Autophagy induction and PDGFR-β knockdown by siRNA-encapsulated nanoparticles cut back chlamydia trachomatis an infection.

C. trachomatis is the commonest sexually transmitted bacterial an infection on this planet. Though the an infection could be simply managed by means of antibiotics, a number of experiences of scientific isolates which can be proof against antibiotics have prompted us to seek for different methods to handle this illness.

On this paper, we developed a nanoparticle formulation (PDGFR-β siRNA-PEI-PLGA-PEG NP) that may concurrently induce autophagy in human cells and knock down PDGFR-β gene expression, an necessary floor binding protein for C. trachomatis, as a technique to cut back vaginal an infection of C. trachomatis.

PDGFR-β siRNA-PEI-PLGA-PEG NP considerably induced autophagy in human vaginal epithelial cells (VK2/E6E7) 48 hr publish remedy by bettering autophagic degradation exercise with out inflicting irritation, apoptosis or any lower in cell viability. Beclin-1, VPS34 (markers for initiation stage of autophagy), UVRAG, TECPR-1 (markers for degradation stage of autophagy) had been discovered to be considerably upregulated after remedy with PDGFR-β siRNA-PEI-PLGA-PEG NP.

 

 

vegf-a
vegf-a

 

 

PDGF-BB, murine recombinant

4489-1000
EUR 5362

PDGF-BB, murine recombinant

4489-50
EUR 729

Recombinant Human PDGF-BB Protein

PROTP01127-4 10ug
EUR 317
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Recombinant Human PDGF-BB Protein

RP00834 10 μg
EUR 221

PDGF-BB, human recombinant protein

P1047-.01 10 µg
EUR 313
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein

P1047-.05 50 µg
EUR 877
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, human recombinant protein

P1047-1 1 mg
EUR 6522
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB/ Rat PDGF- BB ELISA Kit

ELA-E0633r 96 Tests
EUR 886

Human CellExp? PDGF-BB, human recombinant

7276-10
EUR 419

Human PDGF-BB Protein

abx060208-100ug 100 ug
EUR 523

Human PDGF-BB Protein

abx060258-100ug 100 ug
EUR 523

rec PDGF BB (human)

H-7530.0002 2.0µg
EUR 162

rec PDGF BB (human)

H-7530.0010 10.0µg
EUR 381

Recombinant Murine PDGF-BB Protein

PROTP31240-1 10ug
EUR 317
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

PDGF-BB, murine recombinant protein

P1048-.01 10 µg
EUR 313
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein

P1048-.05 50 µg
EUR 877
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF-BB, murine recombinant protein

P1048-1 1 mg
EUR 6522
Description: The platelet-derived growth factor BB (PDGF-BB) is a member of the PDGF family and is a disulfide-linked homodimer. PDGF family consists of proteins PDGF-A, -B that form three disulfide-linked homodimers (PDGF-AA, -BB and -AB).

PDGF BB antibody

70R-PR020 50 ug
EUR 273
Description: Affinity purified Rabbit polyclonal PDGF BB antibody

rHu PDGF-BB

AK8292-0002 2µg Ask for price

rHu PDGF-BB

AK8292-0010 10µg Ask for price

rHu PDGF-BB

AK8292-0100 100µg Ask for price

rHu PDGF-BB

AK8292-1000 1mg Ask for price

anti-PDGF BB

YF-PA13686 50 ug
EUR 363
Description: Mouse polyclonal to PDGF BB

anti-PDGF BB

YF-PA24331 50 ul
EUR 334
Description: Mouse polyclonal to PDGF BB

PDGF BB protein

30R-2611 10 ug
EUR 359
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein

30R-2612 10 ug
EUR 302
Description: Purified recombinant Mouse PDGF BB protein

PDGF BB protein

30R-AP004 2 ug
EUR 133
Description: Purified recombinant Human PDGF BB protein

PDGF BB protein

30R-AP051 10 ug
EUR 273
Description: Purified recombinant Human PDGF BB protein

PDGF-BB Antibody

5488-200
EUR 316

PDGF-BB Antibody

5488-30T
EUR 146

PDGF-BB Antibody

5489-100
EUR 316

PDGF-BB Antibody

5489-30T
EUR 146

PDGF-BB, Mouse

HY-P7087 100ug
EUR 946

PDGF-BB, Rat

HY-P7278 50ug
EUR 383

PDGF-BB, CF

PR15026CF 50 ug
EUR 1087

PDGF-BB, CF

PR15027CF 50 ug
EUR 396

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-10ug 10ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

C199-50ug 50ug
EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein

PROTP01127-2 Regular: 10ug
EUR 317
Description: Platelet-Derived Growth Factor BB Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.3 kDa. PDGF-BB is purified by proprietary chromatographic techniques.

PDGF-BB ELISA KIT|Human

EF000205 96 Tests
EUR 689

PDGF-BB (P.pastoris-expressed), Human

HY-P7055A 10ug
EUR 268

Human PDGF-BB ELISA Kit

EHP0050 96Tests
EUR 521

Human PDGF-BB ELISA Kit

EHP0634 96Tests
EUR 521

Human PDGF-BB ELISA Kit

RK04112 96 Tests
EUR 521

Polyclonal PDGF-BB Antibody

APR08990G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

Polyclonal PDGF-BB Antibody

APR00412G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PDGF-BB . This antibody is tested and proven to work in the following applications:

PDGF-BB Platelet Derived Growth Factor-BB Human Recombinant Protein, HEK

PROTP01127-3 Regular: 10ug
EUR 317
Description: PDGF-BB Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight of 25kDa due to glycosylation.;The PDGF-BB is purified by proprietary chromatographic techniques.

PDGF-BB Platelet-Derived Growth Factor BB Mouse Recombinant Protein

PROTP31240 Regular: 10ug
EUR 317
Description: Platelet-Derived Growth Factor BB Mouse Recombinant produced in E.coli, is a homodimeric, non-glycosylated, polypeptide chain containing 2x110 (total of 2 chains 220aa) amino acids and having a total molecular weight of 24.7 kDa.;PDGF-BB is purified by proprietary chromatographic techniques.

PDGF-BB Platelet-Derived Growth Factor BB Rat Recombinant Protein

PROTQ05028 Regular: 10ug
EUR 317
Description: PDGF-BB Rat Recombinant produced in E.coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide of two B chains containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.4 kDa.;The PDGF-BB is purified by proprietary chromatographic techniques.

Human PDGF-BB PicoKine ELISA Kit

EK0956 96 wells
EUR 425
Description: For quantitative detection of human PDGF-BB in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

rHu PDGF-BB (yeast) (cGMP)

AK8274-1000 1mg Ask for price

Sheep PDGF-BB ELISA Kit

ESP0050 96Tests
EUR 521

Rabbit PDGF-BB ELISA Kit

ERTP0634 96Tests
EUR 521

Monkey PDGF-BB ELISA Kit

EMKP0050 96Tests
EUR 521

Mouse PDGF-BB ELISA Kit

EMP0050 96Tests
EUR 521

Mouse PDGF-BB ELISA Kit

EMP0634 96Tests
EUR 521

Porcine PDGF-BB ELISA Kit

EPP0050 96Tests
EUR 521

Porcine PDGF-BB ELISA Kit

EPP0634 96Tests
EUR 521

Rat PDGF-BB ELISA Kit

ERP0050 96Tests
EUR 521

Rat PDGF-BB ELISA Kit

ERP0634 96Tests
EUR 521

Rabbit PDGF-BB ELISA Kit

ERTP0050 96Tests
EUR 521

Bovine PDGF-BB ELISA Kit

EBP0634 96Tests
EUR 521

Chicken PDGF-BB ELISA Kit

ECKP0050 96Tests
EUR 521

Canine PDGF-BB ELISA Kit

ECP0050 96Tests
EUR 521

Canine PDGF-BB ELISA Kit

ECP0634 96Tests
EUR 521

Anserini PDGF-BB ELISA Kit

EAP0634 96Tests
EUR 521

Bovine PDGF-BB ELISA Kit

EBP0050 96Tests
EUR 521

Goat PDGF-BB ELISA Kit

EGTP0050 96Tests
EUR 521

Goat PDGF-BB ELISA Kit

EGTP0634 96Tests
EUR 521

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

CN-03344H1 96T
EUR 457

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

CN-03344H2 48T
EUR 306

Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit

CSB-E08923h-24T 1 plate of 24 wells
EUR 165
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Platelet-Derived Growth Factor-BB, PDGF-BB ELISA kit

1-CSB-E08923h
  • EUR 900.00
  • EUR 5476.00
  • EUR 2900.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor-BB, PDGF-BB in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit

GA-E0112HM-48T 48T
EUR 289

Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit

GA-E0112HM-96T 96T
EUR 466

Human Platelet-Derived Growth Factor-BB,PDGF-BB ELISA kit

201-12-0073 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Platelet Derived Growth Factor-BB (PDGF-BB) CLIA Kit

abx197499-96tests 96 tests
EUR 825

Human PDGF-BB(Platelet Derived Growth Factor-BB) ELISA Kit

EH0254 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human Platelet-Derived Growth Factor-BB(PDGF-BB)ELISA Kit

QY-E00600 96T
EUR 361

Recombinant Rat PDGF BB Protein, Untagged, E.coli-10ug

QP10805-10ug 10ug
EUR 201

Recombinant Rat PDGF BB Protein, Untagged, E.coli-1mg

QP10805-1mg 1mg
EUR 3573

Recombinant Rat PDGF BB Protein, Untagged, E.coli-2ug

QP10805-2ug 2ug
EUR 155

 

 

Recombinant Human PDGF-BB Protein

 

Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells.

The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development.

Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Moreover, PDGFR-β siRNA-PEI-PLGA-PEG NP decreased PDGFR-β mRNA expression by 50% and protein expression by 43% in VK2/E6E7 cells 48 hr publish remedy.

Remedy of cells with PDGFR-β siRNA-PEI-PLGA-PEG NP considerably decreased the intracellular C. trachomatis and extracellular launch of C. trachomatis by roughly 65% and 67%, respectively, in vitro via augmenting autophagic degradation pathways and lowering bacterial binding concurrently.

Deregulation of VEGFR-2 and PDGFR Expression and Microvascular Density in a Triple-Damaging Mannequin of Canine Malignant Mammary Tumors with Lymph Node or Lung Metastasis.

Canine mammary tumors (CMT) symbolize the commonest most cancers in noncastrated feminine canines. Apparently, triple-negative tumors are the commonest molecular subtype in feminine canines. On this examine, we proposed to judge the expression of vascular endothelial development issue receptor 2 (VEGFR-2), Platelet-derived development issue receptor (PDGFR), and microvascular density (MVD) in a bunch of metastatic and nonmetastatic triple-negative CMT and evaluate the expression primarily based on scientific parameters.
Twenty-six feminine canines with triple-negative mammary tumors had been divided into three teams: nonmetastatic tumors (NMT) (n = 11), tumors with lymph node metastasis (LNM) (n = 10), and tumors with lung metastasis (LM) (n = 5).

Recombinant Human Platelet-Derived Growth Factor BB/PDGF-BB

We noticed elevated VEGFR-2 expression in LNM in contrast with NMT and a constructive correlation between tumor grade and VEGFR-2 expression. A constructive correlation was famous between VEGFR-2 and PDGFR expression.
Relating to microvascular density (MVD), we recognized the next variety of vessels in main tumors with lymph node metastasis and lung metastasis in contrast with tumors with no metastasis. The first tumors with lung metastasis exhibited an elevated MVD in contrast with carcinoma with lymph node metastasis.
Total, our outcomes counsel a deregulation of VEGFR-2 and PDGFR and excessive MVD in metastatic tumors, indicating a task for angiogenesis in tumor development.

 

 

 

Mouse Platelet Derived Growth Factor C (PDGFC) ELISA Kit

RD-PDGFC-Mu-48Tests 48 Tests
EUR 472

Mouse Platelet Derived Growth Factor C (PDGFC) ELISA Kit

RD-PDGFC-Mu-96Tests 96 Tests
EUR 653

Human Platelet Derived Growth Factor C (PDGFC) ELISA Kit

DLR-PDGFC-Hu-48T 48T
EUR 463
Description: A sandwich quantitative ELISA assay kit for detection of Human Platelet Derived Growth Factor C (PDGFC) in samples from plasma.

Human Platelet Derived Growth Factor C (PDGFC) ELISA Kit

DLR-PDGFC-Hu-96T 96T
EUR 599
Description: A sandwich quantitative ELISA assay kit for detection of Human Platelet Derived Growth Factor C (PDGFC) in samples from plasma.

Mouse Platelet Derived Growth Factor C (PDGFC) ELISA Kit

DLR-PDGFC-Mu-48T 48T
EUR 474
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Platelet Derived Growth Factor C (PDGFC) in samples from plasma.

Mouse Platelet Derived Growth Factor C (PDGFC) ELISA Kit

DLR-PDGFC-Mu-96T 96T
EUR 614
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Platelet Derived Growth Factor C (PDGFC) in samples from plasma.

PDGFC Antibody

1-CSB-PA108491
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PDGFC. Recognizes PDGFC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

PDGFC Antibody

1-CSB-PA146607
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PDGFC. Recognizes PDGFC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

PDGFC Antibody

1-CSB-PA243546
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PDGFC. Recognizes PDGFC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000

PDGFC Antibody

37811-100ul 100ul
EUR 252

PDGFC Conjugated Antibody

C37811 100ul
EUR 397

PDGFC siRNA

20-abx928112
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

PDGFC siRNA

20-abx928113
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

PDGFC siRNA

20-abx903903
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

PDGFC Rabbit pAb

A15174-100ul 100 ul
EUR 308

PDGFC Rabbit pAb

A15174-200ul 200 ul
EUR 459

PDGFC Rabbit pAb

A15174-20ul 20 ul
EUR 183

PDGFC Rabbit pAb

A15174-50ul 50 ul
EUR 223

Human PDGFC ELISA Kit

ELA-E0528h 96 Tests
EUR 824

PDGFC ELISA KIT|Human

EF000342 96 Tests
EUR 689

Sheep PDGFC ELISA Kit

ESP0081 96Tests
EUR 521

Monkey PDGFC ELISA Kit

EMKP0081 96Tests
EUR 521

Mouse PDGFC ELISA Kit

EMP0081 96Tests
EUR 521

Porcine PDGFC ELISA Kit

EPP0081 96Tests
EUR 521

Rat PDGFC ELISA Kit

ERP0081 96Tests
EUR 521

Rabbit PDGFC ELISA Kit

ERTP0081 96Tests
EUR 521

Mouse PDGFC shRNA Plasmid

20-abx974532
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Rat PDGFC shRNA Plasmid

20-abx986548
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Bovine PDGFC ELISA Kit

EBP0081 96Tests
EUR 521

Chicken PDGFC ELISA Kit

ECKP0081 96Tests
EUR 521

Canine PDGFC ELISA Kit

ECP0081 96Tests
EUR 521

Human PDGFC ELISA Kit

EHP0081 96Tests
EUR 521

Anserini PDGFC ELISA Kit

EAP0081 96Tests
EUR 521

Goat PDGFC ELISA Kit

EGTP0081 96Tests
EUR 521

Human PDGFC shRNA Plasmid

20-abx961041
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Platelet Derived Growth Factor C (PDGFC) Antibody

20-abx131438
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Platelet Derived Growth Factor C (PDGFC) Antibody

20-abx103486
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Platelet Derived Growth Factor C (PDGFC) Antibody

20-abx103487
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Platelet Derived Growth Factor C (PDGFC) Antibody

20-abx241696
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Platelet Derived Growth Factor C (PDGFC) Antibody

20-abx241697
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Platelet Derived Growth Factor C (PDGFC) Antibody

20-abx178044
  • EUR 1302.00
  • EUR 620.00
  • 1 mg
  • 200 ug

Platelet Derived Growth Factor C (PDGFC) Antibody

20-abx174096
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Platelet Derived Growth Factor C (PDGFC) Antibody

20-abx174097
  • EUR 913.00
  • EUR 467.00
  • 1 mg
  • 200 ug

Platelet Derived Growth Factor C (PDGFC) Antibody

20-abx326887
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Pdgfc ORF Vector (Rat) (pORF)

ORF073284 1.0 ug DNA
EUR 506

PDGFC ORF Vector (Human) (pORF)

ORF027574 1.0 ug DNA
EUR 405

Pdgfc ORF Vector (Mouse) (pORF)

ORF053678 1.0 ug DNA
EUR 506

Guinea Pig PDGFC ELISA Kit

EGP0081 96Tests
EUR 521

PDGFC ELISA Kit (Mouse) (OKCD00764)

OKCD00764 96 Wells
EUR 857
Description: Description of target: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.8 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.6"PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor."_x005F_x005F_x000D_Li X., Ponten A., Aase K., Karlsson L., Abramsson A., Uutela M., Backstrom G., Hellstrom M., Bostrom H., Li H., Soriano P., Betsholtz C., Heldin C.H., Alitalo K., Ostman A., Eriksson U._x005F_x005F_x000D_Nat. Cell Biol. 2:302-309(2000) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, DEVELOPMENTAL STAGE.Ref.7"Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."_x005F_x005F_x000D_Gilbertson D.G., Duff M.E., West J.W., Kelly J.D., Sheppard P.O., Hofstrand P.D., Gao Z., Shoemaker K., Bukowski T.R., Moore M., Feldhaus A.L., Humes J.M., Palmer T.E., Hart C.E._x005F_x005F_x000D_J. Biol. Chem. 276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY.Ref.10"Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy."_x005F_x005F_x000D_Ponten A., Li X., Thoren P., Aase K., Sjoblom T., Ostman A., Eriksson U._x005F_x005F_x000D_Am. J. Pathol. 163:673-682(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.11"Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis."_x005F_x005F_x000D_Zhuo Y., Zhang J., Laboy M., Lasky J.A._x005F_x005F_x000D_Am. J. Physiol. 286:L182-L188(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION BY BLEOMYCIN.Ref.14"Tissue plasminogen activator is a potent activator of PDGF-CC."_x005F_x005F_x000D_Fredriksson L., Li H., Fieber C., Li X., Eriksson U._x005F_x005F_x000D_EMBO J. 23:3793-3802(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, ACTIVATION BY PROTEOLYTIC CLEAVAGE.Ref.15"A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling."_x005F_x005F_x000D_Ding H., Wu X., Bostrom H., Kim I., Wong N., Tsoi B., O'Rourke M., Koh G.Y., Soriano P., Betsholtz C., Hart T.C., Marazita M.L., Field L.L., Tam P.P., Nagy A._x005F_x005F_x000D_Nat. Genet. 36:1111-1116(2004) [PubMed] [Europe PMC] [Abstract]Cited for: DISRUPTION PHENOTYPE, FUNCTION.Ref.16"Linkage between elevated PDGF-C expression and myocardial fibrogenesis in coxsackievirus B3-induced chronic myocarditis."_x005F_x005F_x000D_Yang D., Qiu D._x005F_x005F_x000D_Eur. Heart J. 26:642-643(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION BY COXSACKIEVIRUS B3 INFECTION, DISEASE.Ref.22"PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis."_x005F_x005F_x000D_Eitner F., Bucher E., van Roeyen C., Kunter U., Rong S., Seikrit C., Villa L., Boor P., Fredriksson L., Backstrom G., Eriksson U., Ostman A., Floege J., Ostendorf T._x005F_x005F_x000D_J. Am. Soc. Nephrol. 19:281-289(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 12.1 pg/mL

Pdgfc ELISA Kit (Mouse) (OKBB01268)

OKBB01268 96 Wells
EUR 505
Description: Description of target: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. It is mapped to 3; 3 E3. Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

Pdgfc ELISA Kit (Rat) (OKBB01269)

OKBB01269 96 Wells
EUR 505
Description: Description of target: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. It is mapped to 2q33-q34. Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation. ;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

PDGFC ELISA Kit (Human) (OKCD08309)

OKCD08309 96 Wells
EUR 975
Description: Description of target: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 43pg/mL

PDGFC ELISA Kit (Rat) (OKCD08310)

OKCD08310 96 Wells
EUR 1053
Description: Description of target: expressed in the embryonic spinal cord floor plate and ventricular zone, adult expression is localized to motoneurons in several regions of the brain.;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: < 0.128ng/mL

PDGFC ELISA Kit (Human) (OKAN04684)

OKAN04684 96 Wells
EUR 792
Description: Description of target: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 43 pg/mL

PDGFC ELISA Kit (Mouse) (OKAN05945)

OKAN05945 96 Wells
EUR 792
Description: Description of target: ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 12.1 pg/mL

PDGFC ELISA Kit (Mouse) (OKEH06376)

OKEH06376 96 Wells
EUR 766
Description: Description of target: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.85 ng/mL

Platelet-derived growth factor C (PDGFC) polyclonal antibody

ABP-PAB-10942 100 ug Ask for price

Pdgfc sgRNA CRISPR Lentivector set (Rat)

K6990301 3 x 1.0 ug
EUR 339

Pdgfc sgRNA CRISPR Lentivector set (Mouse)

K4339001 3 x 1.0 ug
EUR 339

PDGFC sgRNA CRISPR Lentivector set (Human)

K1620301 3 x 1.0 ug
EUR 339

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse)

4-PAC920Mu02
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC)

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Human)

4-PAC920Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor C (PDGFC)

Platelet Derived Growth Factor C (PDGFC) Polyclonal Antibody (Mouse)

4-PAC920Mu01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Platelet Derived Growth Factor C (PDGFC)

PDGFC 3'UTR Luciferase Stable Cell Line

TU017655 1.0 ml
EUR 1521

Pdgfc 3'UTR Luciferase Stable Cell Line

TU116124 1.0 ml Ask for price

Pdgfc 3'UTR GFP Stable Cell Line

TU166124 1.0 ml Ask for price

Pdgfc 3'UTR Luciferase Stable Cell Line

TU216013 1.0 ml Ask for price

Pdgfc 3'UTR GFP Stable Cell Line

TU266013 1.0 ml Ask for price

PDGFC 3'UTR GFP Stable Cell Line

TU067655 1.0 ml
EUR 1521

PDGFC Protein Vector (Human) (pPB-C-His)

PV110294 500 ng
EUR 552

PDGFC Protein Vector (Human) (pPB-N-His)

PV110295 500 ng
EUR 552

PDGFC Protein Vector (Human) (pPM-C-HA)

PV110296 500 ng
EUR 552

PDGFC Protein Vector (Human) (pPM-C-His)

PV110297 500 ng
EUR 552

PDGFC Protein Vector (Rat) (pPB-C-His)

PV293134 500 ng
EUR 603

PDGFC Protein Vector (Rat) (pPB-N-His)

PV293135 500 ng
EUR 603

PDGFC Protein Vector (Rat) (pPM-C-HA)

PV293136 500 ng
EUR 603

PDGFC Protein Vector (Rat) (pPM-C-His)

PV293137 500 ng
EUR 603

PDGFC Protein Vector (Mouse) (pPB-C-His)

PV214710 500 ng
EUR 603

PDGFC Protein Vector (Mouse) (pPB-N-His)

PV214711 500 ng
EUR 603

PDGFC Protein Vector (Mouse) (pPM-C-HA)

PV214712 500 ng
EUR 603

PDGFC Protein Vector (Mouse) (pPM-C-His)

PV214713 500 ng
EUR 603