Autophagy induction and PDGFR-β knockdown by siRNA-encapsulated nanoparticles cut back chlamydia trachomatis an infection.
C. trachomatis is the commonest sexually transmitted bacterial an infection on this planet. Though the an infection could be simply managed by means of antibiotics, a number of experiences of scientific isolates which can be proof against antibiotics have prompted us to seek for different methods to handle this illness.
On this paper, we developed a nanoparticle formulation (PDGFR-β siRNA-PEI-PLGA-PEG NP) that may concurrently induce autophagy in human cells and knock down PDGFR-β gene expression, an necessary floor binding protein for C. trachomatis, as a technique to cut back vaginal an infection of C. trachomatis.
PDGFR-β siRNA-PEI-PLGA-PEG NP considerably induced autophagy in human vaginal epithelial cells (VK2/E6E7) 48 hr publish remedy by bettering autophagic degradation exercise with out inflicting irritation, apoptosis or any lower in cell viability. Beclin-1, VPS34 (markers for initiation stage of autophagy), UVRAG, TECPR-1 (markers for degradation stage of autophagy) had been discovered to be considerably upregulated after remedy with PDGFR-β siRNA-PEI-PLGA-PEG NP.
 PDGF-BB, murine recombinant |
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| 4489-1000 | Biovision | EUR 5362 | |
PDGF-BB, murine recombinant |
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| 4489-50 | Biovision | EUR 729 | |
 Recombinant Human PDGF-BB Protein |
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| PROTP01127-4 | BosterBio | 10ug | EUR 317 |
|
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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Recombinant Human PDGF-BB Protein |
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| RP00834 | Abclonal | 10 μg | EUR 221 |
 PDGF-BB, human recombinant protein |
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| P1047-.01 | ApexBio | 10 µg | EUR 313 |
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Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB, human recombinant protein |
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| P1047-.05 | ApexBio | 50 µg | EUR 877 |
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Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB, human recombinant protein |
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| P1047-1 | ApexBio | 1 mg | EUR 6522 |
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Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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 PDGF-BB/ Rat PDGF- BB ELISA Kit |
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| ELA-E0633r | Lifescience Market | 96 Tests | EUR 886 |
 Human CellExp? PDGF-BB, human recombinant |
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| 7276-10 | Biovision | EUR 419 | |
 Human PDGF-BB Protein |
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| abx060208-100ug | Abbexa | 100 ug | EUR 523 |
Human PDGF-BB Protein |
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| abx060258-100ug | Abbexa | 100 ug | EUR 523 |
) rec PDGF BB (human) |
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| H-7530.0002 | Bachem | 2.0µg | EUR 162 |
rec PDGF BB (human) |
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| H-7530.0010 | Bachem | 10.0µg | EUR 381 |
 Recombinant Murine PDGF-BB Protein |
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| PROTP31240-1 | BosterBio | 10ug | EUR 317 |
|
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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 PDGF-BB, murine recombinant protein |
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| P1048-.01 | ApexBio | 10 µg | EUR 313 |
|
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB, murine recombinant protein |
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| P1048-.05 | ApexBio | 50 µg | EUR 877 |
|
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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PDGF-BB, murine recombinant protein |
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| P1048-1 | ApexBio | 1 mg | EUR 6522 |
|
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB). |
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 PDGF BB antibody |
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| 70R-PR020 | Fitzgerald | 50 ug | EUR 273 |
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Description: Affinity purified Rabbit polyclonal PDGF BB antibody |
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 rHu PDGF-BB |
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| AK8292-0002 | Akron Biotech | 2µg | Ask for price |
rHu PDGF-BB |
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| AK8292-0010 | Akron Biotech | 10µg | Ask for price |
rHu PDGF-BB |
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| AK8292-0100 | Akron Biotech | 100µg | Ask for price |
rHu PDGF-BB |
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| AK8292-1000 | Akron Biotech | 1mg | Ask for price |
 anti-PDGF BB |
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| YF-PA13686 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse polyclonal to PDGF BB |
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anti-PDGF BB |
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| YF-PA24331 | Abfrontier | 50 ul | EUR 334 |
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Description: Mouse polyclonal to PDGF BB |
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 PDGF BB protein |
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| 30R-2611 | Fitzgerald | 10 ug | EUR 359 |
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Description: Purified recombinant Human PDGF BB protein |
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PDGF BB protein |
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| 30R-2612 | Fitzgerald | 10 ug | EUR 302 |
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Description: Purified recombinant Mouse PDGF BB protein |
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PDGF BB protein |
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| 30R-AP004 | Fitzgerald | 2 ug | EUR 133 |
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Description: Purified recombinant Human PDGF BB protein |
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PDGF BB protein |
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| 30R-AP051 | Fitzgerald | 10 ug | EUR 273 |
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Description: Purified recombinant Human PDGF BB protein |
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 PDGF-BB Antibody |
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| 5488-200 | Biovision | EUR 316 | |
PDGF-BB Antibody |
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| 5488-30T | Biovision | EUR 146 | |
PDGF-BB Antibody |
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| 5489-100 | Biovision | EUR 316 | |
PDGF-BB Antibody |
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| 5489-30T | Biovision | EUR 146 | |
 PDGF-BB, Mouse |
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| HY-P7087 | MedChemExpress | 100ug | EUR 946 |
 PDGF-BB, Rat |
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| HY-P7278 | MedChemExpress | 50ug | EUR 383 |
 PDGF-BB, CF |
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| PR15026CF | Neuromics | 50 ug | EUR 1087 |
PDGF-BB, CF |
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| PR15027CF | Neuromics | 50 ug | EUR 396 |
 Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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| C199-10ug | Novoprotein | 10ug | EUR 202 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
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Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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| C199-1mg | Novoprotein | 1mg | EUR 2283 |
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Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
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Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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| C199-500ug | Novoprotein | 500ug | EUR 1613 |
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Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
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Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
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| C199-50ug | Novoprotein | 50ug | EUR 496 |
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Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
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 PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein |
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| PROTP01127-2 | BosterBio | Regular: 10ug | EUR 317 |
|
Description: Platelet-Derived Growth Factor BB Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.3 kDa. PDGF-BB is purified by proprietary chromatographic techniques. |
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 PDGF-BB ELISA KIT|Human |
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| EF000205 | Lifescience Market | 96 Tests | EUR 689 |
, Human) PDGF-BB (P.pastoris-expressed), Human |
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| HY-P7055A | MedChemExpress | 10ug | EUR 268 |
 Human PDGF-BB ELISA Kit |
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| EHP0050 | Abclonal | 96Tests | EUR 521 |
Human PDGF-BB ELISA Kit |
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| EHP0634 | Abclonal | 96Tests | EUR 521 |
Human PDGF-BB ELISA Kit |
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| RK04112 | Abclonal | 96 Tests | EUR 521 |
 Polyclonal PDGF-BB Antibody |
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| APR08990G | Leading Biology | 0.1mg | EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications: |
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Polyclonal PDGF-BB Antibody |
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| APR00412G | Leading Biology | 0.1mg | EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications: |
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 PDGF-BB Platelet Derived Growth Factor-BB Human Recombinant Protein, HEK |
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| PROTP01127-3 | BosterBio | Regular: 10ug | EUR 317 |
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Description: PDGF-BB Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight of 25kDa due to glycosylation.;The PDGF-BB is purified by proprietary chromatographic techniques. |
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 PDGF-BB Platelet-Derived Growth Factor BB Mouse Recombinant Protein |
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| PROTP31240 | BosterBio | Regular: 10ug | EUR 317 |
|
Description: Platelet-Derived Growth Factor BB Mouse Recombinant produced in E.coli, is a homodimeric, non-glycosylated, polypeptide chain containing 2x110 (total of 2 chains 220aa) amino acids and having a total molecular weight of 24.7 kDa.;PDGF-BB is purified by proprietary chromatographic techniques. |
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 PDGF-BB Platelet-Derived Growth Factor BB Rat Recombinant Protein |
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| PROTQ05028 | BosterBio | Regular: 10ug | EUR 317 |
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Description: PDGF-BB Rat Recombinant produced in E.coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide of two B chains containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.4 kDa.;The PDGF-BB is purified by proprietary chromatographic techniques. |
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 Human PDGF-BB PicoKine ELISA Kit |
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| EK0956 | BosterBio | 96 wells | EUR 425 |
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Description: For quantitative detection of human PDGF-BB in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
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 (cGMP)) rHu PDGF-BB (yeast) (cGMP) |
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| AK8274-1000 | Akron Biotech | 1mg | Ask for price |
 Sheep PDGF-BB ELISA Kit |
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| ESP0050 | Abclonal | 96Tests | EUR 521 |
 Rabbit PDGF-BB ELISA Kit |
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| ERTP0634 | Abclonal | 96Tests | EUR 521 |
 Monkey PDGF-BB ELISA Kit |
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| EMKP0050 | Abclonal | 96Tests | EUR 521 |
 Mouse PDGF-BB ELISA Kit |
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| EMP0050 | Abclonal | 96Tests | EUR 521 |
Mouse PDGF-BB ELISA Kit |
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| EMP0634 | Abclonal | 96Tests | EUR 521 |
 Porcine PDGF-BB ELISA Kit |
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| EPP0050 | Abclonal | 96Tests | EUR 521 |
Porcine PDGF-BB ELISA Kit |
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| EPP0634 | Abclonal | 96Tests | EUR 521 |
 Rat PDGF-BB ELISA Kit |
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| ERP0050 | Abclonal | 96Tests | EUR 521 |
Rat PDGF-BB ELISA Kit |
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| ERP0634 | Abclonal | 96Tests | EUR 521 |
Rabbit PDGF-BB ELISA Kit |
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| ERTP0050 | Abclonal | 96Tests | EUR 521 |
 Bovine PDGF-BB ELISA Kit |
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| EBP0634 | Abclonal | 96Tests | EUR 521 |
 Chicken PDGF-BB ELISA Kit |
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| ECKP0050 | Abclonal | 96Tests | EUR 521 |
 Canine PDGF-BB ELISA Kit |
|||
| ECP0050 | Abclonal | 96Tests | EUR 521 |
Canine PDGF-BB ELISA Kit |
|||
| ECP0634 | Abclonal | 96Tests | EUR 521 |
 Anserini PDGF-BB ELISA Kit |
|||
| EAP0634 | Abclonal | 96Tests | EUR 521 |
Bovine PDGF-BB ELISA Kit |
|||
| EBP0050 | Abclonal | 96Tests | EUR 521 |
 Goat PDGF-BB ELISA Kit |
|||
| EGTP0050 | Abclonal | 96Tests | EUR 521 |
Goat PDGF-BB ELISA Kit |
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| EGTP0634 | Abclonal | 96Tests | EUR 521 |
 Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit |
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| CN-03344H1 | ChemNorm | 96T | EUR 457 |
Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit |
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| CN-03344H2 | ChemNorm | 48T | EUR 306 |
 Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit |
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| CSB-E08923h-24T | Cusabio | 1 plate of 24 wells | EUR 165 |
|
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit |
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| 1-CSB-E08923h | Cusabio |
|
|
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Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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ELISA Kit) Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit |
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| GA-E0112HM-48T | GenAsia Biotech | 48T | EUR 289 |
Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit |
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| GA-E0112HM-96T | GenAsia Biotech | 96T | EUR 466 |
Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit |
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| 201-12-0073 | SunredBio | 96 tests | EUR 440 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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 CLIA Kit) Human Platelet Derived Growth Factor-BB (PDGF-BB) CLIA Kit |
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| abx197499-96tests | Abbexa | 96 tests | EUR 825 |
 ELISA Kit) Human PDGF-BB(Platelet Derived Growth Factor-BB) ELISA Kit |
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| EH0254 | FN Test | 96T | EUR 524.1 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml |
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Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit |
|||
| QY-E00600 | Qayee Biotechnology | 96T | EUR 361 |
 Recombinant Rat PDGF BB Protein, Untagged, E.coli-10ug |
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| QP10805-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Rat PDGF BB Protein, Untagged, E.coli-1mg |
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| QP10805-1mg | EnQuireBio | 1mg | EUR 3573 |
 Recombinant Rat PDGF BB Protein, Untagged, E.coli-2ug |
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| QP10805-2ug | EnQuireBio | 2ug | EUR 155 |
Recombinant Human PDGF-BB Protein |
|
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells.
The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). |
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Moreover, PDGFR-β siRNA-PEI-PLGA-PEG NP decreased PDGFR-β mRNA expression by 50% and protein expression by 43% in VK2/E6E7 cells 48 hr publish remedy.
Remedy of cells with PDGFR-β siRNA-PEI-PLGA-PEG NP considerably decreased the intracellular C. trachomatis and extracellular launch of C. trachomatis by roughly 65% and 67%, respectively, in vitro via augmenting autophagic degradation pathways and lowering bacterial binding concurrently.
Deregulation of VEGFR-2 and PDGFR Expression and Microvascular Density in a Triple-Damaging Mannequin of Canine Malignant Mammary Tumors with Lymph Node or Lung Metastasis.
Canine mammary tumors (CMT) symbolize the commonest most cancers in noncastrated feminine canines. Apparently, triple-negative tumors are the commonest molecular subtype in feminine canines. On this examine, we proposed to judge the expression of vascular endothelial development issue receptor 2 (VEGFR-2), Platelet-derived development issue receptor (PDGFR), and microvascular density (MVD) in a bunch of metastatic and nonmetastatic triple-negative CMT and evaluate the expression primarily based on scientific parameters.
Twenty-six feminine canines with triple-negative mammary tumors had been divided into three teams: nonmetastatic tumors (NMT) (n = 11), tumors with lymph node metastasis (LNM) (n = 10), and tumors with lung metastasis (LM) (n = 5).
Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB |
We noticed elevated VEGFR-2 expression in LNM in contrast with NMT and a constructive correlation between tumor grade and VEGFR-2 expression. A constructive correlation was famous between VEGFR-2 and PDGFR expression.
Relating to microvascular density (MVD), we recognized the next variety of vessels in main tumors with lymph node metastasis and lung metastasis in contrast with tumors with no metastasis. The first tumors with lung metastasis exhibited an elevated MVD in contrast with carcinoma with lymph node metastasis.
Total, our outcomes counsel a deregulation of VEGFR-2 and PDGFR and excessive MVD in metastatic tumors, indicating a task for angiogenesis in tumor development.
 ELISA Kit) Mouse Platelet Derived Growth Factor C (PDGFC) ELISA Kit |
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| RD-PDGFC-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 472 |
Mouse Platelet Derived Growth Factor C (PDGFC) ELISA Kit |
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| RD-PDGFC-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 653 |
 ELISA Kit) Human Platelet Derived Growth Factor C (PDGFC) ELISA Kit |
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| DLR-PDGFC-Hu-48T | DL Develop | 48T | EUR 463 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Platelet Derived Growth Factor C (PDGFC) in samples from plasma. |
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Human Platelet Derived Growth Factor C (PDGFC) ELISA Kit |
|||
| DLR-PDGFC-Hu-96T | DL Develop | 96T | EUR 599 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Platelet Derived Growth Factor C (PDGFC) in samples from plasma. |
|||
Mouse Platelet Derived Growth Factor C (PDGFC) ELISA Kit |
|||
| DLR-PDGFC-Mu-48T | DL Develop | 48T | EUR 474 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Platelet Derived Growth Factor C (PDGFC) in samples from plasma. |
|||
Mouse Platelet Derived Growth Factor C (PDGFC) ELISA Kit |
|||
| DLR-PDGFC-Mu-96T | DL Develop | 96T | EUR 614 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Platelet Derived Growth Factor C (PDGFC) in samples from plasma. |
|||
 PDGFC Antibody |
|||
| 1-CSB-PA108491 | Cusabio |
|
|
|
Description: A polyclonal antibody against PDGFC. Recognizes PDGFC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200 |
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PDGFC Antibody |
|||
| 1-CSB-PA146607 | Cusabio |
|
|
|
Description: A polyclonal antibody against PDGFC. Recognizes PDGFC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200 |
|||
PDGFC Antibody |
|||
| 1-CSB-PA243546 | Cusabio |
|
|
|
Description: A polyclonal antibody against PDGFC. Recognizes PDGFC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000 |
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PDGFC Antibody |
|||
| 37811-100ul | SAB | 100ul | EUR 252 |
 PDGFC Conjugated Antibody |
|||
| C37811 | SAB | 100ul | EUR 397 |
 PDGFC siRNA |
|||
| 20-abx928112 | Abbexa |
|
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PDGFC siRNA |
|||
| 20-abx928113 | Abbexa |
|
|
PDGFC siRNA |
|||
| 20-abx903903 | Abbexa |
|
|
 Polyclonal Goat anti-GST α-form |
|||
| GST-ANTI-1 | Detroit R&D | 50 uL | EUR 280 |
 Polyclonal Goat anti-GST μ-form |
|||
| GST-ANTI-2 | Detroit R&D | 50 uL | EUR 280 |
 Polyclonal Goat anti-GST p-form |
|||
| GST-ANTI-3 | Detroit R&D | 50 uL | EUR 280 |
 PDGFC Rabbit pAb |
|||
| A15174-100ul | Abclonal | 100 ul | EUR 308 |
PDGFC Rabbit pAb |
|||
| A15174-200ul | Abclonal | 200 ul | EUR 459 |
PDGFC Rabbit pAb |
|||
| A15174-20ul | Abclonal | 20 ul | EUR 183 |
PDGFC Rabbit pAb |
|||
| A15174-50ul | Abclonal | 50 ul | EUR 223 |
 Human PDGFC ELISA Kit |
|||
| ELA-E0528h | Lifescience Market | 96 Tests | EUR 824 |
 PDGFC ELISA KIT|Human |
|||
| EF000342 | Lifescience Market | 96 Tests | EUR 689 |
 Sheep PDGFC ELISA Kit |
|||
| ESP0081 | Abclonal | 96Tests | EUR 521 |
 Monkey PDGFC ELISA Kit |
|||
| EMKP0081 | Abclonal | 96Tests | EUR 521 |
 Mouse PDGFC ELISA Kit |
|||
| EMP0081 | Abclonal | 96Tests | EUR 521 |
 Porcine PDGFC ELISA Kit |
|||
| EPP0081 | Abclonal | 96Tests | EUR 521 |
 Rat PDGFC ELISA Kit |
|||
| ERP0081 | Abclonal | 96Tests | EUR 521 |
 Rabbit PDGFC ELISA Kit |
|||
| ERTP0081 | Abclonal | 96Tests | EUR 521 |
 Mouse PDGFC shRNA Plasmid |
|||
| 20-abx974532 | Abbexa |
|
|
 Rat PDGFC shRNA Plasmid |
|||
| 20-abx986548 | Abbexa |
|
|
 Bovine PDGFC ELISA Kit |
|||
| EBP0081 | Abclonal | 96Tests | EUR 521 |
 Chicken PDGFC ELISA Kit |
|||
| ECKP0081 | Abclonal | 96Tests | EUR 521 |
 Canine PDGFC ELISA Kit |
|||
| ECP0081 | Abclonal | 96Tests | EUR 521 |
Human PDGFC ELISA Kit |
|||
| EHP0081 | Abclonal | 96Tests | EUR 521 |
 Anserini PDGFC ELISA Kit |
|||
| EAP0081 | Abclonal | 96Tests | EUR 521 |
 Goat PDGFC ELISA Kit |
|||
| EGTP0081 | Abclonal | 96Tests | EUR 521 |
 Human PDGFC shRNA Plasmid |
|||
| 20-abx961041 | Abbexa |
|
|
 Antibody) Platelet Derived Growth Factor C (PDGFC) Antibody |
|||
| 20-abx131438 | Abbexa |
|
|
Platelet Derived Growth Factor C (PDGFC) Antibody |
|||
| 20-abx103486 | Abbexa |
|
|
Platelet Derived Growth Factor C (PDGFC) Antibody |
|||
| 20-abx103487 | Abbexa |
|
|
Platelet Derived Growth Factor C (PDGFC) Antibody |
|||
| 20-abx241696 | Abbexa |
|
|
Platelet Derived Growth Factor C (PDGFC) Antibody |
|||
| 20-abx241697 | Abbexa |
|
|
Platelet Derived Growth Factor C (PDGFC) Antibody |
|||
| 20-abx178044 | Abbexa |
|
|
Platelet Derived Growth Factor C (PDGFC) Antibody |
|||
| 20-abx174096 | Abbexa |
|
|
Platelet Derived Growth Factor C (PDGFC) Antibody |
|||
| 20-abx174097 | Abbexa |
|
|
Platelet Derived Growth Factor C (PDGFC) Antibody |
|||
| 20-abx326887 | Abbexa |
|
|
 (pORF)) Pdgfc ORF Vector (Rat) (pORF) |
|||
| ORF073284 | ABM | 1.0 ug DNA | EUR 506 |
 (pORF)) PDGFC ORF Vector (Human) (pORF) |
|||
| ORF027574 | ABM | 1.0 ug DNA | EUR 405 |
 (pORF)) Pdgfc ORF Vector (Mouse) (pORF) |
|||
| ORF053678 | ABM | 1.0 ug DNA | EUR 506 |
 Guinea Pig PDGFC ELISA Kit |
|||
| EGP0081 | Abclonal | 96Tests | EUR 521 |
 (OKCD00764)) PDGFC ELISA Kit (Mouse) (OKCD00764) |
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| OKCD00764 | Aviva Systems Biology | 96 Wells | EUR 857 |
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Description: Description of target: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.8 Publications
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.6"PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor."_x005F_x005F_x000D_Li X., Ponten A., Aase K., Karlsson L., Abramsson A., Uutela M., Backstrom G., Hellstrom M., Bostrom H., Li H., Soriano P., Betsholtz C., Heldin C.H., Alitalo K., Ostman A., Eriksson U._x005F_x005F_x000D_Nat. Cell Biol. 2:302-309(2000) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, DEVELOPMENTAL STAGE.Ref.7"Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."_x005F_x005F_x000D_Gilbertson D.G., Duff M.E., West J.W., Kelly J.D., Sheppard P.O., Hofstrand P.D., Gao Z., Shoemaker K., Bukowski T.R., Moore M., Feldhaus A.L., Humes J.M., Palmer T.E., Hart C.E._x005F_x005F_x000D_J. Biol. Chem. 276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY.Ref.10"Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy."_x005F_x005F_x000D_Ponten A., Li X., Thoren P., Aase K., Sjoblom T., Ostman A., Eriksson U._x005F_x005F_x000D_Am. J. Pathol. 163:673-682(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.11"Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis."_x005F_x005F_x000D_Zhuo Y., Zhang J., Laboy M., Lasky J.A._x005F_x005F_x000D_Am. J. Physiol. 286:L182-L188(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION BY BLEOMYCIN.Ref.14"Tissue plasminogen activator is a potent activator of PDGF-CC."_x005F_x005F_x000D_Fredriksson L., Li H., Fieber C., Li X., Eriksson U._x005F_x005F_x000D_EMBO J. 23:3793-3802(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, ACTIVATION BY PROTEOLYTIC CLEAVAGE.Ref.15"A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling."_x005F_x005F_x000D_Ding H., Wu X., Bostrom H., Kim I., Wong N., Tsoi B., O'Rourke M., Koh G.Y., Soriano P., Betsholtz C., Hart T.C., Marazita M.L., Field L.L., Tam P.P., Nagy A._x005F_x005F_x000D_Nat. Genet. 36:1111-1116(2004) [PubMed] [Europe PMC] [Abstract]Cited for: DISRUPTION PHENOTYPE, FUNCTION.Ref.16"Linkage between elevated PDGF-C expression and myocardial fibrogenesis in coxsackievirus B3-induced chronic myocarditis."_x005F_x005F_x000D_Yang D., Qiu D._x005F_x005F_x000D_Eur. Heart J. 26:642-643(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION BY COXSACKIEVIRUS B3 INFECTION, DISEASE.Ref.22"PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis."_x005F_x005F_x000D_Eitner F., Bucher E., van Roeyen C., Kunter U., Rong S., Seikrit C., Villa L., Boor P., Fredriksson L., Backstrom G., Eriksson U., Ostman A., Floege J., Ostendorf T._x005F_x005F_x000D_J. Am. Soc. Nephrol. 19:281-289(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 12.1 pg/mL |
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 (OKBB01268)) Pdgfc ELISA Kit (Mouse) (OKBB01268) |
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| OKBB01268 | Aviva Systems Biology | 96 Wells | EUR 505 |
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Description: Description of target: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. It is mapped to 3; 3 E3. Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml |
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 (OKBB01269)) Pdgfc ELISA Kit (Rat) (OKBB01269) |
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| OKBB01269 | Aviva Systems Biology | 96 Wells | EUR 505 |
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Description: Description of target: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. It is mapped to 2q33-q34. Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation. ;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml |
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 (OKCD08309)) PDGFC ELISA Kit (Human) (OKCD08309) |
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| OKCD08309 | Aviva Systems Biology | 96 Wells | EUR 975 |
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Description: Description of target: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 43pg/mL |
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 (OKCD08310)) PDGFC ELISA Kit (Rat) (OKCD08310) |
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| OKCD08310 | Aviva Systems Biology | 96 Wells | EUR 1053 |
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Description: Description of target: expressed in the embryonic spinal cord floor plate and ventricular zone, adult expression is localized to motoneurons in several regions of the brain.;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: < 0.128ng/mL |
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 (OKAN04684)) PDGFC ELISA Kit (Human) (OKAN04684) |
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| OKAN04684 | Aviva Systems Biology | 96 Wells | EUR 792 |
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Description: Description of target: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 43 pg/mL |
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 (OKAN05945)) PDGFC ELISA Kit (Mouse) (OKAN05945) |
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| OKAN05945 | Aviva Systems Biology | 96 Wells | EUR 792 |
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Description: Description of target: ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 12.1 pg/mL |
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 (OKEH06376)) PDGFC ELISA Kit (Mouse) (OKEH06376) |
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| OKEH06376 | Aviva Systems Biology | 96 Wells | EUR 766 |
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Description: Description of target: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.85 ng/mL |
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 polyclonal antibody) Platelet-derived growth factor C (PDGFC) polyclonal antibody |
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| ABP-PAB-10942 | Allele Biotech | 100 ug | Ask for price |
) Pdgfc sgRNA CRISPR Lentivector set (Rat) |
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| K6990301 | ABM | 3 x 1.0 ug | EUR 339 |
) Pdgfc sgRNA CRISPR Lentivector set (Mouse) |
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| K4339001 | ABM | 3 x 1.0 ug | EUR 339 |
) PDGFC sgRNA CRISPR Lentivector set (Human) |
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| K1620301 | ABM | 3 x 1.0 ug | EUR 339 |
 Polyclonal Antibody (Mouse)) Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse) |
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| 4-PAC920Mu02 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC) |
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 Polyclonal Antibody (Human)) Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Human) |
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| 4-PAC920Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor C (PDGFC) |
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Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse) |
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| 4-PAC920Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC) |
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 PDGFC 3'UTR Luciferase Stable Cell Line |
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| TU017655 | ABM | 1.0 ml | EUR 1521 |
 Pdgfc 3'UTR Luciferase Stable Cell Line |
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| TU116124 | ABM | 1.0 ml | Ask for price |
 Pdgfc 3'UTR GFP Stable Cell Line |
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| TU166124 | ABM | 1.0 ml | Ask for price |
Pdgfc 3'UTR Luciferase Stable Cell Line |
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| TU216013 | ABM | 1.0 ml | Ask for price |
Pdgfc 3'UTR GFP Stable Cell Line |
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| TU266013 | ABM | 1.0 ml | Ask for price |
 PDGFC 3'UTR GFP Stable Cell Line |
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| TU067655 | ABM | 1.0 ml | EUR 1521 |
 (pPB-C-His)) PDGFC Protein Vector (Human) (pPB-C-His) |
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| PV110294 | ABM | 500 ng | EUR 552 |
 (pPB-N-His)) PDGFC Protein Vector (Human) (pPB-N-His) |
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| PV110295 | ABM | 500 ng | EUR 552 |
 (pPM-C-HA)) PDGFC Protein Vector (Human) (pPM-C-HA) |
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| PV110296 | ABM | 500 ng | EUR 552 |
 (pPM-C-His)) PDGFC Protein Vector (Human) (pPM-C-His) |
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| PV110297 | ABM | 500 ng | EUR 552 |
 (pPB-C-His)) PDGFC Protein Vector (Rat) (pPB-C-His) |
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| PV293134 | ABM | 500 ng | EUR 603 |
 (pPB-N-His)) PDGFC Protein Vector (Rat) (pPB-N-His) |
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| PV293135 | ABM | 500 ng | EUR 603 |
 (pPM-C-HA)) PDGFC Protein Vector (Rat) (pPM-C-HA) |
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| PV293136 | ABM | 500 ng | EUR 603 |
 (pPM-C-His)) PDGFC Protein Vector (Rat) (pPM-C-His) |
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| PV293137 | ABM | 500 ng | EUR 603 |
 (pPB-C-His)) PDGFC Protein Vector (Mouse) (pPB-C-His) |
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| PV214710 | ABM | 500 ng | EUR 603 |
 (pPB-N-His)) PDGFC Protein Vector (Mouse) (pPB-N-His) |
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| PV214711 | ABM | 500 ng | EUR 603 |
 (pPM-C-HA)) PDGFC Protein Vector (Mouse) (pPM-C-HA) |
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| PV214712 | ABM | 500 ng | EUR 603 |
 (pPM-C-His)) PDGFC Protein Vector (Mouse) (pPM-C-His) |
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| PV214713 | ABM | 500 ng | EUR 603 |
