Autophagy induction and PDGFR-β knockdown by siRNA-encapsulated nanoparticles cut back chlamydia trachomatis an infection.

C. trachomatis is the commonest sexually transmitted bacterial an infection on this planet. Though the an infection could be simply managed by means of antibiotics, a number of experiences of scientific isolates which can be proof against antibiotics have prompted us to seek for different methods to handle this illness.

On this paper, we developed a nanoparticle formulation (PDGFR-β siRNA-PEI-PLGA-PEG NP) that may concurrently induce autophagy in human cells and knock down PDGFR-β gene expression, an necessary floor binding protein for C. trachomatis, as a technique to cut back vaginal an infection of C. trachomatis.

PDGFR-β siRNA-PEI-PLGA-PEG NP considerably induced autophagy in human vaginal epithelial cells (VK2/E6E7) 48 hr publish remedy by bettering autophagic degradation exercise with out inflicting irritation, apoptosis or any lower in cell viability. Beclin-1, VPS34 (markers for initiation stage of autophagy), UVRAG, TECPR-1 (markers for degradation stage of autophagy) had been discovered to be considerably upregulated after remedy with PDGFR-β siRNA-PEI-PLGA-PEG NP.

 

 

vegf-a
vegf-a

 

 

Recombinant Human PDGF-BB protein
CD01148-2ug 2ug
EUR 176
Description: Platelet-derived growth factor (PDGF) presenting in serum but absent from plasma was first discovered in animal study by Lynch and co-workers in the late 1980s. It is a disulfide-linked dimer consisting of two peptides-chain A and chain B. PDGF has three subforms: PDGF-AA, PDGF-BB, PDGF-AB. It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two receptors (PDGFR-α and PDGFR-β).

Recombinant Human PDGF-BB protein
CD01149-10ug 10ug
EUR 353
Description: Recombinant Human Platelet-Derived Growth Factor BB is produced by our E.coli expression system and the target gene encoding Ser82-Thr190 is expressed.

Recombinant Human PDGF-BB protein
CD01149-50ug 50ug
EUR 1035
Description: Recombinant Human Platelet-Derived Growth Factor BB is produced by our E.coli expression system and the target gene encoding Ser82-Thr190 is expressed.

Recombinant Human PDGF-BB Protein
E40KMP1742 20ug
EUR 495

RECOMBINANT HUMAN PDGF BB HOMODIMER
MBS232238-001mg 0.01mg
EUR 510

RECOMBINANT HUMAN PDGF BB HOMODIMER
MBS232238-5x001mg 5x0.01mg
EUR 2130

Recombinant Human PDGF-BB Protein
MBS9140264-005mg 0.05mg
EUR 500

Recombinant Human PDGF-BB Protein
MBS9140264-5x005mg 5x0.05mg
EUR 2075

Recombinant Human PDGF-BB Protein
PROTP01127-4 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Human PDGF-BB Protein
RP00834 10 μg
EUR 1137.14

Recombinant Human PDGF-BB Protein
RP01763 100μg
EUR 311.74

Human PDGF-BB Recombinant Protein
200-055 5 µg
EUR 52.5
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Human PDGF-BB Recombinant Protein
200-055S 2 µg
EUR 47.25
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Human PDGF-BB Recombinant Protein
200-056 20 µg
EUR 136.5
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB, human recombinant protein
P1047-.01 10 µg
EUR 272.8
Description: Growth Factors|PDGF

PDGF-BB, human recombinant protein
P1047-.05 50 µg
EUR 692
Description: PDGF-BB, platelet-derived growth factor, expressed in E.Coli.

PDGF-BB, human recombinant protein
P1047-.1 100ug
EUR 1300.8
Description: Growth Factors|PDGF

PDGF-BB, human recombinant protein
P1047-.5 500ug
EUR 2918.4
Description: Growth Factors|PDGF

PDGF-BB, human recombinant protein
P1047-1 1 mg
EUR 5414
Description: PDGF-BB, platelet-derived growth factor, expressed in E.Coli.

Genorise® Recombinant Human PDGF-BB
GR104258 5 µg
EUR 285

Recombinant Human PDGF-BB Protein (Active)
PKSH032906-10ug 10ug
EUR 178
Description: Human

Recombinant Human PDGF-BB Protein (Active)
PKSH032906-50ug 50ug
EUR 523
Description: Human

Human PDGF-BB Recombinant Protein Lyophilized
IHUPDGFBBRLY10UG each
EUR 535
Description: Human PDGF-BB Recombinant Protein Lyophilized

Human PDGF-BB Recombinant Protein Lyophilized
IHUPDGFBBRLY2UG each
EUR 341
Description: Human PDGF-BB Recombinant Protein Lyophilized

Human PDGF-BB Recombinant Protein Lyophilized
MBS8433107-INQUIRE INQUIRE Ask for price

Human PDGF-BB Recombinant Protein Lyophilized
MBS8433108-INQUIRE INQUIRE Ask for price

Human CellExp™ PDGF-BB, human recombinant
7276-10 each Ask for price

Platelet Derived Growth Factor BB, Recombinant, Human (PDGF-BB)
MBS650362-001mg 0.01mg
EUR 420

Platelet Derived Growth Factor BB, Recombinant, Human (PDGF-BB)
MBS650362-5x001mg 5x0.01mg
EUR 1730

Platelet Derived Growth Factor BB, Recombinant, Human (PDGF-BB)
MBS650366-0002mg 0.002mg
EUR 340

Platelet Derived Growth Factor BB, Recombinant, Human (PDGF-BB)
MBS650366-001mg 0.01mg
EUR 490

Platelet Derived Growth Factor BB, Recombinant, Human (PDGF-BB)
MBS650366-5x001mg 5x0.01mg
EUR 2055

Platelet Derived Growth Factor BB, Recombinant, Human (PDGF-BB)
MBS650457-0002mg 0.002mg
EUR 340

Platelet Derived Growth Factor BB, Recombinant, Human (PDGF-BB)
MBS650457-001mg 0.01mg
EUR 490

Platelet Derived Growth Factor BB, Recombinant, Human (PDGF-BB)
MBS650457-5x001mg 5x0.01mg
EUR 2055

Platelet Derived Growth Factor BB, Recombinant, Human (PDGF-BB)
MBS650980-001mg 0.01mg
EUR 595

Platelet Derived Growth Factor BB, Recombinant, Human (PDGF-BB)
MBS650980-5x001mg 5x0.01mg
EUR 2535

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
C199-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
AP74931 1mg
EUR 3209

Recombinant Rat PDGF-BB
P1206-.01 10ug
EUR 272.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Rat PDGF-BB
P1206-.1 100ug
EUR 1404.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Rat PDGF-BB
P1206-.5 500ug
EUR 3152.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Rat PDGF-BB
REGFP-1601 10ug Ask for price

Recombinant Human Platelet Derived Growth Factor-BB (rHu PDGF-BB)
AK8274-0100 100µg
EUR 1740

Recombinant Human Platelet Derived Growth Factor-BB (rHu PDGF-BB)
AK8274-1000 1mg
EUR 4500

PDGF-BB, murine recombinant
4489-10 each
EUR 320.4

PDGF-BB, murine recombinant
4489-1000 each
EUR 6434.4

PDGF-BB, murine recombinant
4489-50 each
EUR 874.8

Recombinant Murine PDGF-BB
MEGFP-1601 10ug Ask for price

Recombinant Human PDGF-BB Protein (His Tag)(Active)
PKSH030442-1mg 1mg
EUR 4715
Description: Human

Recombinant Human PDGF-BB Protein (His Tag)(Active)
PKSH030442-50ug 50ug
EUR 805
Description: Human

PDGF-BB Recombinant Protein
91-179 0.05 mg
EUR 821.4
Description: Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.

PDGF-BB Recombinant Protein
40-158-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-158-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-458-0002mg 0.002 mg
EUR 311.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-458-001mg 0.01 mg
EUR 437.1
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB Recombinant Protein
40-607 0.01 mg
EUR 481.2
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet a-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-a and PDGFR-β. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). .

PDGF-BB Recombinant Protein
11-380 0.05 mg
EUR 714.3
Description: PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB Protein
MBS2553100-001mg 0.01mg
EUR 220

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB Protein
MBS2553100-005mg 0.05mg
EUR 505

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB Protein
MBS2553100-5x005mg 5x0.05mg
EUR 2270

PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein
PROTP01127-2 Regular: 10ug
EUR 380.4
Description: Platelet-Derived Growth Factor BB Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.3 kDa. PDGF-BB is purified by proprietary chromatographic techniques.

Human PDGF-BB Recombinant Protein Tag Free Lyophilized
IHUPDGFBBRTFLY50UG each
EUR 851
Description: Human PDGF-BB Recombinant Protein Tag Free Lyophilized

Human PDGF-BB Recombinant Protein Tag Free Lyophilized
MBS8433109-INQUIRE INQUIRE Ask for price

PDGF-BB Platelet Derived Growth Factor-BB Human Recombinant Protein, HEK
PROTP01127-3 Regular: 10ug
EUR 380.4
Description: PDGF-BB Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight of 25kDa due to glycosylation.;The PDGF-BB is purified by proprietary chromatographic techniques.

Platelet-derived Growth Factor (PDGF-BB) human (RECOMBINANT)
GF-070-3 10ug
EUR 100

Platelet-derived Growth Factor (PDGF-BB) human (RECOMBINANT)
GF-070-5 100ug
EUR 500

Platelet-derived Growth Factor (PDGF-BB) human (RECOMBINANT)
GF-070-8 500ug
EUR 2000

Recombinant Rat PDGF-BB protein
CD00081-10ug 10ug
EUR 409
Description: Platelet-derived growth factor (PDGF) presenting in serum but absent from plasma was first discovered in animal study by Lynch and co-workers in the late 1980s. It is a disulfide-linked dimer consisting of two peptides-chain A and chain B. PDGF has three subforms: PDGF-AA, PDGF-BB, PDGF-AB. It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two receptors (PDGFR-α and PDGFR-β).

Recombinant Rat PDGF-BB protein
CD00081-2ug 2ug
EUR 176
Description: Platelet-derived growth factor (PDGF) presenting in serum but absent from plasma was first discovered in animal study by Lynch and co-workers in the late 1980s. It is a disulfide-linked dimer consisting of two peptides-chain A and chain B. PDGF has three subforms: PDGF-AA, PDGF-BB, PDGF-AB. It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two receptors (PDGFR-α and PDGFR-β).

Mouse PDGF-BB Recombinant Protein
M10-125 10 µg
EUR 196.35
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Mouse PDGF-BB Recombinant Protein
M10-125S 2 µg
EUR 92.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Murine PDGF-BB Protein
PROTP31240-1 10ug
EUR 380.4
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB, murine recombinant protein
P1048-.01 10 µg
EUR 272.8
Description: Growth Factors|PDGF

PDGF-BB, murine recombinant protein
P1048-.05 50 µg
EUR 1052.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein
P1048-.1 100ug
EUR 1171.2
Description: Growth Factors|PDGF

PDGF-BB, murine recombinant protein
P1048-.5 500ug
EUR 2627.2
Description: Growth Factors|PDGF

PDGF-BB, murine recombinant protein
P1048-1 1 mg
EUR 7826.4
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

OPSD00017-2UG - Recombinant PDGF-BB
OPSD00017-2UG 2ug
EUR 108

OPSD00144-2UG - Recombinant PDGF-BB
OPSD00144-2UG 2ug
EUR 108

Recombinant Platelet Derived Growth Factor BB (PDGF BB)
RPU50975-100ug 100ug
EUR 443.3

 

 

Recombinant Human PDGF-BB Protein

 

Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells.

The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development.

Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Moreover, PDGFR-β siRNA-PEI-PLGA-PEG NP decreased PDGFR-β mRNA expression by 50% and protein expression by 43% in VK2/E6E7 cells 48 hr publish remedy.

Remedy of cells with PDGFR-β siRNA-PEI-PLGA-PEG NP considerably decreased the intracellular C. trachomatis and extracellular launch of C. trachomatis by roughly 65% and 67%, respectively, in vitro via augmenting autophagic degradation pathways and lowering bacterial binding concurrently.

Deregulation of VEGFR-2 and PDGFR Expression and Microvascular Density in a Triple-Damaging Mannequin of Canine Malignant Mammary Tumors with Lymph Node or Lung Metastasis.

Canine mammary tumors (CMT) symbolize the commonest most cancers in noncastrated feminine canines. Apparently, triple-negative tumors are the commonest molecular subtype in feminine canines. On this examine, we proposed to judge the expression of vascular endothelial development issue receptor 2 (VEGFR-2), Platelet-derived development issue receptor (PDGFR), and microvascular density (MVD) in a bunch of metastatic and nonmetastatic triple-negative CMT and evaluate the expression primarily based on scientific parameters.
Twenty-six feminine canines with triple-negative mammary tumors had been divided into three teams: nonmetastatic tumors (NMT) (n = 11), tumors with lymph node metastasis (LNM) (n = 10), and tumors with lung metastasis (LM) (n = 5).

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB
We noticed elevated VEGFR-2 expression in LNM in contrast with NMT and a constructive correlation between tumor grade and VEGFR-2 expression. A constructive correlation was famous between VEGFR-2 and PDGFR expression.
Relating to microvascular density (MVD), we recognized the next variety of vessels in main tumors with lymph node metastasis and lung metastasis in contrast with tumors with no metastasis. The first tumors with lung metastasis exhibited an elevated MVD in contrast with carcinoma with lymph node metastasis.
Total, our outcomes counsel a deregulation of VEGFR-2 and PDGFR and excessive MVD in metastatic tumors, indicating a task for angiogenesis in tumor development.

 

 

 

PDGFC Antibody
E037811 100μg/100μl
EUR 255
Description: Available in various conjugation types.

PDGFC Antibody
E312274 200ul
EUR 275
Description: Available in various conjugation types.

PDGFC Antibody
E38PA5714 100ul
EUR 225
Description: Available in various conjugation types.

PDGFC Antibody
MBS7129481-005mL 0.05mL
EUR 190

PDGFC Antibody
MBS7129481-01mL 0.1mL
EUR 270

PDGFC Antibody
MBS7129481-5x01mL 5x0.1mL
EUR 1205

PDGFC Antibody
MBS7129482-005mL 0.05mL
EUR 190

PDGFC Antibody
MBS7129482-01mL 0.1mL
EUR 270

PDGFC Antibody
MBS7129482-5x01mL 5x0.1mL
EUR 1205

PDGFC Antibody
MBS7122903-005mg 0.05mg
EUR 150

PDGFC Antibody
MBS7122903-01mg 0.1mg
EUR 190

PDGFC Antibody
MBS7122903-5x01mg 5x0.1mg
EUR 845

PDGFC Antibody
MBS9631330-01mL 0.1mL
EUR 260

PDGFC Antibody
MBS9631330-02mL 0.2mL
EUR 305

PDGFC Antibody
MBS9631330-5x02mL 5x0.2mL
EUR 1220

PDGFC Antibody
MBS9633713-1mg 1mg
EUR 375

PDGFC Antibody
MBS9633713-5x1mg 5x1mg
EUR 1545

PDGFC Antibody
MBS8583407-01mL 0.1mL
EUR 305

PDGFC Antibody
MBS8583407-01mLAF405L 0.1mL(AF405L)
EUR 465

PDGFC Antibody
MBS8583407-01mLAF405S 0.1mL(AF405S)
EUR 465

PDGFC Antibody
MBS8583407-01mLAF610 0.1mL(AF610)
EUR 465

PDGFC Antibody
MBS8583407-01mLAF635 0.1mL(AF635)
EUR 465

PDGFC Antibody
MBS9403509-01mL 0.1mL
EUR 305

PDGFC Antibody
MBS9403509-5x01mL 5x0.1mL
EUR 1230

PDGFC Antibody (N-term)
MBS9206841-008mL 0.08mL
EUR 210

PDGFC Antibody (N-term)
MBS9206841-04mL 0.4mL
EUR 430

PDGFC Antibody (N-term)
MBS9206841-5x04mL 5x0.4mL
EUR 1910

PDGFC Antibody - middle region
MBS3223288-01mL 0.1mL
EUR 455

PDGFC Antibody - middle region
MBS3223288-5x01mL 5x0.1mL
EUR 1995

OACD06377-1ML - PDGFC Antibody
OACD06377-1ML 1ml
EUR 649

OACD06377-100UL - PDGFC Antibody
OACD06377-100UL 100ul
EUR 199

PDGFC Polyclonal Antibody
E-AB-91057-120uL 120uL
EUR 320
Description: Unconjugated

PDGFC Polyclonal Antibody
E-AB-91057-200uL 200uL
EUR 530
Description: Unconjugated

PDGFC Polyclonal Antibody
E-AB-91057-60uL 60uL
EUR 200
Description: Unconjugated

PDGFC Polyclonal Antibody
E-AB-91057-each each Ask for price
Description: Unconjugated

PDGFC Polyclonal Antibody
E-AB-13501-120uL 120uL
EUR 240
Description: Unconjugated

PDGFC Polyclonal Antibody
E-AB-13501-200uL 200uL
EUR 399
Description: Unconjugated

PDGFC Polyclonal Antibody
E-AB-13501-20uL 20uL
EUR 73
Description: Unconjugated

PDGFC Polyclonal Antibody
E-AB-13501-60uL 60uL
EUR 143
Description: Unconjugated

PDGFC Polyclonal Antibody
E-AB-16697-120uL 120uL
EUR 240
Description: Unconjugated

PDGFC Polyclonal Antibody
E-AB-16697-200uL 200uL
EUR 399
Description: Unconjugated

PDGFC Polyclonal Antibody
E-AB-16697-20uL 20uL
EUR 73
Description: Unconjugated

PDGFC Polyclonal Antibody
E-AB-16697-60uL 60uL
EUR 143
Description: Unconjugated

PDGFC Conjugated Antibody
C37811 100ul
EUR 476.4

PDGFC polyclonal antibody
BS76161 50ul
EUR 358
Description: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

PDGFC Polyclonal Antibody
E915174 100ul
EUR 225
Description: Available in various conjugation types.

PDGFC Polyclonal Antibody
MBS2518203-002mL 0.02mL
EUR 135

PDGFC Polyclonal Antibody
MBS2518203-006mL 0.06mL
EUR 190

PDGFC Polyclonal Antibody
MBS2518203-012mL 0.12mL
EUR 265

PDGFC Polyclonal Antibody
MBS2518203-02mL 0.2mL
EUR 415

PDGFC Polyclonal Antibody
MBS2518203-5x02mL 5x0.2mL
EUR 1835

PDGFC Polyclonal Antibody
MBS2529439-002mL 0.02mL
EUR 135

PDGFC Polyclonal Antibody
MBS2529439-006mL 0.06mL
EUR 190

PDGFC Polyclonal Antibody
MBS2529439-012mL 0.12mL
EUR 265

PDGFC Polyclonal Antibody
MBS2529439-02mL 0.2mL
EUR 415

PDGFC Polyclonal Antibody
MBS2529439-5x02mL 5x0.2mL
EUR 1835

PDGFC Polyclonal Antibody
MBS9135160-002mL 0.02mL
EUR 200

PDGFC Polyclonal Antibody
MBS9135160-005mL 0.05mL
EUR 255

PDGFC Polyclonal Antibody
MBS9135160-01mL 0.1mL
EUR 345

PDGFC Polyclonal Antibody
MBS9135160-02mL 0.2mL
EUR 545

PDGFC Polyclonal Antibody
MBS9135160-5x02mL 5x0.2mL
EUR 2265

PDGFC Polyclonal Antibody
MBS8569859-01mL 0.1mL
EUR 305

PDGFC Polyclonal Antibody
MBS8569859-01mLAF405L 0.1mL(AF405L)
EUR 565

PDGFC Polyclonal Antibody
MBS8569859-01mLAF405S 0.1mL(AF405S)
EUR 565

PDGFC Polyclonal Antibody
MBS8569859-01mLAF610 0.1mL(AF610)
EUR 565

PDGFC Polyclonal Antibody
MBS8569859-01mLAF635 0.1mL(AF635)
EUR 565

PDGFC Conjugated Antibody
MBS9448249-01mLAF350 0.1mL(AF350)
EUR 480

PDGFC Conjugated Antibody
MBS9448249-01mLAF405 0.1mL(AF405)
EUR 480

PDGFC Conjugated Antibody
MBS9448249-01mLAF488 0.1mL(AF488)
EUR 480

PDGFC Conjugated Antibody
MBS9448249-01mLAF555 0.1mL(AF555)
EUR 480

PDGFC Conjugated Antibody
MBS9448249-01mLBiotin 0.1mL(Biotin)
EUR 480

PDGFC Polyclonal Antibody
RD79220A-120uL 120μL
EUR 360
Description: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

PDGFC Polyclonal Antibody
RD79220A-200uL 200μL
EUR 630
Description: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

PDGFC Polyclonal Antibody
RD79220A-20uL 20μL
EUR 109.5
Description: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

PDGFC Polyclonal Antibody
RD79220A-60uL 60μL
EUR 214.5
Description: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

PDGFC Polyclonal Antibody
RD77033A-120uL 120μL
EUR 360
Description: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

PDGFC Polyclonal Antibody
RD77033A-200uL 200μL
EUR 630
Description: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

PDGFC Polyclonal Antibody
RD77033A-20uL 20μL
EUR 109.5
Description: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

PDGFC Polyclonal Antibody
RD77033A-60uL 60μL
EUR 214.5
Description: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

Pdgfc Antibody - N-terminal region
MBS3215346-01mL 0.1mL
EUR 455

Pdgfc Antibody - N-terminal region
MBS3215346-5x01mL 5x0.1mL
EUR 1995

PDGFC Antibody - C-terminal region
MBS3215347-01mL 0.1mL
EUR 455

PDGFC Antibody - C-terminal region
MBS3215347-5x01mL 5x0.1mL
EUR 1995

PDGFC Antibody - N-terminal region
MBS3221869-01mL 0.1mL
EUR 455