, each receptors of SDF-1. PDGFRα signaling induces SDF-1 expression and secretion, and the autocrine activation of this pathway in L-CSCs.
Autocrine SDF-1/CXCR4 signaling induces L-CSC proliferation and survival, and mediates PDGFRα-induced invasion, selling in vivo lung metastasis. Validation of those findings in affected person samples of pores and skin SCCs exhibits a powerful correlation between the expression of SDF1, PDGFRA, and PDGFRB, which is upregulated, alongside CXCR4 in tumor cells of superior SCCs.
Moreover, PDGFR regulates SDF-1 expression and inhibition of SDF-1/CXCR4 and PDGFR pathways blocks distant metastasis of human PD/S-SCCs. Our outcomes point out that purposeful crosstalk between PDGFR/SDF-1 signaling regulates tumor cell invasion and metastasis in human and mouse superior SCCs, and recommend that CXCR4 and/or PDGFR inhibitors might be used to dam metastasis of those aggressive tumors.

Corrigendum Antiproliferative results of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell strains by way of PDGFR‑β, PDGF‑BB, c‑Package and SCF expression.

 

  • An reader drew to our consideration that the above research appeared to comprise a excessive stage of overlap with an article by the identical authors revealed within the journal Drug Design, Improvement and Remedy [Kadivar A, Kamalidehghan B, Akbari Javar H, Karimi B, Sedghi R and Noordin MI: Antiproliferation effect of imatinib mesylate on MCF7, T‑47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF genes. Drug Des Devel Ther 11: 469‑481, 2017].
  • Following an inside investigation and likewise in liaison with the authors, it was established that, though the research have been performed alongside broadly comparable strains, the papers contained fully totally different knowledge involving two totally different subsets of cell strains; the submission to Drug Des Devel Ther aimed to discover the results of imatinib mesylate on three totally different teams, with every group being represented by a cell line, whereas the submission to Int J Mol Med explored the effectiveness of imatinib mesylate in breast most cancers cell strains.
  • Regardless of this, contemplating the relatedness of the articles and the truth that the paper to Drug Des Devel Ther was submitted first and revealed whereas the Int J Mol Med paper was passing by the peer‑evaluation course of, the authors concede that they need to have correctly referenced their paper submitted to Drug Des Devel Ther within the Int J Mol Med paper.
  • Notice that the publishers of Drug Des Devel Ther, with whom we have been liaising, agreed with the choice to concern a Corrigendum for this paper that acknowledges the article revealed in Drug Des Devel Ther.
  • The authors remorse their failure to acknowledge the associated paper on this occasion, and apologize to the readership for this oversight. [the original article was published in International Journal of Molecular Medicine 14: 414‑424, 2018; DOI: 10.3892/ijmm.2018.3590].

 

Mouse anti-Human CD4, PE-Cy5 Conjugated mAb.
E16HC004-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD4, PE-Cy5 Conjugated mAb.
E16HC004-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD4, PE-Cy5 Conjugated mAb.
E16HC0041-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD4, PE-Cy5 Conjugated mAb.
E16HC0041-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD8, PE-Cy5 Conjugated mAb.
E16HC008-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD8, PE-Cy5 Conjugated mAb.
E16HC008-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD14, PE-Cy5 Conjugated mAb
28053-50Tests 50 Tests
EUR 302.4

Mouse anti-Human CD19, PE-Cy5 Conjugated mAb
28074-50Tests 50 Tests
EUR 302.4

Mouse anti-Human CD45, PE-Cy5 Conjugated mAb
28144-50Tests 50 Tests
EUR 303.6

Mouse anti-Human CD14, PE-Cy5 Conjugated mAb.
E16HC0142-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD14, PE-Cy5 Conjugated mAb.
E16HC0142-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD19, PE-Cy5 Conjugated mAb.
E16HC019-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD19, PE-Cy5 Conjugated mAb.
E16HC019-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD20, PE-Cy5 Conjugated mAb.
E16HC020-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD20, PE-Cy5 Conjugated mAb.
E16HC020-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD25, PE-Cy5 Conjugated mAb.
E16HC0251-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD25, PE-Cy5 Conjugated mAb.
E16HC0251-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD34, PE-Cy5 Conjugated mAb.
E16HC0341-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD34, PE-Cy5 Conjugated mAb.
E16HC0341-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD38, PE-Cy5 Conjugated mAb.
E16HC0381-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD38, PE-Cy5 Conjugated mAb.
E16HC0381-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD40, PE-Cy5 Conjugated mAb.
E16HC040-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD40, PE-Cy5 Conjugated mAb.
E16HC040-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD41, PE-Cy5 Conjugated mAb.
E16HC0411-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD41, PE-Cy5 Conjugated mAb.
E16HC0411-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD45, PE-Cy5 Conjugated mAb.
E16HC045-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD45, PE-Cy5 Conjugated mAb.
E16HC045-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse IgM Isotype Control, PE-Cy5 Conjugated mAb
E16MCC004-050 50Tests
EUR 145
Description: Available in various conjugation types.

Mouse IgM Isotype Control, PE-Cy5 Conjugated mAb
E16MCC004-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control, PE-Cy5 Conjugated mAb
E16MCC001-050 50Tests
EUR 145
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control, PE-Cy5 Conjugated mAb
E16MCC001-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse anti-Human CD45RO, PE-Cy5 Conjugated mAb.
E16HC0456-050 50Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD45RO, PE-Cy5 Conjugated mAb.
E16HC0456-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse IgG2a Isotype Control, PE-Cy5 Conjugated mAb
E16MCC002-050 50Tests
EUR 145
Description: Available in various conjugation types.

Mouse IgG2a Isotype Control, PE-Cy5 Conjugated mAb
E16MCC002-100 100Tests
EUR 255
Description: Available in various conjugation types.

Mouse IgG2b Isotype Control, PE-Cy5 Conjugated mAb
E16MCC003-050 50Tests
EUR 145
Description: Available in various conjugation types.

Mouse IgG2b Isotype Control, PE-Cy5 Conjugated mAb
E16MCC003-100 100Tests
EUR 255
Description: Available in various conjugation types.

Cy3 Conjugated Avidin
BA1037 0.5ml
EUR 194.4

Cy5®-streptavidin conjugate
16913 1 mg
EUR 166

PE-Cy5 (Phycoerhthrin-Cy5 Conjugate)
7850-250 each
EUR 444

Mouse anti-Human CD4/CD8/CD3, FITC/PE/PE-Cy5 Conjugated mAb
28249-20Tests 20 Tests
EUR 302.4

Mouse anti-Human CD4/CD8/CD3, FITC/PE/PE-Cy5 Conjugated mAb
E16HT001-020 50Tests
EUR 145
Description: Available in various conjugation types.

Mouse anti-Human CD4/CD8/CD3, FITC/PE/PE-Cy5 Conjugated mAb
E16HT001-050 100Tests
EUR 225
Description: Available in various conjugation types.

Mouse Anti-Human CD3/CD19/CD45, FITC/PE/PE-Cy5 Conjugated mAb
28252-20Tests 20 Tests
EUR 302.4

Cy3 Conjugated anti-Rat IgG SABC Kit
SA1079 1 kit
EUR 426

Cy3 Conjugated anti-Goat IgG SABC Kit
SA1076 1 kit
EUR 426

Cy3 Conjugated anti-Mouse IgG SABC Kit
SA1072 1 kit
EUR 426

Cy3 Conjugated anti-Mouse IgM SABC Kit
SA1073 1 kit
EUR 450

Cy3 Conjugated anti-Human IgG SABC Kit
SA1078 1 kit
EUR 426

Cy3 Conjugated anti-Rabbit IgG SABC Kit
SA1074 1 kit
EUR 426

Annexin V-Cy5 conjugate
20066 100 Tests
EUR 222

Annexin V-Cy5 conjugate
20066-100Tests 100 Tests
EUR 222
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium.

Goat anti-Human IgG(H+L) ，Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1031-100 100μl
EUR 286.8

Goat anti-Human IgG(H+L) ，Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1031-1000 1000μl
EUR 520.8

Goat anti-Human IgG(H+L) ，Cross absorbed against mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1031-500 500μl
EUR 411.6

Streptavidin: RPE-Cy5 Conjugate
R-1099 0.2 ml Ask for price

RatioWorks™ Cal-590L®/Cy5-Dextran Conjugate *MW 10,000*
20527-1mg 1 mg
EUR 505
Description: Calcium measurement is critical for numerous biological investigations.

RatioWorks™ Cal-520L®/Cy5-Dextran Conjugate *MW 10,000*
20603-1mg 1 mg
EUR 558
Description: Calcium measurement is critical for numerous biological investigations.

2',3'-cGAMP-Cy5 conjugate
20318 100 ug
EUR 989

2',3'-cGAMP-Cy5 conjugate
20318-100ug 100 ug
EUR 989
Description: 2',3'-cGAMP or cGAMP (Cyclic guanosine monophosphate"adenosine monophosphate) is produced in mammalian cells by cGAS (cGAMP synthase) from ATP and GTP upon cytosolic DNA stimulation.

RPE-Cy5-streptavidin conjugate
16918 100 ug
EUR 99

RPE-Cy5-streptavidin conjugate
16919 1 mg
EUR 308

RPE-Cy5-streptavidin conjugate
16918-100ug 100 ug
EUR 99
Description: Streptavidin conjugates are widely used together with a biotin conjugate for specific detection of a variety of biological molecules since streptavidin has a very high binding affinity for biotin and its conjugates.

RPE-Cy5-streptavidin conjugate
16919-1mg 1 mg
EUR 308
Description: Streptavidin conjugates are widely used together with a biotin conjugate for specific detection of a variety of biological molecules since streptavidin has a very high binding affinity for biotin and its conjugates.

RatioWorks™ Cal-520L®/Cy5-Dextran Conjugate *MW 10,000*
20603 1 mg
EUR 558

Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH2011-100 100μl
EUR 286.8

Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH2011-1000 1000μl
EUR 520.8

Rabbit anti-Rat IgG (H+L) I,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO ConjugatedHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH2011-500 500μl
EUR 411.6

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1021-100 100μl
EUR 286.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1021-1000 1000μl
EUR 520.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulinsHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1021-500 500μl
EUR 411.6

GFP (HRP conjugated)
E8ET1702-69 100ul
EUR 275
Description: Available in various conjugation types.

Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1022-100 100μl
EUR 286.8

Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1022-1000 1000μl
EUR 520.8

Goat anti-Rabbit IgG(H+L) ,Cross absorbed against human and mouse immunoglobulinsHRPO ConjugatedHRPO Conjugated HRPO Conjugated HRPO ConjugatedHRPO Conjugated
E16SPH1022-500 500μl
EUR 411.6

Goat Anti-Human IgG Secondary Antibody Cy3 Conjugated
L30211 1.0 ml
EUR 134.4

Goat Anti-Mouse IgG Secondary Antibody Cy3 Conjugated
L30311 1.0 ml
EUR 134.4

Goat Anti-Rabbit IgG Secondary Antibody Cy3 Conjugated
L30111 1.0 ml
EUR 134.4

GAPDH (HRP conjugated)
E8ET1702-66 100ul
EUR 275
Description: Available in various conjugation types.

GAPDH (HRP Conjugated)
E11-12057 100ul
EUR 255
Description: Available in various conjugation types.

HRP Conjugated Avidin
BA1081-0.5 0.5ml
EUR 175.2

HRP Conjugated Avidin
BA1081-1 1ml
EUR 279.6

OVA Conjugated Amylin
RPU50817-100ug 100ug
EUR 431.2