Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis by the PDGFR/ROCK1 sign pathway
The targets of this research have been to analyze the position of the Notch1/PDGFRβ/ROCK1 signaling pathway within the pathogenesis of pulmonary fibrosis and to discover the opportunity of treating fibrosis by focusing on Notch1. Lung tissues from sufferers with pulmonary fibrosis have been examined for the expression of Notch1/PDGFRβ/ROCK1 utilizing RT-qPCR, western blotting, and immunostaining.
Cultured mouse lung pericytes have been transfected with Notch1-overexpressed vectors or shRNA focusing on PDGFRβ/ROCK1 to look at cell behaviors, together with proliferation, cell cycle arrest, and differentiation towards myofibroblasts.
Lastly, a mouse pulmonary fibrosis mannequin was ready, and a Notch1 inhibitor was administered to watch tissue morphology and pericyte cell behaviors. Human pulmonary fibrotic tissues offered with overexpression of Notch1, PDGFRβ, and ROCK1, along with a outstanding transition of pericytes into myofibroblasts.
In cultured mouse lung pericytes, overexpression of Notch1 led to the accelerated proliferation and differentiation of cells, and it additionally elevated the expression of the PDGFRβ and ROCK1 proteins. The knockdown of PDGFRβ/ROCK1 in pericytes remarkably suppressed pericyte proliferation and differentiation.
As additional substantiation, the administration of a Notch1 inhibitor in a mouse mannequin of lung fibrosis inhibited the PDGFRβ/ROCK1 pathway, suppressed pericyte proliferation and differentiation, and alleviated the severity of fibrosis.
Our outcomes confirmed that the Notch1 signaling pathway was aberrantly activated in pulmonary fibrosis, and this pathway could facilitate illness development by way of mediating pericyte proliferation and differentiation. The inhibition of the Notch1 pathway could present one promising remedy technique for pulmonary fibrosis.
 Monoclonal Antibody PE-Cyanine7 Conjugated, Flow Validated) Anti-Mouse Ly-6G (Gr-1) Monoclonal Antibody PE-Cyanine7 Conjugated, Flow Validated |
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| FC30404-1-PE-Cy7 | BosterBio | 25ug, 100ug | EUR 131 |
|
Description: Rat Monoclonal Mouse Ly-6G (Gr-1) Antibody PE-Cyanine7 Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Mouse. |
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 CY7 |
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| HY-D0825 | MedChemExpress | 10mM/1mL | EUR 506 |
 CY7-SE |
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| HY-D0824 | MedChemExpress | 25mg | EUR 394 |
 APC-Cy7 Tandem |
|||
| 2625 | AAT Bioquest | 1 mg | EUR 219 |
 Cy7-PEG-NH2 |
|||
| abx085304-2kDa50mg | Abbexa | 2 kDa; 50 mg | EUR 954 |
Cy7-PEG-NH2 |
|||
| abx085304-34kDa50mg | Abbexa | 3.4 kDa; 50 mg | EUR 954 |
 CY7-PEG-DSPE |
|||
| abx085409-2kDa50mg | Abbexa | 2 kDa; 50 mg | EUR 901 |
 Cy7-PEG-NH2,2K |
|||
| FL080005-2K-50mg | Biochempeg | 50mg | EUR 667 |
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy7-PEG-NH2,3.4K |
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| FL080005-3.4K-50mg | Biochempeg | 50mg | EUR 667 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy7-PEG-NH2,5K |
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| FL080005-5K-50mg | Biochempeg | 50mg | EUR 667 |
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy7 NHS ester |
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| A8109-25 | ApexBio | 25 mg | EUR 1036 |
|
Description: Sulfo-Cy7 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. This reagent allows prepare Cy7-labeled biomolecules, especially useful for the labeling of delicate proteins, and proteins prone to denaturation. |
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Cy7 NHS ester |
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| A8109-5 | ApexBio | 5 mg | EUR 525 |
|
Description: Sulfo-Cy7 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. This reagent allows prepare Cy7-labeled biomolecules, especially useful for the labeling of delicate proteins, and proteins prone to denaturation. |
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 Monoclonal Antibody (Pan-species), APC-Cy7) Fluorescein Isothiocyanate (APC-Cy7) Monoclonal Antibody (Pan-species), APC-Cy7 |
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| 4-MAO843Ge21-APC-Cy7 | Cloud-Clone |
|
|
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Description: A Mouse monoclonal antibody against Pan-species Fluorescein Isothiocyanate (APC-Cy7). This antibody is labeled with APC-Cy7. |
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) CD117 antibody (Allophycocyanin-CY7) |
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| 61R-CD117bMSAP5 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rat monoclonal CD117 antibody (Allophycocyanin-CY7) |
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) CD11a antibody (PE-CY7) |
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| 61R-CD11aaMSPE7 | Fitzgerald | 100 ug | EUR 435 |
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Description: Rat monoclonal CD11a antibody (PE-CY7) |
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) CD16 antibody (PE-CY7) |
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| 61R-CD16gMSPEC7 | Fitzgerald | 100 ug | EUR 300 |
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Description: Rat monoclonal CD16 antibody (PE-CY7) |
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) CD19 antibody (PE-CY7) |
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| 61R-CD19aMSPEC7 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rat monoclonal CD19 antibody (PE-CY7) |
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) CD19 antibody (Allophycocyanin-CY7) |
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| 61R-CD19cHUAPC7 | Fitzgerald | 100 tests | EUR 457 |
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Description: Mouse monoclonal CD19 antibody (Allophycocyanin-CY7) |
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CD19 antibody (PE-CY7) |
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| 61R-CD19cHUPEC7 | Fitzgerald | 100 tests | EUR 446 |
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Description: Mouse monoclonal CD19 antibody (PE-CY7) |
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) CD20 antibody (Allophycocyanin-CY7) |
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| 61R-CD20bHUAPC7 | Fitzgerald | 100 tests | EUR 446 |
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Description: Mouse monoclonal CD20 antibody (Allophycocyanin-CY7) |
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) CD20 antibody (PE-CY7) |
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| 61R-CD20bHUPEC7 | Fitzgerald | 100 tests | EUR 446 |
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Description: Mouse monoclonal CD20 antibody (PE-CY7) |
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) CD23 antibody (PE-CY7) |
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| 61R-CD23cMSPEC7 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rat monoclonal CD23 antibody (PE-CY7) |
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) CD25 antibody (PE-CY7) |
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| 61R-CD25cMSPEC7 | Fitzgerald | 100 ug | EUR 300 |
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Description: Rat monoclonal CD25 antibody (PE-CY7) |
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CD25 antibody (PE-CY7) |
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| 61R-CD25dMSPEC7 | Fitzgerald | 100 ug | EUR 370 |
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Description: Rat monoclonal CD25 antibody (PE-CY7) |
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) CD31 antibody (PE-CY7) |
|||
| 61R-CD31jMSPEC7 | Fitzgerald | 100 ug | EUR 300 |
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Description: Rat monoclonal CD31 antibody (PE-CY7) |
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) CD3 antibody (Allophycocyanin-CY7) |
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| 61R-CD3gHUAPCC7 | Fitzgerald | 100 tests | EUR 446 |
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Description: Mouse monoclonal CD3 antibody (Allophycocyanin-CY7) |
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) CD3 antibody (PE-CY7) |
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| 61R-CD3gHUPEC7 | Fitzgerald | 100 tests | EUR 446 |
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Description: Mouse monoclonal CD3 antibody (PE-CY7) |
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) CD44 antibody (PE-CY7) |
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| 61R-CD44hHUPEC7 | Fitzgerald | 100 tests | EUR 446 |
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Description: Mouse monoclonal CD44 antibody (PE-CY7) |
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) CD45.1 antibody (Allophycocyanin-CY7) |
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| 61R-CD45gMSAPC7 | Fitzgerald | 100 ug | EUR 381 |
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Description: Mouse monoclonal CD45.1 antibody (Allophycocyanin-CY7) |
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) CD45.1 antibody (PE-CY7) |
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| 61R-CD45gMSPEC7 | Fitzgerald | 100 ug | EUR 300 |
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Description: Mouse monoclonal CD45.1 antibody (PE-CY7) |
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) CD45.2 antibody (PE-CY7) |
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| 61R-CD45hMSAPC7 | Fitzgerald | 100 ug | EUR 316 |
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Description: Mouse monoclonal CD45.2 antibody (PE-CY7) |
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) CD45R antibody (PE-CY7) |
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| 61R-CD45RcMSPE7 | Fitzgerald | 100 ug | EUR 300 |
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Description: Rat monoclonal CD45R antibody (PE-CY7) |
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) CD49b antibody (Allophycocyanin-CY7) |
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| 61R-CD49cMSAPC7 | Fitzgerald | 100 ug | EUR 435 |
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Description: Rat monoclonal CD49b antibody (Allophycocyanin-CY7) |
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) CD4 antibody (PE-CY7) |
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| 61R-CD4eMSPEC7 | Fitzgerald | 100 ug | EUR 300 |
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Description: Rat monoclonal CD4 antibody (PE-CY7) |
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) CD4 antibody (Allophycocyanin-CY7) |
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| 61R-CD4kHUAPCC7 | Fitzgerald | 100 tests | EUR 457 |
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Description: Mouse monoclonal CD4 antibody (Allophycocyanin-CY7) |
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CD4 antibody (PE-CY7) |
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| 61R-CD4kHUPEC7 | Fitzgerald | 100 tests | EUR 446 |
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Description: Mouse monoclonal CD4 antibody (PE-CY7) |
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) CD62L antibody (Allophycocyanin-CY7) |
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| 61R-CD62dMSAPC7 | Fitzgerald | 100 ug | EUR 381 |
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Description: Rat monoclonal CD62L antibody (Allophycocyanin-CY7) |
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) CD62L antibody (PE-CY7) |
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| 61R-CD62dMSPEC7 | Fitzgerald | 100 ug | EUR 300 |
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Description: Rat monoclonal CD62L antibody (PE-CY7) |
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) CD69 antibody (PE-CY7) |
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| 61R-CD69aMSPEC | Fitzgerald | 100 ug | EUR 300 |
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Description: Hamster monoclonal CD69 antibody (PE-CY7) |
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) CD86 antibody (PE-CY7) |
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| 61R-CD86bMSPEC7 | Fitzgerald | 100 ug | EUR 370 |
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Description: Rat monoclonal CD86 antibody (PE-CY7) |
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CD86 antibody (PE-CY7) |
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| 61R-CD86cMSPEC7 | Fitzgerald | 100 ug | EUR 403 |
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Description: Rat monoclonal CD86 antibody (PE-CY7) |
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) CD8a antibody (PE-CY7) |
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| 61R-CD8abMSPEC7 | Fitzgerald | 100 ug | EUR 300 |
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Description: Rat monoclonal CD8a antibody (PE-CY7) |
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 Cy7®-streptavidin conjugate |
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| 16914 | AAT Bioquest | 1 mg | EUR 176 |
 RPE-Cy7-streptavidin conjugate |
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| 16916 | AAT Bioquest | 100 ug | EUR 219 |
RPE-Cy7-streptavidin conjugate |
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| 16917 | AAT Bioquest | 1 mg | EUR 876 |
 Annexin V-Cy7 conjugate |
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| 20068 | AAT Bioquest | 100 Tests | EUR 219 |
 Anti-EGFR PE-Cy7 |
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| T7-680-T025 | ExBio | 25 tests | EUR 154 |
Anti-EGFR PE-Cy7 |
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| T7-680-T100 | ExBio | 100 tests | EUR 268 |
 Anti-Helios PE-Cy7 |
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| T7-771-T025 | ExBio | 25 tests | EUR 154 |
Anti-Helios PE-Cy7 |
|||
| T7-771-T100 | ExBio | 100 tests | EUR 268 |
 CY7-PEG-DSPE?2K |
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| FL080096-2K-50mg | Biochempeg | 50mg | EUR 494 |
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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) Cy7 azide (non-sulfonated) |
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| A8115-25 | ApexBio | 25 mg | EUR 1616 |
|
Description: Cy7 azide is a labeling reagent that ready for the use in Click Chemistry labeling. This labeling dye is a near-infrared dye which has low aqueous solubility. |
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Cy7 azide (non-sulfonated) |
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| A8115-5 | ApexBio | 5 mg | EUR 583 |
|
Description: Cy7 azide is a labeling reagent that ready for the use in Click Chemistry labeling. This labeling dye is a near-infrared dye which has low aqueous solubility. |
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) Cy7 maleimide (non-sulfonated) |
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| A8141-25 | ApexBio | 25 mg | EUR 525 |
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Description: Cy7 maleimide is a near-infrared, sulfhydryl reactive dye which has low aqueous solubility. This reagent can label the proteins contain free sulfhydryl groups. |
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Cy7 maleimide (non-sulfonated) |
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| A8141-5 | ApexBio | 5 mg | EUR 293 |
|
Description: Cy7 maleimide is a near-infrared, sulfhydryl reactive dye which has low aqueous solubility. This reagent can label the proteins contain free sulfhydryl groups. |
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 Streptavidin-PE-Cy7 conjugate |
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| SV-PEC7-100 | Alpha Diagnostics | 100 tests | EUR 286 |
 Anti-Hu CD45 APC-Cy7 |
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| T4-160-T100 | ExBio | 100 tests | EUR 268 |
 Anti-Hu CD49d APC-Cy7 |
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| T4-171-T100 | ExBio | 100 tests | EUR 268 |
 Anti-Hu CD3 APC-Cy7 |
|||
| T4-173-T025 | ExBio | 25 tests | EUR 154 |
Anti-Hu CD3 APC-Cy7 |
|||
| T4-173-T100 | ExBio | 100 tests | EUR 268 |
 Anti-Hu CD8 APC-Cy7 |
|||
| T4-207-T025 | ExBio | 25 tests | EUR 154 |
Anti-Hu CD8 APC-Cy7 |
|||
| T4-207-T100 | ExBio | 100 tests | EUR 268 |
 Anti-Hu CD9 APC-Cy7 |
|||
| T4-208-T025 | ExBio | 25 tests | EUR 154 |
Anti-Hu CD9 APC-Cy7 |
|||
| T4-208-T100 | ExBio | 100 tests | EUR 268 |
 Anti-Hu CD10 APC-Cy7 |
|||
| T4-209-T025 | ExBio | 25 tests | EUR 154 |
Anti-Hu CD10 APC-Cy7 |
|||
| T4-209-T100 | ExBio | 100 tests | EUR 268 |
 Anti-Hu CD25 APC-Cy7 |
|||
| T4-218-T100 | ExBio | 100 tests | EUR 268 |
 Anti-Hu CD43 APC-Cy7 |
|||
| T4-220-T025 | ExBio | 25 tests | EUR 154 |
Anti-Hu CD43 APC-Cy7 |
|||
| T4-220-T100 | ExBio | 100 tests | EUR 268 |
Anti-Hu CD45 APC-Cy7 |
|||
| T4-222-T025 | ExBio | 25 tests | EUR 154 |
Anti-Hu CD45 APC-Cy7 |
|||
| T4-222-T100 | ExBio | 100 tests | EUR 268 |
 Anti-Hu CD71 APC-Cy7 |
|||
| T4-235-T025 | ExBio | 25 tests | EUR 154 |
Anti-Hu CD71 APC-Cy7 |
|||
| T4-235-T100 | ExBio | 100 tests | EUR 268 |
 Anti-Hu CD14 APC-Cy7 |
|||
| T4-293-T025 | ExBio | 25 tests | EUR 154 |
Anti-Hu CD14 APC-Cy7 |
|||
| T4-293-T100 | ExBio | 100 tests | EUR 268 |
 Anti-Hu CD19 APC-Cy7 |
|||
| T4-305-T025 | ExBio | 25 tests | EUR 154 |
Anti-Hu CD19 APC-Cy7 |
|||
| T4-305-T100 | ExBio | 100 tests | EUR 268 |
 Anti-Hu CD27 APC-Cy7 |
|||
| T4-308-T100 | ExBio | 100 tests | EUR 268 |
PDGFR-induced autocrine SDF-1 signaling in most cancers cells promotes metastasis in superior pores and skin carcinoma.
Superior and undifferentiated pores and skin squamous cell carcinomas (SCCs) exhibit aggressive development and enhanced metastasis functionality, which is related in mice with an growth of the most cancers stem-like cell (CSC) inhabitants and with adjustments within the regulatory mechanisms that management the proliferation and invasion of those cells. Certainly, autocrine activation of PDGFRα induces CSC invasion and promotes distant metastasis in superior SCCs. Nevertheless, the mechanisms concerned on this course of have been unclear.
Right here, we present that CSCs of mouse superior SCCs (L-CSCs) specific CXCR4 and CXCR7, each receptors of SDF-1. PDGFRα signaling induces SDF-1 expression and secretion, and the autocrine activation of this pathway in L-CSCs.
Autocrine SDF-1/CXCR4 signaling induces L-CSC proliferation and survival, and mediates PDGFRα-induced invasion, selling in vivo lung metastasis. Validation of those findings in affected person samples of pores and skin SCCs exhibits a powerful correlation between the expression of SDF1, PDGFRA, and PDGFRB, which is upregulated, alongside CXCR4 in tumor cells of superior SCCs.
Moreover, PDGFR regulates SDF-1 expression and inhibition of SDF-1/CXCR4 and PDGFR pathways blocks distant metastasis of human PD/S-SCCs. Our outcomes point out that purposeful crosstalk between PDGFR/SDF-1 signaling regulates tumor cell invasion and metastasis in human and mouse superior SCCs, and recommend that CXCR4 and/or PDGFR inhibitors might be used to dam metastasis of those aggressive tumors.
Corrigendum Antiproliferative results of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell strains by way of PDGFR‑β, PDGF‑BB, c‑Package and SCF expression.
- An reader drew to our consideration that the above research appeared to comprise a excessive stage of overlap with an article by the identical authors revealed within the journal Drug Design, Improvement and Remedy [Kadivar A, Kamalidehghan B, Akbari Javar H, Karimi B, Sedghi R and Noordin MI: Antiproliferation effect of imatinib mesylate on MCF7, T‑47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF genes. Drug Des Devel Ther 11: 469‑481, 2017].
- Following an inside investigation and likewise in liaison with the authors, it was established that, though the research have been performed alongside broadly comparable strains, the papers contained fully totally different knowledge involving two totally different subsets of cell strains; the submission to Drug Des Devel Ther aimed to discover the results of imatinib mesylate on three totally different teams, with every group being represented by a cell line, whereas the submission to Int J Mol Med explored the effectiveness of imatinib mesylate in breast most cancers cell strains.
- Regardless of this, contemplating the relatedness of the articles and the truth that the paper to Drug Des Devel Ther was submitted first and revealed whereas the Int J Mol Med paper was passing by the peer‑evaluation course of, the authors concede that they need to have correctly referenced their paper submitted to Drug Des Devel Ther within the Int J Mol Med paper.
- Notice that the publishers of Drug Des Devel Ther, with whom we have been liaising, agreed with the choice to concern a Corrigendum for this paper that acknowledges the article revealed in Drug Des Devel Ther.
- The authors remorse their failure to acknowledge the associated paper on this occasion, and apologize to the readership for this oversight. [the original article was published in International Journal of Molecular Medicine 14: 414‑424, 2018; DOI: 10.3892/ijmm.2018.3590].
 CY5-SE |
|||
| HY-D0819 | MedChemExpress | 25mg | EUR 463 |
 CY5-YNE |
|||
| HY-D0820 | MedChemExpress | 10mM/1mL | EUR 786 |
 CY5-N3 |
|||
| HY-D0832 | MedChemExpress | 5mg | EUR 533 |
 Cy5 azide |
|||
| A8128-25 | ApexBio | 25 mg | EUR 1732 |
|
Description: Sulfo-Cy5 azide is a sulfonated, hydrophilic and highly water soluble dye for Click chemistry. Due to this features, the dye can be used for labeling biomolecules, especially useful for the labeling of delicate proteins and proteins prone to denaturation, purely aqueous conditions. |
|||
Cy5 azide |
|||
| A8128-5 | ApexBio | 5 mg | EUR 618 |
|
Description: Sulfo-Cy5 azide is a sulfonated, hydrophilic and highly water soluble dye for Click chemistry. Due to this features, the dye can be used for labeling biomolecules, especially useful for the labeling of delicate proteins and proteins prone to denaturation, purely aqueous conditions. |
|||
 Mouse anti-Human CD3, PE-Cy5 Conjugated mAb |
|||
| 28006-50Tests | SAB | 50 Tests | EUR 253 |
 Mouse anti-Human CD4, PE-Cy5 Conjugated mAb |
|||
| 28013-50Tests | SAB | 50 Tests | EUR 253 |
 Mouse anti-Human CD8, PE-Cy5 Conjugated mAb |
|||
| 28028-50Tests | SAB | 50 Tests | EUR 253 |
 Mouse anti-Human CD14, PE-Cy5 Conjugated mAb |
|||
| 28053-50Tests | SAB | 50 Tests | EUR 252 |
 Mouse anti-Human CD19, PE-Cy5 Conjugated mAb |
|||
| 28074-50Tests | SAB | 50 Tests | EUR 252 |
 Mouse anti-Human CD45, PE-Cy5 Conjugated mAb |
|||
| 28144-50Tests | SAB | 50 Tests | EUR 253 |
) CD117 antibody (CY5) |
|||
| 61R-CD117bMSCY5 | Fitzgerald | 100 ug | EUR 413 |
|
Description: Rat monoclonal CD117 antibody (CY5) |
|||
) CD11b antibody (CY5) |
|||
| 61R-CD11baMSCY5 | Fitzgerald | 100 ug | EUR 413 |
|
Description: Rat monoclonal CD11b antibody (CY5) |
|||
) CD19 antibody (CY5) |
|||
| 61R-CD19aMSCY5 | Fitzgerald | 100 ug | EUR 435 |
|
Description: Rat monoclonal CD19 antibody (CY5) |
|||
CD19 antibody (CY5) |
|||
| 61R-CD19cHUCY5 | Fitzgerald | 100 tests | EUR 435 |
|
Description: Mouse monoclonal CD19 antibody (CY5) |
|||
) CD3e antibody (CY5) |
|||
| 61R-CD3egMSCY | Fitzgerald | 100 ug | EUR 284 |
|
Description: Hamster monoclonal CD3e antibody (CY5) |
|||
CD3e antibody (CY5) |
|||
| 61R-CD3ehMSCY | Fitzgerald | 100 ug | EUR 284 |
|
Description: Rat monoclonal CD3e antibody (CY5) |
|||
) CD3 antibody (CY5) |
|||
| 61R-CD3gHUCY5 | Fitzgerald | 100 tests | EUR 446 |
|
Description: Mouse monoclonal CD3 antibody (CY5) |
|||
) CD45.1 antibody (CY5) |
|||
| 61R-CD45gMSCY5 | Fitzgerald | 100 ug | EUR 457 |
|
Description: Mouse monoclonal CD45.1 antibody (CY5) |
|||
) CD45.2 antibody (CY5) |
|||
| 61R-CD45hMSCY5 | Fitzgerald | 100 ug | EUR 381 |
|
Description: Mouse monoclonal CD45.2 antibody (CY5) |
|||
) CD45R antibody (CY5) |
|||
| 61R-CD45RcMSCY5 | Fitzgerald | 100 ug | EUR 413 |
|
Description: Rat monoclonal CD45R antibody (CY5) |
|||
) CD4 antibody (CY5) |
|||
| 61R-CD4eMSCY | Fitzgerald | 100 ug | EUR 403 |
|
Description: Rat monoclonal CD4 antibody (CY5) |
|||
CD4 antibody (CY5) |
|||
| 61R-CD4kHUCY5 | Fitzgerald | 100 tests | EUR 435 |
|
Description: Mouse monoclonal CD4 antibody (CY5) |
|||
) CD8a antibody (CY5) |
|||
| 61R-CD8abMSCY5 | Fitzgerald | 100 ug | EUR 413 |
|
Description: Rat monoclonal CD8a antibody (CY5) |
|||
CD8a antibody (CY5) |
|||
| 61R-CD8adCKCY5 | Fitzgerald | 100 ug | EUR 543 |
|
Description: Mouse monoclonal CD8a antibody (CY5) |
|||
CD8a antibody (CY5) |
|||
| 61R-CD8aeCKCY5 | Fitzgerald | 100 ug | EUR 457 |
|
Description: Mouse monoclonal CD8a antibody (CY5) |
|||
 Azido-Cy5 tyramide |
|||
| 11061 | AAT Bioquest | 1 mg | EUR 306 |
 PE-Cy5 Tandem |
|||
| 2610 | AAT Bioquest | 1 mg | EUR 219 |
 Cy5-PEG-SH |
|||
| abx085228-1kDa50mg | Abbexa | 1 kDa; 50 mg | EUR 871 |
Cy5-PEG-SH |
|||
| abx085228-2kDa50mg | Abbexa | 2 kDa; 50 mg | EUR 913 |
Cy5-PEG-SH |
|||
| abx085228-34kDa50mg | Abbexa | 3.4 kDa; 50 mg | EUR 940 |
Cy5-PEG-SH |
|||
| abx085228-5kDa50mg | Abbexa | 5 kDa; 50 mg | EUR 940 |
 Cy5-PEG-COOH |
|||
| abx085357-10kDa50mg | Abbexa | 10 kDa; 50 mg | EUR 499 |
Cy5-PEG-COOH |
|||
| abx085357-20kDa50mg | Abbexa | 20 kDa; 50 mg | EUR 499 |
Cy5-PEG-COOH |
|||
| abx085357-2kDa50mg | Abbexa | 2 kDa; 50 mg | EUR 535 |
Cy5-PEG-COOH |
|||
| abx085357-5kDa50mg | Abbexa | 5 kDa; 50 mg | EUR 535 |
 Cy5-PEG-Mal |
|||
| abx085358-10kDa50mg | Abbexa | 10 kDa; 50 mg | EUR 546 |
Cy5-PEG-Mal |
|||
| abx085358-1kDa50mg | Abbexa | 1 kDa; 50 mg | EUR 546 |
Cy5-PEG-Mal |
|||
| abx085358-2kDa50mg | Abbexa | 2 kDa; 50 mg | EUR 570 |
 Glucagon-Cy5 Peptide |
|||
| abx267068-1mg | Abbexa | 1 mg | EUR 2068 |
 Cy5 NHS ester |
|||
| A8108-25 | ApexBio | 25 mg | EUR 746 |
|
Description: Sulfo-Cy5 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. For the labeling of various amine-containing molecules in aqueous phase, no organic co-solvent is needed. |
|||
Cy5 NHS ester |
|||
| A8108-5 | ApexBio | 5 mg | EUR 293 |
|
Description: Sulfo-Cy5 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. For the labeling of various amine-containing molecules in aqueous phase, no organic co-solvent is needed. |
|||
 Cy5 carboxylic acid |
|||
| A8137-25 | ApexBio | 25 mg | EUR 1036 |
|
Description: Sulfo-Cy5 carboxylic acid is a non-activated, sulfonated, hydrophilic and highly water soluble dye. Non-Sulfo-Cy5 carboxylic acid analog is available. For kinds of researches related experiments, using pre-activated sulfo-Cy5 NHS ester is preferred |
|||
Cy5 carboxylic acid |
|||
| A8137-5 | ApexBio | 5 mg | EUR 525 |
|
Description: Sulfo-Cy5 carboxylic acid is a non-activated, sulfonated, hydrophilic and highly water soluble dye. Non-Sulfo-Cy5 carboxylic acid analog is available. For kinds of researches related experiments, using pre-activated sulfo-Cy5 NHS ester is preferred |
|||
 Annexin V-Cy5 Reagent |
|||
| 1013-1000 | Biovision | EUR 1132 | |
Annexin V-Cy5 Reagent |
|||
| 1013-200 | Biovision | EUR 403 | |
 Cy5®-streptavidin conjugate |
|||
| 16913 | AAT Bioquest | 1 mg | EUR 176 |
 Annexin V-Cy5 conjugate |
|||
| 20066 | AAT Bioquest | 100 Tests | EUR 219 |
-OH) FMOC-Lys(Cy5)-OH |
|||
| 5055 | AAT Bioquest | 100 mg | EUR 654 |
) CD45RO Antibody (PE-Cy5) |
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| abx134008-100Assays | Abbexa | 100 Assays | EUR 495 |
CD45RO Antibody (PE-Cy5) |
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| abx134008-50Assays | Abbexa | 50 Assays | EUR 398 |
 Streptavidin: RPE-Cy5 Conjugate |
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| R-1099 | EpiGentek | 0.2 ml | Ask for price |
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Description: fast delivery possible |
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 Cy5-PEG-SH,10K |
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| FL078003-10K-50mg | Biochempeg | 50mg | EUR 544 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-SH,1K |
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| FL078003-1K-50mg | Biochempeg | 50mg | EUR 605 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-SH,2K |
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| FL078003-2K-50mg | Biochempeg | 50mg | EUR 568 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-SH,3.4K |
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| FL078003-3.4K-50mg | Biochempeg | 50mg | EUR 544 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-SH,5K |
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| FL078003-5K-50mg | Biochempeg | 50mg | EUR 544 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-COOH,10K |
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| FL078017-10K-50mg | Biochempeg | 50mg | EUR 470 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-COOH,1K |
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| FL078017-1K-50mg | Biochempeg | 50mg | EUR 470 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-COOH,20K |
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| FL078017-20K-50mg | Biochempeg | 50mg | EUR 470 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-COOH,2K |
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| FL078017-2K-50mg | Biochempeg | 50mg | EUR 470 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-COOH,3.4K |
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| FL078017-3.4K-50mg | Biochempeg | 50mg | EUR 470 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-COOH,5K |
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| FL078017-5K-50mg | Biochempeg | 50mg | EUR 470 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-Mal,10K |
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| FL078022-10K-50mg | Biochempeg | 50mg | EUR 470 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-Mal,1K |
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| FL078022-1K-50mg | Biochempeg | 50mg | EUR 470 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-Mal,20K |
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| FL078022-20K-50mg | Biochempeg | 50mg | EUR 470 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-Mal,2K |
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| FL078022-2K-50mg | Biochempeg | 50mg | EUR 470 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-Mal,3.4K |
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| FL078022-3.4K-50mg | Biochempeg | 50mg | EUR 470 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 Cy5-PEG-Mal,5K |
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| FL078022-5K-50mg | Biochempeg | 50mg | EUR 470 |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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 PE-Cy5 Calibration Kit |
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| ECFP-F4-5K | Spherotech | 5X1 mL | EUR 310 |
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Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. |
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) Cy5 azide (non-sulfonated) |
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| A8113-25 | ApexBio | 25 mg | EUR 1616 |
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Description: Cy5 azide is a labeling reagent ready for the use in Click Chemistry reaction which available as 10 mM solution in DMSO. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. |
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Cy5 azide (non-sulfonated) |
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| A8113-5 | ApexBio | 5 mg | EUR 583 |
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Description: Cy5 azide is a labeling reagent ready for the use in Click Chemistry reaction which available as 10 mM solution in DMSO. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. |
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) Cy5 alkyne (non-sulfonated) |
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| A8131-25 | ApexBio | 25 mg | EUR 1616 |
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Description: Cy5 alkyne, with low aqueous solubility is a dye ready for the use in Click Chemistry reaction. Various molecules via Click Chemistry reaction can be attached by this deeply colored, and photostable Cy5 fluorophore. |
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Cy5 alkyne (non-sulfonated) |
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| A8131-5 | ApexBio | 5 mg | EUR 583 |
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Description: Cy5 alkyne, with low aqueous solubility is a dye ready for the use in Click Chemistry reaction. Various molecules via Click Chemistry reaction can be attached by this deeply colored, and photostable Cy5 fluorophore. |
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) Cy5 maleimide (non-sulfonated) |
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| A8139-25 | ApexBio | 25 mg | EUR 525 |
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Description: Cy5 maleimide is a mono-reactive dye for selectively labeling peptides and proteins which couples with thiol groups. |
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Cy5 maleimide (non-sulfonated) |
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| A8139-5 | ApexBio | 5 mg | EUR 293 |
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Description: Cy5 maleimide is a mono-reactive dye for selectively labeling peptides and proteins which couples with thiol groups. |
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) Cy5 amine (non-sulfonated) |
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| A8143-25 | ApexBio | 25 mg | EUR 525 |
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Description: Cy5 amine is a reactive dye which contains amino group. This dye can be coupled with a variety of activated esters and other electrophilic reagents. |
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Cy5 amine (non-sulfonated) |
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| A8143-5 | ApexBio | 5 mg | EUR 293 |
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Description: Cy5 amine is a reactive dye which contains amino group. This dye can be coupled with a variety of activated esters and other electrophilic reagents. |
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) Cy5 hydrazide (non-sulfonated) |
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| A8145-25 | ApexBio | 25 mg | EUR 525 |
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Description: Cy5 hydrazide is a reactive dye which reacts smoothly and nearly quantitatively with various carbonyl groups encountered in biomolecules. The labeling regent is used for the labeling of aldehydes and ketones. |
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Cy5 hydrazide (non-sulfonated) |
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| A8145-5 | ApexBio | 5 mg | EUR 293 |
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Description: Cy5 hydrazide is a reactive dye which reacts smoothly and nearly quantitatively with various carbonyl groups encountered in biomolecules. The labeling regent is used for the labeling of aldehydes and ketones. |
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) Cy5 NHS ester(Et) |
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| A8769-25 | ApexBio | 25 mg | EUR 525 |
Cy5 NHS ester(Et) |
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| A8769-5 | ApexBio | 5 mg | EUR 293 |
 Cy5 Bis NHS ester |
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| A8773-25 | ApexBio | 25 mg | EUR 525 |
