Autophagy induction and PDGFR-β knockdown by siRNA-encapsulated nanoparticles cut back chlamydia trachomatis an infection.
C. trachomatis is the commonest sexually transmitted bacterial an infection on this planet. Though the an infection could be simply managed by means of antibiotics, a number of experiences of scientific isolates which can be proof against antibiotics have prompted us to seek for different methods to handle this illness.
On this paper, we developed a nanoparticle formulation (PDGFR-β siRNA-PEI-PLGA-PEG NP) that may concurrently induce autophagy in human cells and knock down PDGFR-β gene expression, an necessary floor binding protein for C. trachomatis, as a technique to cut back vaginal an infection of C. trachomatis.
PDGFR-β siRNA-PEI-PLGA-PEG NP considerably induced autophagy in human vaginal epithelial cells (VK2/E6E7) 48 hr publish remedy by bettering autophagic degradation exercise with out inflicting irritation, apoptosis or any lower in cell viability. Beclin-1, VPS34 (markers for initiation stage of autophagy), UVRAG, TECPR-1 (markers for degradation stage of autophagy) had been discovered to be considerably upregulated after remedy with PDGFR-β siRNA-PEI-PLGA-PEG NP.

PDGF-BB, Human |
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HY-P7055 | MedChemExpress | 10ug | EUR 321.6 |
PDGF-BB, human |
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RC216-21 | Bio Basic | 2ug | EUR 125.26 |
PDGF-BB/ Rat PDGF- BB ELISA Kit |
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ELA-E0633r | Lifescience Market | 96 Tests | EUR 1063.2 |
PDGF-BB, human recombinant protein |
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P1047-.01 | ApexBio | 10 µg | EUR 375.6 |
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
PDGF-BB, human recombinant protein |
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P1047-.05 | ApexBio | 50 µg | EUR 1052.4 |
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
PDGF-BB, human recombinant protein |
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P1047-1 | ApexBio | 1 mg | EUR 7826.4 |
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
Recombinant Human PDGF-BB Protein |
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PROTP01127-4 | BosterBio | 10ug | EUR 380.4 |
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
Recombinant Human PDGF-BB Protein |
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RP00834 | Abclonal | 10 μg | EUR 265.2 |
PDGF-BB Recombinant Protein |
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40-158-0002mg | ProSci | 0.002 mg | EUR 311.1 |
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
PDGF-BB Recombinant Protein |
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40-158-001mg | ProSci | 0.01 mg | EUR 437.1 |
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
PDGF-BB Recombinant Protein |
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40-607 | ProSci | 0.01 mg | EUR 481.2 |
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet a-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-a and PDGFR-β. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). . |
PDGF-BB Recombinant Protein |
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40-458-0002mg | ProSci | 0.002 mg | EUR 311.1 |
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
PDGF-BB Recombinant Protein |
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40-458-001mg | ProSci | 0.01 mg | EUR 437.1 |
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
PDGF-BB Recombinant Protein |
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11-380 | ProSci | 0.05 mg | EUR 714.3 |
Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. |
PDGF-BB Recombinant Protein |
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91-179 | ProSci | 0.05 mg | EUR 821.4 |
Description: Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. |
PDGF-BB, murine recombinant |
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4489-10 | Biovision | each | EUR 320.4 |
PDGF-BB, murine recombinant |
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4489-1000 | Biovision | each | EUR 6434.4 |
PDGF-BB, murine recombinant |
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4489-50 | Biovision | each | EUR 874.8 |
Human PDGF-BB Protein |
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abx060208-100ug | Abbexa | 100 ug | EUR 627.6 |
Human PDGF-BB Protein |
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abx060258-100ug | Abbexa | 100 ug | EUR 627.6 |
rec PDGF BB (human) |
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H-7530.0002 | Bachem | 2.0µg | EUR 194.4 |
rec PDGF BB (human) |
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H-7530.0010 | Bachem | 10.0µg | EUR 457.2 |
PDGF BB protein |
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30R-2611 | Fitzgerald | 10 ug | EUR 430.8 |
Description: Purified recombinant Human PDGF BB protein |
PDGF BB protein |
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30R-2612 | Fitzgerald | 10 ug | EUR 362.4 |
Description: Purified recombinant Mouse PDGF BB protein |
PDGF BB protein |
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30R-AP004 | Fitzgerald | 2 ug | EUR 159.6 |
Description: Purified recombinant Human PDGF BB protein |
PDGF BB protein |
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30R-AP051 | Fitzgerald | 10 ug | EUR 327.6 |
Description: Purified recombinant Human PDGF BB protein |
PDGF BB antibody |
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70R-PR020 | Fitzgerald | 50 ug | EUR 327.6 |
Description: Affinity purified Rabbit polyclonal PDGF BB antibody |
rHu PDGF-BB |
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AK8292-0002 | Akron Biotech | 2µg | Ask for price |
rHu PDGF-BB |
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AK8292-0010 | Akron Biotech | 10µg | Ask for price |
rHu PDGF-BB |
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AK8292-0100 | Akron Biotech | 100µg | Ask for price |
rHu PDGF-BB |
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AK8292-1000 | Akron Biotech | 1mg | Ask for price |
PDGF-BB, Mouse |
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HY-P7087 | MedChemExpress | 100ug | EUR 1135.2 |
PDGF-BB, Rat |
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HY-P7278 | MedChemExpress | 50ug | EUR 459.6 |
PDGF-BB, CF |
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PR15026CF | Neuromics | 50 ug | EUR 1304.4 |
PDGF-BB, CF |
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PR15027CF | Neuromics | 50 ug | EUR 475.2 |
anti-PDGF BB |
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YF-PA24331 | Abfrontier | 50 ul | EUR 400.8 |
Description: Mouse polyclonal to PDGF BB |
anti-PDGF BB |
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YF-PA13686 | Abfrontier | 50 ug | EUR 435.6 |
Description: Mouse polyclonal to PDGF BB |
PDGF-BB Antibody |
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5488-200 | Biovision | each | EUR 379.2 |
PDGF-BB Antibody |
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5488-30T | Biovision | each | EUR 175.2 |
PDGF-BB Antibody |
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5489-100 | Biovision | each | EUR 379.2 |
PDGF-BB Antibody |
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5489-30T | Biovision | each | EUR 175.2 |
Genorise® Recombinant Human PDGF-BB |
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GR104258 | Genorise Scientific | 5 µg | EUR 342 |
PDGF-BB, murine recombinant protein |
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P1048-.01 | ApexBio | 10 µg | EUR 375.6 |
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
PDGF-BB, murine recombinant protein |
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P1048-.05 | ApexBio | 50 µg | EUR 1052.4 |
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
PDGF-BB, murine recombinant protein |
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P1048-1 | ApexBio | 1 mg | EUR 7826.4 |
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
Recombinant Murine PDGF-BB Protein |
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PROTP31240-1 | BosterBio | 10ug | EUR 380.4 |
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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C199-10ug | Novoprotein | 10ug | EUR 242.4 |
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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C199-1mg | Novoprotein | 1mg | EUR 2739.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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C199-500ug | Novoprotein | 500ug | EUR 1935.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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C199-50ug | Novoprotein | 50ug | EUR 595.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
Human CellExp™ PDGF-BB, human recombinant |
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7276-10 | Biovision | each | Ask for price |
Human PDGF-BB ELISA Kit |
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EHP0050 | Abclonal | 96Tests | EUR 625.2 |
Human PDGF-BB ELISA Kit |
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EHP0634 | Abclonal | 96Tests | EUR 625.2 |
PDGF-BB ELISA KIT|Human |
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EF000205 | Lifescience Market | 96 Tests | EUR 826.8 |
PDGF-BB (P.pastoris-expressed), Human |
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HY-P7055A | MedChemExpress | 10ug | EUR 321.6 |
Human PDGF-BB ELISA Kit |
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RK04112 | Abclonal | 96 Tests | EUR 625.2 |
Recombinant Human Platelet Derived Growth Factor-BB (rHu PDGF-BB) |
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AK8274-0100 | Akron Biotech | 100µg | EUR 1740 |
Recombinant Human Platelet Derived Growth Factor-BB (rHu PDGF-BB) |
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AK8274-1000 | Akron Biotech | 1mg | EUR 4500 |
PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein |
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PROTP01127-2 | BosterBio | Regular: 10ug | EUR 380.4 |
Description: Platelet-Derived Growth Factor BB Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.3 kDa. PDGF-BB is purified by proprietary chromatographic techniques. |
Polyclonal PDGF-BB Antibody |
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APR00412G | Leading Biology | 0.1mg | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications: |
Polyclonal PDGF-BB Antibody |
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APR08990G | Leading Biology | 0.1mg | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications: |
Genorise® Recombinant Porcine PDGF-BB |
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GR104253 | Genorise Scientific | 5 µg | EUR 342 |
Genorise® Recombinant Equine PDGF-BB |
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GR104254 | Genorise Scientific | 5 µg | EUR 342 |
Genorise® Recombinant Canine PDGF-BB |
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GR104255 | Genorise Scientific | 5 µg | EUR 342 |
Genorise® Recombinant Bovine PDGF-BB |
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GR104256 | Genorise Scientific | 5 µg | EUR 342 |
Genorise® Recombinant Sheep PDGF-BB |
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GR104257 | Genorise Scientific | 5 µg | EUR 342 |
Genorise® Recombinant Mouse PDGF-BB |
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GR104259 | Genorise Scientific | 5 µg | EUR 342 |
Genorise® Recombinant Rat PDGF-BB |
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GR104260 | Genorise Scientific | 5 µg | EUR 342 |
Genorise® Recombinant Rabbit PDGF-BB |
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GR104261 | Genorise Scientific | 5 µg | EUR 342 |
Genorise® Recombinant Chicken PDGF-BB |
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GR104262 | Genorise Scientific | 5 µg | EUR 342 |
Genorise® Recombinant Monkey PDGF-BB |
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GR175014 | Genorise Scientific | 5 mg | EUR 342 |
Genorise® Recombinant Donkey PDGF-BB |
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GR176014 | Genorise Scientific | 5 mg | EUR 342 |
PDGF-BB Platelet Derived Growth Factor-BB Human Recombinant Protein, HEK |
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PROTP01127-3 | BosterBio | Regular: 10ug | EUR 380.4 |
Description: PDGF-BB Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight of 25kDa due to glycosylation.;The PDGF-BB is purified by proprietary chromatographic techniques. |
Human PDGF-BB PicoKine ELISA Kit |
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EK0956 | BosterBio | 96 wells | EUR 510 |
Description: For quantitative detection of human PDGF-BB in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
Nori Human PDGF-BB ELISA Kit |
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GR111035 | Genorise Scientific | 96-well | EUR 553.2 |
PDGF-BB Platelet-Derived Growth Factor BB Mouse Recombinant Protein |
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PROTP31240 | BosterBio | Regular: 10ug | EUR 380.4 |
Description: Platelet-Derived Growth Factor BB Mouse Recombinant produced in E.coli, is a homodimeric, non-glycosylated, polypeptide chain containing 2x110 (total of 2 chains 220aa) amino acids and having a total molecular weight of 24.7 kDa.;PDGF-BB is purified by proprietary chromatographic techniques. |
PDGF-BB Platelet-Derived Growth Factor BB Rat Recombinant Protein |
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PROTQ05028 | BosterBio | Regular: 10ug | EUR 380.4 |
Description: PDGF-BB Rat Recombinant produced in E.coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide of two B chains containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.4 kDa.;The PDGF-BB is purified by proprietary chromatographic techniques. |
Porcine PDGF-BB ELISA Kit |
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EPP0050 | Abclonal | 96Tests | EUR 625.2 |
Porcine PDGF-BB ELISA Kit |
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EPP0634 | Abclonal | 96Tests | EUR 625.2 |
Rabbit PDGF-BB ELISA Kit |
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ERTP0050 | Abclonal | 96Tests | EUR 625.2 |
Rabbit PDGF-BB ELISA Kit |
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ERTP0634 | Abclonal | 96Tests | EUR 625.2 |
Rat PDGF-BB ELISA Kit |
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ERP0050 | Abclonal | 96Tests | EUR 625.2 |
Rat PDGF-BB ELISA Kit |
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ERP0634 | Abclonal | 96Tests | EUR 625.2 |
Goat PDGF-BB ELISA Kit |
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EGTP0050 | Abclonal | 96Tests | EUR 625.2 |
Recombinant Human PDGF-BB Protein |
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells.
The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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Moreover, PDGFR-β siRNA-PEI-PLGA-PEG NP decreased PDGFR-β mRNA expression by 50% and protein expression by 43% in VK2/E6E7 cells 48 hr publish remedy.
Remedy of cells with PDGFR-β siRNA-PEI-PLGA-PEG NP considerably decreased the intracellular C. trachomatis and extracellular launch of C. trachomatis by roughly 65% and 67%, respectively, in vitro via augmenting autophagic degradation pathways and lowering bacterial binding concurrently.
Deregulation of VEGFR-2 and PDGFR Expression and Microvascular Density in a Triple-Damaging Mannequin of Canine Malignant Mammary Tumors with Lymph Node or Lung Metastasis.
Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
Mouse Platelet Derived Growth Factor C (PDGFC) ELISA Kit |
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RD-PDGFC-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 566.4 |
Mouse Platelet Derived Growth Factor C (PDGFC) ELISA Kit |
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RD-PDGFC-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 783.6 |
Human Platelet Derived Growth Factor C (PDGFC) ELISA Kit |
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RDR-PDGFC-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 577.2 |
Human Platelet Derived Growth Factor C (PDGFC) ELISA Kit |
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RDR-PDGFC-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 798 |
Mouse Platelet Derived Growth Factor C (PDGFC) ELISA Kit |
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RDR-PDGFC-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 591.6 |
Mouse Platelet Derived Growth Factor C (PDGFC) ELISA Kit |
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RDR-PDGFC-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 819.6 |
PDGFC Antibody |
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37811-100ul | SAB | 100ul | EUR 302.4 |
PDGFC Antibody |
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DF16042 | Affbiotech | 100ul | EUR 420 |
PDGFC Antibody |
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1-CSB-PA108491 | Cusabio |
|
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Description: A polyclonal antibody against PDGFC. Recognizes PDGFC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200 |
PDGFC Antibody |
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1-CSB-PA146607 | Cusabio |
|
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Description: A polyclonal antibody against PDGFC. Recognizes PDGFC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200 |
PDGFC Antibody |
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1-CSB-PA243546 | Cusabio |
|
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Description: A polyclonal antibody against PDGFC. Recognizes PDGFC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000 |
PDGFC Antibody |
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F40106-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 165 |
PDGFC Antibody |
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F40106-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 379 |
PDGFC Conjugated Antibody |
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C37811 | SAB | 100ul | EUR 476.4 |
PDGFC siRNA |
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20-abx903903 | Abbexa |
|
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PDGFC siRNA |
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20-abx928112 | Abbexa |
|
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PDGFC siRNA |
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20-abx928113 | Abbexa |
|
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Polyclonal Goat anti-GST α-form |
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GST-ANTI-1 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST μ-form |
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GST-ANTI-2 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST p-form |
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GST-ANTI-3 | Detroit R&D | 50 uL | EUR 336 |
PDGFC Rabbit pAb |
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A15174-100ul | Abclonal | 100 ul | EUR 369.6 |
PDGFC Rabbit pAb |
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A15174-200ul | Abclonal | 200 ul | EUR 550.8 |
PDGFC Rabbit pAb |
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A15174-20ul | Abclonal | 20 ul | EUR 219.6 |
PDGFC Rabbit pAb |
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A15174-50ul | Abclonal | 50 ul | EUR 267.6 |
Human PDGFC shRNA Plasmid |
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20-abx961041 | Abbexa |
|
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Mouse PDGFC shRNA Plasmid |
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20-abx974532 | Abbexa |
|
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Rat PDGFC shRNA Plasmid |
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20-abx986548 | Abbexa |
|
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Porcine PDGFC ELISA Kit |
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EPP0081 | Abclonal | 96Tests | EUR 625.2 |
Rabbit PDGFC ELISA Kit |
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ERTP0081 | Abclonal | 96Tests | EUR 625.2 |
Rat PDGFC ELISA Kit |
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ERP0081 | Abclonal | 96Tests | EUR 625.2 |
Goat PDGFC ELISA Kit |
|||
EGTP0081 | Abclonal | 96Tests | EUR 625.2 |
Monkey PDGFC ELISA Kit |
|||
EMKP0081 | Abclonal | 96Tests | EUR 625.2 |
Mouse PDGFC ELISA Kit |
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EMP0081 | Abclonal | 96Tests | EUR 625.2 |
Human PDGFC ELISA Kit |
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EHP0081 | Abclonal | 96Tests | EUR 625.2 |
Bovine PDGFC ELISA Kit |
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EBP0081 | Abclonal | 96Tests | EUR 625.2 |
Chicken PDGFC ELISA Kit |
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ECKP0081 | Abclonal | 96Tests | EUR 625.2 |
Canine PDGFC ELISA Kit |
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ECP0081 | Abclonal | 96Tests | EUR 625.2 |
Anserini PDGFC ELISA Kit |
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EAP0081 | Abclonal | 96Tests | EUR 625.2 |
PDGFC ELISA KIT|Human |
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EF000342 | Lifescience Market | 96 Tests | EUR 826.8 |
Sheep PDGFC ELISA Kit |
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ESP0081 | Abclonal | 96Tests | EUR 625.2 |
Human PDGFC ELISA Kit |
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ELA-E0528h | Lifescience Market | 96 Tests | EUR 988.8 |
Platelet Derived Growth Factor C (PDGFC) Antibody |
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20-abx103486 | Abbexa |
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Platelet Derived Growth Factor C (PDGFC) Antibody |
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20-abx103487 | Abbexa |
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Platelet Derived Growth Factor C (PDGFC) Antibody |
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20-abx131438 | Abbexa |
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Platelet Derived Growth Factor C (PDGFC) Antibody |
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20-abx178044 | Abbexa |
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Platelet Derived Growth Factor C (PDGFC) Antibody |
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20-abx241696 | Abbexa |
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Platelet Derived Growth Factor C (PDGFC) Antibody |
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20-abx241697 | Abbexa |
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Platelet Derived Growth Factor C (PDGFC) Antibody |
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20-abx326887 | Abbexa |
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Platelet Derived Growth Factor C (PDGFC) Antibody |
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20-abx174096 | Abbexa |
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Platelet Derived Growth Factor C (PDGFC) Antibody |
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20-abx174097 | Abbexa |
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PDGFC Antibody / Platelet-derived growth factor C |
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RQ6785 | NSJ Bioreagents | 100ug | EUR 419 |
Description: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. |
PDGFC ELISA Kit (Mouse) (OKAN05945) |
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OKAN05945 | Aviva Systems Biology | 96 Wells | EUR 950.4 |
Description: Description of target: ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 12.1 pg/mL |
Pdgfc ELISA Kit (Mouse) (OKBB01268) |
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OKBB01268 | Aviva Systems Biology | 96 Wells | EUR 606 |
Description: Description of target: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. It is mapped to 3; 3 E3. Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml |
Pdgfc ELISA Kit (Rat) (OKBB01269) |
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OKBB01269 | Aviva Systems Biology | 96 Wells | EUR 606 |
Description: Description of target: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. It is mapped to 2q33-q34. Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation. ;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml |
PDGFC ELISA Kit (Mouse) (OKEH06376) |
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OKEH06376 | Aviva Systems Biology | 96 Wells | EUR 919.2 |
Description: Description of target: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.85 ng/mL |
PDGFC ELISA Kit (Human) (OKAN04684) |
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OKAN04684 | Aviva Systems Biology | 96 Wells | EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 43 pg/mL |
Pdgfc ORF Vector (Rat) (pORF) |
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ORF073284 | ABM | 1.0 ug DNA | EUR 607.2 |
PDGFC ORF Vector (Human) (pORF) |
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ORF027574 | ABM | 1.0 ug DNA | EUR 486 |
Pdgfc ORF Vector (Mouse) (pORF) |
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ORF053678 | ABM | 1.0 ug DNA | EUR 607.2 |
Guinea Pig PDGFC ELISA Kit |
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EGP0081 | Abclonal | 96Tests | EUR 625.2 |
PDGFC ELISA Kit (Human) (OKCD08309) |
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OKCD08309 | Aviva Systems Biology | 96 Wells | EUR 1170 |
Description: Description of target: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 43pg/mL |
PDGFC ELISA Kit (Rat) (OKCD08310) |
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OKCD08310 | Aviva Systems Biology | 96 Wells | EUR 1263.6 |
Description: Description of target: expressed in the embryonic spinal cord floor plate and ventricular zone, adult expression is localized to motoneurons in several regions of the brain.;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: < 0.128ng/mL |
PDGFC ELISA Kit (Mouse) (OKCD00764) |
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OKCD00764 | Aviva Systems Biology | 96 Wells | EUR 1028.4 |
Description: Description of target: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.8 Publications
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.6"PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor."_x005F_x005F_x000D_Li X., Ponten A., Aase K., Karlsson L., Abramsson A., Uutela M., Backstrom G., Hellstrom M., Bostrom H., Li H., Soriano P., Betsholtz C., Heldin C.H., Alitalo K., Ostman A., Eriksson U._x005F_x005F_x000D_Nat. Cell Biol. 2:302-309(2000) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, DEVELOPMENTAL STAGE.Ref.7"Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."_x005F_x005F_x000D_Gilbertson D.G., Duff M.E., West J.W., Kelly J.D., Sheppard P.O., Hofstrand P.D., Gao Z., Shoemaker K., Bukowski T.R., Moore M., Feldhaus A.L., Humes J.M., Palmer T.E., Hart C.E._x005F_x005F_x000D_J. Biol. Chem. 276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY.Ref.10"Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy."_x005F_x005F_x000D_Ponten A., Li X., Thoren P., Aase K., Sjoblom T., Ostman A., Eriksson U._x005F_x005F_x000D_Am. J. Pathol. 163:673-682(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.11"Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis."_x005F_x005F_x000D_Zhuo Y., Zhang J., Laboy M., Lasky J.A._x005F_x005F_x000D_Am. J. Physiol. 286:L182-L188(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION BY BLEOMYCIN.Ref.14"Tissue plasminogen activator is a potent activator of PDGF-CC."_x005F_x005F_x000D_Fredriksson L., Li H., Fieber C., Li X., Eriksson U._x005F_x005F_x000D_EMBO J. 23:3793-3802(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, ACTIVATION BY PROTEOLYTIC CLEAVAGE.Ref.15"A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling."_x005F_x005F_x000D_Ding H., Wu X., Bostrom H., Kim I., Wong N., Tsoi B., O'Rourke M., Koh G.Y., Soriano P., Betsholtz C., Hart T.C., Marazita M.L., Field L.L., Tam P.P., Nagy A._x005F_x005F_x000D_Nat. Genet. 36:1111-1116(2004) [PubMed] [Europe PMC] [Abstract]Cited for: DISRUPTION PHENOTYPE, FUNCTION.Ref.16"Linkage between elevated PDGF-C expression and myocardial fibrogenesis in coxsackievirus B3-induced chronic myocarditis."_x005F_x005F_x000D_Yang D., Qiu D._x005F_x005F_x000D_Eur. Heart J. 26:642-643(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION BY COXSACKIEVIRUS B3 INFECTION, DISEASE.Ref.22"PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis."_x005F_x005F_x000D_Eitner F., Bucher E., van Roeyen C., Kunter U., Rong S., Seikrit C., Villa L., Boor P., Fredriksson L., Backstrom G., Eriksson U., Ostman A., Floege J., Ostendorf T._x005F_x005F_x000D_J. Am. Soc. Nephrol. 19:281-289(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 12.1 pg/mL |
Platelet-derived growth factor C (PDGFC) polyclonal antibody |
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ABP-PAB-10942 | Allele Biotech | 100 ug | Ask for price |
Pdgfc sgRNA CRISPR Lentivector set (Rat) |
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K6990301 | ABM | 3 x 1.0 ug | EUR 406.8 |
PDGFC sgRNA CRISPR Lentivector set (Human) |
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K1620301 | ABM | 3 x 1.0 ug | EUR 406.8 |
Pdgfc sgRNA CRISPR Lentivector set (Mouse) |
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K4339001 | ABM | 3 x 1.0 ug | EUR 406.8 |
Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Human) |
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4-PAC920Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor C (PDGFC) |
Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse) |
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4-PAC920Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC) |
Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse) |
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4-PAC920Mu02 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC) |
PDGFC Chemi-Luminescent ELISA Kit (Rat) (OKCD03865) |
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OKCD03865 | Aviva Systems Biology | 96 Wells | EUR 1279.2 |
Description: Description of target: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function .;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.6 pg/L |
PDGFC Chemi-Luminescent ELISA Kit (Human) (OKCD03866) |
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OKCD03866 | Aviva Systems Biology | 96 Wells | EUR 1185.6 |
Description: Description of target: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.1;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.37 pg/mL |
PDGFC Chemi-Luminescent ELISA Kit (Mouse) (OKCD03867) |
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OKCD03867 | Aviva Systems Biology | 96 Wells | EUR 1232.4 |
Description: Description of target: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.6 pg/mL |
Pdgfc sgRNA CRISPR Lentivector (Rat) (Target 1) |
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K6990302 | ABM | 1.0 ug DNA | EUR 184.8 |
Pdgfc sgRNA CRISPR Lentivector (Rat) (Target 2) |
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K6990303 | ABM | 1.0 ug DNA | EUR 184.8 |
Pdgfc sgRNA CRISPR Lentivector (Rat) (Target 3) |
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K6990304 | ABM | 1.0 ug DNA | EUR 184.8 |
PDGFC sgRNA CRISPR Lentivector (Human) (Target 1) |
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K1620302 | ABM | 1.0 ug DNA | EUR 184.8 |
PDGFC sgRNA CRISPR Lentivector (Human) (Target 2) |
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K1620303 | ABM | 1.0 ug DNA | EUR 184.8 |
PDGFC sgRNA CRISPR Lentivector (Human) (Target 3) |
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K1620304 | ABM | 1.0 ug DNA | EUR 184.8 |
Pdgfc sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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K4339002 | ABM | 1.0 ug DNA | EUR 184.8 |
Pdgfc sgRNA CRISPR Lentivector (Mouse) (Target 2) |
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K4339003 | ABM | 1.0 ug DNA | EUR 184.8 |
Pdgfc sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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K4339004 | ABM | 1.0 ug DNA | EUR 184.8 |
PDGFC ELISA Kit (Human) : 96 Wells (OKEH00498) |
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OKEH00498 | Aviva Systems Biology | 96 Wells | EUR 652.8 |
Description: Description of target: Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding to receptors induces their activation by tyrosine phosphorylation. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintainance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Seems to be involved in palatogenesis.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 36 pg/mL |
PDGFC ELISA Kit (Rat) : 96 Wells (OKEH00499) |
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OKEH00499 | Aviva Systems Biology | 96 Wells | EUR 794.4 |
Description: Description of target: Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding to receptors induces their activation by tyrosine phosphorylation. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintainance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Seems to be involved in palatogenesis.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.176 ng/mL |