Autophagy induction and PDGFR-β knockdown by siRNA-encapsulated nanoparticles cut back chlamydia trachomatis an infection.

C. trachomatis is the commonest sexually transmitted bacterial an infection on this planet. Though the an infection could be simply managed by means of antibiotics, a number of experiences of scientific isolates which can be proof against antibiotics have prompted us to seek for different methods to handle this illness.

On this paper, we developed a nanoparticle formulation (PDGFR-β siRNA-PEI-PLGA-PEG NP) that may concurrently induce autophagy in human cells and knock down PDGFR-β gene expression, an necessary floor binding protein for C. trachomatis, as a technique to cut back vaginal an infection of C. trachomatis.

PDGFR-β siRNA-PEI-PLGA-PEG NP considerably induced autophagy in human vaginal epithelial cells (VK2/E6E7) 48 hr publish remedy by bettering autophagic degradation exercise with out inflicting irritation, apoptosis or any lower in cell viability. Beclin-1, VPS34 (markers for initiation stage of autophagy), UVRAG, TECPR-1 (markers for degradation stage of autophagy) had been discovered to be considerably upregulated after remedy with PDGFR-β siRNA-PEI-PLGA-PEG NP.

 

 

vegf-a
vegf-a

 

 

Genorise® Recombinant Human PDGF-BB
GR104258 5 µg
EUR 285

Recombinant Rat PDGF-BB
REGFP-1601 10ug Ask for price

PDGF-BB, murine recombinant
4489-10 each
EUR 320.4

PDGF-BB, murine recombinant
4489-1000 each
EUR 6434.4

PDGF-BB, murine recombinant
4489-50 each
EUR 874.8

Recombinant Murine PDGF-BB
MEGFP-1601 10ug Ask for price

PDGF-BB Recombinant Protein
11-380 0.05 mg
EUR 714.3
Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

PDGF-BB Recombinant Protein
40-158-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-158-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-458-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-458-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-607 0.01 mg
EUR 481.2
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet a-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-a and PDGFR-β. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). .

PDGF-BB Recombinant Protein
91-179 0.05 mg
EUR 821.4
Description: Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.

Human CellExp™ PDGF-BB, human recombinant
7276-10 each Ask for price

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Murine PDGF-BB Protein
PROTP31240-1 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB, murine recombinant protein
P1048-.01 10 µg
EUR 375.6
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein
P1048-.05 50 µg
EUR 1052.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein
P1048-1 1 mg
EUR 7826.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

Recombinant Human Platelet Derived Growth Factor-BB (rHu PDGF-BB)
AK8274-0100 100µg
EUR 1740

Recombinant Human Platelet Derived Growth Factor-BB (rHu PDGF-BB)
AK8274-1000 1mg
EUR 4500

PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein
PROTP01127-2 Regular: 10ug
EUR 380.4
Description: Platelet-Derived Growth Factor BB Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.3 kDa. PDGF-BB is purified by proprietary chromatographic techniques.

Genorise® Recombinant Rat PDGF-BB
GR104260 5 µg
EUR 285

Genorise® Recombinant Sheep PDGF-BB
GR104257 5 µg
EUR 285

Genorise® Recombinant Mouse PDGF-BB
GR104259 5 µg
EUR 285

Genorise® Recombinant Donkey PDGF-BB
GR176014 5 mg
EUR 285

Genorise® Recombinant Equine PDGF-BB
GR104254 5 µg
EUR 285

Genorise® Recombinant Canine PDGF-BB
GR104255 5 µg
EUR 285

Genorise® Recombinant Bovine PDGF-BB
GR104256 5 µg
EUR 285

Genorise® Recombinant Rabbit PDGF-BB
GR104261 5 µg
EUR 285

Genorise® Recombinant Monkey PDGF-BB
GR175014 5 mg
EUR 285

Genorise® Recombinant Porcine PDGF-BB
GR104253 5 µg
EUR 285

Genorise® Recombinant Chicken PDGF-BB
GR104262 5 µg
EUR 285

PDGF-BB Platelet Derived Growth Factor-BB Human Recombinant Protein, HEK
PROTP01127-3 Regular: 10ug
EUR 380.4
Description: PDGF-BB Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight of 25kDa due to glycosylation.;The PDGF-BB is purified by proprietary chromatographic techniques.

Genorise® Recombinant Guinea Pig PDGF-BB
GR177014 5 mg
EUR 285

Genorise® Recombinant feline PDGF-BB protein
GR186010 5 mg
EUR 285

Recombinant Human PDGF-AA
HEGFP-0508 10ug Ask for price

PDGF-AA, human recombinant
4482-10 each
EUR 398.4

PDGF-AA, human recombinant
4482-1000 each
EUR 8346

PDGF-AA, human recombinant
4482-50 each
EUR 1123.2

PDGF-AB, human recombinant
4485-10 each
EUR 398.4

PDGF-AB, human recombinant
4485-1000 each
EUR 8346

PDGF-AB, human recombinant
4485-50 each
EUR 1123.2

PDGF-CC, human recombinant
7183-10 each
EUR 248.4

PDGF-CC, human recombinant
7183-50 each
EUR 810

PDGF-BB Platelet-Derived Growth Factor BB Rat Recombinant Protein
PROTQ05028 Regular: 10ug
EUR 380.4
Description: PDGF-BB Rat Recombinant produced in E.coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide of two B chains containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.4 kDa.;The PDGF-BB is purified by proprietary chromatographic techniques.

PDGF-BB Platelet-Derived Growth Factor BB Mouse Recombinant Protein
PROTP31240 Regular: 10ug
EUR 380.4
Description: Platelet-Derived Growth Factor BB Mouse Recombinant produced in E.coli, is a homodimeric, non-glycosylated, polypeptide chain containing 2x110 (total of 2 chains 220aa) amino acids and having a total molecular weight of 24.7 kDa.;PDGF-BB is purified by proprietary chromatographic techniques.

Recombinant Rat PDGF BB Protein, Untagged, E.coli-1mg
QP10805-1mg 1mg
EUR 4287.6

Recombinant Rat PDGF BB Protein, Untagged, E.coli-2ug
QP10805-2ug 2ug
EUR 186

Recombinant Rat PDGF BB Protein, Untagged, E.coli-10ug
QP10805-10ug 10ug
EUR 241.2

Recombinant Human PDGF-AA Protein
PROTP04085-4 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids).

Recombinant Human PDGF-AB Protein
PROTP20033-2 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).

Recombinant Human PDGF-CC Protein
PROTQ9NRA1-1 20ug
EUR 380.4
Description: The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules epithelial cell development. Mature PDGFs are stored in platelet α-granules and are released upon platelet activation. PDGF-AA, -AB, -BB and –CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor. Recombinant human PDGF-CC is a 25kDa protein consisting of two identical disulfide-linked 114 amino-acid polypeptide chains.

Recombinant Human PDGFAA/PDGF-AA Protein
RP00909 10 μg
EUR 265.2

PDGF BBHuman, Platelet Derived Growth Factor-BB Human Recombinant Protein, Yeast
PROTP01127 Regular: 10ug
EUR 380.4
Description: Platelet-Derived Growth Factor BB Human Recombinant is a glycosylated homodimer produced in Saccharomyces cerevisiae, containing 2x109 amino acids and having a molecular mass of 32kDa. ;PDGF-BB is purified by proprietary chromatographic techniques.

Genorise® Recombinant human PDGF-AA
GR104202 5 µg
EUR 285

Human CellExp? PDGF R alpha / PDGFRA, Human Recombinant
P1460-10 each
EUR 196.8

Human CellExp? PDGF R alpha / PDGFRA, Human Recombinant
P1460-50 each
EUR 574.8

Human CellExp™ PDGF-AA, Human Recombinant
6476-10 each Ask for price

Human CellExp™ PDGF-AA, Human Recombinant
6476-50 each Ask for price

Human CellExp™ PDGF-CC, Human Recombinant
P1526-10 10 µg
EUR 260.4

Human CellExp™ PDGF-CC, Human Recombinant
P1526-50 50 µg
EUR 782.4

Recombinant Human PDGF CC Protein, His, E.coli-1mg
QP10806-1mg 1mg
EUR 3308.4

Recombinant Human PDGF CC Protein, His, E.coli-5ug
QP10806-5ug 5ug
EUR 186

Recombinant Human PDGF CC Protein, His, E.coli-20ug
QP10806-20ug 20ug
EUR 241.2

Recombinant Rat PDGF-AA
REGFP-1602 10ug Ask for price

PDGF-AA, murine recombinant
4483-10 each
EUR 398.4

PDGF-AA, murine recombinant
4483-1000 each
EUR 8346

PDGF-B Recombinant Protein
96-936 0.05 mg
EUR 651.3
Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

Recombinant Human PDGF AB Protein, Untagged, E.coli-1mg
QP10804-1mg 1mg
EUR 4287.6

Recombinant Human PDGF AB Protein, Untagged, E.coli-2ug
QP10804-2ug 2ug
EUR 186

PDGF-CC Recombinant Protein
40-146-0005mg 0.005 mg
EUR 311.1
Description: The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules epithelial cell development. Mature PDGFs are stored in platelet α-granules and are released upon platelet activation. PDGF-AA, -AB, -BB and -CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor. Recombinant human PDGF-CC is a 25kDa protein consisting of two identical disulfide-linked 114 amino-acid polypeptide chains.

PDGF-CC Recombinant Protein
40-146-002mg 0.02 mg
EUR 437.1
Description: The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules epithelial cell development. Mature PDGFs are stored in platelet α-granules and are released upon platelet activation. PDGF-AA, -AB, -BB and -CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor. Recombinant human PDGF-CC is a 25kDa protein consisting of two identical disulfide-linked 114 amino-acid polypeptide chains.

PDGF-AA Recombinant Protein
40-157-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids).

PDGF-AA Recombinant Protein
40-157-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids).

PDGF-AA Recombinant Protein
40-457-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-AA is a 28.7 kDa disulfide-linked homodimer of two A chains (250 total amino acids).

PDGF-AA Recombinant Protein
40-457-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-AA is a 28.7 kDa disulfide-linked homodimer of two A chains (250 total amino acids).

PDGF-AB Recombinant Protein
40-512-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-B. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-B interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).

PDGF-AB Recombinant Protein
40-512-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-B. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-B interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).

PDGF-AA Recombinant Protein
92-262 0.05 mg
EUR 821.4
Description: Platelet-derived growth factor subunit A (PDGFA), belongs to the PDGF/VEGF growth factor family. PDGFA is a secreted protein, stored in platelet alpha-granules and released by platelets upon wounding. PDGFA is potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. It plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. PDGFA is required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis, normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. It plays an important role in wound healing; Signaling is modulated by the formation of heterodimers with PDGFB.

PDGF-AA Recombinant Protein
92-294 0.05 mg
EUR 821.4
Description: Platelet-derived growth factor subunit A (PDGFA), belongs to the PDGF/VEGF growth factor family. PDGFA is a secreted protein, stored in platelet alpha-granules and released by platelets upon wounding. PDGFA is potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. It plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. PDGFA is required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis, normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. It plays an important role in wound healing; Signaling is modulated by the formation of heterodimers with PDGFB.

 

 

Recombinant Human PDGF-BB Protein

 

Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells.

The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development.

Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Moreover, PDGFR-β siRNA-PEI-PLGA-PEG NP decreased PDGFR-β mRNA expression by 50% and protein expression by 43% in VK2/E6E7 cells 48 hr publish remedy.

Remedy of cells with PDGFR-β siRNA-PEI-PLGA-PEG NP considerably decreased the intracellular C. trachomatis and extracellular launch of C. trachomatis by roughly 65% and 67%, respectively, in vitro via augmenting autophagic degradation pathways and lowering bacterial binding concurrently.

Deregulation of VEGFR-2 and PDGFR Expression and Microvascular Density in a Triple-Damaging Mannequin of Canine Malignant Mammary Tumors with Lymph Node or Lung Metastasis.

Canine mammary tumors (CMT) symbolize the commonest most cancers in noncastrated feminine canines. Apparently, triple-negative tumors are the commonest molecular subtype in feminine canines. On this examine, we proposed to judge the expression of vascular endothelial development issue receptor 2 (VEGFR-2), Platelet-derived development issue receptor (PDGFR), and microvascular density (MVD) in a bunch of metastatic and nonmetastatic triple-negative CMT and evaluate the expression primarily based on scientific parameters.
Twenty-six feminine canines with triple-negative mammary tumors had been divided into three teams: nonmetastatic tumors (NMT) (n = 11), tumors with lymph node metastasis (LNM) (n = 10), and tumors with lung metastasis (LM) (n = 5).

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
We noticed elevated VEGFR-2 expression in LNM in contrast with NMT and a constructive correlation between tumor grade and VEGFR-2 expression. A constructive correlation was famous between VEGFR-2 and PDGFR expression.
Relating to microvascular density (MVD), we recognized the next variety of vessels in main tumors with lymph node metastasis and lung metastasis in contrast with tumors with no metastasis. The first tumors with lung metastasis exhibited an elevated MVD in contrast with carcinoma with lymph node metastasis.
Total, our outcomes counsel a deregulation of VEGFR-2 and PDGFR and excessive MVD in metastatic tumors, indicating a task for angiogenesis in tumor development.

 

 

 

Platelet Derived Growth Factor C (PDGFC) Antibody
20-abx103486
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Platelet Derived Growth Factor C (PDGFC) Antibody
20-abx103487
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Platelet Derived Growth Factor C (PDGFC) Antibody
20-abx174096
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

Platelet Derived Growth Factor C (PDGFC) Antibody
20-abx174097
  • EUR 1095.60
  • EUR 560.40
  • 1 mg
  • 200 ug

Platelet Derived Growth Factor C (PDGFC) Antibody
20-abx178044
  • EUR 1562.40
  • EUR 744.00
  • 1 mg
  • 200 ug

Platelet Derived Growth Factor C (PDGFC) Antibody
20-abx326887
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Platelet Derived Growth Factor C (PDGFC) Antibody
20-abx131438
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

PDGFC Antibody / Platelet-derived growth factor C
RQ6785 100ug
EUR 356.15
Description: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

Platelet-derived growth factor C (PDGFC) polyclonal antibody
ABP-PAB-10942 100 ug Ask for price

PDGFC siRNA
20-abx903903
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PDGFC siRNA
20-abx928112
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PDGFC siRNA
20-abx928113
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Human)
4-PAC920Hu01
  • EUR 296.40
  • EUR 3012.00
  • EUR 750.00
  • EUR 372.00
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor C (PDGFC)

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse)
4-PAC920Mu01
  • EUR 301.20
  • EUR 3091.20
  • EUR 768.00
  • EUR 379.20
  • EUR 258.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC)

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse)
4-PAC920Mu02
  • EUR 301.20
  • EUR 3091.20
  • EUR 768.00
  • EUR 379.20
  • EUR 258.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC)

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Human), PE
4-PAC920Hu01-PE
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with PE.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), PE
4-PAC920Mu01-PE
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with PE.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), PE
4-PAC920Mu02-PE
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with PE.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Human), APC
4-PAC920Hu01-APC
  • EUR 414.00
  • EUR 3930.00
  • EUR 1094.40
  • EUR 528.00
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with APC.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Human), Cy3
4-PAC920Hu01-Cy3
  • EUR 502.80
  • EUR 5190.00
  • EUR 1410.00
  • EUR 654.00
  • EUR 301.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with Cy3.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Human), FITC
4-PAC920Hu01-FITC
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with FITC.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Human), HRP
4-PAC920Hu01-HRP
  • EUR 379.20
  • EUR 3426.00
  • EUR 968.40
  • EUR 477.60
  • EUR 247.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with HRP.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), APC
4-PAC920Mu01-APC
  • EUR 421.20
  • EUR 4038.00
  • EUR 1122.00
  • EUR 538.80
  • EUR 266.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with APC.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), Cy3
4-PAC920Mu01-Cy3
  • EUR 512.40
  • EUR 5334.00
  • EUR 1446.00
  • EUR 668.40
  • EUR 304.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with Cy3.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), FITC
4-PAC920Mu01-FITC
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with FITC.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), HRP
4-PAC920Mu01-HRP
  • EUR 385.20
  • EUR 3519.60
  • EUR 992.40
  • EUR 486.00
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with HRP.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), APC
4-PAC920Mu02-APC
  • EUR 421.20
  • EUR 4038.00
  • EUR 1122.00
  • EUR 538.80
  • EUR 266.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with APC.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), Cy3
4-PAC920Mu02-Cy3
  • EUR 512.40
  • EUR 5334.00
  • EUR 1446.00
  • EUR 668.40
  • EUR 304.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with Cy3.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), FITC
4-PAC920Mu02-FITC
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with FITC.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), HRP
4-PAC920Mu02-HRP
  • EUR 385.20
  • EUR 3519.60
  • EUR 992.40
  • EUR 486.00
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with HRP.

PDGFC Rabbit pAb
A15174-100ul 100 ul
EUR 369.6

PDGFC Rabbit pAb
A15174-200ul 200 ul
EUR 550.8

PDGFC Rabbit pAb
A15174-20ul 20 ul
EUR 219.6

PDGFC Rabbit pAb
A15174-50ul 50 ul
EUR 267.6

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Human), APC-Cy7
4-PAC920Hu01-APC-Cy7
  • EUR 685.20
  • EUR 7716.00
  • EUR 2046.00
  • EUR 912.00
  • EUR 382.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with APC-Cy7.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), APC-Cy7
4-PAC920Mu01-APC-Cy7
  • EUR 699.60
  • EUR 7932.00
  • EUR 2100.00
  • EUR 933.60
  • EUR 388.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with APC-Cy7.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), APC-Cy7
4-PAC920Mu02-APC-Cy7
  • EUR 699.60
  • EUR 7932.00
  • EUR 2100.00
  • EUR 933.60
  • EUR 388.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with APC-Cy7.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Human), Biotinylated
4-PAC920Hu01-Biotin
  • EUR 373.20
  • EUR 2952.00
  • EUR 872.40
  • EUR 457.20
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with Biotin.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), Biotinylated
4-PAC920Mu01-Biotin
  • EUR 379.20
  • EUR 3031.20
  • EUR 892.80
  • EUR 464.40
  • EUR 265.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with Biotin.

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse), Biotinylated
4-PAC920Mu02-Biotin
  • EUR 379.20
  • EUR 3031.20
  • EUR 892.80
  • EUR 464.40
  • EUR 265.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC). This antibody is labeled with Biotin.

Rat PDGFC ELISA Kit
ERP0081 96Tests
EUR 625.2

Goat PDGFC ELISA Kit
EGTP0081 96Tests
EUR 625.2

Mouse PDGFC ELISA Kit
EMP0081 96Tests
EUR 625.2

Sheep PDGFC ELISA Kit
ESP0081 96Tests
EUR 625.2

Human PDGFC ELISA Kit
ELA-E0528h 96 Tests
EUR 988.8

PDGFC ELISA KIT|Human
EF000342 96 Tests
EUR 826.8

Human PDGFC ELISA Kit
EHP0081 96Tests
EUR 625.2

Rabbit PDGFC ELISA Kit
ERTP0081 96Tests
EUR 625.2

Monkey PDGFC ELISA Kit
EMKP0081 96Tests
EUR 625.2

Bovine PDGFC ELISA Kit
EBP0081 96Tests
EUR 625.2

Canine PDGFC ELISA Kit
ECP0081 96Tests
EUR 625.2

Anti-PDGFC antibody
STJ117368 100 µl
EUR 332.4
Description: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

Rat PDGFC shRNA Plasmid
20-abx986548
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Porcine PDGFC ELISA Kit
EPP0081 96Tests
EUR 625.2

Chicken PDGFC ELISA Kit
ECKP0081 96Tests
EUR 625.2

Anserini PDGFC ELISA Kit
EAP0081 96Tests
EUR 625.2

Mouse PDGFC shRNA Plasmid
20-abx974532
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human PDGFC shRNA Plasmid
20-abx961041
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Pdgfc ORF Vector (Rat) (pORF)
ORF073284 1.0 ug DNA
EUR 607.2

Guinea Pig PDGFC ELISA Kit
EGP0081 96Tests
EUR 625.2

PDGFC ORF Vector (Human) (pORF)
ORF027574 1.0 ug DNA
EUR 486

Pdgfc ORF Vector (Mouse) (pORF)
ORF053678 1.0 ug DNA
EUR 607.2

Pdgfc ELISA Kit (Rat) (OKBB01269)
OKBB01269 96 Wells
EUR 606
Description: Description of target: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. It is mapped to 2q33-q34. Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation. ;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

PDGFC ELISA Kit (Rat) (OKCD08310)
OKCD08310 96 Wells
EUR 1263.6
Description: Description of target: expressed in the embryonic spinal cord floor plate and ventricular zone, adult expression is localized to motoneurons in several regions of the brain.;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: < 0.128ng/mL

Pdgfc ELISA Kit (Mouse) (OKBB01268)
OKBB01268 96 Wells
EUR 606
Description: Description of target: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. It is mapped to 3; 3 E3. Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

PDGFC ELISA Kit (Human) (OKAN04684)
OKAN04684 96 Wells
EUR 950.4
Description: Description of target: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 43 pg/mL

PDGFC ELISA Kit (Mouse) (OKAN05945)
OKAN05945 96 Wells
EUR 950.4
Description: Description of target: ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 12.1 pg/mL

PDGFC ELISA Kit (Human) (OKCD08309)
OKCD08309 96 Wells
EUR 1170
Description: Description of target: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 43pg/mL

PDGFC ELISA Kit (Mouse) (OKCD00764)
OKCD00764 96 Wells
EUR 1028.4
Description: Description of target: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.8 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.6"PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor."_x005F_x005F_x000D_Li X., Ponten A., Aase K., Karlsson L., Abramsson A., Uutela M., Backstrom G., Hellstrom M., Bostrom H., Li H., Soriano P., Betsholtz C., Heldin C.H., Alitalo K., Ostman A., Eriksson U._x005F_x005F_x000D_Nat. Cell Biol. 2:302-309(2000) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, DEVELOPMENTAL STAGE.Ref.7"Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."_x005F_x005F_x000D_Gilbertson D.G., Duff M.E., West J.W., Kelly J.D., Sheppard P.O., Hofstrand P.D., Gao Z., Shoemaker K., Bukowski T.R., Moore M., Feldhaus A.L., Humes J.M., Palmer T.E., Hart C.E._x005F_x005F_x000D_J. Biol. Chem. 276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY.Ref.10"Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy."_x005F_x005F_x000D_Ponten A., Li X., Thoren P., Aase K., Sjoblom T., Ostman A., Eriksson U._x005F_x005F_x000D_Am. J. Pathol. 163:673-682(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.11"Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis."_x005F_x005F_x000D_Zhuo Y., Zhang J., Laboy M., Lasky J.A._x005F_x005F_x000D_Am. J. Physiol. 286:L182-L188(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION BY BLEOMYCIN.Ref.14"Tissue plasminogen activator is a potent activator of PDGF-CC."_x005F_x005F_x000D_Fredriksson L., Li H., Fieber C., Li X., Eriksson U._x005F_x005F_x000D_EMBO J. 23:3793-3802(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, ACTIVATION BY PROTEOLYTIC CLEAVAGE.Ref.15"A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling."_x005F_x005F_x000D_Ding H., Wu X., Bostrom H., Kim I., Wong N., Tsoi B., O'Rourke M., Koh G.Y., Soriano P., Betsholtz C., Hart T.C., Marazita M.L., Field L.L., Tam P.P., Nagy A._x005F_x005F_x000D_Nat. Genet. 36:1111-1116(2004) [PubMed] [Europe PMC] [Abstract]Cited for: DISRUPTION PHENOTYPE, FUNCTION.Ref.16"Linkage between elevated PDGF-C expression and myocardial fibrogenesis in coxsackievirus B3-induced chronic myocarditis."_x005F_x005F_x000D_Yang D., Qiu D._x005F_x005F_x000D_Eur. Heart J. 26:642-643(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION BY COXSACKIEVIRUS B3 INFECTION, DISEASE.Ref.22"PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis."_x005F_x005F_x000D_Eitner F., Bucher E., van Roeyen C., Kunter U., Rong S., Seikrit C., Villa L., Boor P., Fredriksson L., Backstrom G., Eriksson U., Ostman A., Floege J., Ostendorf T._x005F_x005F_x000D_J. Am. Soc. Nephrol. 19:281-289(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 12.1 pg/mL

PDGFC ELISA Kit (Mouse) (OKEH06376)
OKEH06376 96 Wells
EUR 919.2
Description: Description of target: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.85 ng/mL

PDGF-C Antibody
39250-100ul 100ul
EUR 468

Pdgfc 3'UTR GFP Stable Cell Line
TU166124 1.0 ml Ask for price

PDGFC 3'UTR GFP Stable Cell Line
TU067655 1.0 ml
EUR 1825.2

Pdgfc 3'UTR GFP Stable Cell Line
TU266013 1.0 ml Ask for price

Pdgfc sgRNA CRISPR Lentivector set (Rat)
K6990301 3 x 1.0 ug
EUR 406.8

PDGFC sgRNA CRISPR Lentivector set (Human)
K1620301 3 x 1.0 ug
EUR 406.8

Pdgfc sgRNA CRISPR Lentivector set (Mouse)
K4339001 3 x 1.0 ug
EUR 406.8

PDGFC Protein Vector (Rat) (pPM-C-HA)
PV293136 500 ng
EUR 723.6

PDGFC ELISA Kit (Rat) : 96 Wells (OKEH00499)
OKEH00499 96 Wells
EUR 794.4
Description: Description of target: Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding to receptors induces their activation by tyrosine phosphorylation. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintainance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Seems to be involved in palatogenesis.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.176 ng/mL

PDGFC Protein Vector (Rat) (pPB-C-His)
PV293134 500 ng
EUR 723.6

PDGFC Protein Vector (Rat) (pPB-N-His)
PV293135 500 ng
EUR 723.6

PDGFC Protein Vector (Rat) (pPM-C-His)
PV293137 500 ng
EUR 723.6

PDGFC Protein Vector (Human) (pPM-C-HA)
PV110296 500 ng
EUR 662.4

PDGFC Protein Vector (Mouse) (pPM-C-HA)
PV214712 500 ng
EUR 723.6