Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis by the PDGFR/ROCK1 sign pathway

The targets of this research have been to analyze the position of the Notch1/PDGFRβ/ROCK1 signaling pathway within the pathogenesis of pulmonary fibrosis and to discover the opportunity of treating fibrosis by focusing on Notch1. Lung tissues from sufferers with pulmonary fibrosis have been examined for the expression of Notch1/PDGFRβ/ROCK1 utilizing RT-qPCR, western blotting, and immunostaining.
Cultured mouse lung pericytes have been transfected with Notch1-overexpressed vectors or shRNA focusing on PDGFRβ/ROCK1 to look at cell behaviors, together with proliferation, cell cycle arrest, and differentiation towards myofibroblasts.
Lastly, a mouse pulmonary fibrosis mannequin was ready, and a Notch1 inhibitor was administered to watch tissue morphology and pericyte cell behaviors. Human pulmonary fibrotic tissues offered with overexpression of Notch1, PDGFRβ, and ROCK1, along with a outstanding transition of pericytes into myofibroblasts.
In cultured mouse lung pericytes, overexpression of Notch1 led to the accelerated proliferation and differentiation of cells, and it additionally elevated the expression of the PDGFRβ and ROCK1 proteins. The knockdown of PDGFRβ/ROCK1 in pericytes remarkably suppressed pericyte proliferation and differentiation.
As additional substantiation, the administration of a Notch1 inhibitor in a mouse mannequin of lung fibrosis inhibited the PDGFRβ/ROCK1 pathway, suppressed pericyte proliferation and differentiation, and alleviated the severity of fibrosis.
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Our outcomes confirmed that the Notch1 signaling pathway was aberrantly activated in pulmonary fibrosis, and this pathway could facilitate illness development by way of mediating pericyte proliferation and differentiation. The inhibition of the Notch1 pathway could present one promising remedy technique for pulmonary fibrosis.

 

Catalase (CAT) Monoclonal Antibody (Human), APC-Cy7

4-MAC418Hu22-APC-Cy7
  • EUR 609.60
  • EUR 6636.00
  • EUR 1776.00
  • EUR 804.00
  • EUR 350.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Catalase (CAT). This antibody is labeled with APC-Cy7.

Catalase (CAT) Monoclonal Antibody (Human), APC-Cy7

4-MAC418Hu23-APC-Cy7
  • EUR 501.60
  • EUR 5102.40
  • EUR 1393.20
  • EUR 650.40
  • EUR 304.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Catalase (CAT). This antibody is labeled with APC-Cy7.

Ferroportin (FPN) Monoclonal Antibody (Human), APC-Cy7

4-MAC489Hu24-APC-Cy7
  • EUR 702.00
  • EUR 7975.20
  • EUR 2110.80
  • EUR 937.20
  • EUR 391.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Ferroportin (FPN). This antibody is labeled with APC-Cy7.

Reelin (RELN) Monoclonal Antibody (Human), APC-Cy7

4-MAC775Hu21-APC-Cy7
  • EUR 723.60
  • EUR 8277.60
  • EUR 2186.40
  • EUR 967.20
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Reelin (RELN). This antibody is labeled with APC-Cy7.

Reelin (RL) Monoclonal Antibody (Rat), APC-Cy7

4-MAC775Ra21-APC-Cy7
  • EUR 760.80
  • EUR 8796.00
  • EUR 2316.00
  • EUR 1020.00
  • EUR 415.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Reelin (RL). This antibody is labeled with APC-Cy7.

Serglycin (SRGN) Monoclonal Antibody (Human), APC-Cy7

4-MAC869Hu22-APC-Cy7
  • EUR 715.20
  • EUR 8148.00
  • EUR 2154.00
  • EUR 955.20
  • EUR 394.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Serglycin (SRGN). This antibody is labeled with APC-Cy7.

Supervillin (SVIL) Monoclonal Antibody (Human), APC-Cy7

4-MAC881Hu21-APC-Cy7
  • EUR 715.20
  • EUR 8148.00
  • EUR 2154.00
  • EUR 955.20
  • EUR 394.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Supervillin (SVIL). This antibody is labeled with APC-Cy7.

Mesothelin (MSLN) Monoclonal Antibody (Human), APC-Cy7

4-MAH615Hu21-APC-Cy7
  • EUR 715.20
  • EUR 8148.00
  • EUR 2154.00
  • EUR 955.20
  • EUR 394.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Mesothelin (MSLN). This antibody is labeled with APC-Cy7.

Klotho (KL) Monoclonal Antibody (Human), APC-Cy7

4-MAH757Hu21-APC-Cy7
  • EUR 715.20
  • EUR 8148.00
  • EUR 2154.00
  • EUR 955.20
  • EUR 394.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Klotho (KL). This antibody is labeled with APC-Cy7.

Klotho (KL) Monoclonal Antibody (Rat), APC-Cy7

4-MAH757Ra21-APC-Cy7
  • EUR 760.80
  • EUR 8796.00
  • EUR 2316.00
  • EUR 1020.00
  • EUR 415.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Klotho (KL). This antibody is labeled with APC-Cy7.

Biglycan (BGN) Monoclonal Antibody (Rat), APC-Cy7

4-MAJ226Ra21-APC-Cy7
  • EUR 760.80
  • EUR 8796.00
  • EUR 2316.00
  • EUR 1020.00
  • EUR 415.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Biglycan (BGN). This antibody is labeled with APC-Cy7.

Calprotectin (CALPRO) Monoclonal Antibody (Human), APC-Cy7

4-MAK504Hu21-APC-Cy7
  • EUR 912.00
  • EUR 10956.00
  • EUR 2856.00
  • EUR 1236.00
  • EUR 480.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Calprotectin (CALPRO). This antibody is labeled with APC-Cy7.

Amphiregulin (AREG) Polyclonal Antibody (Bovine), APC-Cy7

4-PAA006Bo01-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Amphiregulin (AREG). This antibody is labeled with APC-Cy7.

Amphiregulin (AREG) Polyclonal Antibody (Rat), APC-Cy7

4-PAA006Ra01-APC-Cy7
  • EUR 672.00
  • EUR 7543.20
  • EUR 2002.80
  • EUR 894.00
  • EUR 378.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Amphiregulin (AREG). This antibody is labeled with APC-Cy7.

Angiogenin (ANG) Polyclonal Antibody (Bovine), APC-Cy7

4-PAA007Bo01-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Angiogenin (ANG). This antibody is labeled with APC-Cy7.

Angiogenin (ANG) Polyclonal Antibody (Human), APC-Cy7

4-PAA007Hu01-APC-Cy7
  • EUR 494.40
  • EUR 4994.40
  • EUR 1365.60
  • EUR 639.60
  • EUR 300.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Angiogenin (ANG). This antibody is labeled with APC-Cy7.

Angiogenin (ANG) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA007Mu01-APC-Cy7
  • EUR 645.60
  • EUR 7154.40
  • EUR 1905.60
  • EUR 855.60
  • EUR 364.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Angiogenin (ANG). This antibody is labeled with APC-Cy7.

Angiogenin (ANG) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA007Mu02-APC-Cy7
  • EUR 645.60
  • EUR 7154.40
  • EUR 1905.60
  • EUR 855.60
  • EUR 364.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Angiogenin (ANG). This antibody is labeled with APC-Cy7.

Angiogenin (ANG) Polyclonal Antibody (Pig), APC-Cy7

4-PAA007Po01-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Angiogenin (ANG). This antibody is labeled with APC-Cy7.

Angiogenin (ANG) Polyclonal Antibody (Rat), APC-Cy7

4-PAA007Ra01-APC-Cy7
  • EUR 672.00
  • EUR 7543.20
  • EUR 2002.80
  • EUR 894.00
  • EUR 378.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Angiogenin (ANG). This antibody is labeled with APC-Cy7.

Cortisone (COR) Polyclonal Antibody (General), APC-Cy7

4-PAA067Ge01-APC-Cy7
  • EUR 618.00
  • EUR 6765.60
  • EUR 1808.40
  • EUR 816.00
  • EUR 354.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Cortisone (COR). This antibody is labeled with APC-Cy7.

Androsterone (ADT) Polyclonal Antibody (General), APC-Cy7

4-PAA070Ge01-APC-Cy7
  • EUR 618.00
  • EUR 6765.60
  • EUR 1808.40
  • EUR 816.00
  • EUR 354.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Androsterone (ADT). This antibody is labeled with APC-Cy7.

Leptin (LEP) Polyclonal Antibody (Bovine), APC-Cy7

4-PAA084Bo01-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Leptin (LEP). This antibody is labeled with APC-Cy7.

Leptin (LEP) Polyclonal Antibody (Horse), APC-Cy7

4-PAA084Eq01-APC-Cy7
  • EUR 742.80
  • EUR 8536.80
  • EUR 2251.20
  • EUR 993.60
  • EUR 405.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Horse Leptin (LEP). This antibody is labeled with APC-Cy7.

Leptin (LEP) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA084Mu01-APC-Cy7
  • EUR 645.60
  • EUR 7154.40
  • EUR 1905.60
  • EUR 855.60
  • EUR 364.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leptin (LEP). This antibody is labeled with APC-Cy7.

Leptin (LEP) Polyclonal Antibody (Rat), APC-Cy7

4-PAA084Ra01-APC-Cy7
  • EUR 672.00
  • EUR 7543.20
  • EUR 2002.80
  • EUR 894.00
  • EUR 378.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Leptin (LEP). This antibody is labeled with APC-Cy7.

Betacellulin (bTC) Polyclonal Antibody (Human), APC-Cy7

4-PAA112Hu01-APC-Cy7
  • EUR 632.40
  • EUR 6981.60
  • EUR 1862.40
  • EUR 837.60
  • EUR 361.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with APC-Cy7.

Betacellulin (bTC) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA112Mu01-APC-Cy7
  • EUR 566.40
  • EUR 6031.20
  • EUR 1624.80
  • EUR 742.80
  • EUR 332.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with APC-Cy7.

Betacellulin (bTC) Polyclonal Antibody (Rat), APC-Cy7

4-PAA112Ra01-APC-Cy7
  • EUR 672.00
  • EUR 7521.60
  • EUR 1996.80
  • EUR 891.60
  • EUR 376.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Betacellulin (bTC). This antibody is labeled with APC-Cy7.

Orexin (OX) Polyclonal Antibody (Human), APC-Cy7

4-PAA346Hu01-APC-Cy7
  • EUR 632.40
  • EUR 6981.60
  • EUR 1862.40
  • EUR 837.60
  • EUR 360.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Orexin (OX). This antibody is labeled with APC-Cy7.

Thyroglobulin (TG) Polyclonal Antibody (Bovine), APC-Cy7

4-PAA355Bo05-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Thyroglobulin (TG). This antibody is labeled with APC-Cy7.

Thyroglobulin (TG) Polyclonal Antibody (Human), APC-Cy7

4-PAA355Hu01-APC-Cy7
  • EUR 632.40
  • EUR 6981.60
  • EUR 1862.40
  • EUR 837.60
  • EUR 361.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Thyroglobulin (TG). This antibody is labeled with APC-Cy7.

Thyroglobulin (TG) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA355Mu01-APC-Cy7
  • EUR 645.60
  • EUR 7154.40
  • EUR 1905.60
  • EUR 855.60
  • EUR 364.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Thyroglobulin (TG). This antibody is labeled with APC-Cy7.

Thyroglobulin (TG) Polyclonal Antibody (Pig), APC-Cy7

4-PAA355Po05-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Thyroglobulin (TG). This antibody is labeled with APC-Cy7.

Copeptin (CPP) Polyclonal Antibody (Human), APC-Cy7

4-PAA365Hu01-APC-Cy7
  • EUR 631.20
  • EUR 6938.40
  • EUR 1851.60
  • EUR 834.00
  • EUR 358.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Copeptin (CPP). This antibody is labeled with APC-Cy7.

Gelsolin (GS) Polyclonal Antibody (Bovine), APC-Cy7

4-PAA372Bo01-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Gelsolin (GS). This antibody is labeled with APC-Cy7.

Gelsolin (GS) Polyclonal Antibody (Human), APC-Cy7

4-PAA372Hu01-APC-Cy7
  • EUR 578.40
  • EUR 6204.00
  • EUR 1668.00
  • EUR 760.80
  • EUR 337.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Gelsolin (GS). This antibody is labeled with APC-Cy7.

Gelsolin (GS) Polyclonal Antibody (Human), APC-Cy7

4-PAA372Hu02-APC-Cy7
  • EUR 578.40
  • EUR 6204.00
  • EUR 1668.00
  • EUR 760.80
  • EUR 337.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Gelsolin (GS). This antibody is labeled with APC-Cy7.

Gelsolin (GS) Polyclonal Antibody (Human), APC-Cy7

4-PAA372Hu03-APC-Cy7
  • EUR 578.40
  • EUR 6204.00
  • EUR 1668.00
  • EUR 760.80
  • EUR 337.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Gelsolin (GS). This antibody is labeled with APC-Cy7.

Gelsolin (GS) Polyclonal Antibody (Human), APC-Cy7

4-PAA372Hu04-APC-Cy7
  • EUR 578.40
  • EUR 6204.00
  • EUR 1668.00
  • EUR 760.80
  • EUR 337.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Gelsolin (GS). This antibody is labeled with APC-Cy7.

Gelsolin (GSN) Polyclonal Antibody (Human), APC-Cy7

4-PAA372Hu05-APC-Cy7
  • EUR 609.60
  • EUR 6636.00
  • EUR 1776.00
  • EUR 804.00
  • EUR 350.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Gelsolin (GSN). This antibody is labeled with APC-Cy7.

Gelsolin (GS) Polyclonal Antibody (Rat), APC-Cy7

4-PAA372Ra01-APC-Cy7
  • EUR 672.00
  • EUR 7543.20
  • EUR 2002.80
  • EUR 894.00
  • EUR 378.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Gelsolin (GS). This antibody is labeled with APC-Cy7.

Desmin (Des) Polyclonal Antibody (Human), APC-Cy7

4-PAA373Hu01-APC-Cy7
  • EUR 632.40
  • EUR 6981.60
  • EUR 1862.40
  • EUR 837.60
  • EUR 361.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Desmin (Des). This antibody is labeled with APC-Cy7.

Follistatin (FS) Polyclonal Antibody (Human), APC-Cy7

4-PAA391Hu01-APC-Cy7
  • EUR 632.40
  • EUR 6981.60
  • EUR 1862.40
  • EUR 837.60
  • EUR 361.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Follistatin (FS). This antibody is labeled with APC-Cy7.

Dehydroepiandrosterone (DHEA) Polyclonal Antibody (General), APC-Cy7

4-PAA398Ge01-APC-Cy7
  • EUR 618.00
  • EUR 6765.60
  • EUR 1808.40
  • EUR 816.00
  • EUR 354.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Dehydroepiandrosterone (DHEA). This antibody is labeled with APC-Cy7.

Dihydrotestosterone (DHT) Polyclonal Antibody (General), APC-Cy7

4-PAA443Ge01-APC-Cy7
  • EUR 618.00
  • EUR 6765.60
  • EUR 1808.40
  • EUR 816.00
  • EUR 354.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Dihydrotestosterone (DHT). This antibody is labeled with APC-Cy7.

Insulin (INS) Polyclonal Antibody (Bovine), APC-Cy7

4-PAA448Bo01-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Insulin (INS). This antibody is labeled with APC-Cy7.

Insulin (INS) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA448Mu01-APC-Cy7
  • EUR 645.60
  • EUR 7154.40
  • EUR 1905.60
  • EUR 855.60
  • EUR 364.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Insulin (INS). This antibody is labeled with APC-Cy7.

Insulin (INS) Polyclonal Antibody (Pig), APC-Cy7

4-PAA448Po01-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Insulin (INS). This antibody is labeled with APC-Cy7.

Insulin (INS) Polyclonal Antibody (Pig), APC-Cy7

4-PAA448Po02-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Insulin (INS). This antibody is labeled with APC-Cy7.

Thyroxine (T4) Polyclonal Antibody (General), APC-Cy7

4-PAA452Ge01-APC-Cy7
  • EUR 566.40
  • EUR 6031.20
  • EUR 1624.80
  • EUR 742.80
  • EUR 332.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Thyroxine (T4). This antibody is labeled with APC-Cy7.

Triiodothyronine (T3) Polyclonal Antibody (General), APC-Cy7

4-PAA453Ge01-APC-Cy7
  • EUR 566.40
  • EUR 6031.20
  • EUR 1624.80
  • EUR 742.80
  • EUR 332.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Triiodothyronine (T3). This antibody is labeled with APC-Cy7.

Estriol (E3) Polyclonal Antibody (General), APC-Cy7

4-PAA455Ge01-APC-Cy7
  • EUR 618.00
  • EUR 6765.60
  • EUR 1808.40
  • EUR 816.00
  • EUR 354.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Estriol (E3). This antibody is labeled with APC-Cy7.

Androstenedione (ASD) Polyclonal Antibody (General), APC-Cy7

4-PAA456Ge01-APC-Cy7
  • EUR 618.00
  • EUR 6765.60
  • EUR 1808.40
  • EUR 816.00
  • EUR 354.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Androstenedione (ASD). This antibody is labeled with APC-Cy7.

Testosterone (Testo) Polyclonal Antibody (General), APC-Cy7

4-PAA458Ge01-APC-Cy7
  • EUR 618.00
  • EUR 6765.60
  • EUR 1808.40
  • EUR 816.00
  • EUR 354.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Testosterone (Testo). This antibody is labeled with APC-Cy7.

Progesterone (PG) Polyclonal Antibody (General), APC-Cy7

4-PAA459Ge01-APC-Cy7
  • EUR 618.00
  • EUR 6765.60
  • EUR 1808.40
  • EUR 816.00
  • EUR 354.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Progesterone (PG). This antibody is labeled with APC-Cy7.

Estradiol (E2) Polyclonal Antibody (General), APC-Cy7

4-PAA461Ge01-APC-Cy7
  • EUR 566.40
  • EUR 6031.20
  • EUR 1624.80
  • EUR 742.80
  • EUR 332.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Estradiol (E2). This antibody is labeled with APC-Cy7.

Cortisol (Cor) Polyclonal Antibody (General), APC-Cy7

4-PAA462Ge01-APC-Cy7
  • EUR 618.00
  • EUR 6765.60
  • EUR 1808.40
  • EUR 816.00
  • EUR 354.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Cortisol (Cor). This antibody is labeled with APC-Cy7.

Adrenomedullin (ADM) Polyclonal Antibody (Bovine), APC-Cy7

4-PAA220Bo01-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Adrenomedullin (ADM). This antibody is labeled with APC-Cy7.

Adrenomedullin (ADM) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA220Mu01-APC-Cy7
  • EUR 645.60
  • EUR 7154.40
  • EUR 1905.60
  • EUR 855.60
  • EUR 364.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Adrenomedullin (ADM). This antibody is labeled with APC-Cy7.

Adrenomedullin (ADM) Polyclonal Antibody (Rat), APC-Cy7

4-PAA220Ra01-APC-Cy7
  • EUR 672.00
  • EUR 7543.20
  • EUR 2002.80
  • EUR 894.00
  • EUR 378.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Adrenomedullin (ADM). This antibody is labeled with APC-Cy7.

Tyrosinase (TYR) Polyclonal Antibody (Pig), APC-Cy7

4-PAA238Po01-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Tyrosinase (TYR). This antibody is labeled with APC-Cy7.

Androstenediol (AED) Polyclonal Antibody (General), APC-Cy7

4-PAA240Ge01-APC-Cy7
  • EUR 618.00
  • EUR 6765.60
  • EUR 1808.40
  • EUR 816.00
  • EUR 354.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Androstenediol (AED). This antibody is labeled with APC-Cy7.

Nischarin (NISCH) Polyclonal Antibody (Human), APC-Cy7

4-PAA249Hu01-APC-Cy7
  • EUR 632.40
  • EUR 6981.60
  • EUR 1862.40
  • EUR 837.60
  • EUR 361.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Nischarin (NISCH). This antibody is labeled with APC-Cy7.

Nischarin (NISCH) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA249Mu01-APC-Cy7
  • EUR 645.60
  • EUR 7154.40
  • EUR 1905.60
  • EUR 855.60
  • EUR 364.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Nischarin (NISCH). This antibody is labeled with APC-Cy7.

Trypsin (TRY) Polyclonal Antibody (Pig), APC-Cy7

4-PAA250Po01-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Trypsin (TRY). This antibody is labeled with APC-Cy7.

Talin (TLN) Polyclonal Antibody (Human), APC-Cy7

4-PAA278Hu01-APC-Cy7
  • EUR 632.40
  • EUR 6981.60
  • EUR 1862.40
  • EUR 837.60
  • EUR 361.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Talin (TLN). This antibody is labeled with APC-Cy7.

Talin (TLN) Polyclonal Antibody (Human), APC-Cy7

4-PAA278Hu02-APC-Cy7
  • EUR 631.20
  • EUR 6938.40
  • EUR 1851.60
  • EUR 834.00
  • EUR 358.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Talin (TLN). This antibody is labeled with APC-Cy7.

Talin (TLN) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA278Mu01-APC-Cy7
  • EUR 645.60
  • EUR 7154.40
  • EUR 1905.60
  • EUR 855.60
  • EUR 364.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Talin (TLN). This antibody is labeled with APC-Cy7.

Glutathione (GSH) Polyclonal Antibody (General), APC-Cy7

4-PAA294Ge01-APC-Cy7
  • EUR 618.00
  • EUR 6765.60
  • EUR 1808.40
  • EUR 816.00
  • EUR 354.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against General Glutathione (GSH). This antibody is labeled with APC-Cy7.

Lactoperoxidase (LPO) Polyclonal Antibody (Human), APC-Cy7

4-PAA296Hu01-APC-Cy7
  • EUR 632.40
  • EUR 6981.60
  • EUR 1862.40
  • EUR 837.60
  • EUR 361.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Lactoperoxidase (LPO). This antibody is labeled with APC-Cy7.

Lactoperoxidase (LPO) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA296Mu01-APC-Cy7
  • EUR 645.60
  • EUR 7154.40
  • EUR 1905.60
  • EUR 855.60
  • EUR 364.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Lactoperoxidase (LPO). This antibody is labeled with APC-Cy7.

Myoglobin (MYO) Polyclonal Antibody (Bovine), APC-Cy7

4-PAA480Bo01-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Myoglobin (MYO). This antibody is labeled with APC-Cy7.

Myoglobin (MYO) Polyclonal Antibody (Chicken), APC-Cy7

4-PAA480Ga01-APC-Cy7
  • EUR 672.00
  • EUR 7543.20
  • EUR 2002.80
  • EUR 894.00
  • EUR 378.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Chicken Myoglobin (MYO). This antibody is labeled with APC-Cy7.

Myoglobin (MYO) Polyclonal Antibody (Sheep), APC-Cy7

4-PAA480Ov01-APC-Cy7
  • EUR 766.80
  • EUR 8882.40
  • EUR 2337.60
  • EUR 1028.40
  • EUR 416.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Sheep Myoglobin (MYO). This antibody is labeled with APC-Cy7.

Myoglobin (MYO) Polyclonal Antibody (Pig), APC-Cy7

4-PAA480Po01-APC-Cy7
  • EUR 728.40
  • EUR 8320.80
  • EUR 2197.20
  • EUR 972.00
  • EUR 399.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Myoglobin (MYO). This antibody is labeled with APC-Cy7.

Nestin (NES) Polyclonal Antibody (Human), APC-Cy7

4-PAA500Hu01-APC-Cy7
  • EUR 632.40
  • EUR 6981.60
  • EUR 1862.40
  • EUR 837.60
  • EUR 361.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with APC-Cy7.

Nestin (NES) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA500Mu01-APC-Cy7
  • EUR 645.60
  • EUR 7154.40
  • EUR 1905.60
  • EUR 855.60
  • EUR 364.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with APC-Cy7.

PDGFR-induced autocrine SDF-1 signaling in most cancers cells promotes metastasis in superior pores and skin carcinoma.

 

 

Superior and undifferentiated pores and skin squamous cell carcinomas (SCCs) exhibit aggressive development and enhanced metastasis functionality, which is related in mice with an growth of the most cancers stem-like cell (CSC) inhabitants and with adjustments within the regulatory mechanisms that management the proliferation and invasion of those cells. Certainly, autocrine activation of PDGFRα induces CSC invasion and promotes distant metastasis in superior SCCs. Nevertheless, the mechanisms concerned on this course of have been unclear.
Right here, we present that CSCs of mouse superior SCCs (L-CSCs) specific CXCR4 and CXCR7, each receptors of SDF-1. PDGFRα signaling induces SDF-1 expression and secretion, and the autocrine activation of this pathway in L-CSCs.
Autocrine SDF-1/CXCR4 signaling induces L-CSC proliferation and survival, and mediates PDGFRα-induced invasion, selling in vivo lung metastasis. Validation of those findings in affected person samples of pores and skin SCCs exhibits a powerful correlation between the expression of SDF1, PDGFRA, and PDGFRB, which is upregulated, alongside CXCR4 in tumor cells of superior SCCs.
Moreover, PDGFR regulates SDF-1 expression and inhibition of SDF-1/CXCR4 and PDGFR pathways blocks distant metastasis of human PD/S-SCCs. Our outcomes point out that purposeful crosstalk between PDGFR/SDF-1 signaling regulates tumor cell invasion and metastasis in human and mouse superior SCCs, and recommend that CXCR4 and/or PDGFR inhibitors might be used to dam metastasis of those aggressive tumors.

Corrigendum Antiproliferative results of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell strains by way of PDGFR‑β, PDGF‑BB, c‑Package and SCF expression.

 

  • An reader drew to our consideration that the above research appeared to comprise a excessive stage of overlap with an article by the identical authors revealed within the journal Drug Design, Improvement and Remedy [Kadivar A, Kamalidehghan B, Akbari Javar H, Karimi B, Sedghi R and Noordin MI: Antiproliferation effect of imatinib mesylate on MCF7, T‑47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF genes. Drug Des Devel Ther 11: 469‑481, 2017].
  • Following an inside investigation and likewise in liaison with the authors, it was established that, though the research have been performed alongside broadly comparable strains, the papers contained fully totally different knowledge involving two totally different subsets of cell strains; the submission to Drug Des Devel Ther aimed to discover the results of imatinib mesylate on three totally different teams, with every group being represented by a cell line, whereas the submission to Int J Mol Med explored the effectiveness of imatinib mesylate in breast most cancers cell strains.
  • Regardless of this, contemplating the relatedness of the articles and the truth that the paper to Drug Des Devel Ther was submitted first and revealed whereas the Int J Mol Med paper was passing by the peer‑evaluation course of, the authors concede that they need to have correctly referenced their paper submitted to Drug Des Devel Ther within the Int J Mol Med paper.
  • Notice that the publishers of Drug Des Devel Ther, with whom we have been liaising, agreed with the choice to concern a Corrigendum for this paper that acknowledges the article revealed in Drug Des Devel Ther.
  • The authors remorse their failure to acknowledge the associated paper on this occasion, and apologize to the readership for this oversight. [the original article was published in International Journal of Molecular Medicine 14: 414‑424, 2018; DOI: 10.3892/ijmm.2018.3590].

 

Cy5 phosphoramidite

6071 100 umoles
EUR 60

DBCO-Cy5

923 1 mg
EUR 158.4

CY5-SE

HY-D0819 25mg
EUR 555.6

CY5-YNE

HY-D0820 10mM/1mL
EUR 943.2

CY5-N3

HY-D0832 5mg
EUR 639.6

Cy5-Dctp

PA55021 EACH
EUR 388.74

Cy5-Dutp

PA55022 EACH
EUR 388.74

Cy5-Ctp

25801087 EACH
EUR 432.06

Cy5 tyramide

11066 1 mg
EUR 109

Cy5 aldehyde

9011 5 mg
EUR 318

Cy5 aldehyde

9012 1 mg
EUR 203

Cy5 tetrazine

902 1 mg
EUR 222

Mouse anti-Human CD3, PE-Cy5 Conjugated mAb

28006-50Tests 50 Tests
EUR 303.6

Mouse anti-Human CD4, PE-Cy5 Conjugated mAb

28013-50Tests 50 Tests
EUR 303.6

Mouse anti-Human CD8, PE-Cy5 Conjugated mAb

28028-50Tests 50 Tests
EUR 303.6

Mouse anti-Human CD14, PE-Cy5 Conjugated mAb

28053-50Tests 50 Tests
EUR 302.4

Mouse anti-Human CD19, PE-Cy5 Conjugated mAb

28074-50Tests 50 Tests
EUR 302.4

Mouse anti-Human CD45, PE-Cy5 Conjugated mAb

28144-50Tests 50 Tests
EUR 303.6

Cy5 NHS ester

A8108-25 25 mg
EUR 895.2
Description: Sulfo-Cy5 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. For the labeling of various amine-containing molecules in aqueous phase, no organic co-solvent is needed.

Cy5 NHS ester

A8108-5 5 mg
EUR 351.6
Description: Sulfo-Cy5 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. For the labeling of various amine-containing molecules in aqueous phase, no organic co-solvent is needed.

Cy5 carboxylic acid

A8137-25 25 mg
EUR 1243.2
Description: Sulfo-Cy5 carboxylic acid is a non-activated, sulfonated, hydrophilic and highly water soluble dye. Non-Sulfo-Cy5 carboxylic acid analog is available. For kinds of researches related experiments, using pre-activated sulfo-Cy5 NHS ester is preferred

Cy5 carboxylic acid

A8137-5 5 mg
EUR 630
Description: Sulfo-Cy5 carboxylic acid is a non-activated, sulfonated, hydrophilic and highly water soluble dye. Non-Sulfo-Cy5 carboxylic acid analog is available. For kinds of researches related experiments, using pre-activated sulfo-Cy5 NHS ester is preferred

CD117 antibody (CY5)

61R-CD117bMSCY5 100 ug
EUR 495.6
Description: Rat monoclonal CD117 antibody (CY5)

CD11b antibody (CY5)

61R-CD11baMSCY5 100 ug
EUR 495.6
Description: Rat monoclonal CD11b antibody (CY5)

CD19 antibody (CY5)

61R-CD19aMSCY5 100 ug
EUR 522
Description: Rat monoclonal CD19 antibody (CY5)

CD19 antibody (CY5)

61R-CD19cHUCY5 100 tests
EUR 522
Description: Mouse monoclonal CD19 antibody (CY5)

CD3e antibody (CY5)

61R-CD3egMSCY 100 ug
EUR 340.8
Description: Hamster monoclonal CD3e antibody (CY5)

CD3e antibody (CY5)

61R-CD3ehMSCY 100 ug
EUR 340.8
Description: Rat monoclonal CD3e antibody (CY5)

CD3 antibody (CY5)

61R-CD3gHUCY5 100 tests
EUR 535.2
Description: Mouse monoclonal CD3 antibody (CY5)

CD45.1 antibody (CY5)

61R-CD45gMSCY5 100 ug
EUR 548.4
Description: Mouse monoclonal CD45.1 antibody (CY5)

CD45.2 antibody (CY5)

61R-CD45hMSCY5 100 ug
EUR 457.2
Description: Mouse monoclonal CD45.2 antibody (CY5)

CD45R antibody (CY5)

61R-CD45RcMSCY5 100 ug
EUR 495.6
Description: Rat monoclonal CD45R antibody (CY5)

CD4 antibody (CY5)

61R-CD4eMSCY 100 ug
EUR 483.6
Description: Rat monoclonal CD4 antibody (CY5)

CD4 antibody (CY5)

61R-CD4kHUCY5 100 tests
EUR 522
Description: Mouse monoclonal CD4 antibody (CY5)

CD8a antibody (CY5)

61R-CD8abMSCY5 100 ug
EUR 495.6
Description: Rat monoclonal CD8a antibody (CY5)

CD8a antibody (CY5)

61R-CD8adCKCY5 100 ug
EUR 651.6
Description: Mouse monoclonal CD8a antibody (CY5)

CD8a antibody (CY5)

61R-CD8aeCKCY5 100 ug
EUR 548.4
Description: Mouse monoclonal CD8a antibody (CY5)

Azido-Cy5 tyramide

11061 1 mg
EUR 367.2

PE-Cy5 Tandem

2610 1 mg
EUR 262.8

Cy5-PEG-SH

abx085228-1kDa50mg 1 kDa; 50 mg
EUR 1045.2

Cy5-PEG-SH

abx085228-2kDa50mg 2 kDa; 50 mg
EUR 1095.6

Cy5-PEG-SH

abx085228-34kDa50mg 3.4 kDa; 50 mg
EUR 1128

Cy5-PEG-SH

abx085228-5kDa50mg 5 kDa; 50 mg
EUR 1128

Cy5-PEG-COOH

abx085357-10kDa50mg 10 kDa; 50 mg
EUR 598.8

Cy5-PEG-COOH

abx085357-20kDa50mg 20 kDa; 50 mg
EUR 598.8

Cy5-PEG-COOH

abx085357-2kDa50mg 2 kDa; 50 mg
EUR 642

Cy5-PEG-COOH

abx085357-5kDa50mg 5 kDa; 50 mg
EUR 642

Cy5-PEG-Mal

abx085358-10kDa50mg 10 kDa; 50 mg
EUR 655.2

Cy5-PEG-Mal

abx085358-1kDa50mg 1 kDa; 50 mg
EUR 655.2

Cy5-PEG-Mal

abx085358-2kDa50mg 2 kDa; 50 mg
EUR 684

Glucagon-Cy5 Peptide

abx267068-1mg 1 mg
EUR 2481.6

Cy5 Streptavidin 1mg

PA45001 EACH
EUR 247.38

Cy5 biotin conjugate

3100 5 mg
EUR 222

Cy5 NHS ester(Et)

A8769-25 25 mg
EUR 630

Cy5 NHS ester(Et)

A8769-5 5 mg
EUR 351.6

Cy5 Bis NHS ester

A8773-25 25 mg
EUR 630

Cy5 Bis NHS ester

A8773-5 5 mg
EUR 351.6

Cy5 Bis carboxylic acid

A8775-25 25 mg
EUR 630

Cy5 Bis carboxylic acid

A8775-5 5 mg
EUR 351.6

Cy5 carboxylic acid(Et)

A8777-25 25 mg
EUR 630

Cy5 carboxylic acid(Et)

A8777-5 5 mg
EUR 351.6

Cy5 azide (non-sulfonated)

A8113-25 25 mg
EUR 1939.2
Description: Cy5 azide is a labeling reagent ready for the use in Click Chemistry reaction which available as 10 mM solution in DMSO. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction.

Cy5 azide (non-sulfonated)

A8113-5 5 mg
EUR 699.6
Description: Cy5 azide is a labeling reagent ready for the use in Click Chemistry reaction which available as 10 mM solution in DMSO. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction.

Cy5 alkyne (non-sulfonated)

A8131-25 25 mg
EUR 1939.2
Description: Cy5 alkyne, with low aqueous solubility is a dye ready for the use in Click Chemistry reaction. Various molecules via Click Chemistry reaction can be attached by this deeply colored, and photostable Cy5 fluorophore.

Cy5 alkyne (non-sulfonated)

A8131-5 5 mg
EUR 699.6
Description: Cy5 alkyne, with low aqueous solubility is a dye ready for the use in Click Chemistry reaction. Various molecules via Click Chemistry reaction can be attached by this deeply colored, and photostable Cy5 fluorophore.

Cy5 maleimide (non-sulfonated)

A8139-25 25 mg
EUR 630
Description: Cy5 maleimide is a mono-reactive dye for selectively labeling peptides and proteins which couples with thiol groups.

Cy5 maleimide (non-sulfonated)

A8139-5 5 mg
EUR 351.6
Description: Cy5 maleimide is a mono-reactive dye for selectively labeling peptides and proteins which couples with thiol groups.

Cy5 amine (non-sulfonated)

A8143-25 25 mg
EUR 630
Description: Cy5 amine is a reactive dye which contains amino group. This dye can be coupled with a variety of activated esters and other electrophilic reagents.

Cy5 amine (non-sulfonated)

A8143-5 5 mg
EUR 351.6
Description: Cy5 amine is a reactive dye which contains amino group. This dye can be coupled with a variety of activated esters and other electrophilic reagents.

Cy5 hydrazide (non-sulfonated)

A8145-25 25 mg
EUR 630
Description: Cy5 hydrazide is a reactive dye which reacts smoothly and nearly quantitatively with various carbonyl groups encountered in biomolecules. The labeling regent is used for the labeling of aldehydes and ketones.

Cy5 hydrazide (non-sulfonated)

A8145-5 5 mg
EUR 351.6
Description: Cy5 hydrazide is a reactive dye which reacts smoothly and nearly quantitatively with various carbonyl groups encountered in biomolecules. The labeling regent is used for the labeling of aldehydes and ketones.

Cy5-PEG-SH,10K

FL078003-10K-50mg 50mg
EUR 652.8
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-SH,1K

FL078003-1K-50mg 50mg
EUR 726
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-SH,2K

FL078003-2K-50mg 50mg
EUR 681.6
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-SH,3.4K

FL078003-3.4K-50mg 50mg
EUR 652.8
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-SH,5K

FL078003-5K-50mg 50mg
EUR 652.8
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-COOH,10K

FL078017-10K-50mg 50mg
EUR 564
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-COOH,1K

FL078017-1K-50mg 50mg
EUR 564
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-COOH,20K

FL078017-20K-50mg 50mg
EUR 564
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-COOH,2K

FL078017-2K-50mg 50mg
EUR 564
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-COOH,3.4K

FL078017-3.4K-50mg 50mg
EUR 564
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-COOH,5K

FL078017-5K-50mg 50mg
EUR 564
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cy5-PEG-Mal,10K

FL078022-10K-50mg 50mg
EUR 564
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.